KEGG 04071 Sphingolipid signaling pathway
[list]

Species hsa(Human) mmu(Mouse) rno(Rat) mcc(Monkey) cfa(Dog) fca(Domestic cat)
UMAP
Representative coexpressed gene network LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
hsa04071 Sphingolipid signaling pathway 21
hsa04015 Rap1 signaling pathway 10
hsa04261 Adrenergic signaling in cardiomyocytes 10
hsa04728 Dopaminergic synapse 10
hsa05142 Chagas disease 10
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
mmu04071 Sphingolipid signaling pathway 48
mmu05200 Pathways in cancer 26
mmu05163 Human cytomegalovirus infection 25
mmu05170 Human immunodeficiency virus 1 infection 25
mmu04010 MAPK signaling pathway 23
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
rno04071 Sphingolipid signaling pathway 40
rno05200 Pathways in cancer 20
rno05160 Hepatitis C 17
rno05163 Human cytomegalovirus infection 17
rno04010 MAPK signaling pathway 16
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
mcc04071 Sphingolipid signaling pathway 40
mcc05163 Human cytomegalovirus infection 24
mcc05200 Pathways in cancer 21
mcc05170 Human immunodeficiency virus 1 infection 19
mcc05417 Lipid and atherosclerosis 18
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
cfa04071 Sphingolipid signaling pathway 20
cfa05200 Pathways in cancer 14
cfa04010 MAPK signaling pathway 11
cfa05163 Human cytomegalovirus infection 11
cfa05170 Human immunodeficiency virus 1 infection 10
LCNkegg
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
fca04071 Sphingolipid signaling pathway 33
fca05200 Pathways in cancer 20
fca05163 Human cytomegalovirus infection 16
fca05417 Lipid and atherosclerosis 15
fca04072 Phospholipase D signaling pathway 15
Gene list in the network
Symbol Function*
AKT2 AKT serine/threonine kinase 2
RHOA ras homolog family member A
ASAH1 N-acylsphingosine amidohydrolase 1
CTSD cathepsin D
GNAI2 G protein subunit alpha i2
GNAI3 G protein subunit alpha i3
GTF2E2 general transcription factor IIE subunit 2
GZMH granzyme H
NRAS NRAS proto-oncogene, GTPase
PLCB3 phospholipase C beta 3
PLD1 phospholipase D1
PLD2 phospholipase D2
PPP2CB protein phosphatase 2 catalytic subunit beta
PPP2R2A protein phosphatase 2 regulatory subunit Balpha
PPP2R2B protein phosphatase 2 regulatory subunit Bbeta
MAPK11 mitogen-activated protein kinase 11
MAP2K2 mitogen-activated protein kinase kinase 2
PSAP prosaposin
PSEN1 presenilin 1
RAC1 Rac family small GTPase 1
MAPK12 mitogen-activated protein kinase 12
USF2 upstream transcription factor 2, c-fos interacting
SGPL1 sphingosine-1-phosphate lyase 1
SPTLC2 serine palmitoyltransferase long chain base subunit 2
SMNDC1 survival motor neuron domain containing 1
S1PR5 sphingosine-1-phosphate receptor 5
TMEM144 transmembrane protein 144
PPP2R2D protein phosphatase 2 regulatory subunit Bdelta
Symbol Function*
Akt1 thymoma viral proto-oncogene 1
Akt2 thymoma viral proto-oncogene 2
Rhoa ras homolog family member A
Bcl2 B cell leukemia/lymphoma 2
Rb1cc1 RB1-inducible coiled-coil 1
Cenpb centromere protein B
Coro1a coronin, actin binding protein 1A
Cpa3 carboxypeptidase A3, mast cell
Ctsb cathepsin B
Ctsd cathepsin D
Degs1 delta(4)-desaturase, sphingolipid 1
Fcer1a Fc receptor, IgE, high affinity I, alpha polypeptide
Ms4a2 membrane-spanning 4-domains, subfamily A, member 2
Gna12 guanine nucleotide binding protein, alpha 12
Gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting 2
Gnb2 guanine nucleotide binding protein (G protein), beta 2
Hras Harvey rat sarcoma virus oncogene
Agfg1 ArfGAP with FG repeats 1
Kng1 kininogen 1
