Publication for Gria4 and Grm8

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Gria4	glutamate receptor, ionotropic, AMPA4 (alpha 4)	14802			[link]
mmu	Grm8	glutamate receptor, metabotropic 8	14823

Pubmed ID	Priority	Text
21382421	0.98	mGluR8, like mGluR4, mGluR6, and mGluR7, a member of group-III receptors, is coupled to the inhibition of adenylyl cyclase.
	0.92	mGluR8-/- mice might involve mGluR4, as the mGluR4 PAM VU 0155041 also reduced measures of anxiety in wild-type mice.
	0.92	mGluR8-/- mice might involve mGluR4-mediated signaling.
19110202	0.98	mGluR8, but not mGluR4, was expressed in MS lesions, in particular in cells of the microglia/macrophage lineage with an amoeboid morphology.
	0.86	mGluR4, mGluR6, and mGluR8 - but not mGluR7.
30897826	0.98	mGluR4, mGluR6, mGluR7 and mGluR8) are predominantly expressed presynaptically where they function as auto- and hetero-receptors and regulate neurotransmitter release.
	0.91	mGluR4 are highly expressed in the olfactory bulb, cortex, thalamus, hippocampus and basal ganglia, mGluR7 are expressed in the olfactory bulb, cortex, hippocampus, amygdala, thalamus and hypothalamus, whereas mGluR8 are expressed in the olfactory bulb, cortex and hippocampus.
20385173	0.98	mGluR8, a member of group-III receptors that also comprises mGluR4, mGluR6, and mGluR7, is coupled to the inhibition of adenylyl cyclase.
22389834	0.98	mGluR4, mGluR7, and mGluR8) are expressed in the presynaptic active zone and reduce synaptic vesicle release upon stimulation by agonists.
28212543	0.98	mGluR4 and mGluR8 was reported in human lung adenocarcinoma samples and lung carcinoma cell line and treatment with mGluR8 agonist reduced cell growth and increased apoptosis in this lineage.
29280965	0.98	mGluR4, mGluR7 and mGluR8 are widely expressed in nearly all nervous tissues involved in nociception, suggesting their involvement in the molecular basis of pain.
20055706	0.97	mGluR4 knockout animals appear to be resistant to several of the features of alcohol addiction, and mGluR8 levels are regulated by cocaine and amphetamine administration, suggesting roles for group III receptors in drug abuse.
	0.95	mGluR8 is expressed at lower levels than mGluR4 and mGluR7 but is widely distributed in the brain.
	0.95	mGluR4, mGluR8 has been localized predominantly presynaptically but has been identified in some postsynaptic locations and in the periphery (reviewed in).
	0.94	mGluR8 over mGluR4.
30800054	0.97	mGluR 4, mGluR7, and mGluR8) are expressed in GABAergic and glutamatergic terminals in the basal ganglia.
	0.96	mGluR4, mGluR7, and mGluR8 are expressed in neurons, they are also expressed in oligodendrocyte precursor cells and recently formed oligodendrocytes.
	0.90	mGluR4 or mGluR8 exhibit improved reactivity to stressors.
22536173	0.97	mGluR4, mGluR7, and mGluR8, mGluR6 is exclusively expressed at postsynaptic dendritic specializations of "ON bipolar cells" (bipolar cells that respond with depolarization to light) in the retina and transmits the "light on" signal in vision (Masu et al.,; Vardi et al.,).
	0.55	mGluR4 and mGluR8 in the hippocampus (Shigemoto et al.,).
22634360	0.97	mGluR4, mGluR6, mGluR7, and mGluR8) receptors are commonly found in presynaptic neuronal elements, where they decrease neurotransmitter release by inhibition of adenylyl cyclase.
	0.52	mGluR4/8 versus mGluR7, the lack of significant mGluR8-mediated physiological and behavioral effects in the striatum and GPe, the lack of L-AP4 effects in mGluR4 knockout mice, and the restricted expression of mGluR6 in the retina, it is reasonable to suggest that the main L-AP4-mediated physiological effects described in the present study were induced by mGluR4 activation, although minor contributions of mGluR7 and mGluR8 cannot be completely ruled out.
24078068	0.97	mGluR4, mGluR7, and/or mGluR8) are distributed primarily in presynaptic terminals.
	0.93	mGluR4 and mGluR8 are important for drug action.
28559797	0.97	mGluR4, mGluR7 and mGluR8 are known to be present on presynaptic elements of the hippocampus.
	0.96	mGLUR4, mGLUR7 and mGLUR8 can be found on GABAergic terminals in the hippocampus (for review, see).
21093567	0.97	mGluR4 and mGluR8) mGluRs decreases between the second and third postnatal weeks.
21456037	0.97	mGluR4 and mGluR6 to mGluR8) receptor activity inhibits the adenylyl cyclase signal transduction pathway.
