KEGG 04931 Insulin resistance
[list]

Species hsa(Human) mmu(Mouse) rno(Rat) mcc(Monkey) cfa(Dog) fca(Domestic cat)
UMAP
Representative coexpressed gene network LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
hsa04931 Insulin resistance 25
hsa04910 Insulin signaling pathway 12
hsa04152 AMPK signaling pathway 10
hsa04151 PI3K-Akt signaling pathway 9
hsa04920 Adipocytokine signaling pathway 9
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
mmu04931 Insulin resistance 37
mmu04910 Insulin signaling pathway 22
mmu04151 PI3K-Akt signaling pathway 18
mmu04152 AMPK signaling pathway 17
mmu04920 Adipocytokine signaling pathway 16
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
rno04931 Insulin resistance 45
rno04910 Insulin signaling pathway 25
rno04152 AMPK signaling pathway 19
rno04151 PI3K-Akt signaling pathway 17
rno04922 Glucagon signaling pathway 17
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
mcc04931 Insulin resistance 35
mcc04910 Insulin signaling pathway 20
mcc05415 Diabetic cardiomyopathy 18
mcc04151 PI3K-Akt signaling pathway 14
mcc04152 AMPK signaling pathway 13
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
cfa04931 Insulin resistance 31
cfa04920 Adipocytokine signaling pathway 13
cfa04151 PI3K-Akt signaling pathway 11
cfa04152 AMPK signaling pathway 10
cfa04922 Glucagon signaling pathway 10
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
fca04931 Insulin resistance 30
fca04910 Insulin signaling pathway 17
fca04920 Adipocytokine signaling pathway 16
fca04932 Non-alcoholic fatty liver disease 13
fca04068 FoxO signaling pathway 12
Gene list in the network
Symbol Function*
AFM afamin
CEBPD CCAAT enhancer binding protein delta
CREB1 cAMP responsive element binding protein 1
FOXO1 forkhead box O1
MTOR mechanistic target of rapamycin kinase
G6PC1 glucose-6-phosphatase catalytic subunit 1
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GSK3B glycogen synthase kinase 3 beta
PCK1 phosphoenolpyruvate carboxykinase 1
PCK2 phosphoenolpyruvate carboxykinase 2, mitochondrial
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
PPP1CA protein phosphatase 1 catalytic subunit alpha
PRKCD protein kinase C delta
PTPN6 protein tyrosine phosphatase non-receptor type 6
PTPN11 protein tyrosine phosphatase non-receptor type 11
RBP4 retinol binding protein 4
RPS6KA1 ribosomal protein S6 kinase A1
RPS6KB2 ribosomal protein S6 kinase B2
SLC2A2 solute carrier family 2 member 2
SLC2A3 solute carrier family 2 member 3
STAT3 signal transducer and activator of transcription 3
TNFRSF1A TNF receptor superfamily member 1A
ZNF148 zinc finger protein 148
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
IRS2 insulin receptor substrate 2
SOCS3 suppressor of cytokine signaling 3
KIAA0100 KIAA0100
SEC24D SEC24 homolog D, COPII coat complex component
DMTF1 cyclin D binding myb like transcription factor 1
OGA O-GlcNAcase
SBNO2 strawberry notch homolog 2
MLXIPL MLX interacting protein like
TRIB3 tribbles pseudokinase 3
CREB3L2 cAMP responsive element binding protein 3 like 2
CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1
PPP1R3B protein phosphatase 1 regulatory subunit 3B
Symbol Function*
Akt1 thymoma viral proto-oncogene 1
Akt2 thymoma viral proto-oncogene 2
Aldoa aldolase A, fructose-bisphosphate
Bcl3 B cell leukemia/lymphoma 3
Socs3 suppressor of cytokine signaling 3
Coro1a coronin, actin binding protein 1A
Fkbp8 FK506 binding protein 8
G6pc2 glucose-6-phosphatase, catalytic, 2