Kras Kirsten rat sarcoma viral oncogene homolog
Il1rl1 interleukin 1 receptor-like 1
Mbd3 methyl-CpG binding domain protein 3
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
Pdpk1 3-phosphoinositide dependent protein kinase 1
Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
Prkca protein kinase C, alpha
Prkcb protein kinase C, beta
Prkce protein kinase C, epsilon
Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)
Mapk11 mitogen-activated protein kinase 11
Rab7 RAB7, member RAS oncogene family
Rac1 Rac family small GTPase 1
Rac2 Rac family small GTPase 2
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian)
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B
Sgpl1 sphingosine phosphate lyase 1
Smpd1 sphingomyelin phosphodiesterase 1, acid lysosomal
Traf2 TNF receptor-associated factor 2
Map2k2 mitogen-activated protein kinase kinase 2
Mapk1 mitogen-activated protein kinase 1
Mapk10 mitogen-activated protein kinase 10
Mapk14 mitogen-activated protein kinase 14
Mapk3 mitogen-activated protein kinase 3
Ppp2r5e protein phosphatase 2, regulatory subunit B', epsilon
Mapk12 mitogen-activated protein kinase 12
Ppp2r2d protein phosphatase 2, regulatory subunit B, delta
Elovl1 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1
Atp6ap1 ATPase, H+ transporting, lysosomal accessory protein 1
Mtch1 mitochondrial carrier 1
Fetub fetuin beta
Cers4 ceramide synthase 4
Dock5 dedicator of cytokinesis 5
Cers5 ceramide synthase 5
Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha
Ppp2r2b protein phosphatase 2, regulatory subunit B, beta
Glyr1 glyoxylate reductase 1 homolog (Arabidopsis)
Sgms2 sphingomyelin synthase 2
Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Cers2 ceramide synthase 2
Csnk1g2 casein kinase 1, gamma 2
Cbll1 Casitas B-lineage lymphoma-like 1
Rasa2 RAS p21 protein activator 2
Hdac10 histone deacetylase 10
Acer1 alkaline ceramidase 1
Ilrun inflammation and lipid regulator with UBA-like and NBR1-like domains
Gm94 predicted gene 94
Ppp2r5a protein phosphatase 2, regulatory subunit B', alpha
Sptlc3 serine palmitoyltransferase, long chain base subunit 3
Sptlc1 serine palmitoyltransferase, long chain base subunit 1
Prss34 protease, serine 34
Kng2 kininogen 2
Symbol Function*
Hdc histidine decarboxylase
Abcc1 ATP binding cassette subfamily C member 1
Nras NRAS proto-oncogene, GTPase
Ppp2ca protein phosphatase 2 catalytic subunit alpha
Ppp2cb protein phosphatase 2 catalytic subunit beta
Kng2 kininogen 2
Fcer1a Fc fragment of IgE receptor Ia
Kng2l1 kininogen 2-like 1
Ms4a2 membrane spanning 4-domains A2
Fcer1g Fc fragment of IgE receptor Ig
Cma1 chymase 1
Gnai3 G protein subunit alpha i3
Prkce protein kinase C, epsilon
Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha
Cpa3 carboxypeptidase A3
Vapa VAMP associated protein A
Map2k2 mitogen activated protein kinase kinase 2
Degs1 delta(4)-desaturase, sphingolipid 1
Mapk12 mitogen-activated protein kinase 12
Pik3r3 phosphoinositide-3-kinase regulatory subunit 3
Bid BH3 interacting domain death agonist
Cfi complement factor I
Mtpn myotrophin
Sgpp1 sphingosine-1-phosphate phosphatase 1
Gna12 G protein subunit alpha 12
Nfkb1 nuclear factor kappa B subunit 1
Pdpk1 3-phosphoinositide dependent protein kinase-1
Asah1 N-acylsphingosine amidohydrolase 1
Laptm5 lysosomal protein transmembrane 5
Braf B-Raf proto-oncogene, serine/threonine kinase
Mapk1 mitogen activated protein kinase 1
Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha
Ppp2r2c protein phosphatase 2, regulatory subunit B, gamma
Rhoa ras homolog family member A
