KEGG 04211 Longevity regulating pathway
[list]

Species hsa(Human) mmu(Mouse) rno(Rat) mcc(Monkey) cfa(Dog) fca(Domestic cat)
UMAP
Representative coexpressed gene network LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
hsa04211 Longevity regulating pathway 18
hsa04152 AMPK signaling pathway 10
hsa04151 PI3K-Akt signaling pathway 8
hsa05016 Huntington disease 8
hsa04932 Non-alcoholic fatty liver disease 7
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
mmu04211 Longevity regulating pathway 32
mmu04152 AMPK signaling pathway 19
mmu04151 PI3K-Akt signaling pathway 17
mmu05010 Alzheimer disease 17
mmu04932 Non-alcoholic fatty liver disease 16
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
rno04211 Longevity regulating pathway 26
rno04152 AMPK signaling pathway 17
rno04151 PI3K-Akt signaling pathway 16
rno04910 Insulin signaling pathway 15
rno04150 mTOR signaling pathway 14
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
mcc04211 Longevity regulating pathway 16
mcc04152 AMPK signaling pathway 10
mcc05200 Pathways in cancer 9
mcc04213 Longevity regulating pathway - multiple species 9
mcc04140 Autophagy - animal 8
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
cfa04211 Longevity regulating pathway 17
cfa04213 Longevity regulating pathway - multiple species 10
cfa04152 AMPK signaling pathway 10
cfa05200 Pathways in cancer 8
cfa04932 Non-alcoholic fatty liver disease 8
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
fca04211 Longevity regulating pathway 19
fca04213 Longevity regulating pathway - multiple species 14
fca04152 AMPK signaling pathway 11
fca04923 Regulation of lipolysis in adipocytes 10
fca04140 Autophagy - animal 10
Gene list in the network
Symbol Function*
ATF4 activating transcription factor 4
BAX BCL2 associated X, apoptosis regulator
CREB1 cAMP responsive element binding protein 1
ATF2 activating transcription factor 2
FABP4 fatty acid binding protein 4
FOXO1 forkhead box O1
FOXO3 forkhead box O3
IGF1R insulin like growth factor 1 receptor
NFKB1 nuclear factor kappa B subunit 1
PPARG peroxisome proliferator activated receptor gamma
RHEB Ras homolog, mTORC1 binding
SOD2 superoxide dismutase 2
STX5 syntaxin 5
IRS2 insulin receptor substrate 2
ADIPOQ adiponectin, C1Q and collagen domain containing
WTAP WT1 associated protein
ATG13 autophagy related 13
CREB3 cAMP responsive element binding protein 3
SF3B1 splicing factor 3b subunit 1
BBC3 BCL2 binding component 3
PRKAG2 protein kinase AMP-activated non-catalytic subunit gamma 2
ATG101 autophagy related 101
CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1
SESN2 sestrin 2
IRAIN IGF1R antisense imprinted non-protein coding RNA
Symbol Function*
Adipoq adiponectin, C1Q and collagen domain containing
Adcy7 adenylate cyclase 7
Akt1 thymoma viral proto-oncogene 1
Akt2 thymoma viral proto-oncogene 2
Fabp4 fatty acid binding protein 4, adipocyte
Atf2 activating transcription factor 2
Atf4 activating transcription factor 4
Bax BCL2-associated X protein
Rb1cc1 RB1-inducible coiled-coil 1
Eef2k eukaryotic elongation factor-2 kinase
Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1
Cidec cell death-inducing DFFA-like effector c
Hras Harvey rat sarcoma virus oncogene
Ins1 insulin I
Ins2 insulin II
Irs3 insulin receptor substrate 3
Kl klotho
Kras Kirsten rat sarcoma viral oncogene homolog
Mbd3 methyl-CpG binding domain protein 3
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
Pik3r1 phosphoinositide-3-kinase regulatory subunit 1
Pik3r2 phosphoinositide-3-kinase regulatory subunit 2
Pparg peroxisome proliferator activated receptor gamma
Prkab1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
Prkag1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian)
Stk11 serine/threonine kinase 11
Try4 trypsin 4
Ulk1 unc-51 like kinase 1
Trpv2 transient receptor potential cation channel, subfamily V, member 2
Atg13 autophagy related 13
Nupr1 nuclear protein transcription regulator 1
Rybp RING1 and YY1 binding protein
Mtch1 mitochondrial carrier 1
Foxo3 forkhead box O3
Cltrn collectrin, amino acid transport regulator
Akt1s1 AKT1 substrate 1 (proline-rich)
Chac1 ChaC, cation transport regulator 1
Csnk1g2 casein kinase 1, gamma 2
Ehmt2 euchromatic histone lysine N-methyltransferase 2
Sesn1 sestrin 1
Bbc3 BCL2 binding component 3
Trib3 tribbles pseudokinase 3
Sesn2 sestrin 2
Ppp1r37 protein phosphatase 1, regulatory subunit 37
Trarg1 trafficking regulator of GLUT4 (SLC2A4) 1
Adig adipogenin
Tmem72 transmembrane protein 72
Symbol Function*
Tsc2 TSC complex subunit 2
Insr insulin receptor
