Publication for CXCR3 and GNLY

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	CXCR3	C-X-C motif chemokine receptor 3	2833			[link]
hsa	GNLY	granulysin	10578

Pubmed ID	Priority	Text
30353048	0.97	CXCR3 and CCR5 ligands, respectively, CXCL9 and CXCL10, and CCL5), and cytotoxic functions (GNLY, PRF, GZMA, GZMB, and GZMH).
31189943	0.97	CXCR3 and CCR5 signaling), GZMA, GZMB and GNLY (effector functions); p values displayed here were calculated using unpaired t-test including only CR and NR.
29427415	0.95	GNLY, LAG3, and HAVCR2, which encodes TIM-3, whereas the CCR8- fraction from thigh skin samples showed greater expression of several immune activation genes, including CCL5, GZMA, GZMB, CXCR3, and genes encoding the inhibitory receptors LAG3 (LAG3) and programmed cell death protein 1 (PD-1) (PDCD1) (Fig. 2C).
21992116	0.90	CXCR3 ligand chemokine pathway (CXCL9, -10, -11) III) CCR5 ligand chemokine pathway (CCL3, -4, -5) and IV) TIA-1 pathway/granzyme A/B/granulysin/perforin pathway.
24741625	0.89	CXCR3, AQP3, CCR9, IFNAR1, and CEACAM1 among the top twenty upregulated genes as well as EIF1AY, DDX3Y UTY, IL7R, IGFBP7, and GNLY among the top twenty downregulated genes are involved in immune function of organism, while other genes function in immune responses was not clearly identified.
29871670	0.88	CXCR3/CCR5 chemokines (including CXCL9, CXCL10, CCL5), Th1 signaling (including IFNG, IL12B, TBX21, CD8A, STAT1, IRF1, CD8B), effector (including GNLY, PRF1, GZMA, GZMB, GZMH) and immune regulatory (including CD274, CTLA4, FOXP3, IDO1, PDCD1) functions.
30744168	0.88	CXCR3/CCR5 chemokines (including CXCL9, CXCL10, CCL5), Th1 signaling (including IFNG, IL12B, TBX21, CD8A, STAT1, IRF1, CD8B), effector (including GNLY, PRF1, GZMA, GZMB, GZMH) and immune regulatory (including CD274, CTLA4, FOXP3, IDO1, PDCD1) functions.
21812928	0.85	granulysin, CXCL10, CXCR3, F as L, FOXP3, Tim-3, and IFNG, and elevated serum levels of granzyme B, perforin, F as L, IL-4, IL-5, IL-6, IFNG, CD40L, Tim3, PI-9 and FOXP3 were identified as diagnostic and sometimes predictive biomarkers of acute rejection.
22216262	0.85	CXCR3, characteristic for type 1 helper T cells, as well as activation markers (HLA-DR, CTLA-4, CD40L) and additional cytotoxic markers (granzyme B and perforin) in granulysin-expressing T cells upon antigen stimulation (Figure 4).
22551296	0.85	GNLY, GZM and TIA accompanied by over expression of CXCR3 and CCR5 with corresponding ligands (CXCL9-11, CCL5).
28344865	0.79	CXCR3/CCR5 chemokine ligands (CXCL9, CXCL10, and CCL5) and effector immune functions (GNLY, PRF1, GZMA, GZMB, and GZMH).
	0.52	CXCR3 and CCR5 ligands, like CXCL9-11 and CCL5, respectively, and the induction of immune-effector mechanisms, such as perforin (PRF1), granzymes (GZMs), and granulysin (GNLY).
29061765	0.75	granulysin, IFN-gamma, IL7-R, chemokine receptor CCR7, MHC-II and CXCR3 are shown.
24293448	0.70	CXCR3), (c) T-helper lineage development (GATA3, STAT4, TBX21), (d) T-cell activation, proliferation, development, signal transduction, survival, and cytokine production (CCR7, CD6, CD28, DPP4, IL23A, IL23R, IL2RB, IL5RA, IL9R, ITK, LCK, PRKCQ, TCF7, ZAP70), (e) generation and long-term maintenance of T-cell immunity (CD27), (f) T-cell-mediated cytotoxicity (GNLY, GZMA), and (g) regulation of B-cell activation, V(D)J recombination, and Ig synthesis (CCR7, IL7R).
27522581	0.69	CXCR3 and CCR5 ligands), activation of immune-effector function genes (including granzymes, perforin, granulysin), and activation of IFN-stimulated genes towards Th1 lineage polarization (IFN-gamma-STAT1-IRF1-IFN-gene pathways).