Ppp2r1a protein phosphatase 2 scaffold subunit A alpha
Septin2 septin 2
Tpm3 tropomyosin 3
Map2k1 mitogen activated protein kinase kinase 1
Ctsd cathepsin D
Fgl1 fibrinogen-like 1
Kng1 kininogen 1
Rab5b RAB5B, member RAS oncogene family
Mapkapk2 MAPK activated protein kinase 2
Hras HRas proto-oncogene, GTPase
Ppp2r5e protein phosphatase 2 regulatory subunit B', epsilon
Abhd17a abhydrolase domain containing 17A, depalmitoylase
Rhot1 ras homolog family member T1
Bbx BBX high mobility group box domain containing
Rela RELA proto-oncogene, NF-kB subunit
Nfkb2 nuclear factor kappa B subunit 2
Cers2 ceramide synthase 2
Traf2 Tnf receptor-associated factor 2
Acer2 alkaline ceramidase 2
Degs2 delta(4)-desaturase, sphingolipid 2
Ppp2r1b protein phosphatase 2 scaffold subunit A beta
Paqr8 progestin and adipoQ receptor family member 8
Slc19a3 solute carrier family 19 member 3
Nsmaf neutral sphingomyelinase activation associated factor
Rac2 Rac family small GTPase 2
Elovl1 ELOVL fatty acid elongase 1
Mapk11 mitogen-activated protein kinase 11
Seh1l SEH1-like nucleoporin
Symbol Function*
CAP1 cyclase associated actin cytoskeleton regulatory protein 1
HIPK3 homeodomain interacting protein kinase 3
FNDC3B fibronectin type III domain containing 3B
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2
AKAP13 A-kinase anchoring protein 13
ROCK1 Rho associated coiled-coil containing protein kinase 1
NSMAF neutral sphingomyelinase activation associated factor
MAPK1 mitogen-activated protein kinase 1
GNAI3 G protein subunit alpha i3
GOLPH3 golgi phosphoprotein 3
DEGS1 delta 4-desaturase, sphingolipid 1
GRAP GRB2-related adaptor protein
RIC8B RIC8 guanine nucleotide exchange factor B
CTSD cathepsin D
ASAH1 N-acylsphingosine amidohydrolase 1
GNAI2 G protein subunit alpha i2
CDK2AP1 cyclin dependent kinase 2 associated protein 1
CERS6 ceramide synthase 6
PJA2 praja ring finger ubiquitin ligase 2
PTEN phosphatase and tensin homolog
GNAQ G protein subunit alpha q
KLHL12 kelch like family member 12
RHOA ras homolog family member A
PPP3CB protein phosphatase 3 catalytic subunit beta
PIK3R3 phosphoinositide-3-kinase regulatory subunit 3
LLGL1 LLGL scribble cell polarity complex component 1
SPTLC2 serine palmitoyltransferase long chain base subunit 2
ABI1 abl interactor 1
VAMP3 vesicle associated membrane protein 3
ROCK2 Rho associated coiled-coil containing protein kinase 2
PPP2R5E protein phosphatase 2 regulatory subunit B'epsilon
MAPK3 mitogen-activated protein kinase 3
SGPP1 sphingosine-1-phosphate phosphatase 1
PCBP1 poly(rC) binding protein 1
PPP3CA protein phosphatase 3 catalytic subunit alpha
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
PPP2CA protein phosphatase 2 catalytic subunit alpha
MAP2K1 mitogen-activated protein kinase kinase 1
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPRE1 microtubule associated protein RP/EB family member 1
PPP2R2A protein phosphatase 2 regulatory subunit Balpha
S1PR4 sphingosine-1-phosphate receptor 4
RAVER1 ribonucleoprotein, PTB binding 1
MAPK12 mitogen-activated protein kinase 12
MAPK9 mitogen-activated protein kinase 9
MAPK11 mitogen-activated protein kinase 11
TP53 tumor protein p53
PPP2R5A protein phosphatase 2 regulatory subunit B'alpha
CEP350 centrosomal protein 350
S1PR1 sphingosine-1-phosphate receptor 1
RAC1 Rac family small GTPase 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
SPHK2 sphingosine kinase 2
GNA13 G protein subunit alpha 13
PRKCA protein kinase C alpha
NCOA1 nuclear receptor coactivator 1
PPP2R5C protein phosphatase 2 regulatory subunit B'gamma
