Publication for FASLG and GNLY

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	FASLG	Fas ligand	356			[link]
hsa	GNLY	granulysin	10578

Pubmed ID	Priority	Text
24394640	0.97	granulysin, perforin/granzyme B, Fas/Fas ligand, and cytokines/chemokines are launched to mediate the disseminated keratinocyte death in skin lesions (Figure 1).
	0.82	granulysin, perforin/granzyme B, Fas/Fas ligand, and cytokines/chemokines, are launched to mediate the disseminated keratinocyte death in skin lesions.
25542607	0.97	granulysin, a molecule expressed by cytotoxic T cells, was also diagnostic of AR, with a higher degree of sensitivity and specificity than other cytotoxic effector molecules including granzyme B, perforin, FasL, CD3, or cytokines such as tumor necrosis factor-alpha (TNFalpha), RANTES, IL-2, IL-10, interferon-gamma (IFN-gamma), and transforming growth factor-beta (TGF-beta).
29209467	0.97	granulysin, granzyme A, granzyme B, perforin, FasL).
30613954	0.97	granulysin, Fas ligand and, more recently, interleukin (IL)-15.4, 5, 6 However, Nakajima et al. suggested that while granulysin and Fas ligand are possible candidate biomarkers,7 the duration of elevation is limited and therefore false-negative results for SJS/TEN are a possibility.
25938070	0.96	Granulysin is produced by cytotoxic T lymphocytes (CTLs), natural killer, and natural killer T cells, and released into the extracellular space alone with other immune mediators (e.g., soluble FasL, granzymeB, and perforin).
29114938	0.96	granulysin,3 perforin,4 granzyme B5 and Fas/FasL.6 In line with that observation, transcriptional network comparison of lesional lichen planus and lupus erythematosus with non-interface skin diseases revealed that differentially expressed genes are attributable to type 1 lymphocytes as well as to the effect of IFN-gamma on keratinocytes, including apoptosis and necroptosis (unpublished data).
29352091	0.96	GNLY, NKG7, FASLG, and CASP10), many were expressed in a cluster-specific manner (Fig. 4, D and E, fig. S4D, and table S5).
29984259	0.95	Fas L, granulysin, or perforin/granzyme pathways.
	0.88	Fas L and by the cytotoxic protein granulysin secreted by activated T cells and NK cells.
	0.77	Fas-ligand (Fas L) expressed by effector cells such as T cells and NK cells or indirectly by secretory pathways including release into the microenvironment of tumour necrosis factor-alpha (TNF-alpha), soluble Fas L, or cytolytic/cytotoxic granules containing the pore-forming perforin proteins, granulysin, and granzymes which are all members of a family of serine proteases.
21255389	0.95	granulysin and the death factor FasL (CD178) that are presumably stored in preformed organelles termed secretory lysosomes (SL).
29607330	0.95	granulysin, perforin/granzyme B, and Fas/Fas ligand which were activated by cytotoxic T lymphocytes and natural killer cells.
22216262	0.94	CD95L on the cell surface of granulysin+ T cells was not detected (data not shown).
	0.71	FAS ligand (Fas-L), perforin and granulysin.
23162553	0.94	Fas ligand (FasL; CD178), TNF-related apoptosis-inducing ligand (TRAIL; CD253), granulysin, and small anti-microbial peptides (see below).
30891164	0.93	granulysin and FasL).
	0.87	GNLY and FasL between each other (Figure 2).
	0.81	granulysin (GNLY, 56 ng/mL), and FasL (2.5 ng/mL) were obtained from >60 isolations using dot plots.
20368575	0.93	granulysin, or binding to receptors with ligands of the TNF superfamily (e.g., FasL and TRAIL).
	0.51	granulysin, FasL, and TRAIL.
19640298	0.92	granulysin, and the TNF family protein FasL (CD178).
	0.92	FasL and lysosomal membrane proteins, which is indicative for the enrichment of SL in fraction 2, we observed a rather high abundance of other cytotoxic effector molecules (including granzyme B, perforin and granulysin) in fractions 4 and 6 (Figure 2).
27999358	0.92	granulysin, Fas-Fas ligand interaction, tumour necrosis factor-alpha (TNF-alpha), TNF-related apoptosis-inducing ligand (TRAIL), and perforin-granzyme B.
	0.81	granulysin, soluble Fas ligand, perforin/granzyme, tumour necrosis factor-alpha (TNF-alpha), and TNF-related apoptosis-inducing ligand.
21912564	0.92	FasL, TRAIL), granulysin mRNA is present in significantly higher levels in CD56+ and CD56+CD3+ cells, but in T lymphocytes only, no differences between granulysin and perforin mRNA levels were observed (unpublished data, manuscript in preparation).
21992116	0.91	granulysin and the interaction between the Fas/Fas ligand and caspase activation represent the major effector mechanisms of cell-mediated immunity.
30788030	0.90	Fas ligand-mediated signaling pathway), and by secretion of factors such as perforin, granulysin and cytokines (TNFa).
	0.65	Fas-ligand and the perforin-granulysin pathways.
29692452	0.89	Fas ligand, granzyme B, soluble CD40 ligand, granulysin, serum high mobility group protein B1 (HMGB1), serum lactate dehydrogenase level, alpha-defensins 1-3 in the blister, Bcl-2 expression in the dermal infiltrate, thymus and activation-regulated chemokine, and glutathione-S transferase-pi expression.
30236030	0.88	FasL, and TRAIL, as well as cytoplasmic cytotoxic granules containing perforin, granulysin, and granzymes A and B. Paradoxically, NK cells also kill other immune cells like macrophages, dendritic cells, and hyper-activated T cells, thus turning off self-immune reactions.
26623214	0.82	FasL, perforin/granzyme B, and granulysin, released from antigen-primed cytotoxic T cells and NK cells cause cell damage and apoptosis.
29967623	0.80	FASL, and GNLY may play important roles in the pathogenesis of children MPP.
21162721	0.76	FasL and granulysin are key players in the pathogenesis of SJS/TEN.
30830062	0.63	Fas ligand, perforin/granzyme B and granulysin are released to mediate keratinocyte apoptosis and detachment of skin and mucous membranes.