22626985	0.97	mGluR4, mGluR7 and mGluR8) are coupled to Gi/o proteins that inhibit adenylate cyclase, preventing the formation of cyclic adenosine 3'5'-monophosphate (cAMP).
24260418	0.97	Grm8 were up-regulated, while the neural markers NeuroD1 and Sox3, the neurotrophins Bdnf exon IX and Ngf, the transcription factor Creb1 and Creb2, the members of the NF-kappabeta family Nfkappab2, Rela, and Relb, and the subunits for glutamate receptors Grin1, Grin2D, Gria1, Gria4, and Grm6 were down-regulated (Figure 1A).
24851087	0.97	mGluR4, mGluR6, mGluR7 and mGluR8) are instead predominantly localized pre-synaptically in axon terminals and modulate neurotransmitter release.
25874256	0.97	mGluR4, mGluR6, mGluR7, and mGluR8) mGluRs are primarily localized within presynaptic regions and involved in the inhibition of neurotransmitter release.
26748024	0.97	mGluR4, mGluR6, mGluR7 and mGluR8), mGluR7, which is the most widely distributed of mGluRs and closely associated with vesicle release sites, has a role in acquisition and extinction of fear memory.
26896755	0.97	mGluR4 and mGluR8 in a lung carcinoma cell line and human lung adenocarcinoma samples was reported.
16162930	0.96	mGluR4, but not mGluR2/3 and mGluR8, are activated by synaptically released glutamate (see below).
	0.96	mGluR4, mGluR7, and mGluR8) are present presynaptically at the young calyx of Held.
	0.95	mGluR8 receptors but not mGluR4, although this receptor is present.
	0.94	mGluR4 and mGluR8 are activated by 50 mum l-2-amino-4-phosphonobutyrate (l-AP-4), resulting in inhibition of presynaptic Ca2+ current and EPSC.
	0.94	mGluR8 and mGluR4 at the rat MNTB in vitro.
	0.89	mGluR8 localization on the extrasynaptic face of the calyx and mGluR4 in the synaptic lumen.
	0.89	mGluR4, mGluR8, and GABAB all cause dramatic inhibition.
	0.88	mGluR8 over mGluR4 or mGluR7 and thus can aid in further elucidating the physiological role of these group III mGluR receptors.
	0.85	mGluR8 over mGluR4 or mGluR7, allows a pharmacological discrimination of these receptors.
	0.77	mGluR4 and mGluR8 at this synapse.
	0.67	mGluR4 or mGluR8 activation was greatly reduced to ~25% for both receptors (Fig. 6C).
	0.62	mGluR4 and mGluR8.
	0.50	mGluR4 and mGluR8 likely share the same second-messenger pathway (for review, see), it is possible that we may be saturating the pre-synaptic inhibitory mechanisms present at the calyx with 50 mum l-AP-4.
31719824	0.96	mGluR8 and likely also mGluR4, exerted neuroprotective actions on neurons exposed to harmful hypoxic or hypoglycemic conditions.
	0.95	mGluR4, but neither mGluR7 nor mGluR8.
	0.90	mGluR4 and mGluR8 are placed at the periphery of presynaptic terminals.
28242339	0.96	mGluR4 and mGluR7 are autoreceptors on presynaptic glutamatergic corticostriatal terminals and/or hetereceptors on GABAergic striatopallidal and striatonigral terminals, while mGluR8 mRNA is highly expressed in the cortex and striatum.
	0.94	mGluR4, mGluR6, mGluR7 and mGluR8, all of which are mainly localized presynaptically.
19750024	0.96	mGluR4, mGluR6, and mGluR8 also have been identified in microglia and astrocytes.
20080129	0.96	mGluR8, is a member of group III that also comprises mGluR4, mGluR6 and mGluR7 and are coupled to the inhibition of adenylyl cyclase.
22884897	0.96	mGluR4, mGluR6, mGluR7, and mGluR8) are generally located presynaptically and regulate neurotransmitter release, and they have been identified as attractive targets for treating anxiety disorders.
25846623	0.96	mGluR4 and mGluR8 have high affinity for glutamate and are localized extrasynaptically on glutamatergic terminals whereas low affinity mGluR7 is found in or near the active zone of the synapse on GABAergic terminals.
27306064	0.96	mGluR4 and mGluR8, which share mGluR7's presynaptic location, mGluR7 shows low affinity for glutamate and is activated only by high glutamate concentrations.
31189778	0.96	R3, mGluR4, and mGluR8, are expressed in beta-cell lines, an alpha-cell line, and rat islets.
31213067	0.96	mGluR4, mGluR6, mGluR7, and mGluR8).
11773238	0.95	mGluR8 or mGluR4.
	0.93	mGluR8 or mGluR4 to reduce the transmitter release process in red cone presynaptic terminals mediated by the 4-AP-sensitive pathway.
	0.84	mGluR8 or mGluR4 in cone presynaptic terminals linked to a 4-AP-sensitive pathway.
