Publication for Hnf4a and Hnf1b

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Hnf4a	hepatic nuclear factor 4, alpha	15378			[link]
mmu	Hnf1b	HNF1 homeobox B	21410

Pubmed ID	Priority	Text
31690008	0.99	HNF1B, HNF4A, MAFA, MNX-1, NKX2.2, NKX6.1, PAX4, PAX6 and PDX-1).
	0.98	Hnf1b, Hnf4a, MafA, Mnx-1, Nkx2.2, Nkx6.1, Pax4, Pax6 and Pdx-1).
26081571	0.98	Hnf4a, Hnf6 (Onecut1) and Hnf1b, and mutants develop hypoplastic cystic livers.
	0.98	HNF1beta, HNF1alpha, HNF4alpha, HNF6 and NR5A2.
	0.98	Hnf4a) or cholangiocyte (Hnf6, Hnf1b, Sox9) fate.
	0.95	HNF1beta+, HNF4alpha+, PDX1- hepatoblasts.
	0.94	HNF1beta+) and hepatocytes (PROX1+, HNF4alpha+).
22388089	0.98	Hnf4alpha and Hnf1alpha whilst promoting the expression of biliary genes Hnf1beta and Hnf6, suggesting that in vitro macrophage derived Wnt is important in the maintenance of hepatocyte phenotype and the suppression of biliary differentiation (Fig 5c).
	0.98	Hnf4alpha and Hnf1alpha whilst inducing the expression of Hes1, as well as the biliary genes Hnf1beta and Hnf6 indicating that in the absence of macrophages, mHPCs form bile ducts as a default lineage pathway and exit from this fate occurs in a Wnt dependent manner (Supplementary Fig 6b).
	0.94	Hnf1beta, Hnf6 and Hnf4alpha versus controls (Supplementary Fig 1b).
	0.89	Hnf1beta positive mHPCs (Fig 6c) and a reduction in the number Hnf4alpha positive mHPCs (Fig 6c).
26448099	0.98	HNF1beta, cytokeratin 19 [CK19]) and hepatocyte (HNF4alpha, albumin) transcriptional differentiation markers (Fig. 2D).
	0.97	HNF1beta, CK19) and hepatocyte (HNF4alpha, albumin) lineages between day 7 and day 14, in a similar fashion to that observed in the EpCAM+ oval cell differentiation assay (Fig. 2D).
	0.97	HNF1beta, CK19) and hepatocyte (HNF4alpha, albumin) lineage differentiation markers in vitro.
	0.94	HNF1beta) and hepatocyte-specific (HNF4alpha, albumin) transcripts (C).
18611952	0.98	HNF1beta, HNF4alpha, Foxa1, Foxa2, HNF6, C/EBPgamma, COUP-TFII, LRH1, USF1, PXR, FXRalpha and GATA6.
	0.93	HNF4alpha, HNF6, Hes1, Fgf1, Vtn) and an increase in expression of one:HNF1beta.
	0.84	HNF4alpha, HNF6) and novel (HNF1beta, Hes1, Fgf1, Vtn, Cited2, Gtl3) targets, following Foxa2 knockdown.
26520657	0.98	HNF1beta was found to be regulated by microRNA-802 with an effect on glucose homeostasis and insulin sensitivity, further supporting the notion that HNF4alpha level is regulated to tune metabolism.
	0.96	HNF1beta and HNF4alpha) where found to result in maturity onset diabetes of the young (MODY).
	0.86	HNF1beta and HNF4alpha)
28404920	0.98	Hnf4alpha, E-cadherin, and Hnf1beta, but not c-Met, was significantly increased upon the removal of SV40 T antigen (Figure 6).
	0.97	Hnf4alpha, c-Met, E-cadherin and Hnf1beta, and found that Wnt9b, Wnt10a and Wnt10a effectively induced the expression of most if not all of these regulator and marker genes (Figure 5B).
	0.97	Hnf4alpha, c-Met, E-cadherin and Hnf1beta (Figure 5B).
30696889	0.98	HNF4A and HNF1B were reported as the master regulatory TFs for induction of CDH16.
	0.96	HNF4A and HNF1B were implicated in nephrogenesis based on in silico mouse and xenopus expression arrays.
	0.92	HNF4A, HNF1B, and HNF1A, and found that only HNF1A, but not HNF4A or HNF1B, upregulated the CDH16 mRNA level by Day 5 (Supplementary Fig. 1f).
23236509	0.98	Hnf1beta, Hnf4alpha, Insm1, Sox9, Pdx1, and Mafa, which were all reduced by at least 1.6-fold (Figure 8H).
