Publication for COL3A1 and COL5A2

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	COL3A1	collagen type III alpha 1 chain	1281			[link]
hsa	COL5A2	collagen type V alpha 2 chain	1290

Pubmed ID	Priority	Text
30948703	0.98	COL3A1, COL1A2, COL5A2, FN1, THBS1, COL5A1, SPARC, COL18A1, and COL11A1 - were confirmed as hub genes (Table 2, Figure 5A).
	0.97	COL3A1, COL1A2, COL5A2, FN1, THBS1, COL5A1, SPARC, COL18A1, and COL11A1.
	0.96	COL3A1, COL1A2, COL5A2, FN1, THBS1, COL5A1, SPARC, COL18A1, and COL11A1) were identified via PPI network analysis.
	0.96	COL3A1, COL1A2, COL5A2, COL5A1, COL18A1, and COL11A1 belong to the collagen family, which comprises 28 members (I-XXVIII).
	0.93	collagen type V alpha2 (COL5A2) encodes the pro-alpha2 chains of type V collagen, and collagen type III alpha1 (COL3A1) encodes the pro-alpha1 chains of type III collagen.
	0.91	COL3A1, COL5A2, and THBS1 was not related to OS of GC patients.
32058995	0.97	COL3A1, COL1A2, BGN, COL5A2, THBS2, TIMP1, SPP1, PDGFRB, and COL4A1 (Table 4).
	0.97	COL3A1, COL1A2, BGN, COL5A2, THBS2, TIMP1, SPP1, PDGFRB, and COL4A1 between GAC and normal gastric tissues in the GEPIA database.
	0.96	COL3A1, COL1A2, BGN, COL5A2, THBS2, TIMP1, SPP1, PDGFRB, and COL4A1.
	0.96	COL3A1, COL5A2, and COL4A1, which belong to the collagen (COL) family, are the top 10 hub genes, which suggests that the collagen gene is likely to be a potential target for gastric adenocarcinoma.
	0.86	COL3A1, COL1A2, BGN, COL5A2, THBS2, TIMP1, SPP1, PDGFRB, and COL4A1 - were distinguished from the PPI network.
31213898	0.97	COL3A1, COL4A1, COL5A2, and COL6A3.
	0.93	COL3A1, COL4A1, COL5A2, and COL6A3) constituted a core network, with relative higher degree value of node (Figure 3).
	0.93	COL3A1, COL4A1, COL5A2, and COL6A3) from the collagen gene family were upregulated in tumor tissues.
	0.91	COL3A1; (D) COL1A1; (E) COL5A2; (F) COL6A3; (G) COL10A1.
31900160	0.97	COL3A1 and COL5A2 in the CCA tumor both in the NCBI GEO and in the Whole Cancer Genome data sets and in agreement with our peptide profiles.
	0.94	COL3A1, COL5A2, collagen chain alpha-1(XVII) (COL17A1), were evident across the different transcriptomics comparisons and in urine proteomic analysis, all indicative of both increased transcript levels and increased peptide excretion in urine.
	0.80	COL3A1), alpha-2(I) (COL1A2), alpha-2(V) (COL5A2), osteopontin (SPP1) and KLK6, and decreased expression of HBA1, HBB, ITIH2, ITIH4, ALB, kininogen-1 (KNG1), collagen chain alpha-6(VI) (COL6A6), CD99 and CD99 antigen-like protein 2 (CD99L2), was identified in the CCA tumor tissue compared to paired non-tumor tissue and tissue from benign liver lesions or normal bile ducts.
27390605	0.97	COL3A1 (B), COL5A2 (C) and COL15A1 (D) genes in W1 and its drug resistant sublines.
	0.88	COL3A1 and COL5A2) were upregulated only in the TOP and PAC resistant cell lines, which can indicate that the structure of fibrillar collagens can be related to TOP and PAC resistance.
28855619	0.97	COL3A1 and COL5A2 mutations associated with EDS pathogenesis, TGFBR2 mutations associated with Marfan-like syndrome, and TGFBR1, TGFBR2 and SMAD3 associated with LDS.
	0.95	Col3A1, Col5A2, FBN1, MSTN, MYH11, MYLK, SLC2A10, SMAD3, TGFBR1, and TGFBR2 were analyzed by NGS among 70 TAAD subjects enrolled from southern China.
19398442	0.97	COL3A1 encodes type III collagen, a fibrillar mono-trimeric extra cellular matrix protein that is present in extensible connective tissues such as skin, lung, and the vascular system, frequently together with type I collagen.
22991566	0.97	collagen molecules were also upregulated, and these are collagen, type I, alpha 2 (COL1A2), collagen, type III, alpha 1 (COL3A1), collagen, type IV, alpha 1 (COL4A1), and collagen, type V, alpha 2 (COL5A2).
29543232	0.97	COL3A1, COL5A1 and COL5A2), Arterial tortuosity syndrome (SLC2A10) and Shprintzen-Goldberg syndrome (SKI).
30198421	0.97	COL3A1, COL5A1 and COL5A2 are known upregulated genes in GC.
31533654	0.97	COL3A1, COL5A2 and COL1A2 expression are associated with drug-resistance in ovarian cancer.
