Publication for Fdps and Mvd

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Fdps	farnesyl diphosphate synthetase	110196			[link]
mmu	Mvd	mevalonate (diphospho) decarboxylase	192156

Pubmed ID	Priority	Text
22252456	0.98	Mvd, Fdps, Nsdhl, Idi1, Sc4mol, Cyp51, and Dhcr7).
22291164	0.98	Fdps, Hmgcs1, Mvd, and Sqle; Supplemental Figure 4), a finding that was also observed in the livers of long-lived Snell dwarf (Pit1dw/dwJ) and ribosomal protein S6 kinase 1 knockout mice (S6K1-/-) mice.
27878435	0.98	MVD, HMGCR, HSD3B7, HMGCS1, LSS, FDFT1, DHCR7, HSD17B7, NSDHL, DHCR24, FDPS, SIGMAR1, SQLE, MVK, that are expressed in the lens.
30271348	0.98	Mvd, Fdps (farnesyl diphosphate synthetase), Sqle (squalene epoxidase), Lss (lanosterol synthase), Dhcr24 (24-dehydrocholesterol reductase), Cyp51, Nsdhl (NAD(P) dependent steroid dehydrogenase-like), Hsd17b7, Ebp, Sc5d, and Dhcr7] exhibited reduced expression compared to ad libitum mice (Figure 8A).
31540279	0.98	mvd, srebp2, and fdps, was significantly increased in H-RasV12-expressing NIH3T3 cells (Figure 4A).
22208362	0.97	Mevalonate (diphospho) decarboxylase (MVD), Farnesyl diphosphate synthase (FDPS), Prenyldiphosphate synthase, subunit 1 (PDSS1), Isopentenyl-diphosphate delta isomerase 1 (IDI1), Cytochrome c oxidase 10 (COX10), Mevalonate kinase (MVK) and Fatty acid desaturase 3 (FADS3) to be significantly downregulated in ob/ob vs. WT, without changing in the comparison between POKO vs. WT (Table 4 and Figure 2).
23060211	0.97	Fdps, Idi1, Mvd, Mvk, and Cyp51 genes has lower expression in palatal tissue from Tgfbr2fl/fl;Wnt1-Cre mouse embryos relative to controls.
29167747	0.97	Fdps, Hmcgs1, and Mvd, which are primarily involved in cholesterol and sterol biosynthesis.
30069000	0.97	Fdps, Hmgcr, Hmgcs1, Hsd17b7, Idi1, Lss, Mvd, Mvk, Msmo1, Nsdhl, Pmvk, Sc5d, Sqle, and Tm7sf2 were significantly decreased in HFD livers.
31549781	0.97	Fdps, Dhcr7, and Mvd) were upregulated with sleep in young and old mice.
23139832	0.95	Fdps (-1.63), Fdft1 (-1.28), Mvd (-1.22), Lss (-1.22), Sc5d (-1.34), and Idi1 (-1.58) were direct targets of SREBF1 and 2 (Fig. 3A).
30483502	0.94	diphosphomevalonate decarboxylase (MVD), farnesyl diphosphate synthase (FDPS), farnesyl-diphosphate farnesyltransferase 1 (FDFT1), squalene epoxidase (SQLE), 7-dehydrocholesterol reductase (DHCR7), or related metabolites may be involved in modulating HSC biology.
22461453	0.93	Mvd, Fdps, Sqle, and Dhcr7).
28150810	0.91	Mvd, Fdps, Lss, Nsdhl, and Scd5d was not subject to down-regulation as a result of Srebf2 knockdown.
25799309	0.87	Mvd, Sc5d, Hmgcr, Sqle, Cnbp, Dhcr24, Nsdhl, Fdps, Sc4mol, Fdft1 and Tm7sf2), cholesterol transport and uptake (e.g., Cd36, Apoa4 and Ldlr), cholesterol homeostasis (e.g., Fabp4, Apoa4, Pcsk9 and Ldlr), triglyceride synthesis (Ces3, Ppap2a, Dgat2, Ppap2c and Pcsk9) and triacylglycerol catabolism (Lpl and Gk2) (Fig. 4A, Fig. 5E, F and S7-S8 Tables), indicating that the decreased expression of these hepatic genes involved in cholesterol and triglyceride metabolism might be responsible, or contribute to the decreased cholesterol and triglyceride levels observed in Rm155LG/Alb-Cre transgenic mice.
29056891	0.62	Fdps (0.41-fold), Sqle (0.28-fold), Cyp51 (0.55-fold), Mvd (0.47-fold), and PPARgamma (0.72-fold) - displayed a similar trend as determined using real-time PCR.
24834104	0.54	Mvd, Mvk, Pmvk, Fdps and Idi1) did differ in the total study set, but the post hoc test only confirmed significant downregulation of Mvd, Mvk and Hmgcr by KO compared to HF (Figure 2, "Mevalonate pathway" and, "Additional metabolic pathways"), while no, or less pronounced decreases were found with FO supplementation.