Publication for TUBB2A and TUBB3

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	TUBB2A	tubulin beta 2A class IIa	7280			[link]
hsa	TUBB3	tubulin beta 3 class III	10381

Pubmed ID	Priority	Text
30126203	0.98	TUBB3 and downregulation of TUBB2A, TUBB2B, TUBB6, TUBB7P pseudogene, and TUBGCP2 in the tumor tissues compared to the normal breast tissues.
	0.98	TUBB2A, TUBB3, TUBB4B, TUBB6, TUBB7P, TUBB8, TUBD1, TUBE1, TUBG1, TUBG2, TUBGCP2, TUBGCP4 and TUBGCP5 is correlated with activity of their promoter chromatin.
	0.98	TUBB3 (P = 0.0038) and reduced expression of TUBB2A (P = 0.0007), TUBB2B (P = 0.0010), TUBB6 (P = 0.0020), TUBB7P (P = 0.0001) and TUBGCP2 (P = 0.0020) in BC tumors compared to the normal breast tissues (Figure 6A).
	0.97	TUBB2A (P = 0.0042), TUBB3 (P = 0.0006), TUBB4B (P = 0.0042), TUBB6 (P = 0.0024) and TUBCP3 (P = 0.0095) in comparison with the taxane-sensitive tumors (Figure 6B).
	0.91	TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B and TUBB6 (Figure 1C).
	0.70	TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6 except TUBB8 (Figure 1A).
24275654	0.98	TUBB2A-C, or TUBB3.
	0.98	TUBB2A, TUBB2B, TUBB2C, and TUBB3 have a serine residue at position 364.
	0.96	TUBB2A, TUBB2B, TUBB2C, and TUBB3 also permitted the direct association of these proteins with LRRK2 (Fig. 3C), whereas the reciprocal A364S substitutions in TUBB and TUBB4 abrogated binding (Fig. 3C).
	0.52	TUBB2A, TUBB2B, TUBB2C, and TUBB3 allows these beta-tubulins to interact with LRRK2.
31186718	0.98	TUBB2A, TUBB3, TUBB4B and TUBB6 mRNA derived from untreated and eribulin-, paclitaxel- or vinblastine-treated OLC-01, OSC-19 and OSC-20 cells.
	0.97	TUBB2A, TUBB3, TUBB4B and TUBB6 genes can selectively differentiate eribulin-sensitive several cancer cells.
	0.97	TUBB2A, TUBB3, TUBB4B and TUBB6 mRNA derived from OLC-01, OSC-19 and OSC-20 cells, presented as fold changes relative to the expression in KD cells.
	0.96	TUBB2A, TUBB3, TUBB4B and TUBB6) in OSC-19 cells and four beta-tubulin subunits (TUBB, TUBB3, TUBB4B and TUBB6) in OSC-20 cells were significantly increased following eribulin treatment.
22485186	0.98	TUBB3 (tubulin, beta 3/microtubule-based movement), TUBB2A (tubulin, beta 2A/microtubule-based movement), UGT1A6 (UDP glucuronosyltransferase 1 family/xenobiotic metabolic process).
	0.93	TUBB3 (tubulin beta 3, 3.2-fold increase) and TUBB2A (tubulin beta 2A, 4.5-fold increase) were found to be upregulated with amnion activation.
25171249	0.98	TUBB2A, TUBB3, TUBB4B, TUBB6) had significant increases in expression under paclitaxel treatment compared to control.
	0.88	TUBB3, TUBB6) significantly correlated with eribulin sensitivity and that of one tubulin (TUBB2A) significantly correlated with paclitaxel sensitivity.
24633327	0.98	TUBB2A/B) is enriched in brain and epithelial cells, betaIII (TUBB3) in specific neuronal cells, betaIV (TUBB4) in ciliary and flagellar structures, and betaVI (TUBB1) in platelets and hematopoietic cells.
27878758	0.98	TUBB2A, TUBB2C, TUBB3, TUBB6, TUBD1, TUBG2, and TUBGCP2.
28406185	0.98	TUBB2A, other members of tubulin family affected by Oct4A knockdown were TUBB6, TUBB2C, TUBB4A, TUBB4, TUBB5, which were prominently down regulated in Oct4A KD xenografts compared to xenografts derived from vector control cells.
30555664	0.98	TUBB2 (Tubulin Beta 2 Class II), TUBB3 (Tubulin Beta 3 Class III), TUKLS (Tukel syndrome), KlF21A (Kinesin Family Member 21A), COL2A1 (Collagen Type XXV Alpha 1 Chain) and PHOX2A (Paired Like Homeobox 2a) genes in different types of CFEOM.
23321512	0.97	TUBB2A, TUBB2B, TUBB2C, TUBB3 and TUBB in A549 and MCF7 cells using one-to-three individual siRNAs per each tubulin isotype.
	0.89	TUBB3, TUBB and TUBB2A-C silenced A549 and MCF7 cells and in A549 cells overexpressing Myc-tagged TUBB3 and TUBB to control cells.
	0.60	TUBB2A-C, TUBB3 and TUBB in the cellular response to epothilones, we performed silencing and overexpression studies in human lung A549 and breast MCF7 cancer cells.
26464822	0.97	TUBB2) and TUBB3 are the most frequent isotypes particularly located in epithelial cells which over-express in some cancer cells.
26493046	0.97	TUBB3, TUBB, TUBB4A, TUBB2A, and TUBG1 genes.
