Publication for Cfl1 and Pfn1

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Cfl1	cofilin 1, non-muscle	12631			[link]
mmu	Pfn1	profilin 1	18643

Pubmed ID	Priority	Text
27496138	0.98	Profilin 1, cofilin 1, and vasodialator stimulated phosphoprotein (VASP) are actin binding proteins (ABP) which regulate actin remodelling and facilitate cancer cell metastases.
	0.98	profilin 1, and cofilin 1 are key facilitators of actin dynamics.
	0.98	profilin 1, and cofilin 1 are regulated through a feedback mechanism involving actin polymerization/stabilization or depolymerization/degradation.
	0.98	profilin 1 and cofilin 1 are associated with VASP and are likely involved in the metastatic process but their interactions with each other and VASP are not fully understood.
	0.98	profilin 1 and cofilin 1 were observed at the tumor leading edge.
	0.98	profilin1 with VASPpS157 and cofilin1 with VASPpS239 in regulation of actin dynamics at the cellular leading edges during migration.
	0.98	profilin 1 localization to the cell edges while it increased its localization into the nucleus in A549 cells and increased cofilin 1 expression near the cell edges and in the nuclear region (Figure 4a).
	0.98	profilin 1, VASPpS157 and cofilin 1 are regulated, specifically in response to the invasive phenotype.
	0.98	profilin1/VASPpS157 from cytoplasm to nucleus and of cofilin1/VASPpS239 to the cell leading edge is related to actin content and thus cell migration and apoptotic cell death of cancer cells.
	0.98	profilin 1 and cofilin 1 may be interacting with phosphorylated VASP and that these interactomes may migrate to different subcellular regions to regulate actin dynamics (Figure 6).
	0.97	profilin1 and cofilin1 are predicted targets.
	0.97	profilin1/VASPpS157 or cofilin1/VASPpS239 suggested an interaction in regulation of actin dynamics.
	0.97	profilin1/VASPpS157, cofilin1/VASPpS239, and/or miR-17~92 cluster are innovative and novel molecular target(s) in cancer metastases and that DHA is a concept based therapeutic for inhibiting metastasis and prolonged cell viability through modulation of actin dynamics.
	0.97	profilin1 and VASPpS157 may have a role in increasing F-actin content and enhancing invasive potential in tumor cells while cofilin1 and VASPpS239 may be involved in maintaining homeostasis.
	0.97	profilin 1 and lower cofilin 1 levels in A549 cells than MLE12 cells (Figure 2 a).
	0.97	profilin1/VASPpS157 and lower cofilin1 expression associated with the cell membrane as observed by microscopy (Figure 2 b).
	0.97	profilin 1 and cofilin 1 as potential targets of miR-92 and -19a/b respectively, and miR-17 as a regulator of ECM facilitating metastatic potential of cancer cells.
	0.97	cofilin 1 and profilin 1.
	0.96	cofilin 1 and increased expression of both profilin 1 and VASPpS157 in A549 cells compared to MLE12 cells.
	0.96	cofilin 1 and profilin1 was observed in the A549 than in the MLE12 cells.
	0.96	cofilin 1 and profilin 1 were higher and VASPpS157 was lower in A549 compared to MLE12 cells in the NE(ch) fraction (Figure 2b).
	0.95	Profilin 1/VASPpS157 and Cofilin 1/VASPpS239 Regulates Metastatic Growth and is Modified by DHA Supplementation
	0.95	profilin 1 and F-actin content, induced cofilin1 expression, and attenuated the effect of cAMP in the A549 cells.
	0.94	cofilin 1, profilin 1, VASP, VASPpS157, and VASPpS239
	0.94	profilin1/pVASP-S157 and cofilin1/pVASP-S239.
	0.93	profilin 1 and cofilin 1 are among the predicted targets of miR~17-92 (predicted by Target Scan).
	0.92	profilin 1 and cofilin 1 in A549 and MLE12 cells were examined at the leading edge of cell growth after a wound.
	0.92	cofilin 1 was found primarily around the nucleus while profilin 1 was primarily found at the invasive cellular edges.
	0.92	profilin1/cofilin1 interaction with VASP phosphorylation or miRs with ABPs complexes in cancer metastasis and cell survival is not known.
	0.90	profilin 1 and VASPpS157 and lower expression of cofilin 1 and VASPpS239 was observed in A549 cells compared to MLE12 cells (Figure 1e).
	0.90	profilin 1 and cofilin 1 have also been shown to regulate cancer cell migration and viability in a similar manner.
