Publication for CDH5 and ESAM

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
hsa	CDH5	cadherin 5	1003			[link]
hsa	ESAM	endothelial cell adhesion molecule	90952

Pubmed ID	Priority	Text
31328152	0.97	endothelial cell adhesion molecule (PECAM-1/CD31) at cell junctions is activated rapidly when exposed to shear and forms a complex with vascular endothelial cadherin (VE-cadherin) and vascular endothelial growth factor receptor 2 (VEGFR2).
31839543	0.97	CDH5, ESAM, FLI1, KDR, NRP1, and TEK) (Figure 4B).
30174281	0.96	CDH-5, cadherin-5; CSTB, cystatin-B; TNFRSF10C, tumor necrosis factor receptor superfamily member 10C; ALCAM, CD166 antigen; GDF-15, growth/differentiation factor 15; AZU1, azurocidin; FAS, Tumor necrosis factor receptor superfamily member 6;; TLT-2, trem-like transcript 2 protein; EPHB4, ephrin type-B receptor 4; PAI, plasminogen activator inhibitor 1; FABP4, fatty acid-binding protein, adipocyte; TR, transferrin receptor protein 1; MMP-9, matrix metalloproteinase-9; TNF-R1, tumor necrosis factor receptor 1; CTSD, cathepsin D; CCL24, c-c motif chemokine 24; TNF-R2; tumor necrosis factor receptor 2; Gal-3, galectin-3; LTBR, lymphotoxin-beta receptor; IL-17RA, interleukin-17 receptor a; TNFRSF14, tumor necrosis factor receptor superfamily member 14; PRTN3, myeloblastin; RARRES2; retinoic acid receptor responder protein 2; RETN, resistin; vWF, von Willebrand factor; IL-18BP, interleukin-18-binding protein; JAM-a, junctional adhesion molecule a; U-PAR, urokinase plasminogen activator surface receptor; MCP-1, monocyte chemotactic protein 1; IGFBP-7, insulin-like growth factor-binding protein 7; SELP, P-selectin; PECAM-1, platelet endothelial cell adhesion molecule; ICAM-2, intercellular adhesion molecule 2; TNFSF13B, tumor necrosis factor ligand superfamily member 13B; PLC, perlecan; DLK-1, protein delta homolog 1; PDGF subunit a, platelet-derived growth factor subunit a; CASP-3, caspase-3; SPON1, spondin-1; IGFBP-1, insulin-like growth factor-binding protein 1; OPN, osteopontin; ITGB2, integrin beta-2; CTSZ, cathepsin Z; CD93, complement component C1q receptor; t-PA, tissue-type plasminogen activator; MEPE, matrix extracellular phosphoglycoprotein; uPA; urokinase-type plasminogen activator; COL1A1, collagen alpha-1(I) chain; LDL receptor; low-density lipoprotein receptor; PON3, paraoxonase 3; TFPI, tissue factor pathway inhibitor
	0.82	CDH-5, cadherin-5; AP-N, aminopeptidase N; KLK6, kallikrein-6; CHIT1, chitotriosidase-1; CSTB, cystatin-B; MPO, myeloperoxidase; TNF-R2; tumor necrosis factor receptor 2; OPG, osteoprotegerin; PGLYRP1, peptidoglycan recognition protein 1; MMP-3, matrix metalloproteinase-3; IL-17RA, interleukin-17 receptor a; CTSD, cathepsin D; TNF-R1, tumor necrosis factor receptor 1; SELE, E-selectin; ALCAM, CD166 antigen; TNFRSF10C, tumor necrosis factor receptor superfamily member 10C; PSP-D, pulmonary surfactant-associated protein D; FABP4, fatty acid-binding protein, adipocyte; GRN, granulins; IL2-RA, interleukin-2 receptor subunit alpha; MB, myoglobin; IL-6RA, interleukin-6 receptor subunit alpha; RETN, resistin; vWF, von Willebrand factor; TNFRSF14, tumor necrosis factor receptor superfamily member 14; CPA1, carboxypeptidase A1; FAS, tumor necrosis factor receptor superfamily member 6; DLK-1, protein delta homolog 1; U-PAR, urokinase plasminogen activator surface receptor; TR-AP, tartrate-resistant acid phosphatase type 5; EPHB4, ephrin type-B receptor 4; IL-17RA, interleukin-17 receptor a; LTBR, lymphotoxin-beta receptor; PI3, elafin; Gal-3, galectin-3; CPB1, carboxypeptidase B; PECAM-1, platelet endothelial cell adhesion molecule; JAM-a, junctional adhesion molecule a; PLC, perlecan; ICAM-2, intercellular adhesion molecule 2; IL-18BP, interleukin-18-binding protein; TNFSF13B, tumor necrosis factor ligand superfamily member 13B; TLT-2, trem-like transcript 2 protein; EGFR, epidermal growth factor receptor; ITGB2, integrin beta-2; IGFBP-7, insulin-like growth factor-binding protein 7; CXCL16, c-x-c motif chemokine 16; IGFBP-1, insulin-like growth factor-binding protein 1; PRTN3, myeloblastin; SELP, P-selectin; TR, transferrin receptor protein 1; AZU1, azurocidin; MMP-9, matrix metalloproteinase-9; RARRES2; retinoic acid receptor responder protein 2; MCP-1, monocyte chemotactic protein 1; OPN, osteopontin; CASP-3, caspase-3; PDGF subunit a, platelet-derived growth factor subunit a; PAI, plasminogen activator inhibitor 1; SPON1, spondin-1; CCL24, c-c motif chemokine 24; CD93, complement component C1q receptor; t-PA, tissue-type plasminogen activator; uPA; urokinase-type plasminogen activator; CTSZ, cathepsin Z; MEPE, matrix extracellular phosphoglycoprotein; TFPI, tissue factor pathway inhibitor
30387148	0.96	vascular endothelial cadherin (VE-cadherin) and platelet endothelial cell adhesion molecule (PECAM-1; van Meeteren & ten Dijke, 2012; Welch-Reardon, Ehsan, & Wang, 2014).