26725114	0.97	TUBB2A), TUBB3, TUBG1, and MAP4 were significantly upregulated as compared to non-failing cardiomyocytes, suggesting a primary role for microtubule disruption in cellular vulnerability to MiCai generation (Figure 6E).
28835377	0.97	TUBB2A, 24 in TUBB2B, 19 in TUBB3, and three in TUBB5), and one exonic deletion in TUBB2B that produce neurological disorders in heterozygous carriers (Supplemental Table S1); all mutations, except for the TUBA8 deletion, appear to act as dominant-negative mutations.
29977480	0.97	TUBB2A is underexpressed but also downregulated by the clear majority of predicted interactions, including by other tubulin variants such as TUBB3 and TUBB4B as well as BRE which was discussed earlier.
30087272	0.97	TUBB3, TUBB, TUBB2A, and TUBG1.
30340542	0.97	TUBB2A, TUBB2B, TUBB3, TUBB5, TUBG1 and TUBA8 genes are also responsible microcephaly and microlissencephaly.
30382096	0.97	TUBB3, TUBB2a, and TUBB2b (Fig. 7b and Supplementary Fig. 8a).
30388878	0.97	TUBB2A), betaV (TUBB6), and betaIII (TUBB3) with 47%, 38%, 8.9%, 3.1%, and 2.2% respectively and with betaIVa (TUBB4), betaIIb (TUBB2B) and betaVI (TUBB1) levels below 0.5% of the total beta tubulin.
30463236	0.97	TUBB2A), betaV (TUBB6), and betaIII (TUBB3), with 47%, 38%, 8.9%, 3.1%, and 2.2%, respectively, and then betaIVa (TUBB4), betaIIb (TUBB2B), and betaVI (TUBB1) with levels below 0.5% of the total expressed beta tubulins.
27935867	0.96	TUBB3, TUBB2A and C, TUBB4Q, TUBB6, VAMP1 and COL9A2.
31269740	0.95	TUBB2 and TUBB3 genes mutations.
	0.94	TUBB3, TUBB4A, TUBB2A, TUBB, TUB8A).
31315202	0.95	TUBB2A), beta2B (TUBB2B), beta2C (TUBB2C), beta3 (TUBB3), beta4 (TUBB4), beta5 (TUBB), beta6 (TUBB6) and beta8 (TUBB8).
30744660	0.94	TUBB2A, MIM#615101; TUBB2B, MIM#612850; TUBB3, MIM#602661; TUBB, MIM#191130; TUBG1, MIM#191135).
22319589	0.93	TUBB2A, p = 0.009, TUBB4, p = 0.005) and of MAP4 (p = 0.001) correlated to resistance.
26789871	0.93	TUBB2A, TUBB2B, TUBB3, TUBB4A and TUBB4B have been described; these cause a broad range of diseases for the most part involving microtubule-based defects in neuronal migration .
26586992	0.92	TUBB3) expression plays the major role and (2) beta-tubulin isotype II (TUBB2) expression as the secondary factor in causing late relapse of tumor.
30871176	0.90	TUBB2A (IIalpha), TUBB2B (IIbeta), TUBB3 (IIIbeta), and TUBB4 (IValpha) have high expression in the brain; TUBB2C (IVbeta) in the heart and skeletal muscles.
23143659	0.89	TUBB2A and TUBB3 (i.e. the genes encoding betaII- and betaIII-tubulin, respectively) mRNA levels in VLB-LDM and VP16-MTD cells (Online Resource 2), suggesting that the repression occurred at the transcriptional level.
26052266	0.87	TUBB2A, TUBB2B, TUBB3, TUBB4A, and TUBB, are identified in a wide spectrum of disorders besides brain malformations.
25344915	0.85	TUBB2A, TUBB2C, TUBB3, TUBB4Q and TUBG1) and claudins (CLDN2, CLDN20, CLDN4 and CLDN5), also resulted to be enriched in MSCs following treatment with TGFalpha.
29345283	0.84	TUBB3 and TUBB6) was significantly associated with eribulin sensitivity and that the expression of one tubulin (TUBB2A) was significantly associated with paclitaxel sensitivity.
29706637	0.82	TUBB2A, TUBB2B, TUBB3, TUBB, and TUBG1, have been associated with a spectrum of cortical malformations through disruption of normal microtubule interactions, which are involved in neuronal cell proliferation, migration and differentiation, as well as axon growth and guidance.
31151415	0.80	TUBB2A, TUBA8, TUBB2B, TUBB3, TUBB5, TUBG1) are associated with a range of brain malformations.
23106811	0.77	tubulin, beta 2A-C, 3 (TUBB2A, TUBB2B, TUBB2C, TUBB3).
29382549	0.75	TUBB2A, TUBB4A, TUBB2B, TUBB3 and TUBA8) cause a variety of brain malformations, such as lissencephaly, polymicrogyria, hypoplasia of the internal capsule, basal ganglia, the hippocampus, cerebellum, brainstem, and cranial nerves, and partial or complete agenesis of the commissural fiber tracts and the corticospinal tract.
25724666	0.74	TUBB3, TUBB2C, TUBB, TUBB2A, TUBB2B) are expressed, whereas in normal breast epithelium (which express TUBB2C, TUBB1, TUBB2A, TUBB6) TUBB3 is virtually absent.
26760504	0.73	TUBB2A, TUBB4A, TUBB2B, TUBB3, TUBB) lead to developmental brain abnormalities, i.e. lissencephaly, polymicrogyria, abnormal basal ganglia as well as cerebellar and brainstem hypoplasia.