Publication for Actr2 and Actr3

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Actr2	ARP2 actin-related protein 2	66713			[link]
mmu	Actr3	ARP3 actin-related protein 3	74117

Pubmed ID	Priority	Text
31698518	0.98	Arp3 subunit in the Arp2/3 complex formation, function39 and maintenance of F-actin levels in CTLs.
	0.98	Arp3 subunit of the Arp2/3 complex leads to a significant reduction in the migratory capacity of CTLs both in vitro and in vivo.
	0.97	ARP (Arp2 and Arp3) that structurally mimic actin monomers.
	0.97	Arp2/3 requires one or more nucleation-promoting factors including the verprolin-homologous protein (WAVE) family, the Wiskott-Aldrich syndrome protein family and the hematopoietic lineage cell-specific protein 1 from the cortactin family.11 When activated, the Arp2/3 complex binds to the side of a pre-existing actin filament, and Arp2 and Arp3, together with an additional actin monomer, form a nucleation core.
	0.96	Arp3 subunits of the Arp2/3 complex in primary T cells.
	0.96	Arp2/3 complex dependent and other actin nucleation-promoting factors such as WAVE2, Wiskott-Aldrich syndrome protein and HS1 have been reported to be important,77, 78, 79 Arp3's role in synapse formation and target cell lysis in primary mouse CTLs were still obscure.
	0.96	Arp3-KD CD8+ T cells could also arise from the potential role of the Arp2/3 complex in many more steps, including early T cell death upon target cell encounter, differentiation into effector memory T cells during the in vitro stimulation, the strength of TCR activation and/or polarization/docking of lytic granules.
	0.93	Arp2/3 in T cell survival has been inferred from ARPC2-deficient mice.25 ARPC2 subunit stabilizes the Arp2/3 complex, and ARPC2 deficiency led to reduced numbers of peripheral T cells without significantly affecting thymocyte development.25 Consistently, we also observed a survival defect in Arp3-depleted CTLs following their activation in vitro and adoptive transfer in vivo.
	0.51	Arp2/3 complex in fibroblasts.66 We only occasionally detected filopodial features on the periphery of Arp3-KD CTLs (data not shown).
24967734	0.98	Arp3, a subunit of the Arp2/3 complex, the primary nucleator of branched-actin arrays in eukaryotic cells.
	0.98	Arp3 becomes prominent and transiently localizes to the BTB at the time of restructuring, suggesting that Arp2/3-dependent branched-actin arrays form at this critical juncture.
	0.98	Arp3 is similarly observed at the apical ES, implying that an Arp2/3-dependent mechanism resembling BTB restructuring is employed during dismantling/reformation of this structure as well.
	0.98	Arp2/3-based branched actin nucleation, and our recent analysis of the expression and localization patterns of Arp3, a subunit of the Arp2/3 complex, led us to propose a model for the involvement of this primary nucleator of branched actin arrays in the cyclical dismantling and restructuring of the BTB.
	0.98	Arp3 subunit of the Arp2/3 complex, which normally localizes to the BTB vicinity during the restructuring phase of stage VIII, displayed a tightly restricted localization to the basal ES in the seminiferous epithelium of mutant mice, analogous to the age-matched control mouse testis ( Fig. 6A, B ).
	0.98	Arp3 and its recruiting partner drebrin E, suggest a molecular scenario in which dismantling of the BTB is properly initiated in the seminiferous epithelium of N-WASPSC-cKO mouse testes during the epithelial cycle, but is arrested at a relatively late stage of the process, when the Arp2/3 actin-nucleation promoting activity of N-WASP must come into play, in order to enable recycling of "old" BTB components and formation of a "new" barrier.
	0.98	Arp3, a subunit of the Arp2/3 complex, and drebrin E, a factor that mediates Arp3 localization in Sertoli cells, preserve their tight basal localization during stage VIII of the seminiferous epithelial cycle in the mutant tubules.
24036843	0.98	Arp2 and Arp3 with shRNA leads to the formation of filopodia and linear actin-based protrusions.
	0.96	Arp2/3 complex has been reported, which revealed that CK-666 binds between the Arp2 and Arp3 subunits to stabilize the inactive conformation of the complex .
	0.95	Arp2/3 complex, blocking movement of the Arp2 and Arp3 subunits into the activated filament-like conformation, while CK-869 binds to a serendipitous pocket on Arp3 and allosterically destabilizes the short pitch Arp3-Arp2 interface.
	0.88	Arp2 and Arp3 (encoded by ARP2 and ARP3 genes, respectively), that closely resemble the structure of monomeric actin, and five additional subunits ARPC1-5 .
