Publication for Scd1 and Scd2

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Scd1	stearoyl-Coenzyme A desaturase 1	20249			[link]
mmu	Scd2	stearoyl-Coenzyme A desaturase 2	20250

Pubmed ID	Priority	Text
24069385	0.98	SCD2 was strongly upregulated in liver tumors from AKT/Ras injected SCD1 -/- mice.
	0.98	SCD1 resulted in a remarkable upregulation of SCD2 mRNA (Figure 5B) and protein (Figure 5C) in AKT/Ras cells, further supporting the existence of a compensatory mechanism triggered by SCD1 loss.
	0.98	SCD1 and SCD2 strongly inhibits AKT/Ras-induced cell growth in vitro.
	0.98	SCD1 and SCD2 genes triggered a striking decline in cell proliferation and massive apoptosis in AKT/Ras cells (Figure 5A).
	0.98	SCD1 and SCD2 led to a marked decrease in the levels of phosphorylated/activated AKT (Figure 5C).
	0.98	SCD1 and SCD2 genes might presumably be required to significantly impair AKT/Ras driven growth.
	0.98	SCD2, but not SCD3 and SCD4, is strongly upregulated in AKT/Ras liver tumor samples depleted of SCD1.
	0.98	SCD1 triggers the (presumably) compensatory upregulation of SCD2, which might confer survival advantages to SCD1-deprived cells.
	0.98	SCD1 and SCD2 genes was able to efficiently restrain AKT/Ras cell growth in vitro.
	0.97	SCD1 and SCD2 genes was highly detrimental for the growth of AKT/Ras cells in vitro.
	0.97	SCD2 is expressed in the normal liver and is responsible for the stearoyl-coeznyme A desaturase activity both in the developing mouse liver and in the SCD1 -/- mouse liver, whereas the role of SCD3 and SCD4 remains unknown.
	0.97	SCD2 expression was increased in AKT/Ras liver tumors from SCD1 +/+ mice when compared with normal livers from wild-type mice.
	0.97	SCD2 mRNA was detected in AKT/Ras tumors from SCD1 -/- mice (Figure 3C).
	0.97	SCD2 might compensate for the loss of SCD1 along AKT/Ras driven hepatocarcinogenesis.
	0.97	SCD1 or SCD2 gene led to a decrease in proliferation and increase of apoptosis (Figure 5A).
	0.97	SCD2 expression could not completely rescue stearoyl-CoA desaturase activity in the SCD1 null tumor cells, as these tumors demonstrated significantly decreased MUFA content in their TG and CE lipid pools.
	0.96	SCD1, but not SCD3 and SCD4 mRNA (Figure 5B), and SCD1 protein (Figure 5C) was observed in AKT/Ras cells depleted of SCD2.
	0.96	SCD1 and SCD2, either alone or in combination, in AKT/Ras-induced proliferation and apoptosis.
	0.96	SCD1 suppression as well as the mechanisms whereby SCD2 contributes to the activation of the ERK/MAPK cascade are currently under investigation.
	0.95	SCD2 in AKT/Ras tumor tissues cannot completely compensate for the loss of SCD1 expression in terms of liver lipid profile.
	0.94	SCD2 was accompanied by a slight upregulation of phosphorylated/activated ERK proteins, whereas levels of AKT activation were not affected by SCD1 silencing (Figure 5C).
	0.94	SCD1/SCD2 axis in mouse HCC.
	0.92	SCD2 completely compensated for the loss of SCD1 in terms of stearoyl-CoA desaturase activity in AKT/Ras tumor tissues.
	0.92	SCD1 and SCD2 strongly inhibits AKT/Ras cell growth in vitro
	0.92	SCD1 and SCD2 would be necessary in the liver tissue to ascertain the requirement of SCD proteins in hepatic steatosis and hepatocarcinogenesis.
	0.91	SCD isoforms (SCD2-SCD4) have been identified.
	0.90	SCD1 and SCD2 genes led to a slightly further decrease of TG and CE levels as well as a slight, additional decrease in MUFA percentage when compared with silencing of either SCD1 or SCD2 alone (Figure 6B and D).
24055053	0.98	SCD1 and SCD2 was required to reduce radiolabel incorporation into Wnt3a in IC15:0 labeled cells, indicating that both isoforms generate MUFAs for Wnt acylation in mouse L-Wnt3a cells.
	0.97	SCD1 and SCD2 are capable of generating 16:1 from 16:0, it is likely that SCD1 and SCD2 are responsible for Wnt3a acylation in L-Wnt3a cells.
	0.97	SCD1 and SCD2, have been shown to be inhibited by CAY10566, but given the high degree of conservation, especially in the catalytic region, it is likely that all isoforms are susceptible to pharmacologic inhibition.