Gys1 glycogen synthase 1, muscle
Ins1 insulin I
Ins2 insulin II
Myd88 myeloid differentiation primary response gene 88
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic
Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
Pik3r2 phosphoinositide-3-kinase regulatory subunit 2
Prkcb protein kinase C, beta
Ppara peroxisome proliferator activated receptor alpha
Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
Prkab1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
Prkag1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit
Pten phosphatase and tensin homolog
Ptpn1 protein tyrosine phosphatase, non-receptor type 1
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian)
Acsm3 acyl-CoA synthetase medium-chain family member 3
Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1
Slc2a2 solute carrier family 2 (facilitated glucose transporter), member 2
Stat3 signal transducer and activator of transcription 3
Stat5a signal transducer and activator of transcription 5A
Thrb thyroid hormone receptor beta
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a
Try4 trypsin 4
Slc27a1 solute carrier family 27 (fatty acid transporter), member 1
Slc27a2 solute carrier family 27 (fatty acid transporter), member 2
Ppp1r3c protein phosphatase 1, regulatory subunit 3C
Slc4a4 solute carrier family 4 (anion exchanger), member 4
Gsk3b glycogen synthase kinase 3 beta
Rps6kb2 ribosomal protein S6 kinase, polypeptide 2
Cyb5r1 cytochrome b5 reductase 1
Acot12 acyl-CoA thioesterase 12
Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
Atp13a2 ATPase type 13A2
Csnk1g2 casein kinase 1, gamma 2
Pdzd8 PDZ domain containing 8
Prkaa2 protein kinase, AMP-activated, alpha 2 catalytic subunit
Ogt O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
Pygl liver glycogen phosphorylase
Ptpa protein phosphatase 2 protein activator
Creb3l3 cAMP responsive element binding protein 3-like 3
Arid5a AT rich interactive domain 5A (MRF1-like)
Trib3 tribbles pseudokinase 3
Aldob aldolase B, fructose-bisphosphate
Gys2 glycogen synthase 2
Leng8 leukocyte receptor cluster (LRC) member 8
Slc30a8 solute carrier family 30 (zinc transporter), member 8
Ppp1r3b protein phosphatase 1, regulatory subunit 3B
Symbol Function*
Agt angiotensinogen
Il6 interleukin 6
Pgm1 phosphoglucomutase 1
Pklr pyruvate kinase L/R
Ptpn1 protein tyrosine phosphatase, non-receptor type 1
Tnf tumor necrosis factor
Insr insulin receptor
Akt2 AKT serine/threonine kinase 2
Slc2a2 solute carrier family 2 member 2
Irs1 insulin receptor substrate 1
Nfkbia NFKB inhibitor alpha
Pik3r1 phosphoinositide-3-kinase regulatory subunit 1
Gys2 glycogen synthase 2
G6pc1 glucose-6-phosphatase catalytic subunit 1
Ppara peroxisome proliferator activated receptor alpha
Cpt1b carnitine palmitoyltransferase 1B
Cpt1a carnitine palmitoyltransferase 1A
Prkce protein kinase C, epsilon
Irs2 insulin receptor substrate 2
Pten phosphatase and tensin homolog
Acaca acetyl-CoA carboxylase alpha
Pygl glycogen phosphorylase L
Slc27a2 solute carrier family 27 member 2
Srebf1 sterol regulatory element binding transcription factor 1
Atf2 activating transcription factor 2
Nfkb1 nuclear factor kappa B subunit 1
Pdpk1 3-phosphoinositide dependent protein kinase-1
Ppargc1a PPARG coactivator 1 alpha
Gsk3b glycogen synthase kinase 3 beta
Foxo1 forkhead box O1
Socs3 suppressor of cytokine signaling 3
Slc27a1 solute carrier family 27 member 1
Cxcl2 C-X-C motif chemokine ligand 2
Braf B-Raf proto-oncogene, serine/threonine kinase
