Publication for Gabarapl1 and Map1lc3b

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Gabarapl1	gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1	57436			[link]
mmu	Map1lc3b	microtubule-associated protein 1 light chain 3 beta	67443

Pubmed ID	Priority	Text
31225455	0.98	LC3b and Gabarapl1.
	0.98	Atg8 orthologues LC3b and Gabarapl1 as well as by activating ULK1.
	0.98	LC3b and Gabarapl1, two Atg8 orthologues, were upregulated by LLC in a C/EBPbeta-dependent manner (Figure 4B).
	0.98	LC3b and Gabarapl1 promoter (Figure 4D).
	0.98	LC3b and Gabarapl1 are upregulated in skeletal muscle of LLC tumor-bearing mice in a C/EBPbeta-dependent manner.
	0.98	LC3b and Gabarapl1 are upregulated in LCM-treated myotubes in a C/EBPbeta-dependent manner.
	0.98	LC3b and Gabarapl1, we observed that the upregulation of these genes in LCM-treated myotubes was inhibited by SB202190 (Figure 5A).
	0.98	LC3b and Gabarapl1 are members of the ATG8 family that are essential for autophagosome formation.
	0.98	LC3b and Gabarapl1.
	0.98	LC3b and Gabarapl1 genes.
	0.98	LC3b and Gabarapl1 through activating C/EBPbeta.
	0.97	LC3b and Gabarapl1 promoters in myotubes.
	0.97	LC3b and Gabarapl1 through the p38beta MAPK ( C/EBPbeta signaling pathway.
	0.97	LC3b and Gabarapl1 upregulation in cachectic muscle of LLC tumor-bearing mice.
	0.97	LC3b and Gabarapl1 upregulation in the muscle of LLC tumor-bearing mice is dependent on p38beta MAPK.
31331823	0.98	microtubule-associated protein 1 light chain 3 beta (Map1lc3b), gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1 (Gabarapl1), and cathepsin L (Ctsl).
	0.98	Map1lc3b, Gabarapl1, and Ctsl in denervated muscles (Figure 3G).
	0.98	Map1lc3b, Gabarapl1, and Ctsl mRNA levels in either denervated muscles or C2C12 myotubes, indicating that CGRP suppresses the autophagic-lysosomal system, at least in part, by transcriptional mechanisms.
	0.98	Map1lc3b, Gabarapl1, and Ctsl .
	0.97	Map1lc3b, and Gabarapl1 in starved C2C12 myotubes (Figure 3K).
23056618	0.98	Lc3b, Gabarapl1, Atg4b, Atg12, and Lamp2a.
	0.97	Lc3b, Gabarapl1 and Lamp2A mRNA levels in WT mice but not in MISR mice (Figure 9D).
	0.73	Lc3b, Pi3kc3, Gabarapl1 and Lamp2A may also be regulated directly by NFkappaB. We should emphasize that we don't exclude the involvement of other transcription factors such as FoxO proteins in the regulation of autophagy in skeletal muscles in response to LPS administration.
24718581	0.98	MAP1LC3 (LC3), Gabarapl1 and Atg.
	0.97	LC3b, Gabarapl1 and Atg4b, key effectors of the autophagy-lysosomal system, were increased further in muscles of Mstn(-/-) mice, compared with wild-type mice, during HS and decreased in both genotypes during reloading.
	0.97	LC3b, Gabarapl1 and Atg4b in the B. femoris muscles of Mstn(-/-) mice, at least during the first two days of unloading.
29444976	0.98	Map1lc3b, Atg4b, Becn1, Gabarapl1, Bnip3), redox regulation (Cat, Txnip) and adaptation to energy stress (Prkaa2) (Fig. 4C).
	0.98	Map1lc3b, Sesn3, Becn1, Gabarapl1, and Gpx3 (Fig. 4D).
	0.97	Map1lc3b, Atg4b, Becn1, Gabarapl1, Bnip3), redox regulation (Txnip) and adaptation to energy stress (Prkaa2) were reduced in cartilage of FoxO KO mice.
31964384	0.98	LC3B and GABARAPL1.
	0.96	microtubule- associated protein 1 light chain 3 beta (MAP1LC3B or LC3B) (24 h, 48 h), the BNIP3L binding partner gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1 (GABARAPL1) (24 h, 48 h), and the PINK1/PARK2-related autophagy receptor sequestosome-1 (SQSTM1) (24 h-72 h) were significantly higher in mice subjected to IT-LPS compared with mice subjected to IT-NaCl (Fig. 4a-d).
	0.91	LC3B-I protein (24 h, 48 h) as well as protein levels of GABARAPL1 (48 h), and SQSTM1 (48 h, 72 h) were higher during the first days post instillation in the IT-LPS mice compared with the control group (Fig. 4e-i).
23690988	0.98	GABARAPL1/GEC1 is a member of the GABARAP subfamily and its mRNA is the most highly expressed Atg8 homologue in the central nervous system.
