Publication for Foxd3 and Sox10

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Foxd3	forkhead box D3	15221			[link]
mmu	Sox10	SRY (sex determining region Y)-box 10	20665

Pubmed ID	Priority	Text
23550053	0.99	FOXD3 and SOX10, leading to a suggested mechanism whereby DISC1 indirectly modulates migration through transcriptional repression of transcription factors with a known role in development.
	0.96	FOXD3 and SOX10, and maturation/integration into existing neural circuitry via AKT/mTOR/GABA, PDE4/cAMP, NDEL1 and FEZ1.
23284303	0.98	Sox10 and several pieces of evidence suggest that FoxD3 is critical for initiating a cascade of neural crest gene expression that controls their emigration from the neural tube.
	0.98	FoxD3 initiates in premigratory neural crest cells at HH8- (Figure 1A), with strong and rapid onset of expression that precedes that of Sox10 or Snail2.
	0.98	FoxD3 transcripts are detected in the premigratory population prior to Sox10, which is expressed in cranial, vagal and trunk neural crest cells only as cells leave the neural tube (arrows on Figure 1E and 1F).
	0.98	FoxD3 and Sox10 at cranial level solidifies its potential crucial activation role in regulation of the cranial neural crest as a factor that initiates the specification module of the neural crest gene regulatory network.
	0.97	FoxD3 and Sox10 reveals differences in the expression domains of these neural crest specifier genes.
	0.95	FoxD3 and Sox10 both have been placed in the same hierarchical level in the neural crest GRN, they are recruited at different time points during neural crest specification.
	0.94	Sox10 and Sox5, have been suggested to regulate FoxD3 expression; however it remains to be determined whether this regulation is direct or indirect.
	0.91	Sox10 (red) and FoxD3 (green) reveals differences in the expression domains of these neural crest specifiers at stages HH9 (E) and HH10 (F).
	0.88	FoxD3 and Sox10 enhancers in the cranial neural crest.
	0.78	FoxD3, Ets1, Snail1/2 and Sox10, amongst others.
	0.78	FoxD3 (this study) and Sox10 clearly suggest that these differences are inherent at the regulatory level.
23266330	0.98	FoxD3, Sox10 and Snail2, resulting in embryos with severe migration defects.
	0.98	FoxD3, Sox10 and Snail2 (Fig. 2), and that its knockdown leads to a loss of migratory neural crest cells (Fig. 5) and later to abnormal craniofacial development (Fig. S2).
	0.98	Sox10, Snail2 and FoxD3, suggesting that Elk3 may be a prerequisite for their subsequent expression.
	0.98	FoxD3 and Sox10, which are required for NC cell specification and migration.
	0.97	FoxD3, Sox10, and Snail2 prompted us to examine the requirement of Elk3 for the expression of the neural plate border gene, Pax7, which is required for neural crest formation during gastrulation and lies upstream of neural crest specifier genes in the neural crest gene regulatory network.
	0.97	FoxD3 and Sox10.
	0.97	FoxD3, Sox10 and Snail2.
	0.92	FoxD3 and Sox10 at HH8 (Fig. 2B, 2D, N= 6/8 and 10/14, respectively), demonstrating the specificity of the effect.
	0.82	FoxD3, Sox10 and Snail2 (Fig. 2A-2F), or to migrate out of the neural tube (Fig. 3, 5), whereas neural development proceeds normally (Fig. 4).
22266424	0.98	Sox10 indicated that Foxd3 expression is maintained in mature enteric glial cells (Fig. 2E).
	0.98	Foxd3 and Sox10-expressing ENPs that did not express the Ednrb-iCre transgene underwent activation, regulative proliferation and differentiation into both neuronal and glial lineages in response to the severe depletion of Ednrb-iCre lineage cells.
	0.97	Sox10, were co-labeled with GFP (Fig. 2D), demonstrating that Foxd3 is maintained in ENPs and glia.
	0.97	Foxd3 revealed that it is comparable to Sox10 expression during ENS development.
	0.97	Foxd3 is required to maintain Sox10-expressing glia within the Ednrb-iCre lineage, consistent with our previous work in other regions of the NC.
	0.93	Sox10 expression (glia, red) in the duodena from adult control (C) and Foxd3 mutant (D) mice showed reduced numbers of glia derived from the Ednrb-iCre lineage.
	0.93	Sox10-positive cells (F) in colons from 14.5 dpc control and mutant embryos again showed a decrease in proliferation in YFP-positive Foxd3 mutant ENPs and a subsequent increase in Sox10-expressing cells that did not co-express YFP.
	0.83	Sox10) in Foxd3 mutant embryos and mice.
26873953	0.98	Foxd3, Twist, and Sox10 participating in EMT are known to regulate the cell-surface molecules, resulting in NC cell delamination.
	0.97	SOX10+ cells were found to maintain the expression of the NC cell marker genes Foxd3, P75, Snail1, Twist1, Id2, and Pax3, while losing the expression of the glial cell markers Gfap, Krox20, and P0 (Fig. 3D).
