| functional annotation |
| Function |
dihydrofolate reductase |
|
| GO BP |
|
GO:0031427 [list] [network] response to methotrexate
|
(1 genes)
|
ISO
|
 |
|
GO:0046452 [list] [network] dihydrofolate metabolic process
|
(2 genes)
|
IBA
ISO
|
|
|
GO:2000121 [list] [network] regulation of removal of superoxide radicals
|
(5 genes)
|
IMP
|
|
|
GO:0006545 [list] [network] glycine biosynthetic process
|
(6 genes)
|
IEA
|
|
|
GO:0046654 [list] [network] tetrahydrofolate biosynthetic process
|
(6 genes)
|
IBA
ISO
|
|
|
GO:0046655 [list] [network] folic acid metabolic process
|
(6 genes)
|
IBA
ISO
|
|
|
GO:0006729 [list] [network] tetrahydrobiopterin biosynthetic process
|
(7 genes)
|
IMP
|
|
|
GO:0031103 [list] [network] axon regeneration
|
(19 genes)
|
ISO
|
|
|
GO:0051000 [list] [network] positive regulation of nitric-oxide synthase activity
|
(20 genes)
|
IMP
|
|
|
GO:0006730 [list] [network] one-carbon metabolic process
|
(40 genes)
|
IEA
|
|
|
| GO CC |
|
| GO MF |
|
GO:0004146 [list] [network] dihydrofolate reductase activity
|
(1 genes)
|
IBA
IDA
ISO
|
|
|
GO:0051871 [list] [network] dihydrofolic acid binding
|
(1 genes)
|
ISO
|
|
|
GO:0051870 [list] [network] methotrexate binding
|
(3 genes)
|
ISO
|
|
|
GO:0000900 [list] [network] translation repressor activity, mRNA regulatory element binding
|
(13 genes)
|
ISO
|
|
|
GO:0005542 [list] [network] folic acid binding
|
(14 genes)
|
ISO
|
|
|
GO:1990825 [list] [network] sequence-specific mRNA binding
|
(14 genes)
|
ISO
|
|
|
GO:0070402 [list] [network] NADPH binding
|
(17 genes)
|
ISO
|
|
|
GO:0008144 [list] [network] drug binding
|
(36 genes)
|
ISO
|
|
|
GO:0050661 [list] [network] NADP binding
|
(46 genes)
|
IBA
ISO
|
|
|
GO:0003729 [list] [network] mRNA binding
|
(365 genes)
|
ISO
|
|
|
GO:0016491 [list] [network] oxidoreductase activity
|
(801 genes)
|
IEA
|
|
|
GO:0003723 [list] [network] RNA binding
|
(1194 genes)
|
IEA
|
|
|
| KEGG |
mmu00670 [list] [network] One carbon pool by folate (19 genes) |
 |
| mmu00790 [list] [network] Folate biosynthesis (26 genes) |
|
| mmu01240 [list] [network] Biosynthesis of cofactors (152 genes) |
|
| mmu01523 [list] [network] Antifolate resistance (29 genes) |
|
| Protein |
NP_034179.1
|
| BLAST |
NP_034179.1
|
| Orthologous |
[Ortholog page]
DHFR (hsa)
Dhfr (rno)
Dhfr (dme)
dhfr (dre)
dhfr-1 (cel)
DHFR2 (hsa)
DHFR (gga)
DHFR (cfa)
zgc:153031 (dre)
LOC609048 (cfa)
LOC707382 (mcc)
DHFR (mcc)
DFR1 (sce)
DHFR (fca)
DHFR2 (mcc)
|
Subcellular
localization
wolf |
|
cyto 8,
cyto_nucl 4,
mito 2
|
(predict for NP_034179.1)
|
|
| Gene coexpression |
Network*for
coexpressed
genes |
| KEGG* ID |
Title |
#genes |
Link to the KEGG* map
(Multiple genes) |
| mmu03030 |
DNA replication |
5 |
 |
| mmu03430 |
Mismatch repair |
5 |
 |
| mmu03420 |
Nucleotide excision repair |
3 |
 |
| mmu04110 |
Cell cycle |
3 |
 |
| mmu00670 |
One carbon pool by folate |
2 |
 |
Genes directly connected with Dhfr on the network
| coex z* |
Locus |
Function* |
Coexpression
detail |
CoexPub |
Entrez Gene ID* |
| 9.1 |
Prim1 |
DNA primase, p49 subunit |
[detail] |
0 |
19075 |
| 8.3 |
Mcm10 |
minichromosome maintenance 10 replication initiation factor |
[detail] |
1 |
70024 |
| 7.9 |
Gmnn |
geminin |
[detail] |
0 |
57441 |
| 7.8 |
Tyms |
thymidylate synthase |
[detail] |
19 |
22171 |
| 7.8 |
Msh3 |
mutS homolog 3 |
[detail] |
0 |
17686 |
| 5.0 |
Gk |
glycerol kinase |
[detail] |
0 |
14933 |
| 5.0 |
Tpmt |
thiopurine methyltransferase |
[detail] |
0 |
22017 |
| 4.9 |
Xylb |
xylulokinase homolog (H. influenzae) |
[detail] |
0 |
102448 |
|
Coexpressed
gene list |
[Coexpressed gene list for Dhfr]
|
| Gene expression |
| All samples |
[Expression pattern for all samples]
|
| Tissue specificity* |
|
Dhfr Gene