	0.81	atg8 family is divided into two subfamilies based on when they intervene in autophagosomal formation, the MAP-lc3 subfamily (Microtubule-Associated Protein light chain 3 A, B and C) and the gabarap subfamily (gabarap for GABAA receptor-associated protein; gabarapl1/gec1 for GABAA receptor-associated protein like 1/glandular epithelial cells 1 and gabarapl2/gate16 for GABAA receptor-associated protein like 2/GTPase activating protein of 16 kDa).
25449263	0.98	Gabarapl1, Gabarapl2, Map1lc3a, and Map1lc3b) we believe, will reduce overall autophagy activity in intestinal cells.
	0.97	Gabarapl1, Gabarapl2, Map1lc3a, and Map1lc3b involved in elongation and closer of autophagosomes were significantly downregulated.
26107816	0.98	LC3B, Bcl2/adenovirus E1B 19 kDa interacting protein 3 (Bnip3) and GABA(A) receptor-associated protein like 1 (Gabarapl1) in the diaphragm (Fig 2G), whereas only Gabarapl1 expression was increased in limb muscle (Fig 2H).
	0.92	LC3B-II protein (2.4-fold) and mRNA markers of the autophagy pathway (LC3B, Gabarapl1, Bnip3), whereas active calpain and E3 ubiquitin ligases (MuRF1, atrogin-1) were unaffected in both muscles.
27172324	0.98	LC3, but also its homologs (GABARAP, GABARAPL1, and GABARAPL2) localize on the PVM of T. gondii in a conjugation-dependent manner.
	0.87	LC3 homologs led to knockdown of Lc3a (reduced to 20.8% +- 3.5), Gabarap (reduced to 9.0% +- 1.8), Gabarapl1 (reduced to 15.4% +- 2.2), and Gabarapl2 (reduced to 30.7% +- 4.0) transcripts (Fig. 3G).
29879393	0.98	MAP1LC3 (LC3B), GABARAPL1 and GABARAPL2 (GATE16) to directly recruit autophagosomes for the elimination of mitochondria in other tissues.
	0.98	LC3B but a much higher affinity for its homologues GABARAPL1 and GATE16 suggesting that these proteins may participate in the BNIP3L-mediated elimination of lens fiber cell mitochondria, ER and GA.
30097599	0.98	Gabarapl1, Gabarapl2, Map1lc3b, and Wipi1) involved in the early phase of phagophore formation in livers of HFD mice in comparison with the control group.
	0.97	Gabarapl1, Gabarapl2, Map1lc3b, and Wipi1 genes (involved in the early phase of phagophore formation and the initiation of autophagy), LC3, Atg12, Atg5, Atg3, Atg7, HDAC6 and Atg16L genes (required for the ubiquitination and phagophore expansion) and Gabarap, Atg4b, Lamp1, and Npc1 (examined in the targeting vacuole and autophagosome-lysosome linkage stages)], but also that this process may underlie the decreased insulin resistance in these models.
30344980	0.98	LC3b and Gabarapl1 proteins and allowing the degradation of protein aggregates via autophagy.
	0.97	LC3b and p62, was up-regulated as soon as eight hours upon denervation and increased over time, reaching statistical significance within eight to twenty-four hours; while the expression of others, such as Atg7 and Gabarapl1 significantly increased only from day three following denervation.
30840891	0.98	LC3B, BNIP3, BNIP3L, p62, GABARAPL1, and ATG12; they were markedly decreased in IPMK KO MEFs (Figure S2B).
	0.98	LC3B, BNIP3, BNIP3L, p62, GABARAPL1, and ATG12 was rescued by both the WT and kinase-dead forms of IPMK (Figure 2D).
23152054	0.98	LC3B, Atg12, Bnip3 and Gabarapl1 mRNA levels (Figure 3e), consistent with Akt and mTOR signalling inhibition and with autophagy induction.
25147502	0.98	GABARAPL1, an Atg8 subfamily protein, is highly expressed in the cortex compared to striatum.
26182361	0.98	Lc3b, Bnip3, Bnip3l, Atg12l, Atg4b, Ulk2 (unc-51 like autophagy activating kinase 2), Gabarapl1 (gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1), Vsp34 and Beclin1.
26698918	0.98	Lc3b, and Atg8 orthologues Gabarap and Gabarapl1 when compared to RT-housed mice (Fig. 1D).
27247826	0.98	LC3B, and LC3C, and GABARAP, GABARAP-L1, and GATE-16 to the lipid phosphatidylethanolamine (PE).
27427974	0.98	GABARAPL1 and LC3B) in the AT-nfe2l2-KO mice (Fig. 3).
27428166	0.98	LC3B in mice) functions in elongation of the autophagosomal membrane and the GABARAP subfamily (GABARAP, GABARAPL1, and GABARAPL2) works in a later stage of autophagosome completion.
27854220	0.98	Map1lc3, Gabarapl1, Bnip3 and Sqstm1, are induced upon fasting and denervation, and that their regulation is driven by the FoxO3 (Forkhead box class O) transcription factor.
28464882	0.98	LC3B, Bnip3 and GabarapL1 was significantly upregulated after LPS.
28847720	0.98	LC3B, GABARAP, GABARAPL1 and GABARAPL2) have been identified.