	0.97	Foxd3, Sox10, and Snail2, as well as the NBP specifier, Tcfap2, were markedly expressed in mouse trunk NC cells.
	0.96	SOX10+ cells, the mRNA levels of Foxd3 and Twist1 were higher than those in MEFs (Fig. 3E,F).
	0.95	Foxd3, Tcfap2a or EMT-related genes Snail1 and Snail2, scarcely generated SOX10+ cells from the MEFs (Fig. 2D,E).
	0.90	SOX10+ cells isolated from MEFs co-expressing SOX9/c-MYC/KLF4 also continued to express Foxd3, P75, Snail1, Twist1, Id2, and Pax3 under the NC cell culture conditions (Fig. 3D).
17507398	0.98	Sox10 and FoxD3 mRNAs (Fig. 1A), suggesting that NC-like cells might develop within the selected population of neuroepithelial cells.
	0.98	Sox10 and FoxD3 (this study) (see also).
	0.97	Sox10 and FoxD3 mRNAs were all detected in RA-treated EBs (data not shown).
	0.93	FoxD3, Sox9 and Sox10 proteins (Fig. 1B).
24465393	0.98	Sox10 and FoxD3).
	0.96	FoxD3 and Sox10 showed remarkably higher expression in trunk EGFP+ cells (Tp) than in Cp at all stages, especially at E12.5 (Fig. 2D).
	0.96	Foxd3 (13-fold) and Sox10 (6.7-fold) (Fig. 3B, right).
	0.95	FoxD3 and Sox10 showed relatively higher expression in tNCCs than that in cNCCs in microarray and also in qRT-PCR analyses.
25670789	0.98	FOXD3, in mouse melanoma cells or in quail neural crest cells, repressed MITF expression even in the presence of PAX3 and SOX10.
	0.98	FOXD3 binding sites in the zebrafish mitfa promoter through which repression is mediated, and the DNA-binding domain of zebrafish FOXD3 is necessary for the repression of transcription in transfected mouse melanoma cells or in fibroblasts co-transfected with SOX10.
	0.98	SOX10, PAX3, FOXD3, SOX2, SOX9, ZIC3 and SNAIL2.
21504042	0.98	FoxD3, Snai2, Sox9, Sox10, and Twist1 were all detected in 14.5dpc enteric progenitors and in RNA isolated from cultured primary neurospheres, but Sox9 and Twist1 were down-regulated and undetectable in multiple preparations of P6 GMS.
	0.95	FoxD3, Snai1, Snai2, Sox9, Sox10, Twist1), neuronal progenitor marker genes (Ascl1, Neurod1, Neurog1, Phox2b, Prph1, Uchl1), and peripheral glia markers (Erbb3, Fabp7, Gfap, Mpz, Nrg1, Nrtn, Olig2, S100b) in Sox10-H2BVenus+ enteric populations at discrete developmental stages.
22583479	0.98	Sox10 gene regulation identified multiple functional enhancers with binding sites for Sox9, Sox10, Pax3, AP2alpha, Lef1, FoxD3 and Slug.
	0.98	FoxD3 leads to upregulation of Sox10, cadherin-7 and beta1-integrin, although it is not known if these are direct targets.
25662262	0.98	Sox10, and FoxD3 play well-defined roles in maintaining the stem cell-like features and self-renewal capacity of early migratory NCCs.
	0.98	Sox10, Sox2, and FoxD3, is important for NCC differentiation into postmitotic neurons.
27521479	0.98	SOX10 (an SRY-related HMG-box transcription factor), FOXD3 (a member of the forkhead protein family) and HAND2, which control the survival and lineage choices of ENS progenitors.
	0.98	Sox10 and Foxd3, raising the possibility that these transcriptional regulators also are targets of TLR4 in the ENS.
17897962	0.98	FoxD3 are genetically upstream of Sox10 in the neural crest, while Sox9 and Olig2 appear to be involved in Sox10 gene induction in cells of the oligodendrocyte lineage.
20128875	0.98	Sox10, FoxD3, Pax3 and Slug, and even lead them to transdifferentiate into glial marker-positive cells.
21605958	0.98	SOX10 and FOXD3- a possible activator of SOX10 expression in cranial neural crest cells.
22848431	0.98	Sox10, FoxD3, AP-2, c-Myc, that specify the neural crest.
23634805	0.98	FoxD3 and Sox10 are expressed by the neural crest at the stage when it arises from the neuroepithelium.
24014420	0.98	Foxd3, Crabp1, Snai2, and Sox10).
28626748	0.98	FOXD3, SOX5, and SOX10 they prematurely start EMT from the neural tube at mid-rostral PSM levels.
28684471	0.98	FoxD3, Sox10, Erbb3 and others were downregulated as cells moved into the Ascl1+/Htr3a+ intermediate "bridge" state, towards chromaffin differentiation (Th+/Chga+) (Fig. 5D,E,I,J).