Irs1 insulin receptor substrate 1
Pik3r1 phosphoinositide-3-kinase regulatory subunit 1
Prkaca protein kinase cAMP-activated catalytic subunit alpha
Pparg peroxisome proliferator-activated receptor gamma
Ddit3 DNA-damage inducible transcript 3
Pik3r2 phosphoinositide-3-kinase regulatory subunit 2
Mtor mechanistic target of rapamycin kinase
Tsc1 TSC complex subunit 1
Adcy3 adenylate cyclase 3
Prkab2 protein kinase AMP-activated non-catalytic subunit beta 2
Atf4 activating transcription factor 4
Nfkb1 nuclear factor kappa B subunit 1
Foxo1 forkhead box O1
Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1
Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Adipoq adiponectin, C1Q and collagen domain containing
Trib3 tribbles pseudokinase 3
Rptor regulatory associated protein of MTOR, complex 1
Mapkapk2 MAPK activated protein kinase 2
Hras HRas proto-oncogene, GTPase
Foxo3 forkhead box O3
Rela RELA proto-oncogene, NF-kB subunit
Hif1an hypoxia inducible factor 1 subunit alpha inhibitor
Nfkb2 nuclear factor kappa B subunit 2
Mlf2 myeloid leukemia factor 2
Rb1cc1 RB1-inducible coiled-coil 1
Focad focadhesin
Trarg1 trafficking regulator of GLUT4 (SLC2A4) 1
Ulk1 unc-51 like autophagy activating kinase 1
Ehmt2 euchromatic histone lysine methyltransferase 2
Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
Klf13 Kruppel-like factor 13
Sesn2 sestrin 2
Acsf2 acyl-CoA synthetase family member 2
Symbol Function*
PPARG peroxisome proliferator activated receptor gamma
ADIPOQ adiponectin, C1Q and collagen domain containing
ATP6V0A1 ATPase H+ transporting V0 subunit a1
CHM CHM Rab escort protein
FOXP1 forkhead box P1
PIK3R1 phosphoinositide-3-kinase regulatory subunit 1
ATF2 activating transcription factor 2
FOXO1 forkhead box O1
FABP4 fatty acid binding protein 4
PJA2 praja ring finger ubiquitin ligase 2
INSR insulin receptor
IGF1R insulin like growth factor 1 receptor
PRKACB protein kinase cAMP-activated catalytic subunit beta
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
RB1CC1 RB1 inducible coiled-coil 1
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
ATF6B activating transcription factor 6 beta
AKT1S1 AKT1 substrate 1
EHMT1 euchromatic histone lysine methyltransferase 1
RPS6KB2 ribosomal protein S6 kinase B2
APPL1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
LOC114670528 pre-mRNA-processing factor 6-like
Symbol Function*
IL6ST interleukin 6 cytokine family signal transducer
PRKACA protein kinase cAMP-activated catalytic subunit alpha
PPARG peroxisome proliferator activated receptor gamma
ADIPOQ adiponectin, C1Q and collagen domain containing
NRAS NRAS proto-oncogene, GTPase
IGF1R insulin like growth factor 1 receptor
EHMT2 euchromatic histone lysine methyltransferase 2
CSDE1 cold shock domain containing E1
RNF10 ring finger protein 10
PDCD4 programmed cell death 4
PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1
ADIPOR1 adiponectin receptor 1
FOXO3 forkhead box O3
SESN1 sestrin 1
CIDEC cell death inducing DFFA like effector c
FKBP8 FKBP prolyl isomerase 8
INSR insulin receptor
SESN3 sestrin 3
PLCG1 phospholipase C gamma 1
PRKAB1 protein kinase AMP-activated non-catalytic subunit beta 1
ADCY9 adenylate cyclase 9
EHMT1 euchromatic histone lysine methyltransferase 1
ZMYM3 zinc finger MYM-type containing 3
FABP4 fatty acid binding protein 4
PIK3R2 phosphoinositide-3-kinase regulatory subunit 2
PRKAB2 protein kinase AMP-activated non-catalytic subunit beta 2
Symbol Function*
ADIPOQ adiponectin, C1Q and collagen domain containing
INSR insulin receptor
AKT2 AKT serine/threonine kinase 2
PLIN4 perilipin 4
USP4 ubiquitin specific peptidase 4
TTC9 tetratricopeptide repeat domain 9
TNS1 tensin 1
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
UBE2H ubiquitin conjugating enzyme E2 H
ABCC10 ATP binding cassette subfamily C member 10
EHMT1 euchromatic histone lysine methyltransferase 1
IRS1 insulin receptor substrate 1
PRKACA protein kinase cAMP-activated catalytic subunit alpha
ADCY6 adenylate cyclase 6
RPS6KB2 ribosomal protein S6 kinase B2
SCP2 sterol carrier protein 2
PIK3R2 phosphoinositide-3-kinase regulatory subunit 2
CAT catalase
PPARG peroxisome proliferator activated receptor gamma
IRS2 insulin receptor substrate 2
MOB2 MOB kinase activator 2
ADCY9 adenylate cyclase 9
PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2
MTOR mechanistic target of rapamycin kinase
ATG101 autophagy related 101
ULK1 unc-51 like autophagy activating kinase 1
ADCY5 adenylate cyclase 5
ADCY1 adenylate cyclase 1


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