	0.89	cofilin 1, profilin 1, and VASP in lung cancer tissues
	0.89	profilin1 expression, and less VASPpS239 and cofilin1 expression than MLE12 cells (Figure 1d-e).
	0.64	cofilin 1 and profilin 1 expression.
27881869	0.98	profilin-1 and cofilin-1 play key roles in enhancing the actin assembly at the plasma membrane, thereby increasing F-actin expression, which drives cell motility and other actin-linked processes.
	0.96	profilin-1, and p-cofilin-1 in response to Ntn-1, believed to be essential in the dynamic regulation of F-actin, was observed for 48 h at 50 ng/mL in a time-dependent manner (Fig. 5A).
24747440	0.98	Pfn-1 phosphorylation in glioma progression, database analysis of GBM gene expression reveals elevated mRNA encoding Pfn-1, but not other actin-binding proteins including cofilin-1, formin, fascin, and N-WASP (Supplementary Fig. 7a, b), suggesting a non-canonical function of Pfn-1 besides regulation of actin dynamics.
30635065	0.98	profilin-1, cofilin-1, and F-actin, in MSCs, a lack of MT2 in MSCs during a mouse skin transplantation experiment resulted in impaired wound healing and less engraftment of MSCs at the wound site.
25941073	0.97	Profilin1, cofilin1, and MYPT1 were significantly increased in HD blood compared to controls.
	0.96	Cofilin1, and MYPT1 was significantly increased while RhoA, Rock1, Profilin1, Cofilin1, and Mypt1 were increased and Limk1 mRNA decreased in 13-week-old R6/2 mice.
	0.95	Profilin1 (2.55-fold, p = 0.0001), Cofilin1 (2.21-fold, p = 0.0089), and Mypt1 (1.95-fold, p = 0.0153), whereas Limk1 mRNA was decreased significantly with a fold change of 0.57 (p = 0.0124) in transgenic R6/2 mice compared with wild-type mice as shown in Fig. 2b.
	0.90	Profilin1, Cofilin1, and Mypt1 mRNA, whereas Limk1 mRNA was decreased significantly in transgenic R6/2 mice (n = 3-4) compared with wild-type mice (n = 3-5).
	0.90	Profilin1 (1.44-fold), Cofilin1 (0.57-fold), and Mypt1 (0.33-fold) comparing older with younger transgenic R6/2 mice.
	0.84	Profilin1 had fold changes of 1.32 and 1.47, respectively, while cofilin1 had the highest fold change of 1.63, sufficient differences to serve as potential peripheral markers of HD clinically.
	0.67	Cofilin1 (1.64-fold, p = 0.0002), and MYPT1 (1.62-fold, p = 0.0242) and no significant difference in RhoA (p = 0.0823), Profilin1 (p = 0.3022), or Limk1 (p = 0.0815) as shown in Fig. 2a.
31506540	0.97	cofilin-1, cofilin-2, profilin-1), and RhoGTPases.
	0.87	profilin-1, Arp2, cofilin-1 pS3, cdc42 (pS71)) were normalized after reversing the diet (Fig. 5a-d).
29877034	0.97	Cfl1, Camk2a, Camk2b, Camk2 g, Camk2n1, Rac1, Cdc42, Rhoa, Rock1, Rock2, Pfn1, Pfn2, Pfn3, Pfn4, Cit, Pkn1, Prok1, Rhpn1, Rhpn2, Gsn, Cttn, Wasf1, Cdk5, Baiap2, Cldn5, Nefl, Fn1, Aamp, Cspg5, Clstn3, Mog, and Ncan), including upregulation or downregulation, in the hippocampi of 7-month-old 3xTg-AD mice compared to Ntg animals (Figures 4a and S4A).
30606613	0.97	Pfn1, Cfl1), and ribosomal components (e.g. Rps14, Rps18, Rpl35, Rps29) (Figure 5B; Table S5).
30463566	0.96	profilin1 and cofilin1 correlate with hyperoxic lung injury and repair and that changes in these ABPs are associated with recruitment of MSCs to the injured lung.
	0.64	profilin1 and cofilin1 level in lung tissue homogenates from mouse pups exposed to hyperoxia until day 7.
21860587	0.91	cofilin 1 (1-24, 1-27), profilin 1 (1-27, 1-28), galectin-1 (1-28), and myotrophin (1-30).
	0.90	cofilin 1, profilin 1, galectin-1, and myotrophin.