28851604	0.98	FoxD3, TCF/Lef, Sox10, as well as other Sox proteins.
29445148	0.98	Sox10, Foxd3, Snai1, Sox2, and Crabp2) and glial (Fabp7, Metrn, Mpz, and Phgdh) progenitors (Fig. 3a and Supplementary Table 1), suggesting a failure in their developmental downregulation in sympathetic neuroblasts, and an increase in gliogenesis.
26988119	0.97	Sox10 and Foxd3 (Figure 3, right), both of which are selectively associated with the neural crest.
	0.96	Sox10 and Foxd3, but are not Wnt1:Cre recombined.
	0.92	Sox10/Foxd3 neural crest-associated populations.
	0.88	Sox10 and Foxd3, and are significantly more proliferative.
21081123	0.97	Sox10 and Foxd3.
21689645	0.97	FoxD3-and Sox10-expressing neural crest cells, suggesting that Olig3 is required to promote dI1-3 interneuron fate without having an effect on neural crest cell development.
25109840	0.97	Sox10, FoxD3, Pax3 and Slug, and even led them to trans-differentiate into glial marker-positive cells.
26119414	0.97	Sox10 and Foxd3.
26787558	0.97	FOXD3, SNAIL, TWIST, SOX10) and extracellular matrix (ECM) remodeling proteins such as matrix metalloproteases (MMPs), however, direct cytoskeletal regulators of CNCC AJs are not yet known.
27370713	0.97	Sox10, Phox2b, Zeb2, as well as Foxd3, Hand2, Ascl1 (formerly known as Mash1), Pax3, Tlx2 (formerly Hox11L1), Hoxb5, Hlx1, Dlx2 and interacting cofactors such as HipK2 have been implicated in ENS development.
31053611	0.97	Sox10, Aldh1a1, Abcg1, Snai1, Foxd3, Aldh2, Lin28, Thy1, and Sem6a (; Fig. 2, D and E; and Fig. S1).
21908409	0.96	FoxD3 activates the U3 enhancer in N2a cells up to 7-fold in the absence of co-transfected Sox10 (Figure 1B).
	0.95	FoxD3 to U3 in the absence of Sox10 (data not shown).
28407732	0.96	Sox10, Foxd3, Sox9, Id1-3, Tfap2a, Ets1, Ngfr and Lin28)
	0.96	Sox10, Foxd3, Sox9, Id1-3, Tfap2a, Ets1, Ngfr and Lin28 (Fig. 3b).
19527705	0.96	foxd3 inhibits the effects of exogenously supplied sox10 activator in our assays with NIH 3T3 cells, suggesting a direct action.
27144312	0.96	Foxd3 and Sox10 expression at all stages examined (Fig 6K-6P).
27776507	0.96	Sox10 and Foxd3, which are expressed by early NC cells, lead to severe reduction of pre-ENCCs and total intestinal aganglionosis.
28681995	0.96	sox10:EGFP) and Tg(foxd3:GFP) embryos demonstrated that 1% ETOH starting at 24 hpf significantly increased the percentage of apoptotic cells in the developing eye at 30 (Fig. 4C' and 4D') and 33 (Fig. 4E' and 4F', Fig. 5, Supplemental Table 4) hpf compared to untreated controls (Fig. 4C-4F).
31336386	0.96	FoxD3, and Sox10 early stage NCC markers in control (heterozygotes) and homozygote mutant embryos showed more Sox9+ and Sox10+ NCC-like cells not only in the mutant retrolental area, but also in the area surrounding the eye discs of ~E12 mutants (Figure 4J).
24244598	0.94	FoxD3 and Sox10 (neural-crest markers) and Dmp-1 and Runx-2 (mature odontogenic markers) in the differentiated iPS cells were also clearly induced on day 12, with an identical expression profile occurring in the differentiated E14Tg2a cells and odontoblast-like KN-3 cells (Figure 3B-b and c).
29295999	0.93	SOX10 knockdown also blocked FOXD3/ERBB3 induction by Vemurafenib, reduced tumor growth and further enhanced the tumor-inhibiting capacity of Vemurafenib (Fig. 7c, d).
26545946	0.86	Sox10, FoxD3, Snai2 together with Msx1, Pax3/7 or Zic1 in the neural plate border.
26250625	0.84	FoxD3, Wnt1 and Sox10 (Simoes-Costa and Bronner, 2015).
24780627	0.79	Foxd3, Alx1, Prrx1, Prrx2, Bcl2, Irx3, Irx5, Msx1, Msx2, Sp5, Etv2, Hhex, Six1, Six2, Nr2f1, Lmo2, Sox10, Nfil3, Atf3, Nkx6-1 and Pitx2.
25844395	0.79	Sox10Dom/+ and Sox10+/+ mice, we observed cells that double-labeled with neuronal (Hu+) and glial (FoxD3+) markers.
20848654	0.51	Sox10, Foxd3, and Ap2a1.