Publication for Plk1 and Ccnb1

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Plk1	polo like kinase 1	18817			[link]
mmu	Ccnb1	cyclin B1	268697

Pubmed ID	Priority	Text
31649851	0.99	PLK1 mediates nuclear translocation of cyclin B1 during prophase and promotes the accumulation of active phosphatase CDC25C, which activates M phase promoting factor (MFP).
	0.98	PLK1 and cyclin B1 after treatment for 24 and 48 h (Fig. 3B), indicating accumulation of cells in the mitotic phase with failure of cytokinesis completion.
22479190	0.98	CyclinB1 is known to play a key priming role in sequential phosphorylation with PLK1.
	0.98	PLK1 in asynchronized cells which suggested that there may be M-phase specific phosphorylation by a mitotic kinase such as Cdk1/CyclinB1.
	0.98	CyclinB1 phosphorylation and subsequently demonstrated that Cdk1/CyclinB1 can in fact act as a priming kinase in conjunction with PLK1 to sequentially phosphorylate Treacle.
	0.97	PLK1 after pre-incubation with Cdk1/CyclinB1 considerably increased the level of Treacle phosphorylation compared to PLK1 alone (Figure 7E).
	0.97	PLK1 do indeed physically interact and furthermore that Treacle is a substrate for PLK1 and Cdk1/CyclinB1 phosphorylation.
22936984	0.98	ccnb1 and plk1.
	0.98	Ccnb1, Cdca2 and Plk1) implicated in normal progression from G2 into M phases of the cell cycle.
	0.97	Ccnb1, Cdc25c, Wee1, Plk1, and Bub1b.
	0.96	ccnb1, and plk1 (Table S1).
	0.93	ccnb1, wee1, cdc20 and plk1.
25254494	0.98	Cyclin B1, Cyclin A2, Plk1, Cks1, Aurora B and Topo 2 alpha, were increased in the SPDEF-/-/TRAMP prostates, a finding consistent with the increased cellular proliferation (Figure 1C).
	0.98	Cyclin B1, Cyclin A2, Plk1, Cks1, Aurora B, and Topo 2 alpha were decreased in prostates of TRAMP/SPDEF OE mice (Figure 4C, right panel), a finding consistent with decreased cellular proliferation and decreased tumor sizes.
	0.98	Cyclin B1, Cyclin A2, Plk1, Cks1, Aurora B, and Topo 2 alpha mRNAs, all of which are known targets of Foxm1 transcription factor.
	0.97	Cyclin B1, Plk1, Aurora B. Recent studies demonstrated that Foxm1 is required for initiation and progression of various cancers, including prostate cancer.
	0.95	Cyclin B1, Cyclin A2, Plk-1, CKS1, Aurora B and Topo2-alpha were found in TRAMP/SPDEF-/- prostates by qRT-PCR.
21779394	0.98	Cyclin B1, Plk-1, nMyc and p21cip1.
	0.98	Cyclin B1, nMyc, Plk-1 and p21cip1.
	0.98	Cyclin B1, Plk-1 and nMyc as determined by qRT-PCR (M).
	0.97	Cyclin B1, Polo-like kinase 1 (Plk-1) and nMyc was found in E14.5 Nkx2.5-Cre/Foxm1fl/fl hearts by qRT-PCR (Figure 4M).
28851945	0.98	cyclin B1 is controlled in somatic cells, because its degradation is regulated by both SAC and Plk1 activities.
	0.97	Plk1 controls both cyclin B1 and cyclin A2 degradation in a SAC-independent manner
	0.92	Plk1 (kd Plk1-YFP) did not affect the degradation of cyclin B1 (Fig. 4b, Table 2), indicating that the observed acceleration of cyclin B1 degradation required Plk1 activity.
	0.86	Plk1 is also unlikely to act through Emi2 since the injection of Emi2-specific morpholinos or siRNAs did not accelerate cyclin B1 or securin degradation during the first embryonic division.
18728229	0.98	Plk1, Cenp-a, Birc5/Survivin, and Ccnb1) in islets.
	0.98	Plk1, Cenp-a, Birc5/survivin, and Ccnb1 (Fig. 2).
	0.98	Plk1, Cenp-a, Birc5/survivin, and Ccnb1).
19835856	0.98	cyclin B1, cyclin D1, Plk1, JNK1, and cMyc (Fig. 7A).
	0.98	cyclin B1, Plk1 and JNK1, whereas expression of cyclin D1 and cMyc was not significantly changed (Fig.7A).
21772266	0.98	cyclin B1 indicate a Plk1 depletion-induced G2/M-arrest (Supplementary Fig. S4b).
	0.97	Plk1 has been implicated in multiple steps of mitotic progression including the activation of Cdk1/cyclin B1 (ref.), centrosome maturation, release of cohesion from chromosomes, activation of the anaphase-promoting complex/cyclosome, formation of bipolar spindles and the regulation of the spindle assembly checkpoint (SAC).
23667535	0.98	Cyclin B1 and PLK1 and pluripotency genes such as OCT4 and SOX2.
	0.79	Cyclin B1 or Plk1 results in embryonic lethality.
30992007	0.98	cyclin B1, SKP2, PLK1, Aurora B kinase, CDC25B, and stathmin1 (STMN1)), coupled with CSC enrichment.
