Publication for Cyp51 and Insig1
Species | Symbol | Function* | Entrez Gene ID* | Other ID | Gene coexpression |
CoexViewer |
---|---|---|---|---|---|---|
mmu | Cyp51 | cytochrome P450, family 51 | 13121 | [link] | ||
mmu | Insig1 | insulin induced gene 1 | 231070 |
Pubmed ID | Priority | Text |
---|---|---|
27977712 | 0.95 | Cyp51; fold change, 5.6), 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr; fold change, 2.5), hydroxysteroid (17-beta) dehydrogenase 7 (Hsd17b7; fold change, 2.8), insulin induced gene 1 (Insig1; fold change, 1.8), sterol-C4-methyl oxidase-like (Sc4mol; fold change, 4.5), and leptin receptor (Lepr; fold change, 1.6) were upregulated. |
0.81 | Cyp51, Hmgcr, and Insig1) and fatty acid beta-oxidation (Acsl3), whereas it significantly downregulated expression of genes related to fatty acid biosynthesis (Scd1, Acot11, and Mlxipl/carbohydrate responsive element-binding protein [ChREBP]), triacylglycerol biosynthesis (Mogat1), oxidative stress (growth differentiation factor 15, Gdf15), inflammatory and immune processes (Cfd, Chi3l1, Ctse, Orm2, Rorc, and Tlr5), ceramide biosynthesis (Sptlc3), and lipid storage (Plin4). | |
19691840 | 0.95 | Insig1 and Sqle while expression of Cyp51a1 and Srebp2 remained unchanged. |
24486573 | 0.81 | CYP51 (I), and INSIG1 (J) with a trend towards such an effect for INSIG2A (K) also. |
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