26842895	0.98	Arp3 subunit of the Arp2/3 complex, as well as other lamellipodial proteins, including cortactin and the NPF N-WASP.
	0.98	Arp3 subunit of Arp2/3, suggesting the hypothesis that Arp2/3 sequestration of inactive FAK might be critical to coupling lamellipodial protrusion to NA formation.
	0.97	Arp2/3 binding is required for transient stabilization and subsequent turnover of NA and inhibition of their maturation, whereas the FAK-Arp2/3 interaction might promote dense NA formation independently of FAK kinase activity.
	0.73	Arp3 subunit of the Arp2/3 complex, and analyzed its localization and effects on protrusion and adhesion dynamics.
30503751	0.98	Arp2/3 signaling axis in N-WASP KO podocytes resulted in a phenocopy of the distorted FA morphology of ARP3 knockout podocytes, supporting a compensatory concept of NPFs in a contextual manner (Figure S5).
	0.98	ARP3, indicating that formin-mediated actin polymerization appears as a prerequisite for protrusion formation, whereas Arp2/3 predominantly determines the level of terminally branched protrusions and influences myosin-2 tension (Figures 5B and 5C).
	0.98	Arp2/3 complex is influencing the alignment of FA complexes in a migration mode termed as haptotaxis, and it was demonstrated that ARP3 is interacting with FA components such as VINCULIN and FAK.
	0.94	Arp2/3 complex-mediated actin nucleation, the nucleation core component Arp3 was deleted by the use of the well-established Nphs2Cre line, which initiates recombination at the late capillary loop stage during glomerular development (Figures 2L and 2M).
20717495	0.98	Arp2/3 complex, which consists of seven subunits, including Arp2, Arp3, and five other actin-related proteins, mediates the formation of new actin filaments at fixed angles to existing filaments to form a branched actin network.
	0.98	Arp2/3 complex, including Arp2 and Arp3, are concentrated in dendritic spines, suggesting a functional role for the Arp2/3 complex in spine function.
21603613	0.98	Arp2/3 complex contains two actin-related proteins, Arp2 and Arp3 that, together with an actin monomer, can assemble into a nucleus ready for elongation, either individually or in association with a socalled mother filament.
	0.98	Arp2/3 complex is inactive in the absence of nucleation promoting factors (NPFs), which can deliver actin monomers and promote nucleation by inducing a conformational change in the complex considered to bring Arp2 and Arp3 in close proximity to each other.
23885122	0.98	Arp2/3 complex sequestration, consistent with the idea that lamellipodial targeting required both its actin filament and Arp2/3 complex-binding activities and with recruitment of cortactin to ectopic actin filament assemblies nucleated by Arp2/3 complex.
	0.90	Arp2/3 activation instead of sequestration, we explored the effect of the C-terminus lacking the WH2 domain (CA), as the WH2 domain is considered essential for delivering actin monomer to Arp2 and Arp3 during nucleation.
23964896	0.98	Arp3, is a major component of the Arp2/3 complex, a seven-subunit protein that plays a major role in the regulation of the actin cytoskeleton (reviewed in Firat-Karalar and Welch, 2011).
	0.98	Arp3, a major part of the Arp2/3 complex, which is an important regulator of actin cytoskeletal dynamics in cell proliferation, neuritogenesis and cell migration.
24498171	0.98	Arp2 and Arp3 are actin-related proteins that are linked by the different Arpc subunits to the mother filament, and they nucleate the growth of new actin filaments.
	0.92	Arp2/3 complex (actin-related protein 2/3 complex) is comprised of Arp2, Arp3, and Arpc1 to Arpc5 (five individual subunits).
25263281	0.98	Actr3 (encoding Arp3) is part of the essential actin polymerization factor Arp2/3, which is composed of seven subunits including Arp2 and ARPC1-5.
	0.98	Arp3 in formation of a functional Arp2/3 complex, required in TLR4-driven primary macrophage spreading.
28827576	0.98	Arp2/3 complex component Arp3 was also decreased in Arpc2-TKO T cells, indicating that the integrity of the Arp2/3 complex was compromised (Supplementary Fig. S1e).
	0.90	Arp2/3 complex is a seven-member complex that includes Arp2 and Arp3, which are structurally similar to actin monomers and contact with actin.
28867487	0.98	Arp2 and Arp3 subunits to induce the conformational change that activates the Arp2/3 complex, and supply the initial actin monomers that are used by the Arp2/3 complex to nucleate a new actin filament.
	0.98	Arp2/3 complex, Figure S2D), as well as to F-actin-Arp2/3 complex-containing dorsal ruffles present on the upper surface of WT cells (Figure 3G).