BAX BCL2 associated X, apoptosis regulator
MAPK14 mitogen-activated protein kinase 14
AP1S1 adaptor related protein complex 1 subunit sigma 1
PLD2 phospholipase D2
TNFRSF1A TNF receptor superfamily member 1A
CTSB cathepsin B
GNA12 G protein subunit alpha 12
Symbol Function*
MS4A2 membrane spanning 4-domains A2
PTEN phosphatase and tensin homolog
NRAS NRAS proto-oncogene, GTPase
RHOA ras homolog family member A
NFKB1 nuclear factor kappa B subunit 1
GNAI2 G protein subunit alpha i2
ACTG1 actin gamma 1
PLCB3 phospholipase C beta 3
SGMS1 sphingomyelin synthase 1
ATAD1 ATPase family AAA domain containing 1
MAPK8 mitogen-activated protein kinase 8
FCER1A Fc fragment of IgE receptor Ia
SPTLC2 serine palmitoyltransferase long chain base subunit 2
TRAF2 TNF receptor associated factor 2
RAC2 Rac family small GTPase 2
EHBP1L1 EH domain binding protein 1 like 1
SPTLC1 serine palmitoyltransferase long chain base subunit 1
PPP2R1A protein phosphatase 2 scaffold subunit Aalpha
SPHK2 sphingosine kinase 2
RELB RELB proto-oncogene, NF-kB subunit
FKBP8 FKBP prolyl isomerase 8
CPA3 carboxypeptidase A3
MINPP1 multiple inositol-polyphosphate phosphatase 1
NFKB2 nuclear factor kappa B subunit 2
CORO1A coronin 1A
PRKCB protein kinase C beta
MAPKAPK2 MAPK activated protein kinase 2
CMA1 chymase 1
AKT1 AKT serine/threonine kinase 1
PIK3R2 phosphoinositide-3-kinase regulatory subunit 2
MAP2K2 mitogen-activated protein kinase kinase 2
TMED2 transmembrane p24 trafficking protein 2
Symbol Function*
CSF1R colony stimulating factor 1 receptor
BAX BCL2 associated X, apoptosis regulator
BCL2 BCL2 apoptosis regulator
NFKB1 nuclear factor kappa B subunit 1
AKT2 AKT serine/threonine kinase 2
BID BH3 interacting domain death agonist
NFKB2 nuclear factor kappa B subunit 2
CHMP4A charged multivesicular body protein 4A
PPP2R1B protein phosphatase 2 scaffold subunit Abeta
MAP2K1 mitogen-activated protein kinase kinase 1
ARRDC1 arrestin domain containing 1
CDK14 cyclin dependent kinase 14
ASAH1 N-acylsphingosine amidohydrolase 1
CPA3 carboxypeptidase A3
SMPD2 sphingomyelin phosphodiesterase 2
MYH10 myosin heavy chain 10
MAP3K5 mitogen-activated protein kinase kinase kinase 5
SGPP2 sphingosine-1-phosphate phosphatase 2
PPP2R5D protein phosphatase 2 regulatory subunit B'delta
PPP2R1A protein phosphatase 2 scaffold subunit Aalpha
DEGS1 delta 4-desaturase, sphingolipid 1
RHOA ras homolog family member A
MLF2 myeloid leukemia factor 2
ABCC10 ATP binding cassette subfamily C member 10
MAPK1 mitogen-activated protein kinase 1
GNA13 G protein subunit alpha 13
FCER1G Fc fragment of IgE receptor Ig
STAT5A signal transducer and activator of transcription 5A
PLCB2 phospholipase C beta 2
WASHC5 WASH complex subunit 5
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
PLD2 phospholipase D2
PLCB1 phospholipase C beta 1
AKT3 AKT serine/threonine kinase 3
PLCB3 phospholipase C beta 3
FCER1A Fc fragment of IgE receptor Ia
ACER1 alkaline ceramidase 1
TRAF2 TNF receptor associated factor 2
TRADD TNFRSF1A associated via death domain
MTMR1 myotubularin related protein 1
NUP153 nucleoporin 153
GNAI3 G protein subunit alpha i3
RAC1 Rac family small GTPase 1
GAB2 GRB2 associated binding protein 2
LOC101101505 high affinity immunoglobulin epsilon receptor subunit beta
PDPK1 3-phosphoinositide dependent protein kinase 1
LOC102901440 uncharacterized LOC102901440
LOC102902042 membrane-spanning 4-domains subfamily A member 3-like
CLEC4O C-type lectin domain family 4 member O


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