Publication for Mvk and Mvd

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Mvk	mevalonate kinase	17855			[link]
mmu	Mvd	mevalonate (diphospho) decarboxylase	192156

Pubmed ID	Priority	Text
22394543	0.98	Mvk, Mvd, Sqle, Cyp51, Nsdhl, Tm7sf2, Dhcr7, Hsd17b7) were found consistently upregulated in the intestinal tissue.
	0.97	mevalonate kinase (Mvk), the phosphomevalonate kinase (Pmvk), the mevalonate decarboxylase (Mvd), the squalene epoxidase (Sqle), the cytochrome P450, family 51 (Cyp51), the 7-dehydrocholesterol reductase (Dhcr7), the hydroxysteroid (17-beta) dehydrogenase 7 (Hsd17b7), the NAD(P) dependent steroid dehydrogenase-like (Nsdhl) and the transmembrane 7 superfamily member 2 (Tm7sf2) genes.
23299886	0.98	Mvk, Pmvk, Mvd, Fdft1 and Sqle/Erg1 in the cholesterol biosynthetic pathway are decreased in SRSF3HKO liver.
	0.89	Mvk, Pmvk, Dhcr7, Erg1, Fdft1 and Mvd is not seen in the Xbp1 liver knockout.
27878435	0.98	MVD, HMGCR, HSD3B7, HMGCS1, LSS, FDFT1, DHCR7, HSD17B7, NSDHL, DHCR24, FDPS, SIGMAR1, SQLE, MVK, that are expressed in the lens.
22208362	0.97	Mevalonate (diphospho) decarboxylase (MVD), Farnesyl diphosphate synthase (FDPS), Prenyldiphosphate synthase, subunit 1 (PDSS1), Isopentenyl-diphosphate delta isomerase 1 (IDI1), Cytochrome c oxidase 10 (COX10), Mevalonate kinase (MVK) and Fatty acid desaturase 3 (FADS3) to be significantly downregulated in ob/ob vs. WT, without changing in the comparison between POKO vs. WT (Table 4 and Figure 2).
23060211	0.97	Mvd, Mvk, and Cyp51 genes has lower expression in palatal tissue from Tgfbr2fl/fl;Wnt1-Cre mouse embryos relative to controls.
30069000	0.97	Mvd, Mvk, Msmo1, Nsdhl, Pmvk, Sc5d, Sqle, and Tm7sf2 were significantly decreased in HFD livers.
28725001	0.96	mevalonate kinase (Mvk), mevalonate diphosphate decarboxylase (Mvd), squalene epoxidase (Sqle), lanosterol synthase (Lss), methylsterol monoxygenase 1 (Msmo1), and 24-dehydrocholesterol reductase (Dhcr24) exhibited a comparable dose-dependent expression pattern (Fig. 3).
30483502	0.95	mevalonate kinase (MVK), phosphomevalonate kinase (PMVK), diphosphomevalonate decarboxylase (MVD), farnesyl diphosphate synthase (FDPS), farnesyl-diphosphate farnesyltransferase 1 (FDFT1), squalene epoxidase (SQLE), 7-dehydrocholesterol reductase (DHCR7), or related metabolites may be involved in modulating HSC biology.
25799309	0.92	Mvk, Mvd, Insig1, Ppap2a, Dgat2, Ppap2c, Pcsk9, Lpl, Gk2, Apoa4, Cd36 and Ldlr) involved in lipogenesis, lipid transport, lipid storage, bile acid biosynthesis, fatty acid synthesis, fatty acid oxidation, fatty acid catabolism, cholesterol biosynthesis, cholesterol transport, cholesterol homeostasis and triglyceride synthesis, indicating that the decreased expression of hepatic genes involved in lipid metabolism might be responsible, or contribute to the altered hepatic and serum lipid profiles (Fig. 8).
	0.86	Mvk, Mvd, Sc5d, Hmgcr, Sqle, Cnbp, Dhcr24, Nsdhl, Fdps, Sc4mol, Fdft1 and Tm7sf2), cholesterol transport and uptake (e.g., Cd36, Apoa4 and Ldlr), cholesterol homeostasis (e.g., Fabp4, Apoa4, Pcsk9 and Ldlr), triglyceride synthesis (Ces3, Ppap2a, Dgat2, Ppap2c and Pcsk9) and triacylglycerol catabolism (Lpl and Gk2) (Fig. 4A, Fig. 5E, F and S7-S8 Tables), indicating that the decreased expression of these hepatic genes involved in cholesterol and triglyceride metabolism might be responsible, or contribute to the decreased cholesterol and triglyceride levels observed in Rm155LG/Alb-Cre transgenic mice.
28150810	0.91	Mvk, Mvd, Fdps, Lss, Nsdhl, and Scd5d was not subject to down-regulation as a result of Srebf2 knockdown.
31311515	0.82	MVK, no miRNA in plants has previously been reported to target MVD.
	0.60	MVK and MVD is quite limited compared to yeast.
24834104	0.58	Mvd, Mvk, Pmvk, Fdps and Idi1) did differ in the total study set, but the post hoc test only confirmed significant downregulation of Mvd, Mvk and Hmgcr by KO compared to HF (Figure 2, "Mevalonate pathway" and, "Additional metabolic pathways"), while no, or less pronounced decreases were found with FO supplementation.