Publication for SPARC and FSTL1

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	SPARC	secreted protein acidic and cysteine rich	6678			[link]
hsa	FSTL1	follistatin like 1	11167

Pubmed ID	Priority	Text
27886258	0.98	FSTL-1 staining was observed at the cell surface, all members of the SPARC family also demonstrated cytoplasmic staining, and in some cases staining in the nucleus could also be observed.
	0.97	FSTL-1 is sometimes overlooked as a member of the SPARC family since it has the least structural and sequence homology to SPARC and it has been suggested that the calcium binding EF hand in FSTL-1 may be non-functional.
	0.97	FSTL-1 is expressed by stromal cells within the pancreas with an expression pattern highly reminiscent of SPARC, and is expressed at high levels specifically by pancreatic stellate cells.
	0.97	SPARC-like expression pattern, exogenous FSTL-1 does not regulate beta cell growth or proliferation
	0.96	FSTL-1 was the most highly specific of the SPARC family proteins.
	0.96	SPARC, FSTL-1 is therefore unlikely to be directly involved in the regulation of islet growth and survival.
	0.94	SPARC family proteins, with the exception of FSTL-1.
	0.94	FSTL-1 may play a related role to SPARC in pancreatic disease and that the function of FSTL-1 warrants further study.
	0.94	SPARC, FSTL-1 has been shown to regulate signalling of the TGF-beta superfamily and to regulate growth factor signalling.
	0.93	FSTL-1 expression is localised to the stromal compartment reminiscent of SPARC.
	0.91	FSTL-1 has the lowest homology to SPARC.
	0.89	FSTL-1 inhibits pancreatic cancer cell growth, suggesting that SPARC and FSTL-1 produced by stromal cells have antagonistic effects on cancer cell growth.
	0.58	SPARC family protein complexity reveals FSTL-1 as an inhibitor of pancreatic cancer cell growth
27626636	0.98	SPARC family of proteins consists of SPARC (osteonectin), Hevin (SPARC-like protein 1), secreted modular calcium binding protein (SMOC) 1 and 2, testican-1, 2 and 3, and follistatin like protein 1.
26199111	0.97	FSTL1 or SPARC after GHRT (ESM 1: Fig. S4), which might require stimulation with an acute exercise bout.
	0.96	SPARC levels after exercise suppressed colon tumorigenesis and muscle-derived FSTL1 attenuated neointimal formation in response to arterial injury.
	0.90	FSTL1 and SPARC are linked to inflammation and insulin resistance.
29435136	0.97	SPARC, FSTL1 was recently shown to inhibit pancreatic cancer growth.
	0.95	SPARC (secreted protein acidic and rich in cysteine) family of matricellular proteins, which has 8 members: SPARC, SPARCL1/Hevin, SPOCK1, -2, -3, SMOC1, -2 and FSTL1.
24090399	0.97	FSTL1, CHI3L1, IGFBP4, SPARC and B2M.
28498809	0.97	FSTL1 contains two domains: one is a follistatin-like domain which suggests that FSTL1 is classed as the secreted protein-acidic and rich in cysteine (SPARC) family of proteins; the other one is an non-functional extracellular calcium-binding domain.
31649549	0.97	SPARC, FABP-3, FSTL-1, and oncostatin were analyzed using various multiplex assays.
31992826	0.97	FSTL1, TIMP2, FAP, SPARC, AEBP1, NOX4, and FBLN2 are known to regulate macrophage mobilization into tumor tissues, and are associated with TAM.
31952198	0.94	FSTL1 belongs to the secreted protein acidic and rich in cysteine (SPARC) family, which contains both extracellular calcium-binding and follistatin-like domains, and regulates cell survival, proliferation, differentiation, inflammation, and other essential processes.
22247067	0.93	follistatin-related protein 1 and SPARC) and insulin-like growth factor IGF-binding proteins.
22675198	0.93	FSTL1 is a secreted protein sharing a characteristic structural module, the follistatin domain, with follistatin, FSTL3, and members of the SPARC (secreted protein acidic and rich in cysteine) matrix protein family.
28433772	0.92	SPARC, FSTL1, FN1, PTX3, and LGALS1 in KM12SM cells cocultured with MSC-CM versus expression in KM12SM cells cultured alone, as determined by qRT-PCR.
	0.91	secreted protein, acidic and rich in cysteine precursor (SPARC); pentraxin-related protein PTX3 precursor (PTX3); fibronectin precursor (FN1); follistatin-related protein 1 precursor (FSTL1); and galectin-1 (LGALS1) were higher in KM12SM cells directly cocultured with MSCs compared with levels in KM12SM cells cultured alone (Table 2 and Figure 2A).
29760587	0.92	FSTL1, SPARC and omentin-1 in mediating insulin sensitivity in skeletal muscle have yet to be studied.
30672160	0.92	FSTL1 = follistatin-related protein 1, IGF1 = insulin-like growth factor 1, SPARC = secreted protein acidic and rich in cysteine, IL-6 = interleukin-6, IL-7 = interleukin-7, IL-10 = interleukin-10, IL-15 = interleukin-15
29115636	0.88	Follistatin like-1 (FSTL1), also named TSC-36, located on chromosome 3, is a BM-40/SPARC/osteonectin family protein which encodes a secreted glycoprotein.
31182131	0.88	secreted protein, acidic, cysteine-rich (SPARC) family, which consists of SPARC, Hevin, testican-2, testican-3, and follistatin-like protein 1.
25853091	0.87	FSTL-1 is a TGF-beta-inducible gene, secreted protein and acidic and rich in cysteine (SPARC)-related, that enhances inflammatory cytokine/chemokine expression and also seems to be implicated in angiogenesis and revascularization.
31137733	0.84	SPARC, IL18, SRPX2, CCL2, PLAT, PLAU, CXCL12, SFRP2, ANGPT1, CXCL14, TGM2, FSTL1, IGFBP5, IGFBP7, LOX, and LOXL1 were diagnosed with the development of GBM.
30501089	0.74	SPARC, as well as less characterized ECM proteins such as MXRA5, LEPRE1, MFAP4, and FSTL1.
30569103	0.50	Fstl1, Fbn1 and Sparc.