Publication for Gclm and Mafg

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Gclm	glutamate-cysteine ligase, modifier subunit	14630			[link]
mmu	Mafg	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)	17134

Pubmed ID	Priority	Text
24296246	0.98	Gclm gene expression is positively regulated by ARE, which is trans-activated by Nrf2 as a heterodimer with small Maf (MafG, MafK and MafF) or Jun (c-Jun, Jun-D, and Jun-B) proteins.
	0.98	Gclm remained unchanged, nuclear sumoylated Nrf2 level and importantly, heterodimerization with MafG and their co-occupancy on the same promoter region were markedly reduced following LPS treatment in RAW cells and in mouse liver.
	0.98	MafG sumoylation, their heterodimerization and trans-activation of the ARE present in Gclc and Gclm promoters.
	0.96	Gclm (Fig. 3A and B, left panels), Nrf2-MafG heterodimer binding as assessed by SeqChIP was markedly reduced to the ARE region in both promoters (Fig. 3A and B, right panels, and densitometry shown in Fig. 3C).
	0.94	Gclm expression, and sumoylation of MafG and Nrf2 in RAW cells
	0.93	Gclm ARE nuclear binding activity by Nrf2 and MafG in RAW cells
	0.71	Gclm, Nrf2, MafG expression, sumoylation and Nrf2:MafG heterodimerization in mice livers
19399914	0.98	MafG competed against Nrf2 for ARE binding and is at least partially responsible for the down-regulation in GCLC, GCLM and GS.