Publication for COL5A2 and FN1

Species Symbol Function* Entrez Gene ID* Other ID Gene
coexpression
CoexViewer
hsa COL5A2 collagen type V alpha 2 chain 1290 [link]
hsa FN1 fibronectin 1 2335

Pubmed ID Priority Text
30948703 0.97 COL5A2, COL11A1, COL18A1, FN1, and SPARC was related to poor OS in patients with GC.
0.93 COL5A2, FN1, THBS1, COL5A1, SPARC, COL18A1, and COL11A1.
0.55 COL5A2, FN1, THBS1, COL5A1, SPARC, COL18A1, and COL11A1.
0.52 COL5A2, FN1, THBS1, COL5A1, SPARC, COL18A1, and COL11A1 - were confirmed as hub genes (Table 2, Figure 5A).
29237464 0.97 fibronectin (FC = +9.2), Collagen type V, alpha2 (ColVA2) (FC = +3.1), Integrin A5 (ITGA5) (FC = + 4.9) or Pleckstrin 2 (PLEK2) (FC = +4.8) along with a downregulation of Wnt11 (FC = -19.1) (Fig. 2a and Additional file 1: Table S1).
0.96 fibronectin, ColVA2, ITGA5 and PLEK2 was notably confirmed, with a dramatic and significant upregulation of expression in the TGF-beta + poly(I:C) condition (Fig. 2b).
31706267 0.96 COL5A2) + 0.2361*log2(FN1)-0.0729*log2(COL1A2)-0.0560*log2(FAP) + 0.1020*log2(POSTN), log2(gene count).
0.96 COL5A2, FN1, COL1A2, FAP and POSTN were identified by lasso regression analysis from DEGs and could diagnose the PC.
0.95 COL5A2, FN1, COL1A2, FAP and POSTN) as a specific predictive signature for the diagnosis of PC.
29719832 0.95 FN1 and type Valpha2 collagen (COL5A2)] (Figure 1I), indicative of enhanced microenvironment-adaptive activity in the malignant cells.
30816427 0.95 FN1, MMP9, COL6A1, COL5A2, COL6A2, ITGA5, FBN1, CTGF, ITGA4, PDGFRB, LUM, PPIB, MMP14, ITGA11 and COPB1 (Table II).
17411443 0.94 COL5A2, IGFBP3, FN1, ANXA2, BGN and PTGDS) and all 4 genes detected from the z-statistic as effect size (PTTG1, COL5A2, IGFBP3 and PTGDS) are associated with angiogenesis.
22228636 0.93 FN1, a member of the integrin signaling pathway, and several other members or close interaction partners of this pathway were upregulated in MI as compared to non-MI tumors in most datasets we investigated; these genes include ACTN1, COL1A2, COL3A1, COL5A2, COL6A3, COL11A1, COL16A1, FBN1, FLNA, LUM, TGFBI, and TNC.
20617897 0.92 FN1 in the fetus increased the risk for SGA; 2) haplotypes in COL1A1 and MMP9 in the mother and FN1 in the fetus were associated with SGA; 3) multilocus analysis with MDR revealed a significant interaction between PLAU and COL5A2 in mothers; 4) pathway analysis (Supplemental Table 2) suggested that maternal and fetal genes involved in extracellular matrix function predispose to SGA; 5) importantly, TIMP2 and FN1 were found to participate in both maternal and fetal networks along with other molecules associated with SGA.
31488082 0.92 FN1 and CTGF, and genes involved in extracellular matrix synthesis and adhesion: COL1A1, COL5A1, COL5A2, ICAM1, and HAS2 (Table 2).
30237810 0.89 COL5A2, and COL11A1), integrin (ITGA6), tenascin (TNXB) and fibronectin (FN1).
30633213 0.88 fibronectin 1 (FN1), carboxyl ester lipase (CEL), integrin subunit alpha 2 (ITGA2), collagen type V alpha 2 chain (COL5A2), matrix metallopeptidase 1 (MMP1), and chymotrypsin-like elastase family member 3B (CELA3B).
0.77 FN1, CEL, ITGA2, COL5A2, MMP1, and CELA3B were the top 10 hub genes, which may be essential to the molecular mechanisms underlying the development of PDAC and may therefore serve as potential therapeutic targets.
27907202 0.84 COL5A2, FN1 and DCN were higher than in PB.
31110246 0.84 COL5A2, COL6A1, COL6A2, COL6A3, COL8A1, and COL12A1), fibronectin (FN1), the matrix metalloproteinases 1, 2, and 14 (MMP1, MMP2, and MMP14), and tissue inhibitor of metalloproteinases 1, 2, and 3 (TIMP1, TIMP2, and TIMP3) were seen in all fibroblasts (Fig. 7c).
30029183 0.78 FN1, COL1A1, COL1A2, COL3A1, COL5A2, TWIST1, SNAI2, and ZEB1.
22208948 0.64 COL5A2, FAP, POSTN, COL1A2, COL3A1, FBN1, TNFAIP6, MMP2, GREM1, BGN, CDH11, SPOCK1, DCN, COPZ2, THY1, PCOLCE, PRRX1) plus the obvious EMT markers SNAI2, FN1, ACTA2.
0.52 COL5A2, COL5A1, VCAN, COL1A1, COL3A1, FN1,SULF1, FBN1, ASPN, SPARC, CTSK, MMP2, BGN, LUM, LOXL2, COL6A3, TIMP3, CDH11, SERPINF1, EDNRA, ACTA2, PDGFRB, SNAI2, LGALS1, GLT8D2, NID2, PRRX1) belong to the set of 64 genes in Table 1 (P = 10-27), as well as VIM (vimentin).



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