Publication for Scd1 and Elovl5

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Scd1	stearoyl-Coenzyme A desaturase 1	20249			[link]
mmu	Elovl5	ELOVL family member 5, elongation of long chain fatty acids (yeast)	68801

Pubmed ID	Priority	Text
31993375	0.98	Scd1, Fads1, Fads2, Elovl2, and Elovl5) was dysregulated in mice inoculated with an aged microbiota.
	0.98	Scd1, Fads1, Fads2, Elovl2, and Elovl5) encoding enzymes involved in fatty acid biosynthesis.
	0.97	Scd1 and Elovl5 expression, respectively (Kindt et al.,).
	0.97	Elovl5, Elovl6, and Scd1 were upregulated (Wang et al.,).
	0.97	ELOVL5 and SCD1 could contribute to and explain the increased production of hepatic MUFA.
	0.96	acyl-CoA desaturase 1 (Scd1), acyl-CoA (8-3)-desaturase (Fads1), acyl-CoA 6-desaturase (Fads2), and elongation of very long chain fatty acids proteins 2 and 5 (Elovl2 and Elovl5).
	0.95	Scd1) and PUFA unsaturation (Fads1 and Fads2) and elongation (Elovl2 and Elovl5) were not impacted by the composition of the gut microbiota (Figure 4).
	0.95	Scd1, Fads1, Fads2, Elovl2, and Elovl5), and in the regulation of lipid metabolism (Srebp1c and Srebp2) was measured (Figure 7).
30218046	0.98	ELOVL5, and SCD1 activity is inhibited by a complex of PPARA and PPARGC1A with LPIN1 and 2, which had lower expression in SPF mice in our experiments (Fig. 3c).
	0.97	SCD1 and ELOVL5 (Fig. 3a, b; reactions II and III).
	0.92	SCD1 and elongation of gamma-linoleic acid (FA 18:3 n-6) to dihomo-gamma-linolenic acid (FA 20:3 n-6) by ELOVL5.
	0.91	SCD1 together with decreased fractions of PUFA lead to increased ELOVL5 activity and enhanced FA 20:3 n-6 levels observed in SPF animals, although this has to be clarified in further studies.
	0.89	SCD1 (Fig. 3a); (III) Elongation of FA18:3 n-6 to FA20:3 n-6 by ELOVL5 (Fig. 3b), with higher values for SPF in all steps.
	0.89	SCD1 and elongation by ELOVL5 might depend on the gut microbial load.
29593532	0.98	Scd1 and Elovl5, leading to elevated plasma and liver TC levels.
	0.97	Scd1, Scd2, Fas, Elovl5, Mylip) expression in liver from ApoE-/- mice.
	0.95	Scd1, Scd2, Fas, Elovl5, and Mylip mRNA expression.
	0.93	Scd1, Scd2, Fas, Elovl5, and Mylip mRNA levels.
31388404	0.98	Elovl5, plus Scd1 which is responsible for introducing a double bond at the delta-9 position of C16:0 and C18:0, are positively regulated by peroxisome proliferator-activated receptor alpha (PPARalpha) and sterol regulatory element-binding transcription factor 1c (SREBP-1c).
	0.98	Elovl5, plus Scd1, are upregulated by PPARalpha and SREBP-1c concomitantly.
	0.97	Scd1) and elongases (Elovl2 and Elovl5), the PPARalpha deficiency reduced the mRNA levels of Fads2, Fads1, and Scd1, but not Elovl2 and Elovl5 (Fig. 2B).
	0.97	Scd1, Elovl5, and Acox were changed in accordance with PPARalpha.
22608008	0.98	Scd1 and (E) Elovl5 in the liver of FT mice (also see Figure S3) accompanied reduced levels of several unsaturated fatty acids including (F) oleate, palmitoleate, eicosenoate and vaccinate (also see Figure S4B).
	0.97	Stearoyl coA desaturase1 (Scd1) (Figure 4D), which codes an enzyme mediating fatty acid desaturation, along with the reduced mRNA levels of the unsaturated fatty acid elongase Elovl5 (Figures 4E and S3) paralleled with >50% decline in several unsaturated fatty acids, including oleate (18:1n9), palmitoleate (16:1n7), vaccenate (18:1n7) and eicosenoate (20:1n9 or 11) (Figures 4F and S4B).
23409094	0.98	ELOVL5, ELOVL6 and SCD-1 in SM-supplemented animals.
	0.92	elongation of very long chain fatty acids protein-5 (ELOVL5) (-42%, P<0.01), ELOVL6 (-31%, P<0.01) and steroyl-CoA desaturase 1 (SCD1) (-31%, P<0.05), were significantly reduced (Table 5).
24074869	0.98	Elovl5, Fads1, Fads2, Scd1 and Scd2.
	0.89	Elovl5, Fads1 and Fads2, involved in the elongation and desaturation of long chain fatty acids to generate anti-inflammatory PUFAs, and Scd1/Scd2 which catalyze the synthesis of 16:1 POA, suggested to be an insulin sensitizing adipokine.
