Publication for Hmgcs1 and Idi1

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Hmgcs1	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1	208715			[link]
mmu	Idi1	isopentenyl-diphosphate delta isomerase	319554

Pubmed ID	Priority	Text
29237705	0.98	Hmgcs1, Hmgcr, Idi1, and Cyp51), as well as the known target gene Axin, were found to be up-regulated (Fig. 5 A).
	0.98	Hmgcs1, Hmgcr, Idi1, and Cyp51 (Fig. S3 D), whereas knocking down the expression of beta-catenin inhibited the expression of these enzymes (Fig. 5 B).
	0.98	IDI1, CYP51, and mouse Hmgcr (Fig. 5 C), suggesting that beta-catenin signaling directly regulates Hmgcs1, Hmgcr, Idi1, and Cyp51 transcription.
	0.97	Hmgcs1, Hmgcr, Cyp51, and Idi1 after disrupted ciliogenesis.
	0.97	Hmgcs1, Hmgcr, Idi1, and Cyp51, and overexpression of beta-catenin significantly activated these promoters in luciferase assays (Fig. S3 E).
19308092	0.98	Hmgcs1, Nsdhl, Cyp51, Sc4mol, Idi1, Sc5d and Sqle) are involved in cholesterol biosynthesis, showing consistent reduction in RML-infected mice but no significant changes in 301V-infected mice (Figure 4, module 3).
19562077	0.98	Idi1 and Hmgcs1, two genes which encode for enzymes involved in cholesterol biosynthesis.
22855714	0.98	Hmgcs1, Srebf2, Hmgcr, Fdft1, Dhcr24, Sqle and Idi1) and in the uptake of extracellular cholesterol (Ldlr) (Fig. 5B).
23166811	0.98	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (Hmgcs1), isopentenyl-diphosphate delta isomerase (Idi1), and NADP dependent steroid dehydrogenase-like (Nsdhl), which were not bound by RXRalpha and are also involved in steroid and cholesterol metabolism, suggesting RXRalpha could directly and indirectly regulate steroid and cholesterol homeostasis (Figure 4A).
24391516	0.98	HMG-CoA synthase 1 (HMGCS1), isopentenyl-diphosphate delta-isomerase 1 (IDI1), CYP51, CYP7A1 and CYP8B1 (Figure 6 and S4F).
27814671	0.98	IDI1, MSMO1, NSDHL, HMGCS1 and ALDOC either catalyze or regulate cholesterol biosynthesis.
30069000	0.98	Hmgcs1, Hsd17b7, Idi1, Lss, Mvd, Mvk, Msmo1, Nsdhl, Pmvk, Sc5d, Sqle, and Tm7sf2 were significantly decreased in HFD livers.
30294300	0.98	Hmgcs1, Idi1, Mvd).
22441164	0.97	HMG-CoA synthase 1 (HMGCS1), HMGCR, FPPS, IDI1, SQS, squalene epoxidase (SQLE), lanosterol synthase (LSS), 7-dehydrocholesterol reductase (DHCR7), LDL receptor (LDLR) and Insig-1 were all significantly increased 1.6- to 4.7-fold in P0 129 Pex2-/- versus control mouse liver.
29352187	0.97	Hmgcs1), isopentenyl-diphosphate Delta-isomerase 1 (Idi1), farnesyl pyrophosphate synthase (Fdps), sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (Nsdhl), 3-keto-steroid reductase (Hsd17b7) and 7-dehydrocholesterol reductase (Dhcr7), were increased in AB mice compared with vehicle control mice, and this increase was reversed by secondary bile acid supplementation (Fig. 4A-F).
29399633	0.97	HMGCS1, PMVK, MVD, SQLE, IDI1, ACSL3, and FASN (data S2B).
22912762	0.96	3-hydroxy-3-methylglutaryl-Coenzyme A synthethase 1 (Hmgcs1), isopentenyl-diphosphate-isomerase (Idi1) and NAD(P)H steroid dehydrogenase-like protein (Nsdhl)) were significantly decreased in the Mig-6d/d mice compared to Mig-6f/f mice while others (3-hydroxy-3-methylglutaryl-Coenzyme A reductase (Hmgcr)) were not.
22234961	0.93	HMGCS1, HSD17B7, and IDI1; they showed a similar trend of repression further suggesting a general regulation of the cholesterol biosynthetic pathway by AHR (Fig. 5).
27355629	0.83	isopentenyl-diphosphate delta isomerase (Idi1), 3-hydroxy-3-methyglutaryl-coenzyme A synthase 1 (HMG-CoA reductase, Hmgcs1), methylsterol monoxygenase 1 (Sc4mol), 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr) and squalene epoxidase (Sqle) are in the list of the most significantly downregulated genes in this analysis (Table 2).