Publication for Klf4 and Thbd

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Klf4	Kruppel-like factor 4 (gut)	16600			[link]
mmu	Thbd	thrombomodulin	21824

Pubmed ID	Priority	Text
26634653	0.98	KLF4 or both markedly attenuated Nor1-induced TM expression in ECs (Figure 3D), further suggesting that Nor1 increases TM expression through inducing KLF2 and KLF4 transcriptional activities in vascular ECs.
	0.98	KLF4 have been shown to play essential roles in the regulation of TM expression at transcriptional levels.
	0.98	TM promoter activity indirectly through induction of both KLF2 and KLF4 in ECs.
	0.97	TM expression predominantly through increasing TM mRNA stability, while Nor1 involves an induction of KLF2 and KLF4 in ECs.
	0.69	KLF4 attenuates Nor1-induced TM expression.
24526695	0.98	KLF4 interact with the cofactor p300 to augment transcription of eNOS and thrombomodulin.
	0.98	KLF4 are potent inducers of eNOS and thrombomodulin expression and also inhibit cytokine-induced expression of adhesion factors-including VCAM-1, E-selectin- and other inflammatory mediators .
	0.98	KLF4 increase thrombomodulin and tissue plasminogen activator expression (tPA) and decrease plasminogen activator inhibitor (PAI-1) and cytokine-stimulated tissue factor expression , consistent with an anti-thrombotic effect.
30660098	0.98	KLF4 induced the expression of its known target genes eNOS, argininosuccinate synthetase1 (ASS1) and thrombomodulin.
	0.98	KLF4 attenuated NF-kappaB activity and inhibited the expression of vascular cell adhesion molecule-1 (VCAM-1) and plasminogen activator inhibitor-1 (PAI-1); KLF4 also induces the gene expression of eNOS and thrombomodulin to maintain endothelium under an anti-adhesive and anti-thrombotic state.
	0.98	KLF4 leads to decreased expression of its target genes eNOS, ASS1 and thrombomodulin (Fig. 2), which might impair the protective effects of KLF4.
25625206	0.98	Klf4 and a number of known KLF2/4 target genes, including Nos3, Aqp1, Jam2, Thbd, and Palmd (Fig. 3A, B & D).
	0.98	Thbd, and Palmd, as well as Klf4, Adamts4 and Adamts5 (Fig. 5C, D).
20724706	0.98	KLF4 in ECs under physiologic conditions, and elevated expression of KLF4 in cultured ECs induced the expression of several anti-inflammatory and anti-thrombotic factors, notably endothelial nitric oxide synthase (eNOS) and thrombomodulin (TM).
29459900	0.98	KLF4 overexpression also increases transcription of anti-thrombotic factor thrombomodulin as well via a physical association with its cofactor, p. 300.
31387590	0.98	KLF-4 further modulates downstream molecules, including NOS3, TM, and MCP-1.
27901106	0.97	KLF4, KLF10, FOSL2, SERPINE1, THBD, MEF2D, and MAFF, showed a clear correlation with increased levels of PIM1/2 (Fig. 7C and D).
	0.78	KLF4, KLF10, FOSL2, SERPINE1, THBD, MEF2D, and MAFF.
29984197	0.93	KLF4, eNOS, and thrombomodulin, while increasing MCP-1.