[←][→] mmu  Top2a Gene
functional annotation
Function   topoisomerase (DNA) II alpha  
GO BP
GO:0045870 [list] [network] positive regulation of single stranded viral RNA replication via double stranded DNA intermediate  (2 genes)  ISO  
GO:1905463 [list] [network] negative regulation of DNA duplex unwinding  (3 genes)  ISO  
GO:0051309 [list] [network] female meiosis chromosome separation  (4 genes)  TAS  
GO:0030263 [list] [network] apoptotic chromosome condensation  (5 genes)  IBA ISO  
GO:0006266 [list] [network] DNA ligation  (6 genes)  ISO  
GO:0006265 [list] [network] DNA topological change  (7 genes)  IDA ISO  
GO:0040016 [list] [network] embryonic cleavage  (9 genes)  IMP  
GO:0000712 [list] [network] resolution of meiotic recombination intermediates  (17 genes)  IBA  
GO:0007143 [list] [network] female meiotic nuclear division  (41 genes)  IMP  
GO:0030261 [list] [network] chromosome condensation  (41 genes)  IMP  
GO:0042752 [list] [network] regulation of circadian rhythm  (128 genes)  IMP  
GO:0000819 [list] [network] sister chromatid segregation  (131 genes)  IBA  
GO:0002244 [list] [network] hematopoietic progenitor cell differentiation  (144 genes)  IMP  
GO:0048511 [list] [network] rhythmic process  (264 genes)  IEA  
GO:0007059 [list] [network] chromosome segregation  (273 genes)  IDA IMP ISO  
GO:0043065 [list] [network] positive regulation of apoptotic process  (598 genes)  ISO  
GO:0006259 [list] [network] DNA metabolic process  (654 genes)  IEA  
GO:0006974 [list] [network] cellular response to DNA damage stimulus  (691 genes)  ISO  
GO:0045944 [list] [network] positive regulation of transcription by RNA polymerase II  (1250 genes)  IMP  
GO CC
GO:0009330 [list] [network] DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex  (1 genes)  ISO  
GO:0005814 [list] [network] centriole  (125 genes)  ISO  
GO:0000775 [list] [network] chromosome, centromeric region  (195 genes)  IDA  
GO:0000228 [list] [network] nuclear chromosome  (261 genes)  ISO  
GO:0000793 [list] [network] condensed chromosome  (301 genes)  IDA IMP  
GO:1990904 [list] [network] ribonucleoprotein complex  (831 genes)  ISO  
GO:0005730 [list] [network] nucleolus  (895 genes)  IDA ISO  
GO:0005654 [list] [network] nucleoplasm  (3580 genes)  ISO TAS  
GO:0032991 [list] [network] protein-containing complex  (5540 genes)  ISO  
GO:0005634 [list] [network] nucleus  (7226 genes)  IBA IDA ISO  
GO:0005737 [list] [network] cytoplasm  (11434 genes)  ISO  
GO MF
GO:0003918 [list] [network] DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity  (4 genes)  IDA IGI ISO  
GO:0003916 [list] [network] DNA topoisomerase activity  (8 genes)  ISO  
GO:0008301 [list] [network] DNA binding, bending  (17 genes)  ISO  
GO:0005080 [list] [network] protein kinase C binding  (64 genes)  ISO  
GO:0043130 [list] [network] ubiquitin binding  (84 genes)  ISO  
GO:0008094 [list] [network] ATPase, acting on DNA  (102 genes)  ISO  
GO:0042826 [list] [network] histone deacetylase binding  (130 genes)  ISO  
GO:0016853 [list] [network] isomerase activity  (175 genes)  IEA  
GO:0000287 [list] [network] magnesium ion binding  (207 genes)  ISO  
GO:0008022 [list] [network] protein C-terminus binding  (232 genes)  ISO  
GO:0046982 [list] [network] protein heterodimerization activity  (305 genes)  ISO  
GO:0003682 [list] [network] chromatin binding  (648 genes)  ISO  
GO:0042803 [list] [network] protein homodimerization activity  (780 genes)  ISO  
GO:0005524 [list] [network] ATP binding  (1396 genes)  ISO  
GO:0043565 [list] [network] sequence-specific DNA binding  (1606 genes)  ISO  
GO:0000166 [list] [network] nucleotide binding  (2052 genes)  IEA  
GO:0019899 [list] [network] enzyme binding  (2298 genes)  ISO  
GO:0003677 [list] [network] DNA binding  (2338 genes)  ISO  
GO:0046872 [list] [network] metal ion binding  (3573 genes)  IEA  
GO:0005515 [list] [network] protein binding  (9507 genes)  IPI  
KEGG mmu01524 [list] [network] Platinum drug resistance (80 genes)
Protein NP_035753.2  XP_006533216.1  XP_006533217.1  XP_006533218.1 
BLAST NP_035753.2  XP_006533216.1  XP_006533217.1  XP_006533218.1 
Orthologous [Ortholog page] TOP2A (hsa)  TOP2B (hsa)  Top2b (mmu)  Top2 (dme)  top-2 (cel)  cin-4 (cel)  R05D3.12 (cel)  top2a (dre)  Top2a (rno)  Top2b (rno)  TOP2A (gga)  TOP2B (gga)  TOP2B (cfa)  TOP2A (cfa)  top2b (dre)  TOP2B (mcc)  TOP2A (mcc)  TOP2 (sce)  SPBC16G5.10 (spo)  SPBC17D1.03c (spo)  TOP2A (fca)  TOP2B (fca) 
Subcellular
localization
wolf
nucl 6,  cyto_nucl 5,  cyto 3,  cyto_mito 2  (predict for NP_035753.2)
nucl 6,  cyto_nucl 5,  cyto 3,  cyto_mito 2  (predict for XP_006533216.1)
nucl 6,  cyto_nucl 5,  cyto 3,  cyto_mito 2  (predict for XP_006533217.1)
nucl 6,  cyto_nucl 5,  cyto 3,  cyto_mito 2  (predict for XP_006533218.1)
Gene coexpression
Network*for
coexpressed
genes
LCNloc
[Cytoscape]
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
mmu04110 Cell cycle 4
mmu04914 Progesterone-mediated oocyte maturation 4
mmu04218 Cellular senescence 3
mmu04114 Oocyte meiosis 3
mmu05161 Hepatitis B 2
Genes directly connected with Top2a on the network
coex z* Locus Function* Coexpression
detail		 CoexPub Entrez Gene ID*
22.9 Mki67 antigen identified by monoclonal antibody Ki 67 [detail] 22 17345
19.7 Cdk1 cyclin-dependent kinase 1 [detail] 21 12534
19.2 Kif11 kinesin family member 11 [detail] 0 16551
19.1 Pbk PDZ binding kinase [detail] 3 52033
17.5 Prc1 protein regulator of cytokinesis 1 [detail] 5 233406
16.8 Bub1 BUB1, mitotic checkpoint serine/threonine kinase [detail] 6 12235
14.4 Pclaf PCNA clamp associated factor [detail] 1 68026
12.8 Ncaph non-SMC condensin I complex, subunit H [detail] 0 215387
9.7 Kif15 kinesin family member 15 [detail] 0 209737
Coexpressed
gene list		 [Coexpressed gene list for Top2a]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity* tissue specificity
Link to other DBs
Entrez Gene ID 21973      
Refseq ID (protein) NP_035753.2 
XP_006533216.1 
XP_006533217.1 
XP_006533218.1 


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