22888325	0.95	mGluR4, mGluR6, mGluR7, and mGluR8).
	0.94	mGluR4 and mGluR8 in rat calvarial osteoblasts.
23976856	0.95	mGluR4, mGluR6, mGluR7, mGluR8).
29339716	0.95	mGluR4, mGluR6, mGluR7, and mGluR8) couple negatively with adenylyl cyclase, suppressing the formation of cAMP, and further inhibiting protein kinase A.
29605730	0.94	mGluR4, mGluR7 and mGluR8, are expressed throughout the BG circuitry (Fig. 1), but mGluR8 is expressed at a lower level than mGluR4, and mGluR7.
	0.75	mGluR4, much less is known about the anti-parkinsonian and neuroprotective properties of other group III mGluR subtypes (mGluR7 and mGluR8). .
22574674	0.94	mGluR4, mGluR6, mGluR7 and mGluR 8) are negatively coupled to adenylyl cyclase [see for review].
19097893	0.93	mGluRs, but despite this fact, mGluR4 has garnered a great deal of attention as a therapeutic target for multiple indications.
	0.56	mGluRs, 6 was observed to be highly selective for mGluR4 in both activation (EC20 glutamate potentiation) and inhibition (depression of EC80) assays (Fig. 5).
22523578	0.93	mglur4, mglur6, mglur7 and mglur8) makes it a challenging task to unequivocally identify the true zebrafish mglur6 ortholog.
	0.77	mGluR4, mGluR7 and mGluR8 is split in mGluR6 (628 bp+308 bp).
29867331	0.93	mGluR4, mGluR6, mGluR7, and mGluR8) are both negatively coupled to adenylate cyclase (Rosemond et al.,; Byrnes et al.,).
22227508	0.92	mGluR4-/- and mGluR8-/- male mice show anxiety phenotypes, but there are clear differences between the anxiety phenotypes of the two mutant models.
	0.90	mGluR4 and mGluR8, in the molecular layer of the cerebellar cortex, the nucleus basalis, the outer layer of the superior colliculus, and the substantia nigra, while very low levels of binding is seen in mGluR4-/- mice.
	0.86	mGluR4 or mGluR8 agonists or allosteric modulators might be required to reduce anxiety levels in patients with lower apoE levels.
	0.67	mGluR4-/- and wild-type mice, likely reflecting mGluR8 binding.
20096339	0.91	mGluR8 receptors (EC50= 30 nM) as compared with other group-III mGluRs (EC50 of 8.8, 3.6, and >100 muM for mGluR4, 6 and 7, respectively,).
	0.90	mGluR4, mGluR6, and mGluR8 in pharmacological assays on transfected cells (EC50 = 0.32, 0.055, and 0.06 muM for mGluR4, 6, and 8, respectively,), and therefore application of L-AP4 is expected to suppress the Off-responses through activation of the mGluR8 receptors.
22609935	0.91	mGluR8 is only one of four group III mGluRs; thus it is highly possible that there is a higher percentage of co-localization of TRPV1 with at least two other group III mGluRs (mGluR4 and 7).
	0.80	mGluR8, mGluR4 and mGluR6 (localization appears to be limited to retina cells) compared to mGluR7.
26022263	0.90	mGluR4 and mGluR8, mGluR7 has low affinity for glutamate and can only be activated when extracellular glutamate concentrations are sufficiently high.
18021417	0.88	mGluR8) have been cloned from mammalian brain tissue, which are classified into three sub-groups: Group I mGluRs (mGluR1 and mGluR5), Group II mGluRs (mGluR2 and mGluR3) and Group III mGluRs (mGluR4, mGluR6, mGluR7 and mGluR8).
24495291	0.87	mGluR4, mGluR6, mGluR7 and mGluR8) mGluRs decrease neuronal excitation by inhibiting adenylyl cyclase (AC) resulting in reduction of intracellular cyclic adenosine monophosphate (cAMP) levels.
24610491	0.87	mGluR4, mGluR6, mGluR7 and mGluR8, which are all negatively coupled to adenylate cyclase.
21472028	0.70	mGluR4 and mGluR8 is abundant in gastric vagal afferents in the ferret nodose ganglion, at their termination site in the NTS (subnucleus gelatinosus) and in gastric vagal motorneurons, while labeling for mGluR6 and mGluR7 is weaker in these regions (Page et al.,; Young et al.,).
27809760	0.70	mGluRs can be classified into three primary classes: Class I consists of mGluR1 and mGluR5 and are associated with phospholipase-C and utilize intracellular calcium signaling cascades; Class II consists of mGluR2 and mGluR3; and Class III consists of mGluR4, mGluR6, mGluR7, and mGluR8 and are negatively coupled with adenylyl cyclase activity.
15054054	0.58	mGluR4 and mGluR8, because the affinity of mGluR7 for L-AP4 is relatively low, and mGluR6 does not occur in the hippocampus.