	0.94	SCD isoforms share >80% amino acid sequence identity, all contain the 8-histidine motif required for catalysis and all exhibit desaturase activity (SCD1, SCD2 and SCD4 desaturate palmitoyl-CoA and stearoyl-CoA; SCD3 activity is restricted to palmitoyl-CoA).
	0.94	SCD isoforms, and one isoform can partially compensate for loss of the other, which likely explains why, despite their metabolic defects, SCD1-/- and SCD2-/- mice are viable.
	0.92	SCD1 is ubiquitously expressed in the mouse, while the other isoforms exhibit predominant expression in brain (SCD2), skin (SCD3), and heart (SCD4).
	0.89	SCD1 siRNA had no effect on Wnt3a fatty acylation, whereas addition of both SCD1- and SCD2-directed siRNAs reduced Porcn-mediated labeling of Wnt3a with 125I-IC15:0 (Fig S2).
	0.85	SCD1 and SCD2 mRNAs (average mRNA expression/HPRT +
21695013	0.98	SCD1 is primarily expressed within undifferentiated sebocytes at the base of the sebaceous gland in the dermal layer, but expression in the epidermis has also been reported, especially under conditions where SCD2, the main epidermal isoform, has been deleted.
	0.97	SCD2 shares significant sequence homology with SCD1 and is primarily expressed in the brain.
	0.97	SCD1 which is mainly expressed in the dermal layer of skin, SCD2 is expressed to a greater extent in the epidermis and plays an important role in maintaining an intact skin permeability barrier.
	0.96	SCD1 expression was variably induced in Scd2-/- mice, and the degree of induction of SCD1 appeared to determine the chance of survival of Scd2-/- mice into adulthood.
	0.59	Scd1 and Scd2, respectively.
	0.59	Scd1-/- and Scd2-/- mice, which show no improvement of alopecia or skin lipid abnormalities despite supplementation of the diet with exogenous monounsaturated fatty acids.
28143772	0.98	Scd1 and Scd2 as Wnt/beta-catenin target genes which are transactivated by beta-catenin interaction with SREBP-1c bound to the novel SRE site in the proximal promoters.
	0.98	Scd2 expression is >100 fold higher than Scd1 in quiescent HSCs cultured for 1 day and both genes are induced at day 2 when spontaneous HSC activation begins (Fig. 1B, left).
	0.98	Scd1 and Scd2 in TICs, supporting these genes are Wnt targets (Fig. 1D left).
	0.97	Scd2 is the major form expressed in TICs while Scd1 is predominant in adult hepatocytes (Fig. 1D middle and right).
	0.97	f Scd2 mRNA with no effect on Scd1 and reveals suppression of HSC activation genes Col1a1 and Acta2, and up regulation of the HSC quiescence gene Ppargamma (Fig. 2A bottom).
	0.89	Scd1-4 with Scd1 being predominant in adult liver and Scd2 in embryonic liver.
21738729	0.98	SCD1 and a moderate increase of SCD2 can be seen after differentiation of 3T3-L1 preadipocytes to adipocytes.
	0.98	SCD2 mRNA expression is uniquely increased (44-fold) in adipocytes from mice fed a HFD, with only slight regulation of SCD1 expression.
	0.98	SCD2, but not SCD1, is required for adipogenesis and maintenance of the adipocyte-specific gene expression in 3T3-L1 adipocytes.
	0.98	SCD1 and SCD2 (2.98, p<0.01) ( Table 1 ) was seen in HSL null mice in the fasted state.
	0.97	SCD1 and SCD2 in WAT lead to lower amount of palmitoleate.
31083413	0.98	stearoyl-CoA desaturase-1 (Scd1), Scd2, glycerol-3-phosphate acyltransferase (Gpam), diacylglycerol O-acyltransferase 1 (Dgat1), and Dgat2, were significantly reduced in arazyme-treated mice (Figure 3A-C).
	0.97	Scd1, Scd2, Gpam, Dgat1, and Dgat2.
	0.97	Scd1, Scd2, Gpam, Dgat1, and Dgat2, inhibiting hepatic fatty acid and TG synthesis.
	0.97	Scd1, Scd2, Gpam, Dgat1, and Dgat2.
	0.95	stearoyl-CoA desaturase-1 (Scd1), Scd2, glycerol-3-phosphate acyltransferase (Gpam), diacylglycerol O-acyltransferase 1 (Dgat1), and Dgat2.
23749645	0.98	Scd1 and Scd2 in Pten null tumors.
	0.97	Scd1/scd2 and Elovl6 observed in tumors.
	0.94	scd1/scd2, fads2 and acsl5 vs. acsl1 ratio, elevated hepatic and circulating vaccenic (18:1n7) and erucic (22:1n9) acids and reduced hepatic and circulating margaric (17:00) and linoleic (18:2n6, LA) acids.
