Publication for Cyp8b1 and Slco1a1

Species Symbol Function* Entrez Gene ID* Other ID Gene
coexpression
CoexViewer
mmu Cyp8b1 cytochrome P450, family 8, subfamily b, polypeptide 1 13124 [link]
mmu Slco1a1 solute carrier organic anion transporter family, member 1a1 28248

Pubmed ID Priority Text
29175453 0.98 Cyp8b1, Cyp27a1, and Cyp7b1) and transporters (Ntcp, Oatp1a1, Oatp1b2, and Mrp3).
28855630 0.97 Cyp8b1, Ntcp, Oatp1, Oatp4, Mrp3, Mrp4, Bsep, and Mrp2 in liver and the reduced Fgf15 and Ibabp in ileum by ANIT exposure.
0.59 Cyp8b1), basolateral uptake transporters (Ntcp, Oatp1 and Oatp4), basolateral efflux transporters (Ostbeta, Mrp3 and Mrp4), and canalicular transporters (Bsep and Mrp2).
29498526 0.97 Cyp8b1, Oatp1, and Oatp2, were all down-regulated in the cholestatic groups.
23470335 0.96 Cyp8b1), and decreases in liver bile acid transporters (Ntcp, Bsep, Oatp1a1, Oatp1b2, and Ostbeta).
30464200 0.95 Cyp8b1 expression, while no changes in the expression of BA transporters (Bsep, Ntcp, Oatp1 and Oatp2) and FGF19 receptors (Fgfr4 and beta-klotho) were found (data not shown), indicating that FGF19-M52 globally reduces BA levels without a direct transcriptional impact on their secretory or transport genes.
30766963 0.95 cytochrome P450 family 8 subfamily B member 1 [Cyp8b1], Cyp27a1, biliary BA secretion (Abcb11), PC secretion (Abcb4), and BA import from the circulation (sodium-taurocholate cotransporting polypeptide [Ntcp], organic anion cotransporting polypeptide [Oatp1]) were all significantly lower in Pemt-/- mice than in Pemt+/+ mice (Fig. 3B).
29366871 0.89 Slco1a1 and Slco1b2, as well as bile-acid-synthesizing enzymes Cyp7a1 and Cyp8b1 (Figs. 2 and 3) were all observed in Cyp1a1(-/-) but not wild-type mice receiving the Western diet plus BaP. The combined treatment also increased MRP4 protein levels and decreased OATP1A1 protein levels in the liver of Cyp1a1(-/-) mice (Fig. 2).



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