Acacb acetyl-CoA carboxylase beta
Rps6ka2 ribosomal protein S6 kinase A2
Oga O-GlcNAcase
Mlxipl MLX interacting protein-like
Ppp1r3b protein phosphatase 1, regulatory subunit 3B
Trib3 tribbles pseudokinase 3
Mapkapk2 MAPK activated protein kinase 2
G0s2 G0/G1switch 2
Cidea cell death-inducing DFFA-like effector a
Ppargc1b PPARG coactivator 1 beta
Slc37a1 solute carrier family 37 member 1
Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3
Mlxip MLX interacting protein
Tbc1d4 TBC1 domain family, member 4
Rela RELA proto-oncogene, NF-kB subunit
Nfkb2 nuclear factor kappa B subunit 2
Ppp1r3c protein phosphatase 1, regulatory subunit 3C
Paqr7 progestin and adipoQ receptor family member 7
Sbno2 strawberry notch homolog 2
Creb3l3 cAMP responsive element binding protein 3-like 3
Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
Ptpa protein phosphatase 2 phosphatase activator
Pck1 phosphoenolpyruvate carboxykinase 1
Rnf150 ring finger protein 150
Cidec cell death-inducing DFFA-like effector c
Irf2bp2 interferon regulatory factor 2 binding protein 2
Ppp1r3d protein phosphatase 1, regulatory subunit 3D
Gys1 glycogen synthase 1
Symbol Function*
GYS1 glycogen synthase 1
PPARA peroxisome proliferator activated receptor alpha
ATP6V0A1 ATPase H+ transporting V0 subunit a1
CYP2C8 cytochrome P450 family 2 subfamily C member 8
FOXP1 forkhead box P1
LOC695047 protein DDI1 homolog 2
SLC2A2 solute carrier family 2 member 2
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
HSPB7 heat shock protein family B (small) member 7
RPS6KA3 ribosomal protein S6 kinase A3
TBC1D4 TBC1 domain family member 4
TCAP titin-cap
PPP1R3C protein phosphatase 1 regulatory subunit 3C
PKM pyruvate kinase M1/2
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
SORT1 sortilin 1
PIK3R1 phosphoinositide-3-kinase regulatory subunit 1
FOXO1 forkhead box O1
PTPN1 protein tyrosine phosphatase non-receptor type 1
PYGB glycogen phosphorylase B
IL6 interleukin 6
INSR insulin receptor
GYS2 glycogen synthase 2
PYGL glycogen phosphorylase L
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
NFKB1 nuclear factor kappa B subunit 1
SLC35A3 solute carrier family 35 member A3
MAPK8 mitogen-activated protein kinase 8
G6PC1 glucose-6-phosphatase catalytic subunit 1
OGA O-GlcNAcase
GSK3B glycogen synthase kinase 3 beta
G6PC3 glucose-6-phosphatase catalytic subunit 3
SLC2A4 solute carrier family 2 member 4
RPS6KA1 ribosomal protein S6 kinase A1
SOCS3 suppressor of cytokine signaling 3
MAPK9 mitogen-activated protein kinase 9
GFPT2 glutamine-fructose-6-phosphate transaminase 2
CRTC2 CREB regulated transcription coactivator 2
RELA RELA proto-oncogene, NF-kB subunit
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
PTPA protein phosphatase 2 phosphatase activator
RPS6KA2 ribosomal protein S6 kinase A2
PYGM glycogen phosphorylase, muscle associated
PIK3R2 phosphoinositide-3-kinase regulatory subunit 2
CPT1B carnitine palmitoyltransferase 1B
SBNO2 strawberry notch homolog 2
CYP4A11 cytochrome P450 family 4 subfamily A member 11
CFHR2 complement factor H related 2
Symbol Function*
PCK1 phosphoenolpyruvate carboxykinase 1
CPT1A carnitine palmitoyltransferase 1A
TNFRSF1A TNF receptor superfamily member 1A
AGT angiotensinogen
TNF tumor necrosis factor
NFKB1 nuclear factor kappa B subunit 1
APOC3 apolipoprotein C3
GFPT2 glutamine-fructose-6-phosphate transaminase 2
KDM3B lysine demethylase 3B
AQP7 aquaporin 7
RBM5 RNA binding motif protein 5
PYGB glycogen phosphorylase B