24074869	0.98	Scd1 and Scd2, the levels of POA were also 2-3-fold increased in the MNKO macrophages (Fig. 6A).
	0.98	Scd1 and Scd2.
	0.85	Scd1/Scd2 which catalyze the synthesis of 16:1 POA, suggested to be an insulin sensitizing adipokine.
25147951	0.98	Scd1, Sc4mol, Fads2, Scd2, Stard4, Ldlr, Insig-1, and Fdps, which are direct targets of SREBPs and involved in the cholesterol/lipid biosynthetic pathways, are down-regulated in S1Pcko cartilage (Table 2) mirroring that seen in the microarray.
	0.98	Scd1, Scd2, Ldlr, Fads2, and Fdps genes at the RNA level in the humerus of S1Pcko mice (Fig. 8).
	0.93	Scd1, Scd2, Ldlr, Fads2, and Fdps genes at the RNA level, shown by in situ hybridization in S1Pcko humerus and by immunohistochemistry (IHC) for Scd1 protein in S1Pcko femur.
30504766	0.98	SCD1 and SCD2 in white adipose tissue (Fig. 4b and Supplementary Figure 12).
	0.98	Scd1 and Scd2 in adipose tissue (Supplementary Figure 16).
	0.91	SCD2 (perhaps SCD3) than SCD1.
31630534	0.98	SCD1 and SCD2 (Fig. 5) which catalyze the conversion of long-chain fatty acids into monounsaturated fatty acids, a critical step in de novo triglyceride synthesis.
	0.97	SCD1 and SCD2) in the context of CDAA feeding, whereas other genes remained largely unaffected (Fig. 5).
	0.94	SCD1 was downregulated to the same extent as in C57Bl/6J [P = 0.6791, BALB/c vs, C57Bl/6J, not significant (NS)], whereas SCD2 and SREBP2 were induced to a considerably lesser degree (P = 0.011 and P = 0.037, respectively), consistent with an attenuated fibrotic response in this model (BALB/c < C57Bl/6; Supplemental Table S7 and Supplemental Fig. S3).
22640645	0.98	Scd1 and Scd2, which possess stearoyll-CoA desaturase activity, have been reported.
	0.80	Scd1, Scd2, Gpat3, Gpat4, Agpat2 and Lpin1 (Figure 1).
24039619	0.98	SCD2 is constitutively expressed, while SCD1 is induced during differentiation, promoting lipogenesis for storage.
	0.91	SCD2 inhibition, which is known to cause decreased SCD1 and PPARY expression in turn.
31554181	0.98	Scd2 hepatic expression decreased in the liver before weaning, and it is replaced by SCD1, which is highly activated in adult liver.
	0.93	SCD1 expression appeared to be dispensable in mice embryos liver, while the Scd2 isoform (SCD5 in human) is crucial at this stage.
32160860	0.98	Scd1 and Scd2 are regulated by Bmal1, and oscillate under LD and S-DD but not L-DD.
	0.75	Scd1 and Scd2.
21711241	0.98	Scd1, Scd2 (stearoyl-Coenzyme A desaturase 1 and 2), and Elovl6 (long chain fatty acid elongase 6).
23823481	0.98	Scd1, Scd2, Acaca, Fasn, Dgat1, Dgat2) and lipid uptake (Pltp, Vldlr, Ldlr, Ldrap1, Lpl,) were increased in LOKO fat depots.
24191950	0.98	Scd1, and Scd2, are robustly down-regulated by fasting in our data (Figure 4E, Table 2).
24212819	0.98	SCD2, SCD3 and SCD4, which exhibit high homology with SCD1, are expressed in a predominantly organ-specific manner.
28779178	0.98	Scd1 and Scd2 (stearoyl-CoA desaturase 1 and 2) were both up-regulated, which would be expected to reduce fatty acid beta-oxidation and improve glucose oxidation.
29366871	0.98	Scd (which includes Scd1, Scd2, Scd3 and Scd4), and Acc in both wild-type and Cyp1a1(-/-) mice (Fig. 3B).
29385670	0.98	Scd1, and Scd2 regulating fatty acid synthesis was significantly increased, in contrast, fatty acid oxidation genes in mitochondria and peroxisome were clearly downregulated in KO mice.
29890821	0.98	SCD isoforms, such as SCD1, SCD2, and SCD4 (Fig. 4E).
29593532	0.97	Scd1, Scd2, Fas, Elovl5, Mylip) expression in liver from ApoE-/- mice.
