Publication for Cyp8b1 and G6pc

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Cyp8b1	cytochrome P450, family 8, subfamily b, polypeptide 1	13124			[link]
mmu	G6pc	glucose-6-phosphatase, catalytic	14377

Pubmed ID	Priority	Text
31102537	0.97	Cyp8b1 expression and relative increase in CA and DCA in L-G6pc-/- mice (Fig. 1C,D) increased the hydrophobicity index of the biliary bile acids entering the intestine (Fig. 4A) whereas hepatic ChREBP knockdown reduced this index (Fig. 4B).
	0.96	CYP8B1 mRNA and protein levels were significantly increased in L-G6pc-/- mice irrespective of the feeding state (Fig. 1H).
	0.96	Cyp8b1 expression was positively correlated to biliary bile acid hydrophobicity in L-G6pc-/- mice (Supporting Fig. S4A) and hypothesized that altered hydrophobicity in response to G6P-ChREBP-CYP8B1 signaling impacts intestinal sterol absorption.
	0.92	Cyp8b1 mRNA levels were also strongly elevated whereas expression of Cyp7a1, Cyp27a1, Cyp7b1, and Cyp2c70 was significantly lower as compared to L-G6pc+/+ littermates (Fig. 1C).
	0.92	G6pc-/- mice whereas administration of shChREBP had the opposite effect (Fig. 2E and Supporting Fig. S2H; Supporting Tables S3, S4, and S5), consistent with the observed decrease in hepatic Cyp8b1 expression (Fig. 2B,C and Supporting Fig. S2B).
29038350	0.52	G6pc expression was increased (logFC = 1.4, FDR = 0.04) in the 9 weeks HFCD cohort, Lpl expression was increased in the 13 week cohort (logFC = 1.4, FDR < 0.001) and 28 week cohorts (logFC = 1.9, FDR < 1e-6), Pltp expression was increased in the week 13 cohort (logFC = 1, FDR < 0.001) and at 28 weeks HFCD (logFC = 1.1, FDR < 1e-5), while Cyp7b1 (logFC = -1.5, FDR < 1e-6), Cyp8b1 (logFC = -1.5, FDR < 1e-6), and Slc10A1 (logFC = -1.3, FDR < 1e-6) expression was decreased after 28 weeks HFCD.
28129116	0.51	Cyp8b1, and Inmt), lipids (Acss2 and Thrsp1), iron (Hamp2), and glucose (G6Pc).