31803317	0.97	COL3A1, and the low abundance collagen, COL5A2, was significantly down-regulated in the Post-M atrophied introitus.
30941059	0.96	COL5A2, COL3A1, MMP2, and COL6A1) were observed in the yellow module and PPI network associated with OA stage.
	0.94	COL5A2, COL3A1, MMP2, COL6A1, etc.) and 72 hub genes in the brown module (LIPE, LPL, LEP, SLC2A4, FABP4, ADH1B, ALDH4A1, ADIPOQ, etc.) were identified.
	0.93	COL5A2, COL3A1, COL6A1 are members of the collagen gene family.
	0.85	COL5A2, COL3A1, and COL6A1 at the core of the yellow module and PPI network were associated with OA in samples collected from cartilage and subchondral bone.
28586059	0.96	COL3A1, COL5A2, COL6A1, COL6A2, COL6A3, COL11A1, COL12A1 and integrin alpha4 (ITGA4) may interact with each other in the dM2 module.
	0.96	COL3A1, COL5A2, COL6A1, COL6A2, COL6A3, COL11A1, COL12A1 and ITGA4 may interact with each other.
	0.92	COL3A1, COL6A3, COL1A2, COL6A2, COL6A1, ITGA4, COL1A1, COL11A1 and COL5A2) and neuroactive ligand-receptor interaction (dM3; P=9.49x10-4; Table IVB).
31212858	0.96	COL3A1, COL5A1, COL5A2, CSF3, HBEGF, MIF, TGFA, VTN), fundamental processes in the induction of EMT and cancer progression.
31417410	0.95	COL3A1, COL5A1, COL5A2, COL5A3, COL7A1), gap junction protein (GJA1), laminin A3 (LAMA3), laminin C2 (LAMC2), integrin B4 (ITGB), and ACPT (Figures 4, 5 and Supplementary Table 1).
30643084	0.94	COL3A1, COL1A2, COL5A2) of mcode 2 were mainly enriched in the "ECM-receptor interaction" (hsa04512) pathway, and nodes in mcode 3 was only enriched in the "Protein digestion and absorption" (hsa04974).
	0.93	COL3A1, COL1A2 and COL5A2) (Fig. 2B), and mcode 3 consisted of twelve down-regulated nodes (e.g. ASPN) (Fig. 2C).
	0.90	COL3A1), collagen type I alpha 2 chain (COL1A2), LUM, ACTA2, SPARC, ASPN, GNAI1 and COL5A2.
19956414	0.94	COL5A2, COL3A1) LAMC1, and FBN as well as several genes involved in ECM deposition and remodeling, such as SPARC/osteonectin.
	0.93	COL5A2, COL5A1, COL4A1, COL3A1, COL1A1, and COL1A2) laminin C, fibrillin 1, and microfibrillar-associated protein 3; and extracellular matrix regulators, such as MMP14, LOXL2, SERPINH1, SPARC, TNFAIP6, and ADAM 12.
24079748	0.94	COL3A1, COL5A2, CXCL12, TIMP4, TNC that are very likely to be involved in the genesis of IAs.
	0.94	COL3A1, COL5A2 are a group of collagen genes in which mutations are associated with several connective diseases such as the involvement of COL3A1 mutations in intracranial aneurysms and Ehlers-Danlos syndrome type IV with aortic and arterial aneurysms.
30633213	0.93	collagen type III alpha 1 chain (COL3A1), fibronectin 1 (FN1), carboxyl ester lipase (CEL), integrin subunit alpha 2 (ITGA2), collagen type V alpha 2 chain (COL5A2), matrix metallopeptidase 1 (MMP1), and chymotrypsin-like elastase family member 3B (CELA3B).
	0.76	COL3A1, FN1, CEL, ITGA2, COL5A2, MMP1, and CELA3B were the top 10 hub genes, which may be essential to the molecular mechanisms underlying the development of PDAC and may therefore serve as potential therapeutic targets.
	0.65	COL3A1, and COL5A2, provided greater insight into the specific molecular mechanisms underlying PDAC occurrence and development, especially in terms of the pathways involved in fat metabolism and ECM-receptor interaction.
26444860	0.93	Col3a1, Col1a1, Col5a2, and Comp, which are known to belong to the Profibrotic/Tgfbeta-regulated pathway.
	0.89	Col3a1, Col1a1, and Spp1 are positively associated but Col5a2 and Tgfbeta are not associated with any gene in the profibrotic/Tgfbeta-regulated pathway.
21422495	0.93	COL3A1, COL5A1, COL5A2}; ITNXB = {AUTOSOMAL DOMINANT INHERITANCE, ECCHYMOSES, JOINT DISLOCATION, MITRAL VALVE PROLAPSE, SOFT SKIN};
31409039	0.92	COL3A1, COL5A1, COL5A2 and ADAMTS2), (ii) collagens folding and cross-linking (PLOD1 and FKBP14), (iii) structure and function of the myomatrix, i.e., the specialized ECM of muscle (TNXB and COL12A1), (iv) glycosaminoglycans biosynthesis (B4GALT7, B3GALT6, CHST14, and DSE), (v) complement pathway (C1S and C1R), and (vi) intracellular processes (SLC39A13, ZNF469, and PRDM5).
