Publication for Ftl1 and Hmox1

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Ftl1	ferritin light polypeptide 1	14325			[link]
mmu	Hmox1	heme oxygenase 1	15368

Pubmed ID	Priority	Text
31333462	0.99	HO-1 and both ferritin subunits, FtH with ferroxidase activity and FtL that induces iron nucleation.
	0.98	HO-1 and FtL levels in the kidney.
	0.98	HO-1, FtL, and FtH and reduced levels of GSH, suggesting a critical protective role against Hb-mediated ROS production and cell toxicity in the kidney.
	0.98	HO-1, FtL, and FtH were found upregulated in kidneys from wild-type mice after hemolysis or in cultured tubular epithelial cells stimulated with Hb/heme.
	0.97	HO-1 and ferritin subunits, heavy (FtH) ( Supplemental Figure 3A-C ) and light ferritin chain (FtL) ( Figure 2I-L ).These
	0.95	HO-1, FtH, and FtL than did wild-type mice with hemolysis.
	0.94	HO-1 and both ferritin subunits, light ferritin (FtL) ( Figure 5A-F ) and heavy ferritin (FtH) ( Supplemental Figure 3D ).
27006955	0.98	Hmox1 and Ftl1 expression, suggesting an initial need for increased heme in macrophages after infection accomplished by FLVCR downregulation, then at later time points, heme is degraded by HMOX1 and iron is sequestered in ferritin.
	0.93	Hmox1 show a dose-responsive decrease and increase in mRNA expression, respectively, whereas Fpn1 and Ftl1 had the maximal drop in expression at the lowest dose of LPS, 10 ng/mL (Figure 2(b)).
	0.89	Hmox1, Fpn1, and Ftl1 mRNA showed a dose-responsive increase to hemin exposure for 10 hours, Flvcr mRNA levels did not change (Figure 1).
	0.87	Hmox1 and Ftl1 expression was not upregulated in M2 macrophages (Figure 4).
	0.77	Hmox1, Fpn1, and Ftl1, which increased.
	0.60	Hmox1, and ferritin light chain (Ftl) in macrophages treated with LPS.
24112193	0.98	HO1, FTL, and BVR, all of which contain Nrf2-responsive ARE elements within their promoter regions, as well as the loss of protection observed in neurons from Nrf2-/- mice.
	0.93	HO1, FTL, and BVR in WT neurons.
	0.90	HO1, FTL, and BVR after treatment with 50 or 100 muM EC prior to OGD.
24486949	0.98	Ho-1), iron export (Fpn) and storage (H- and L-Ferritin), and antioxidant response (Txnrd1, gamma-gcs, Sod1), compared with Flvcr1afl/fl mice (Figure 1E and F; Supplementary Figure 2 for gene expression analysis of 2-month-old mice).
	0.98	Ho-1, Fpn, H- and L-ferritin.
17945001	0.98	Ftl1, Fpn1, and Hmox1 genes, as shown in Figure 3, which reinforces the hypothesis that these modifications are the consequence of iron overload and lipid peroxidation, and contribute to hepatoprotection.
25600948	0.98	Hmox1, Fth, Ftl, and Slc40a1.
29089902	0.98	Ftl1, and Hmox1 mRNA levels in the Hepc KO AM (Figure 4A).
30733505	0.98	heme oxygenase 1 (Hmox1), the first enzyme of the heme oxygenase pathway, and several antioxidant enzymes including glutathione reductase (Gsr), thioredoxin (Txn), thioredoxin reductase (Txnrd1), superoxide dismutase (Sod), peroxiredoxin 1 (Prdx1), ferritin light chain (Ftl1) and ferritin heavy chains (Fth1).
29749404	0.97	HO-1-mediated catabolism yields intracellular free and reactive Fe2+, which is converted to Fe3+ by H-ferritin and stored by L-ferritin or exported by ferroportin-1 (FPN1/SLC40A1/IREG1).
	0.97	HO-1, L-ferritin and H-ferritin and increased levels of intracellular oxidative stress in hamp silenced cells would suggest increased yield of reactive iron from heme, which could have led to mechanisms of cell death characterized as ferroptosis.
	0.96	Ho-1 (p < 0.001), L-ferritin (p < 0.001), H-ferritin (p < 0.01), and C/ebpalpha (p < 0.001), and reduced Hif1alpha mRNA expression (p < 0.05).
	0.95	Ho-1, H-ferritin, L-ferritin, C/ebpalpha).
	0.95	Ho-1, L-ferritin, H-ferritin, C/ebpalpha, Chop, Hif1alpha, and IL-6 compared to cells treated with RLUC siRNA.
	0.94	Ho-1, L-ferritin, H-ferritin, and C/ebpalpha, whereas Chop, Hif1alpha and IL-6 were moderately elevated (c).
	0.94	Ho-1 mRNA at 24 h (p < 0.05 for 1 microM; p < 0.001 for 10 microM) revealed Hb catabolism, whereas the induction of H and L-ferritin mRNA at 24 h (both p < 0.01 for 10 microM) suggested increased intracellular Fe handling and storage.
	0.94	Ho-1, L-ferritin, H-ferritin, C/ebpalpha, Chop, and IL-6, whereas mRNA expression of Hif1alpha was significantly reduced compared to control (ctrl).
	0.94	Ho-1, L-ferritin, Chop, and IL-6 were all significantly elevated after 4 h of 10 microM hemin incubation, whereas H-ferritin was increased by 1 microM hemin.
25874599	0.97	FtL) and HO-1 were higher in FtHLysM-/- macrophages (Figure 3C).
31337415	0.97	Hmox1, Ferroportin, CD163, TfR1, Ceruloplasmin, FtL1, FtH1) associated with a reduction in iron storage and increased turnover.
23676441	0.96	Hmox1, Entpd5, Cbr3, Ppp1r12b, Gclc, Mgst3, Gstm5, Txnrd1, Cat, Meis1, Ftl1, Sdpr, Selenbp2, Pparg, Gstp1, Esd, Mgst1) were down-regulated (Suppl.
28583802	0.96	Hmox1 and the Ftl subunits showed increases in Cyp1b1-/- mice at weaning (Table 3).
24130337	0.94	heme oxygenase-1 [Hmox1]), storage (ferritin light and heavy chains [Ftl1 and Fth1, respectively]), and export (ceruloplasmin [Cp] and ferroportin-1 [Slc40a1]) in MFehi compared with MFelo cells.
31279985	0.92	heme-oxygenase 1 (Hmox1) and ferritin complex (Ftl and Fth), which prevent hydroxyl radical production by releasing Fe2+ from heme molecules and oxidizing Fe2+ to Fe3+, respectively.
27574973	0.90	Ftl (p < 0.0001), Fth1 (p < 0.05), hepcidin (Hamp) (p < 0.001), AcoI (p < 0.05), Sod1 (p < 0.05), and Hmox1 (p < 0.05) mRNA was observed.