	0.78	endothelial cell adhesion molecule 1; shCtrl: shRNA control; alpha-SMA: alpha-smooth muscle actin; shLOXL2: short hairpin-mediated LOXL2 knockdown; TGF-beta: transforming growth factor-beta; VE-cadherin: vascular endothelial cadherin
29234067	0.96	ESAM), junctional complex proteins (CDH5, CDH6, CLDN4, CLDN5, CTNNA1, GJA1, LIN7A, MPDZ, PCDH1, TJP1, VEZT, ZYX), vascular endothelial cell secreted protein CTGF, and chemokine receptor CXCR4.
15176972	0.95	CDH5) and platelet/endothelial cell adhesion molecule (CD31 antigen) (PECAM1) showing increase in both the case pairs.
23388453	0.95	CDH5, PECAM and ESAM, and form immotile tight aggregates composed of approximately 30 VE-cadherin+ epithelioid cells (cores).
29560266	0.95	endothelial cell adhesion molecule; SDF1, stromal cell-derived factor 1; TEM; Ties-expressing macrophage; Treg, regulatory T cell; VE-cadherin, vascular endothelial cadherin; VEGF, vascular endothelial growth factor.
26356571	0.94	VE-cadherin and platelet endothelial cell adhesion molecule (PECAM-1) "perceive" intracellular forces, whereas transducers such as alpha-catenin and vinculin transmit force.
23209022	0.92	VE-Cadherin, tight junction proteins claudin-5 and zonula occludens-1 (ZO-1), tight junction-associated Ig-like transmembrane proteins endothelial cell-selective adhesion molecule (ESAM), junctional adhesion molecule-A (JAM-A), and PECAM-1/CD31.
28377727	0.92	CDH5, MPDZ, CLDN-1, -3, -6, -9, -11, -14, -16, -17, -18, TACSTD2, CXCL8, ETV5, GRM5, FGF1) while no gene expression data were available for 14 interactors (gene symbols: WNK4, CLDN -2, -12, -19, -20, -22, -23, -24, -25, ESAM, CCDC155, SYNE4, ATE1, MARVELD3).
28809853	0.92	ESAM, CDH5 and MMRN2 in blood vessel development, suggesting that the intramodular hub genes could function as potential biomarkers or be lead target sites for future therapeutic interventions.
29317995	0.92	CDH5 (p < 0.001), TJP2 (p = 0.001), and platelet endothelial cell adhesion molecule (PECAM1, p < 0.001).
22623881	0.91	ESAM (endothelial cell selective adhesion molecule), VE-cadherin (vascular endothelial cadherin), and N-cadherin, are known to have a significant in angiogenesis regulation.
24130897	0.89	VE-cadherin and EC-selective adhesion molecule (ESAM).
27812766	0.88	endothelial cell adhesion molecule), CD106/VCAM-1 (vascular cell adhesion molecule 1), CD54/ICAM-1 (intercellular adhesion molecule 1), CD144/VE-cadherin (vascular endothelial cadherin).
28232601	0.88	endothelial cell adhesion molecule), VCAM (vascular cell adhesion molecule), VE-cadherin (cadherin 5) and VEGFA (vascular endothelial growth factor A) (data not shown).
31187898	0.85	endothelial cell adhesion molecule (PECAM-1), vascular endothelial cadherin (VE-cadherin), and occludin.
30327649	0.81	endothelial cell adhesion molecule (gene name PECAM1) and vascular endothelial cadherin (gene name CDH5) were expressed in a distinct group of cells in our dataset (Figure 1B).
25363018	0.76	Vascular endothelial cadherin, platelet endothelial cell adhesion molecule (PECAM), occludin, claudin, and endothelial cell selective adhesion molecule (ESAM) are the major trans-membrane adhesive proteins at endothelial junctions.
32127614	0.76	CDH5, HEY2, JAM2, JAM3, ESAM, TJP2, GJA1, GJA5, TNFRSF21 and AXIN2) and transporters over EC barrier (Fig. 3d; ABCA1, ABCA2, ABCC5, INSR).
23084400	0.72	VE-cad (green stain: i.,vi.,xi.), CD31 (red stain: ii.,vii.,xii.), ESAM (red stain: iii.,viii.,xiii.), JAM-A (red stain: iv.,ix.,xiv.), EpCAM (red stain: v.,x.,xv.), DAPI (blue stain).
	0.67	VE-cadherin, CD31, ESAM and JAM-A at cell junctions (Fig. 3f and Sup Fig. S5a).
22905093	0.68	CDH5; cadherin 5, type 2 (vascular endothelium) CLDN1; claudin 1 CLDN5; claudin 5 CXCL12; chemokine (C-X-C motif) ligand 12 ESAM; endothelial cell adhesion molecule JAM2; junctional adhesion molecule 2 OCLN; occludin (EC:2.1.1.67) VCAM1; vascular cell adhesion molecule 1 VCL; vinculin.
31438519	0.50	endothelial cell adhesion molecule (PECAM1) interaction with myosin in the presence of vascular endothelial cadherin (VE-cadherin), activating downstream VEGFR2 or VEGFR3.