	0.96	Hnf4alpha (MODY1), Hnf1alpha (MODY3), Pdx1 (MODY4), Hnf1beta (MODY5) and Neurod1 (MODY6).
24462361	0.98	HNF1B, HNF3B and HNF4A), hepatic progenitor marker protein (AFP and CK19), liver-associated enzyme (G6P and TAT), transcription factor of fetal liver (GATA4) and epithelial marker (EpCAM) is found in MSCs cultured in ALS and the expression level is significantly higher than in 2D culture (Fig. 4).
	0.93	hepatocyte nuclear factor 1 beta (HNF1B), hepatocyte nuclear factor 3 beta (HNF3B), hepatocyte nuclear factor 4 alpha (HNF4A), alpha-fetoprotein (AFP), cytokeratin-19 (CK19), glucose-6-phosphatase (G6P), tyrosine aminotransferase (TAT), GATA binding protein 4 (GATA4), and epithelial cell adhesion molecule (EpCAM) were examined and found the gene expression levels of differentiating MSCs within the ALS after four weeks of hepatic induction were significantly higher than the those after four weeks of hepatic induction that were in culture dish (Fig. 4).
27358050	0.98	HNF1beta, FOXA2, HNF4alpha, HNF6 and LRH-1 specify hepatocytes.
	0.98	Hnf1beta, Hnf4alpha, Foxa2, Hnf6 and Nr5a2 regulate the expression levels of each other and various hepatic genes.
28217257	0.98	HNF4alpha C/EBPalpha mir-802 HNF1beta pathway might play a role in controlling cell-specific expression of HNF1beta and liver morphogenesis during liver development.
	0.97	Hnf1beta is a direct target of mir-802, and Hnf1beta is overexpressed in adult Hnf4alpha-LivKO mouse livers.
31098302	0.98	HNF4alpha and HNF1beta were expressed and significantly down-regulated at the mRNA level in the transgenic placentas from mice treated with aspirin.
	0.96	Hnf4alpha mRNA abundance was decreased by 3.15 fold in the transgenic placentas of aspirin-treated mice (Hnf1alpha was reduced by only 13%, and Hnf1beta was decreased by 27%).
32226550	0.98	HNF1B, HNF3B, and HNF4A), which are required for proper pancreatic development, were significantly downregulated in the islets of HF-fed Egr1-/- mice (Figure 7B).
	0.98	HNF1B, HNF3A, HNF3B, and HNF4A, are important in regulating early development of pancreas.
20601079	0.98	HNF4alpha, HNF1beta, and HNF6.
22245898	0.98	HNF1beta and the SRY-related HGM box transcription factor 9 (Sox9), and to the down-regulation of hepatocyte-specific transcription factors such as HNF1alpha and HNF4.
23720330	0.98	HNF1beta but at the same time downregulate hepatocyte-enriched transcription factors such as HNF4alpha.
24319661	0.98	Hnf4alpha, Hnf1beta, Gata6, and AFP, were increased following TBX3 overexpression (Figure S2N).
24367609	0.98	HNF4alpha, HNF1alpha, HNF1beta, HNF3beta/Foxa2, and HNF6 form an increasingly robust cross-regulatory network during development from the embryonic to adult liver.
24766136	0.98	HNF1beta, FoxA2 and HNF6 have roles in controlling the onset of the hepatic gene expression during specification of the liver progenitors, while HNF4alpha, although not having an impact on hepatic specification, is essential for subsequent differentiation of hepatic progenitors.
28429721	0.98	Hnf1b, Hnf4a and Nr1h4, all of which play important roles in liver (Fig. 4d).
28642491	0.98	HNF4A together with HNF1B and HNF4G as potential transcriptional regulators of SOM-cluster genes associated with DNAJC22 (Supplementary Fig. 4b).
21386911	0.97	Hnf4a and Hnf1b, RbpJ (Notch signalling), PPARgamma:RxRA and COUP-TF family transcription factors.
	0.96	Hnf1b and Hnf4a transcription factors are associated with kidney development however no direct involvement during proximal tubule development has been reported to date.
	0.94	Hnf1b and Hnf4a shows expression within the proximal tubule and other nephron segments with Hnf1b showing collecting duct expression and Hnf1a showing S-shaped body expression (see GUDMAP data Accession IDs GUDMAP:12560 and GUDMAP:12531 respectively).
23554936	0.97	vHnf1, Hnf4alpha and Pgc1alpha were all downregulated in cKO samples when compared to WT at 9.0 and 9.5 dpc.
	0.97	Hnf4alpha, Ihh, vHnf1, Gata4, Gata6, Ttr and qK were examined (Fig. 5C) and only vHnf1 and Hnf4alpha, two transcription factors required for normal visceral endoderm differentiation, were altered in the cKO between 9.0-9.5 dpc (Fig. 5C, E).
	0.97	vHNF1 and Hnf4alpha.
26942887	0.97	HNF4a and cholangiocytic genes HNF6 and HNF1b.