	0.95	Scd1, Scd2, Fas, Elovl5, and Mylip mRNA expression.
	0.93	Scd1, Scd2, Fas, Elovl5, and Mylip mRNA levels.
31105522	0.97	Scd1 and Scd2 (responsible for synthesis of monounsaturated fatty acids from their saturated precursors), which lead us to surmise that MPTP dramatically impacts physicochemical properties of nerve cell membranes.
	0.96	Scd1, and to a lower extent Elovl5 and Scd2.
	0.96	Scd1, and Scd2 (p < 0.1).
19496086	0.97	Scd1 and Scd2, and several genes encoding cholesterol biosynthetic enzymes.
	0.97	SCD), Scd1 and Scd2.
19344509	0.97	Stearoyl-CoA desaturase (SCD) is an enzyme that catalyzes the Delta9-cis desaturation of saturated fatty acyl-CoA. Both Dhcr7 and Scd2 genes contain a sterol-regulatory element, the binding site for the transcription factor SREBP, in their promoter regions.
22689379	0.97	SCD1 expression is induced after weaning in mouse liver, while SCD2 expression is detected in livers of mouse embryos and neonates.
24465397	0.97	SCD1 and SCD2 enzymes involved in fatty acid synthesis.
26995761	0.97	Scd1 but still express Scd2 showed that SCD1 deficiency resulted in low levels of 16:1 and 18:1 fatty acids as well as lower levels of hepatic triglycerides and cholesteryl esters and lower rates of very-low-density lipoprotein (VLDL) production.
29089222	0.97	SCD1, SCD2 is ubiquitously expressed in most tissues except adult mouse liver.
24818992	0.96	SCD isoforms are suppressed by the addition of a HFD in the Alb-Cre model, in the PTENf/f groups only SCD-2 is significantly suppressed following HFD feeding.
	0.90	SCD-1, SCD-2, FASN and ACLY were significantly increased in the PTENf/f group.
31514294	0.96	SCD-1 and SCD-2 has been reported to protect mice against HFD-induced adiposity.
	0.94	SCD-1, SCD-2, and FAS were significantly decreased in the HFD + 0.6% PPF group compared to the HFD control group (all p < 0.001, Figure 5), while there was no difference in the mRNA level of SREBP-1c between the two groups.
29977610	0.96	Scd1 and Scd2 in AS03-stimulated RAW cells (Fig. 2d) could be secondary to the increase of C16:1/C16:0 and C18:1/C18:0 ratios observed for PC.
31998465	0.96	SCD1, SCD2, SCD3, SCD4, FASN, FADS1, ELOVL6, TECR, and ACSL5) and steroid biosynthesis pathway (CYP51, MSMO1, DHCR7, DHCR24, LSS, NSDHL).
20659319	0.95	Scd1, Scd2, Lpcat1 and Fabp5), cell growth and proliferation (Btg3, Dlk1, Emp2 and Pdia5).
21321096	0.95	Scd1, Scd2, Agpat2 and Adipor2.
21595943	0.94	SCD1 is highly expressed in the liver, SCD4 is exclusively found in the heart, SCD3 is unique to the skin, and SCD2 is almost entirely restricted to the brain.
30808418	0.94	Scd1, Scd2) of FAs were measured.
19689276	0.93	Scd2 is required for Pparg expression and adipogenesis in cultured 3T3-L1 cells, Scd1 is not.
20029635	0.92	stearyl-coenzyme A desaturase 1 (Scd1) gene while Scd2 remained unchanged.
22582025	0.91	SCD1, SCD2, and LPL in Ncb5or-/- mice and for transcript levels of SCD1 and LPL to fall in WT mice.
	0.82	SCD1, SCD2 and LPL transcript levels to a larger extent in Ncb5or-/- mice than that in WT.
30190473	0.90	SCD1, SCD2, SCD3, and SCD4) have been identified, whereas humans express only two Delta9 desaturases (SCD1 and SCD5).
27467521	0.82	Scd-1 and Scd-2 in ATDC5 cells (n = 3 in each group).
	0.80	Scd-1 and Scd-2 was also lower in Elovl6-KD cells than controls (Fig 5B).
21442273	0.82	SCD1 (ste-aroyl-coenzyme A desaturase) and SCD2 mRNA did not significantly differ.
21839170	0.75	SCD index of FFA and TAG, which reflects the relative abundance of monounsaturated and saturated fatty acids, does not differ in islets of WT and Ncb5or-/- mice at age 5 weeks, even though levels of SCD1 and SCD2 transcripts are higher in Ncb5or-/- islets.
28386555	0.62	SCD1, SCD2, SCD3, and SCD4) in the mouse.
19519902	0.54	SCD1, SCD2, SCD3 and SCD4, in rat two isoforms (SCD1, SCD2) and in humans, two SCD isoforms have been identified and characterized.