Publication for Cyp51 and Idi1

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Cyp51	cytochrome P450, family 51	13121			[link]
mmu	Idi1	isopentenyl-diphosphate delta isomerase	319554

Pubmed ID	Priority	Text
29237705	0.98	Idi1, and Cyp51), as well as the known target gene Axin, were found to be up-regulated (Fig. 5 A).
	0.98	Idi1, and Cyp51 (Fig. S3 D), whereas knocking down the expression of beta-catenin inhibited the expression of these enzymes (Fig. 5 B).
	0.98	IDI1, CYP51, and mouse Hmgcr (Fig. 5 C), suggesting that beta-catenin signaling directly regulates Hmgcs1, Hmgcr, Idi1, and Cyp51 transcription.
	0.97	Cyp51, and Idi1 after disrupted ciliogenesis.
	0.97	Idi1, and Cyp51, and overexpression of beta-catenin significantly activated these promoters in luciferase assays (Fig. S3 E).
23040070	0.98	Cyp51, Pmvk, Fdft1, Hsd17b7, Sc4mol, Mvk, and Idi1 was also reduced in both XBP1 and IRE1alpha deficient mice, and hence might contribute to the decreased lipid levels in these mutant mice.
	0.98	Cyp51, Pmvk, Fdft1, Hsd17b7, Sc4mol, Mvk, and Idi1 that were suppressed in both XBP1 and IRE1alpha deficient liver, hence representing direct XBP1 targets.
19308092	0.98	Cyp51, Sc4mol, Idi1, Sc5d and Sqle) are involved in cholesterol biosynthesis, showing consistent reduction in RML-infected mice but no significant changes in 301V-infected mice (Figure 4, module 3).
22252456	0.98	Idi1, Sc4mol, Cyp51, and Dhcr7).
24391516	0.98	isopentenyl-diphosphate delta-isomerase 1 (IDI1), CYP51, CYP7A1 and CYP8B1 (Figure 6 and S4F).
28012437	0.98	Cyp51, Idi1, Hsd17b7) were among the top regulated genes in Atg7 deficient stressed KC, and interestingly these genes were also found strongly induced in mitochondrial dysfunction models.
28150810	0.98	Idi1, Sqle, Cyp51, Msmo1, Hsd17b7, and Dhcr24) were among the genes down-regulated in XX/Sry Sertoli cells, suggesting that the down-regulation of the cholesterogenic genes was primarily the result of the decreased expression of Srebf2.
28238261	0.98	Idi1, Cyp51, Fdft1, and Sqle (1.5-, 7.5-, 5.8-, 4.0-, and 4.3-fold, respectively) (Figure 6A, box 3).
30069000	0.98	Cyp51, Dhcr7, Fdft1, Fdps, Hmgcr, Hmgcs1, Hsd17b7, Idi1, Lss, Mvd, Mvk, Msmo1, Nsdhl, Pmvk, Sc5d, Sqle, and Tm7sf2 were significantly decreased in HFD livers.
19183246	0.97	IDI1), farnesyl diphosphate farnesyl transferase 1 (FDFT1), squalene epoxidase (SQLE), cytochrome P450, family 51 (CYP51) and 24-dehydrocholesterol reductase (DHCR24), which were down-regulated -1.66, -1.46, -1.36, -1.55 and -1.55-fold at 196 dpi, respectively, execute multiple sequential steps in cholesterol biosynthesis.
	0.97	CYP51, DHCR7, DHCR24, FDFT1, FDPS, IDI1, NSDHL and SQLE are members of the mevalonate pathway downstream of the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and represent potent therapeutic targets for cholesterol-lowering agents.
19650929	0.97	isopentenyl-diphosphate delta isomerase (Idd1), Cyp51, lanosterol synthase, mevalonate (diphospho) decarboxylase, and sterol-C4-methyl oxidase-like (Sc4mol).
23060211	0.97	Idi1, Mvd, Mvk, and Cyp51 genes has lower expression in palatal tissue from Tgfbr2fl/fl;Wnt1-Cre mouse embryos relative to controls.
22234961	0.95	CYP51, HMGCS1, HSD17B7, and IDI1; they showed a similar trend of repression further suggesting a general regulation of the cholesterol biosynthetic pathway by AHR (Fig. 5).
22985096	0.93	Idi1, Fdft1, CYP51, Sc4mol, and Ldlr; ) for putative binding sites for the 13 downregulated miRNAs.
31998465	0.89	CYP51, EPT1, G6PC, HSD17B12, IDI1, LIPG, MBOAT1, MVD, NSDHL, PCK1, LIPA, and FABP5).
27069868	0.86	Cyp51, Idi1, and Hsd17b7 (in bold) affect lipid metabolism.
	0.65	Cyp51, Idi1 and Hsd17b7 are involved in lipid metabolism and lipid accumulation is one central feature of the NAFLD/NASH pathology, we wanted to assess the functional relevance of these findings and therefore analyzed the lipid content of liver samples collected from CD fed B6-mtFVB and B6-mtB6 control mice.
29056891	0.57	Idi1 (0.45-fold), Fdps (0.41-fold), Sqle (0.28-fold), Cyp51 (0.55-fold), Mvd (0.47-fold), and PPARgamma (0.72-fold) - displayed a similar trend as determined using real-time PCR.