Publication for Dhfr and Tyms

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Dhfr	dihydrofolate reductase	13361			[link]
mmu	Tyms	thymidylate synthase	22171

Pubmed ID	Priority	Text
19513116	0.98	thymidylate synthase (TYMS) and dihydrofolate reductase (DHFR) undergo sumoylation and nuclear import during S-phase.
	0.98	TYMS localizes to the nucleus at S-phase, and recently SHMT1, DHFR, and TYMS proteins have all been shown to be SUMOylated, providing a mechanism by which all the enzymes required for de novo thymidylate biosynthesis can be localized to the nucleus.
	0.93	thymidylate synthase (TYMS), dihydrofolate reductase (DHFR), and SHMT1.
	0.85	DHFR and TYMS protein were observed in purified nuclei isolated from the livers of wild type and Shmt1-/- mice, and surprisingly, SHMT2 protein was also observed in nuclei isolated from the livers of wild type and Shmt1-/- mice (Figure 3A).
	0.61	DHFR and TYMS activities were found in these purified complexes isolated from nuclei, but no direct evidence for nuclear nucleotide biosynthesis was reported.
27270426	0.98	TS and DHFR significantly increased in A549/A400 (Figure 1a), CL1/A100 and CL1/A200 sublines (Figure 1b).
	0.96	TS and DHFR were significantly increased in the four pemetrexed-resistant A549 sublines.
	0.95	thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT).
2277081	0.98	DHFR and TS mRNA accumulate as thymocytes progress through the cell cycle.
22705496	0.98	Dihydrofolate Reductase (Dhfr), and Thymidylate Synthase (Ts) all express more robustly in asynchronous ES cells than in MEFs.
23483428	0.98	TYMS and DHFR) localise to the nucleus during S and G2/M phase of the cell cycle.
23916769	0.98	dyhidrofolate reductase (DHFR), thymidylate synthase (TS), ribonucleotide reductase (RNR), and thymidine kinase (Tk) were among the first E2F-regulated genes to be described and are known to be induced by E2F1.
28197911	0.98	thymidylate synthase (TYMS), and dihydrofolate reductase (DHFR) are substrates for Ubc9 catalyzed sumoylation and subsequent translocation to the nucleus during the S and G2/M phases of the cell cycle.
29955725	0.98	TYMS, and DHFR) are SUMO-ylated and translocate to the nucleus during the S-phase.
19002265	0.97	DHFR, thymidylate synthase (TS), and RRM1 .
24269626	0.97	dihydrofolate reductase (DHFR), and thymidylate synthase (TS).
24684846	0.96	dihydrofolate reductase (DHFR), and thymidylate synthase(TS) (Figure 2D).
	0.92	dihydrofolate reductase (DHFR) and thymidylate synthase (TS).
31337061	0.96	thymidylate synthase (TS), dihydrofolate reductase (DHFR), glycinamide ribonucleotide formyltransferase (GARFT), and aminoimidazole carboxamide formyltransferase (AICARFT).
21118569	0.94	TYMS drugs are used in cancer treatment, as are other chemicals that inhibit this pathway (such as methotrexate, a DHFR inhibitor).
	0.86	TYMS and DHFR are produced on the same polypeptide (reviewed in).
25032496	0.94	TYMS and DHFR).
29922055	0.94	thymidy-late synthase (TS), glycinamide ribonucleotide formyl transferase (GARFT), and dihydrofolate reductase (DHFR).
26177356	0.93	dihydrofolate reductase (DHFR) sequentially reduces FA to DHF and tetrahydrofolate (THF); DHF is an inhibitor of methyleneTHF reductase (MTHFR) and thymidylate synthase (TYMS).
26853819	0.93	thymidylate synthase (TYMS), and dihydrofolate reductase like 1 (DHFRL1); 2) for the N-formylation of Met-tRNA for the initiation of mitochondrial protein synthesis, and 3) for the generation of formate from the catabolism of the amino acids serine, glycine, dimethylglycine and sarcosine by the enzymes SHMT2, sarcosine dehydrogenase, dimethylglycine dehydrogenase, methylenetetrahydrofolate dehydrogenase 2, methylenetetrahydrofolate dehydrogenase like-2 and methylenetetrahydrofolate dehydrogenase like-1.
21698180	0.91	TS and DHFR in bacteria and metazoans occur as separate entities, that of malaria parasites and other protozoans occur as a TS-DHFR bipeptide coded off a single gene.
23651732	0.86	Dhfr, Mthfd1, Mthfd1l, Mthfd2, Mthfr, Mtr, Shmt1, Slc46a1, and Tyms mildly deregulated; only Tyms and Mthfd2 showed more than a 2-fold expression change.
	0.80	Dhfr, Mtr and Tyms confirmed direction and magnitude of the expression change initially observed in the microassay experiment.