29057166	0.98	LC3B, GABARAPL1, and ATG12, BNIP3L (also known as NIX) and BNIP3, by directly binding to the FoxO response element in their promoters.
29127187	0.98	Map1lc3b and Gabarapl1 as well as Pink1 and Parkin (Fig. 4A).
29167426	0.98	LC3b, GABARAPL1, Atg7, and CathepsinL were considerably increased in vehicle and (-)-JQ1-treated C26-tumor-bearing mice.
29477142	0.98	LC3b or Gabarapl1, thus guiding the cargo into autophagosomes to be digested.
29963746	0.98	Map1lc3, Bnip3, Gabarapl1, Becn1, Prkaa2) in the NP of 2-month-old FOXO mutant mice (Figure 4c).
30510631	0.98	Map1lc3b, Gabarapl1, and Bnip3, was previously shown to be suppressed in mdx mice.
30952864	0.98	ATG8 family proteins (including LC3A, LC3B, LC3C, GABARAP, GABARAPL1, and GABARAPL2) near the cargos.
31480237	0.98	Atg8 family, LC3b, and Gabarapl1.
32194851	0.98	LC3B and LC3C) and GABARAP subfamilies (GABARAP, GABARAPL1 and GABARAPL2) belong to the Atg8 family, and LC3/GABARAP proteins are known to regulate autophagosome biogenesis/maturation and cargo recognition.
21187332	0.97	LC3B, Beclin1, and Gabarapl1, which are reported to be significantly up-regulated in denervated muscles.
	0.97	LC3B, Beclin1, and Gabarapl1 were significantly reduced in denervated skeletal muscle of TRAF6mko mice compared with TRAF6f/f mice (Fig. 5 B).
	0.95	LC3B, Beclin1, and Gabarapl1 were also significantly reduced in denervated TA muscle of TRAF6mko mice compared with TRAF6f/f mice.
26775710	0.97	LC3B, LC3A, and GABARAPL1 in uterine horns from endometriosis-induced mice compared with uterine horns from controls, with a concurrent increase in lipid droplets.
	0.96	LC3B-I (4.00-fold change, P=0.0185), LC3B-II (6.76-fold change, P=0.0364), LC3A-II (1.97-fold change, P=0.0135), and GABARAPL1 (1.95-fold change, P=0.0334) were significantly increased in uterine horns from endometriosis-induced mice relative to those from control mice.
	0.72	LC3B (P=0.0040), GABARAPL1 (P=0.0360), PTEN (P=0.0295), SQSTM1 (P=0.0008), and PRKAA1 (P=0.0065) were significantly reduced.
27793014	0.97	ATG8, GabarapL1/ATG8, Atg12/ATG12, and Bnip3.
30692642	0.97	LC3B, LC3A (two splice variants), LC3C, GABARAP, GABARAPL1, and GABARAPL2) that are implicated in specialized roles of the autophagy pathway (e.g. selective targets for autophagy, involvement in specific steps in autophagosome/autolysosome maturation) or receptor trafficking.
30932373	0.97	Gabarapl1 (6.5-fold), Map1lc3b (~5-fold), Bnip3 (5.5-fold), and Ctsl (5.5-fold) (Figure 1G).
25049998	0.96	MAP1LC3B, ATG12, GABARAP, and GABARAPL1 compared with control IVM oocytes (p<0.05, Figure 5C).
	0.96	MAP1LC3B, ATG12, GABARAP, and GABARAPL1) increased significantly.
	0.89	MAP1LC3B, ATG12, GABARAP, and GABARAPL1), anti-apoptosis (BCL2L1 and BIRC5; p<0.05), and development (NANOG and SOX2; p<0.05) genes, but it did not affect the mRNA expression of pro-apoptosis genes (FAS and CASP3) compared with the control.
15325588	0.96	Atg8L, an as yet uncharacterized fourth Atg8 homologue, from the EL-4 mouse thymoma cell line (Fig. 3).
24586650	0.96	microtubule-associated protein 1 light chain 3beta (MAP1LC3B aka LC3B), GABA(A) receptor-associated protein like 1 (GABARAPL1).
30635357	0.94	GABARAPL1, an Atg8 homologue highly expressed in MNs (; Fig. 3, E and G).
30271348	0.90	Gabarapl1 (gamma-aminobutyric acid A receptor-associated protein-like 1), Map1lc3b (microtubule-associated protein 1 light chain 3 beta)] was not altered (Figure 5).
31500836	0.90	LC3B, LC3C, GABARAP, GABARAPL1 and GABARAPL2.
26034986	0.69	GABARAPL1 (GL1, another ATG8 family member) or interactions of a second cargo adapter NIX with LC3B or GL1 in MDA-MB-436 cells (Fig 1).
18930136	0.66	Atg8 have been identified: MAP-LC3 (microtubule-associated protein light chain 3), GABARAP (gamma-aminobutyric-acid-type-A-receptor-associated protein), GATE-16 (Golgi-associated ATPase enhancer of 16 kDa), and Atg8L, although GABARAP, GATE-16, and Atg8L have not been extensively characterized.