	0.90	HNF4alpha and the epithelial cell marker E-cadherin after differentiation is enhanced and expression of the cholangiocyte marker HNF1beta is reduced in the absence of ADAM10 as assessed by immunoblotting.
21337461	0.97	HNF1beta, HNF6/the Onecut (OC) factors, HNF4alpha, c/ebpalpha, Jagged/Notch, TGFbeta, TNFalpha, Foxa1-3, Hhex, GATA4/6, nuclear hormone receptors, and extracellular matrix interactions.
22905335	0.97	HNF4A, GCK, HNF1A, HNF1B, KLF11, BLK) and kidney (HNF1B) (Table 3).
22618775	0.96	HNF1beta, and HNF4alpha, make it reasonable to propose that elaborate networks of developmentally required transcription factors are retained in mature beta-cells and that they are essential, in combination, to maintain beta-cell gene expression and function.
	0.93	HNF4alpha, HNF1alpha, HNF1beta, IPF1/PDX1, NEUROD1, and perhaps others).
24700364	0.95	HNF4alpha, Krt18, Onecut1, and Onecut2, Foxa2, and in cholangiocytes, Hnf1beta, Muc1, and Krt19 (Table 1).
	0.92	HNF4alpha and beta-GAL did not show any contribution of HNF1beta+ cells to hepatocyte generation (Supporting Fig. 3A-C).
	0.66	HNF1beta or CRE in HNF4alpha+ hepatocytes (Supporting Fig. 1G,H).
21130058	0.95	Hnf4alpha, and Hnf1beta, that can confound careful gene expression analyses and potentially lead to erroneous conclusions.
	0.93	Hnf4a, Sox17, Sox9, Hex, Hnf1beta and Hlxb9 (Fig. 7g).
23570553	0.95	HNF4, HNF1-beta) that also demonstrated high upregulation in the range of 10 to 45 fold increase in expression.
	0.92	HNF4, CLDN6, TTR and HNF1-beta showed a noticeable increase in gene expression.
26276631	0.95	Hnf4alpha, were equally expressed by HybHP and cHP, but other BD markers such as Hnf1beta and EpCam were hardly upregulated (Figure 5D).
30013175	0.95	Hnf4a, Hnf4g, Foxa2, Hnf1b, Hnf1a, Foxa1, Cux1, Cux2, Cebpe, Bhlha15, and Rxrg.
24906150	0.94	Hnf1beta) and increase of hepatocyte markers (ALB, HNF4alpha).
26905303	0.94	HNF1beta, HNF3beta, HNF4alpha, HNF6, Epithelial cell adhesion molecule (EpCAM), Leucine-rich repeated-containing G-protein coupled receptor 5-positive (Lgr5) and Tyrosine aminotransferase (TAT).
16547197	0.92	Hnf4a and vHnf1.
	0.90	Hnf4a were expressed in both the endoderm- and epiblast-like populations while vHnf1 showed no detectable expression in either population (Figure 6C).
29540203	0.92	Hnf4a, and Hnf1b, to explore their targets because only Grhl2 and Hnf4a were identified to activate the important epithelial gene Epcam, and Hnf1b regulated both Cdh1 and Fn1 (Fig. 7b and c).
26856660	0.90	HNF1beta and OPN, but not HNF4alpha, which is indicative of their biliary maturation (Fig. 2).
	0.84	HNF1beta and Sox9, were expressed at normal levels, while the hepatocyte marker HNF4alpha was absent as expected.
	0.59	Hepatocyte Nuclear Factor (HNF)1beta but not the hepatocyte marker HNF4alpha (Fig. 1A), indicating that they were correctly specified and differentiated.
21829703	0.90	MODY1-5 result from mutations in Hnf4alpha, glucokinase, Hnf1alpha, Pdx1, and Tcf2, respectively.
27936029	0.90	Hnf1b, a transcription factor regulated by Hnf6, the expression of Hnf6 paralogs Oc-2 and Oc-3 and major hepatocyte nuclear factors such as Hnf1a, Hnf4a, Foxa2, and C/ebp are unaffected in KO mice (data not shown).
21391226	0.79	HNF1beta at E17.5, differentiation of cells that lined the portal side of the DPM was normal throughout the liver: these cells were SOX9+/HNF4-/Ecadhigh.
21898486	0.72	HNF-1beta and Sox9 was decreased at E16.5 and P3, expression of other transcription factors including HNF-4 and OC-2 were unchanged in DKO mice at these ages compared to control mice (data not shown).
18828795	0.66	HNF4alpha cause MODY1, mutations in HNF1alpha cause MODY3 and mutations in HNF1beta cause MODY5.
22399922	0.57	hepatic nuclear factor 4 alpha (HNF4A), HNF1 homeobox A (HNF1A), pancreatic and duodenal homeobox 1 (PDX1), HNF1 homeobox B (HNF1B) and neurogenic differentiation 1 (NEUROD1).