OGA O-GlcNAcase
PCK2 phosphoenolpyruvate carboxykinase 2, mitochondrial
NFKBIA NFKB inhibitor alpha
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
CPT1B carnitine palmitoyltransferase 1B
IKBKB inhibitor of nuclear factor kappa B kinase subunit beta
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
TNFAIP3 TNF alpha induced protein 3
FGF21 fibroblast growth factor 21
SLC1A5 solute carrier family 1 member 5
RELB RELB proto-oncogene, NF-kB subunit
SLC27A1 solute carrier family 27 member 1
IRS2 insulin receptor substrate 2
TRIB3 tribbles pseudokinase 3
NFKB2 nuclear factor kappa B subunit 2
SESN2 sestrin 2
RPS6KA1 ribosomal protein S6 kinase A1
OSMR oncostatin M receptor
MLXIPL MLX interacting protein like
AKT1 AKT serine/threonine kinase 1
PACS2 phosphofurin acidic cluster sorting protein 2
STAT3 signal transducer and activator of transcription 3
PRKCD protein kinase C delta
CHKB choline kinase beta
PRKCE protein kinase C epsilon
NR1H2 nuclear receptor subfamily 1 group H member 2
RPS6KB2 ribosomal protein S6 kinase B2
SGK2 serum/glucocorticoid regulated kinase 2
PYGM glycogen phosphorylase, muscle associated
CREB3L4 cAMP responsive element binding protein 3 like 4
CRTC2 CREB regulated transcription coactivator 2
RPS6KA2 ribosomal protein S6 kinase A2
EPHX3 epoxide hydrolase 3
ACACB acetyl-CoA carboxylase beta
SLC27A3 solute carrier family 27 member 3
INTS3 integrator complex subunit 3
PLIN2 perilipin 2
CAPN3 calpain 3
Symbol Function*
IL6 interleukin 6
CES1 carboxylesterase 1
LRCH1 leucine rich repeats and calponin homology domain containing 1
MCP-1 monocyte chemoattractant protein 1
ETS2 ETS proto-oncogene 2, transcription factor
KLHL38 kelch like family member 38
SOCS3 suppressor of cytokine signaling 3
RPS6KA3 ribosomal protein S6 kinase A3
PPP1R3C protein phosphatase 1 regulatory subunit 3C
MAPK9 mitogen-activated protein kinase 9
PPP1R3A protein phosphatase 1 regulatory subunit 3A
PTPN11 protein tyrosine phosphatase non-receptor type 11
LPIN1 lipin 1
UBE2H ubiquitin conjugating enzyme E2 H
GPD1 glycerol-3-phosphate dehydrogenase 1
ACACB acetyl-CoA carboxylase beta
SLC27A5 solute carrier family 27 member 5
NR1H2 nuclear receptor subfamily 1 group H member 2
PPARGC1B PPARG coactivator 1 beta
GADD45B growth arrest and DNA damage inducible beta
TSNAX translin associated factor X
PCK1 phosphoenolpyruvate carboxykinase 1
LRP10 LDL receptor related protein 10
NFKBIA NFKB inhibitor alpha
RNF167 ring finger protein 167
GYS2 glycogen synthase 2
PRKAG3 protein kinase AMP-activated non-catalytic subunit gamma 3
PRKAB2 protein kinase AMP-activated non-catalytic subunit beta 2
PPP1CB protein phosphatase 1 catalytic subunit beta
BTNL9 butyrophilin like 9
LOC101093537 myomegalin
PIK3R2 phosphoinositide-3-kinase regulatory subunit 2
CD36 CD36 molecule
PRKAG1 protein kinase AMP-activated non-catalytic subunit gamma 1
SLC2A4 solute carrier family 2 member 4
STAT3 signal transducer and activator of transcription 3
IRS2 insulin receptor substrate 2
PPARA peroxisome proliferator activated receptor alpha
PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2
BCL3 BCL3 transcription coactivator
MLXIPL MLX interacting protein like
RELA RELA proto-oncogene, NF-kB subunit
PHKA1 phosphorylase kinase regulatory subunit alpha 1
MLX MAX dimerization protein MLX
FHL1 four and a half LIM domains 1
TBC1D4 TBC1 domain family member 4
PYGM glycogen phosphorylase, muscle associated


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