32210969	0.92	COL3A1, COL5A2, COL7A1, COL9A2, COL10A1, COL15A1, COL17A1).
22648066	0.91	COL3A1, COL4A1, COL5A1, COL5A2, and COL6A3).
19152976	0.90	COL5A2, COL3A1, and COL1A1 and COL1A2 genes.
	0.53	COL5A2, COL3A1, COL1A1, COL1A2, TNXB, PLOD1, ADAMTS2, CRTAP, LEPRE1 and ZMPSTE24.
22493711	0.90	COL5A2, FAP, POSTN, COL1A2, COL3A1, FBN1, TNFAIP6, MMP2, GREM1, BGN, CDH11, SPOCK1, DCN, COPZ2, THY1, PCOLCE, PRRX1, PDGFRB, SPARC, INHBA, COL6A2, FN1, ACTA2.
29913259	0.88	COL3A1, collagen type III alpha 1 chain gene; COL5A1, collagen type V alpha 1 chain gene; COL5A2, collagen type V alpha 2 chain gene; Ctrl, control; FAP, fibroblast activation protein alpha gene; FC, fold change; FN1, fibronectin 1 gene; IGF1, insulin-like growth factor 1gene; MMP1, matrix metallopeptidase 1 gene; MMP2, matrix metallopeptidase 2 gene; MMP7, matrix metallopeptidase 7 gene; MMP8, matrix metallopeptidase 8 gene; MMP9, matrix metallopeptidase 9 gene; PDGFRA, platelet derived growth factor receptor alpha gene; PDGFRB, platelet derived growth factor receptor beta gene; Pt, patient; TGFB1, transforming growth factor beta 1 gene; TGFB2, transforming growth factor beta 2 gene; VEGFA, vascular endothelial growth factor A gene; VEGFB, vascular endothelial growth factor B gene.
22208948	0.86	COL5A2, COL5A1, VCAN, COL1A1, COL3A1, FN1,SULF1, FBN1, ASPN, SPARC, CTSK, MMP2, BGN, LUM, LOXL2, COL6A3, TIMP3, CDH11, SERPINF1, EDNRA, ACTA2, PDGFRB, SNAI2, LGALS1, GLT8D2, NID2, PRRX1) belong to the set of 64 genes in Table 1 (P = 10-27), as well as VIM (vimentin).
28346524	0.86	COL3A1 and COL5A2 genes but their predicted impact on protein function was benign.
21331163	0.85	COL3A1, COL5A1, COL5A2 and ABCC6 have been excluded in sporadic SCAD patients.
27293393	0.85	COL3A1, and COL5A2) also appeared similar in the two regions (table 2).
29944724	0.84	COL3A1, COL5A2, KLF2, XRA5, OGN, PCOLCE, SPARC, TGFBI, and TNFAIP6, demonstrated expression patterns similar to those found on microarray analysis (Fig 2A-2L).
29050298	0.81	COL3A1, COL5A2, FBN1 and POSTN were hub nodes in the both co-expression module and PPI network, indicating that those hub genes had high connection with clinical trait as well as vital biological processes.
29152649	0.81	COL3A1, COL5A2, TIMP1, COL5A1 and VIM.
30828485	0.75	COL3A1, COL5A2 genes have been reported in OA.
28715450	0.74	COL3A1 and COL5A2, it is noteworthy that TFPI also lies within this admixture mapping peak and is within 1.75 Mb of the top chromosome 2 signal (S5 Fig).
21549012	0.73	COL3A1, COL4A1, COL5A1, COL5A2, CTHRC1, CXCL1, CXCL13, MMP1, P4HA2, PDPN, PLOD2, POSTN, SDHA, SERPINE1, SERPINE2, SERPINH1, THBS2, TNC, GAPDH, RPS18) in 38 samples (19 paired fresh-frozen and FFPE oral carcinoma tissues, archived from 1997-2008) by both NanoString and SYBR Green I fluorescent dye-based quantitative real-time PCR (RQ-PCR).
30718510	0.72	COL3A1, COL4A2, COL5A2 and MMP19 and an increase of COL2A1, COL6A1, COL9A1, COL9A3, and COL11A2 mRNA levels in CEMIP-depleted cells, compared to shEGFP control cells (supplementary data 2).
31536524	0.67	COL3A1, encoding collagen alpha-1(III) chain, COL5A1, encoding collagen alpha-1(V) chain, COL5A2, encoding collagen alpha-2(V) chain, FLNA, encoding filamin-A, are known to be associated with EDS, and TGFBR1, encoding TGF-beta receptor type-1, TGFBR2, encoding TGF-beta receptor type-2, SMAD3, encoding mothers against decapentaplegic homolog 3, are reported to be associated with LDS/TAAD.
22682473	0.66	COL5A2, COL1A2 and COL3A1; for definition of the abbreviations see Table 4) following stimulation of with either TNF-alpha or TGF-beta1; this differential regulation was common for SFB from RA and OA patients (see Additional file 6: Table S1).