25703193	0.98	Scd1, Pdk4, Elovl5, Fgf21, Igfbp1, PPARgamma and Me1).
	0.96	Scd1, Pdk4, Elovl5 and Me1 are suppressed in both male 11 week and female 36 week Cyp1b1-ko mice on the HFD.
26761430	0.98	Scd1) and elongation (Elovl5 & Elovl7) (Fig 12).
	0.58	Scd1 and Elovl7, suppressed Elovl5 expression and had no effect on Fads1, Fads2 or Elov6 expression.
27036855	0.98	Scd1, Elovl5, Pdk4 and Me1, indicate a shift to increased fatty acid oxidation.
	0.84	Scd1 and Elovl5 and serum regulator Igfbp1 are notable conserved changes.
21573029	0.98	Scd1 and Scd3), elongases (Elovl1, Elovl3, Elovl5 and Elovl6) and SPOT14 (Thrsp), and triglyceride synthesis enzymes including Gpam, Lpin1, Agpats (-2, -4, and -5) and Dgat1 ( Tables 8 and 9 ).
21900149	0.98	Scd1 and Elovl5 (Fig. 2B).
23528177	0.98	SCD1, FADS1, FADS2) and elongation (Elovl) (Elovl 5, Elovl 6).
27383786	0.98	Stearoyl coenzyme A desaturase 1 (Scd1), Elongation of very long chain fatty acids protein 5 (Elovl5), Insulin induced gene 2a (Insig2a) and Lysophatidylcholine acyltransferase 3 (Lpcat3, Mboat5), and these increases were reversed in Lxralpha-/-T39-/- mice (Fig 2a).
30364153	0.98	Elovl5, Fads2, Scd1, and Scd2.
30808418	0.97	Scd1, and the elongase Elovl5 were significantly downregulated in M; as opposed to Elovl7 that was upregulated compared to F (Fig. 4c).
	0.94	Elovl5, Elovl6, Elovl7) and desaturation (Scd1, Scd2) of FAs were measured.
31105522	0.97	Scd1, and to a lower extent Elovl5 and Scd2.
	0.97	Elovl5), Acox1 (involved in the final step of n-3 and n-6 PUFA synthesis), and Scd1 and Scd2 (responsible for synthesis of monounsaturated fatty acids from their saturated precursors), which lead us to surmise that MPTP dramatically impacts physicochemical properties of nerve cell membranes.
24358308	0.97	SCD1 as well as two fatty acid elongases, ELOVL5 and ELOVL6, suggesting that the massive accumulation of MUFA was due to both diet and de novo SFA and MUFA synthesis.
24983750	0.97	stearoyl-coenzyme A desaturase 1 (Scd1), acetyl-coenzyme A carboxylase beta (Acacb), NADP-dependent malic enzyme 1 (Me1), and elongation of very long chain fatty acids (Elovl5), were upregulated in the DMSe mice.
25998209	0.97	Scd1, Elovl3, Elovl5, Elovl6, Gpam, Acss2, Acss3, Fasn) and lipid sequestration (Plin2, Fitm1, Cidec), were all increased (Fig. 3D).
31573042	0.97	ELOVL5, SREBP-1, SREBP-2, HMGCoAR, PPARgamma and SCD1, which are associated with lipid synthesis.
28436449	0.96	Elovl5, Fads2 and Scd1 activities were also increased in MCDD mice (Fig. 4a,c and d, respectively).
28820499	0.96	stearoyl-CoA desaturase-1 (SCD1) and fatty acid desaturases (FADSs) which mediate the formation of unsaturated fatty acids, and fatty acid elongase 5 (ELOVL5) which elongates polyunsaturated fatty acids.
23465594	0.95	SCD-1 (-3.51 fold), ELOVL5 (-2.00 fold) and ELOVL3 (-6.51 fold).
	0.89	Scd1, ELOVL5) following chronic ethanol administration.
	0.69	SCD-1 and ELOVL5, but did not have an effect on MCAD or LCAD.
28110829	0.95	SCD-1 desaturation and subsequent production of vaccenic acid by Elovl5 was more activated in the liver of ob/ ob mice starting at 12 weeks of age.
	0.79	SCD-1 desaturation, 16:1(n-7) NEFA, can be further elongated by Elovl6 or Elovl5 to yield stearic acid (18:0 NEFA) and vaccenic acid, respectively.
20003344	0.95	Elovl5, Elovl6) and Stearoyl-Coenzyme A desaturase 1 (Scd1) which catalyzes the rate limiting step in biosynthesis from unsaturated to saturated fatty acids.
24958099	0.95	Elovl5, Elovl6, Fasn, and Fabp5 but had no effect on mRNA for Fabp1 and reduced mRNA for Scd1 (Fig. 4C).
30566857	0.95	Elovl5, Ccnd2/3) and confirmed the absence of BCL6 at genomic regions lacking BCL6 ChIP-seq peaks (Adipoq, Scd1, Fasn) (Figure S5D).
21178610	0.69	Elovl5 and Elovl6), and stearoyl CoA desaturase (SCD).