Publication for PMEPA1 and NKILA

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	PMEPA1	prostate transmembrane protein, androgen induced 1	56937			[link]
hsa	NKILA	NF-kappaB interacting lncRNA	105416157

Pubmed ID	Priority	Text
28412955	0.97	PMEPA1 expression is strongly enhanced by TGF-beta and negative feedback inhibit TGF-beta/Smad signal pathway in return, which brings the hypothesis that NKILA may also participate in the TGF-beta signal pathway.
	0.89	PMEPA1 and NKILA genome location.
26069731	0.96	NKILA (GenBank accession DA866558, see Figure 1), or, - our major criticism - that NKILA is divergently transcribed from prostate transmembrane protein, androgen induced 1 ( PMEPA1) and antisense to some of its transcripts (see Figure 1).
	0.96	PMEPA1 knockdown has been found to be able to attenuate growth and motility of MDA-MB-231 breast cancer cells , which is interesting since Liu et al. found that forced NKILA expression (which might knockdown PMEPA1 expression) in MDA-MK-231 cells achieves similar effects.
	0.94	PMEPA1-001 transcript open reading frame and a part of the intergenic promoter region are highly conserved through evolution, this seems to be true to a lesser degree for NKILA equivalent transcripts ( Supplementary file S1 and discussion therein).
	0.93	NKILA through PMEPA1 on NF-kappaB functions.
	0.88	PMEPA1 expression in breast cancer is associated with poor patient prognosis , and high NKILA expression with better patient prognosis .
	0.81	PMEPA1, a gene which runs antisense to NKILA, and the expression of which is associated with several tumors and which encodes a protein that participates in immune pathways.
	0.77	NKILA regulation of PMEPA1, it would contribute to the establishment of PMEPA1 as an important topic of cancer research.
30125263	0.96	NKILA for NF-kappaB interacting lncRNA, which is not only induced by NF-kappaB, but also interacts with the NF-kappaB /IkappaB complex to prevent overactivation of NF-kappaB. Parts of this report have been questioned with an alternative explanation being put forward that NKILA exerts its effects through its antisense properties to PMEPA1.
32048814	0.96	NKILA), encoded by a gene at chromosome 20q13 just near by the prostate transmembrane protein androgen induced 1 (PMEPA1),96 was increased by NF-kappaB in breast cancer.97 Recently, Lu et al discovered that NKILA expression was negatively associated with tumour metastasis in patients with NSCLC, and the expression of NKILA was regulated through classical TGF-beta signal pathway, which subsequently inhibited migration and invasion of NSCLC cells through interfering NF-kappaB/Snail signal pathway in NSCLC cells.98