19068115	0.98	Arp2/3 complex, a seven subunit complex containing two actin-related proteins (Arp2 and Arp3), is responsible for the generation of branched networks of actin filaments.
20457765	0.98	Arp2/3 complex (a stable complex of seven conserved subunits including the two actin-related proteins Arp2 and Arp3 and as well as ARPC1, ARPC2, ARPC3, ARPC4, and ARPC5) is the main nucleator of actin filaments in lamellipodia and necessary for lamellipodia formation.
29970282	0.98	Arp2/3 prevents wild-type melanoblast motility in dermal explants, which suggests a direct link between Rac-Arp2/3-driven actin polymerisation and melanoblast migration in vivo.
21146522	0.97	Arp3 in mouse embryo fibroblasts had little effect on cell protrusions while others showed that the Arp2/3 complex was required for normal cell protrusion formation.
22385962	0.97	Arp2/3 inhibitor CK-666 and observed that Arp2/3 activity was required for haptotaxis in this cell line (Fig. 5H, S4B).
23272233	0.97	Arp2/3 complex, the first factor shown to drive actin filament nucleation, consists of Arp2, Arp3 and five other subunits; Arpc1 to Arpc5.
26224308	0.97	Arp3, a subunit of the Arp2/3 complex, showed a less dense labeling pattern than cortactin in lamellipodia and partially colocalized with cortactin along the leading edge of lamellipodia (Figure 8, E and F).
11018051	0.96	Arp2/3-activating proteins contain either a DDW or DEW sequence (boxed, except Scar1) within or near their demonstrated Arp2/3 binding regions.
	0.95	Arp3 specifically bound to N-repeat 5 (see Materials and Methods) and NTA beads, but not to GST and repeats beads (Fig. 6 A), indicating that the NTA region is responsible for association with the Arp2/3 complex.
	0.89	Arp2/3 complexes consist of the actin-related proteins Arp2 and Arp3 along with five other proteins designated p41-, p34-, p21-, p20-, and p16-Arc (Machesky and Gould 1999) (also designated as ARPC1-5).
18720401	0.96	Arp3 (Fig. 2H) shows clear localization to the leading edge of a cell spreading at a slightly later time course, which supports published immunolocalization of Arp2/3 complex to lamellipodial protrusions,.
	0.94	Arp2-depleted 3T3 cells (Fig. 4B, D) and in Arp3-depleted Jurkats (, Movie S3) suggest residual Arp2/3 complex activity.
22492726	0.96	Arp2/3 complex is composed of seven stoichiometric subunits, including two actin-related proteins, Arp2 and Arp3, and five additional subunits, ARPC1-5.
21494665	0.95	ARP2 and ARP3 are actin-related proteins that nucleate the growth of the new filament, and the other five proteins link the two actin-related proteins to the mother filament.
	0.89	Arp2/3 complex (actin-related protein 2/3 complex) consists of Arp2, Arp3 and five other subunits; Arpc1 to Arpc5.
	0.87	Arp2 and Arp3, preventing the complex from shifting into an active conformation.
30360779	0.95	Arp2 and Arp3 subunits and blocks the complex's transition from the inactive to active conformation.
	0.88	Arp2 and Arp3 move from an inactive end-to-end or "splayed" conformation to an in-line or "short-pitch" arrangement.
27537257	0.93	Arp3 staining is comparable between Tmod1+/+ and Tmod1-/- mature lens fibers, Tmod1 does not control Arp2/3-driven F-actin branching, which is thus unlikely to play a role in formation or maintenance of the large paddle contours in mature lens fibers.
27385014	0.92	Arp2/3 complex consists of a stable and stoichiometric assembly of seven polypeptides, including Arp2 (Actr2), Arp3 (Actr3) and Arpc1-5.
	0.69	Arp2/3 complex in RGCs throughout cortical neurogenesis (E12.5-16.5) by immunofluorescent staining for the Arp3 subunit.
30463620	0.88	Arp2/3 induction, (iii) Arp3 knockdown and (iv) small-molecule inhibition of Arp2/3 function.
	0.84	Arp3 knockdown, by an Arp2/3 inhibitor, and by latrunculin which disassembles cellular F-actin.
	0.58	Arp3 knockdown, by an Arp2/3 inhibitor, and by latrunculin which disassembles cellular F-actin.
27795858	0.85	Arp2/3 complex consists of seven subunits including two actin related proteins:Arp2 and Arp3.
12566431	0.81	Arp3 signal does not support the hypothesis of an Arp2/3-based nucleation center for filopodial initiation.
21874009	0.66	Arp2/3 complex as determined by anti-Arp2 immuno-staining and Arp3-EGFP expression.