	0.98	CCNB1, PLK1, and BIRC5 (also known as survivin).
18942075	0.98	Ccnb1, Ccnd2, Cdc2a, Cenpa, Gmnn, Mad2l1, Mcm5, Mki67, Odc, Plk1, Tk1, Top2a, Ung, and Tpx2 (Fig. 5A,B), and suggest that v-rasHa cannot abrogate the TGFbeta1 cell cycle arrest program.
21575136	0.98	Plk1, cyclin B1 and Securin, which are important mitotic regulators, remained high in Grx3-KD cells compared with control cells at 10-12 h after DTB release (Fig. 6D).
21825075	0.98	CycB1, cdc2, and cdc25C) and cytokinesis (Aurora kinase B and pololike kinase 1 [PLK1]) was not detectable in ACMs and remained unchanged after TAC, whereas pressure overload in ACMs resulted in up-regulation of the ventricular hypertrophy marker atrial natriuretic peptide (also known as atrial natriuretic factor [ANF]; Fig. 1 A).
23520509	0.98	PLK1, that is the best studied of the family, phosphorylates cyclin B1, activates the cyclin B/Cdk1 complex and cooperates with Aurora kinases, thus controlling mitosis.
24776885	0.98	cyclin B1 inhibiting separase activation and cyclin B2 accelerating aurora-A-mediated Plk1 activation and centrosome separation.
25333283	0.98	Cyclin B1, Cyclin F, Cyclin A2, Cdc5, Cdca7, Cdc6 and PLK1.
25628462	0.98	cyclin B1 and AURKA (Aurora kinase A), but was preceded by a an increase in PLK1 (polo-like kinase 1) abundance (Fig. 4A), events which mark the transition of cells from G2 into M phase.
26615533	0.98	cyclin B1, was found to be the unique activating binding partner of Cdk1 in the Cdk1-Aurora A-Plk1-Mst2-Nek2A signaling cascade that induces centrosome disjunction.
27113289	0.98	cyclin B1 (Ccnb1) (99-fold), which is important for cell proliferation; fibronectin type III domain containing 5 (Fndc5) (94-fold), which is a precursor of the anti-obesity hormone irisin, as well as polo-like kinase 1 (Plk1) (95-fold), which controls several key steps during mitosis.
29888801	0.98	cyclin B1), Cdc25 phosphatases (that activate cyclin-dependent kinases), several mitotic regulators (such as Polo Like Kinase 1, Aurora B kinase and Survivin) and also negatively regulate expression of cell cycle inhibitors such as p27.
32047721	0.97	PLK1, Cyclin B1 and Aurora B) were much higher in tumor cell lysates derived from MELK-overexpressing mice than those from the control group (Figure 5D).
	0.96	PLK1, Cyclin B1 and Aurora B were drastically diminished in cell lysates derived from MELK-depleted mice, compared to those from the shNC group (Figure 5H).
20715180	0.96	Plk1, which interacts with prereplicative complex proteins such as Mcm2 (MGI:105380) and Orc2 (MGI:1328306), being rapidly downregulated, whereas the expression of Ccnb1, Ccna2, Cdc2a, Cenpf, AurkB, and Survivin, which encode proteins involved in the G2/M transition and M phase progression, were not altered 48 hours after transfection of B-mybF/Delta cells with Cre recombinase, although a decline in expression was detectable at 11 days (Supporting Information Fig. S4).
22938163	0.96	polo-like kinase 1 (PLK-1), cyclin B1, and CDK 4 protein levels in forebrain homogenates at 2 weeks off doxycyline are apparent; however, levels of CDK 4 and cyclin B1 decrease at 4 weeks off doxycyline (Figure 1).
23144938	0.96	Plk-1, a known Foxm1 target gene, but did not significantly influence mRNA levels of cyclin B1, CDC 25B, p21cip1, nMYC, myocardin, Hey2, NFATc3 or CaMKIIdelta (Figure 1J).
25808367	0.93	Plk1, Birc5, Cenpe, Ccnb1, Mki67 and Aurka represent the top eight cell cycle expression network members.
22916088	0.92	polo-like kinase 1 (Plk1) signaling pathway, including Plk1(polo-like kinase 1), Bub1 (budding uninhibited by benzimidazoles 1), Bub1b (budding uninhibited by benzimidazoles 1 homolog, beta), Ccnb1 (cyclin B1) and Cdc25c (cell division cycle 25 homolog C), coordinately decreased from E17.5 to PN0.
27267850	0.91	cyclin B1 (CCNB1) and PLK1-phosphorylated phS133-CCNB1 (Fig 4E), compatible with imposition of a strong G2/M checkpoint arrest by STA-8666, with this peaking at 24-48 hours, as previously described, and more marked for 150 mg/kg STA-8666 than observed with irinotecan.
31426861	0.91	polo-like kinase 1 (PLK1) and cyclin B (CCNB1), which are both important cell cycle regulators.
29928511	0.89	Ccnb (cyclin B1), the promoting factors Cdc25b, Marf1, Plk1, Plk4, Bub1b, Emi1 and Securin, or the inhibiting factors Ppp2cb, Gpr3, Wee2, Pkmyt1, Kdm1a, Cdh1, Fzr1, and Cdc14b (Fig. 2c).
27471498	0.66	Ccnb1, Ccnb2, Cdc25b, Espl1, Melk, Mybl2, Plk1, Rgcc, and Rrm2.