Publication for Cd36 and Lpl

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Cd36	CD36 molecule	12491			[link]
mmu	Lpl	lipoprotein lipase	16956

Pubmed ID	Priority	Text
32256662	0.98	fat and skeletal muscle and the expression of LPL in skeletal muscle.
	0.98	LPL and promote lipid oxidation, thereby regulating the fatty acid metabolism in fat and muscle tissues.
	0.97	LPL in visceral fat were absorbed faster than plasma nonesterified fatty acids, which accelerated the deposition of fat, suggesting that LPL plays a role in promoting fat absorption in skeletal muscle.
	0.95	LPL does not accelerate fat deposition in skeletal muscle, indicating differences in the fatty acid uptake pathways between visceral fat and skeletal muscle.
	0.94	fat and PPARgamma and LPL protein level in skeletal muscle in the ECD group.
	0.94	LPL were detected in the skeletal muscle tissue and visceral fat to explore the possible molecular mechanism that ECD plays in eliminating phlegm.
	0.94	LPL is widely distributed in liver tissues, the heart, visceral fat, and skeletal muscle tissue.
	0.94	fat diet by affecting PPARgamma and LPL.
	0.94	fat expression in LPL and PPARgamma illustrates the effectiveness of ECD in eliminating phlegm.
	0.92	fat tissue, it could increase the activity of PPARgamma in the visceral fat, inhibit the action of LPL to accelerate fat deposition in visceral fat, and improve the IR in the adipose tissue.
	0.92	LPL mRNA expression was upregulated in visceral fat in the HFD group, while protein expression was downregulated.
	0.91	LPL mRNA in the visceral fat of mice in the HFD group was upregulated (P < 0.05), and the expression of LPL mRNA in the skeletal muscle was downregulated, although the difference was not statistically significant (P > 0.05).
	0.91	fat of mice was higher than that in the HFD group (P < 0.05), and the expression of LPL mRNA and protein was lower than that in the HFD group (P > 0.05).
	0.81	LPL, the expression levels of PPARgamma, LPL mRNA, and protein in visceral fat and skeletal muscle of mice were detected.
	0.75	LPL Gene in a High-Fat Diet C57BL/6 Mice Model
25089147	0.98	LPL and the scavenger receptors low density lipoprotein receptor-related protein 1 (LRP-1), CD36 and CD68 mediate the uptake of modified and native lipoproteins by macrophages and may also play a role in DC lipid accumulation.
	0.97	LPL (Figure 5A) and CD36 expression (Figure 5B) in mesLNs significantly increased in pDCs, CD4+CD8alpha- and CD4-CD8alpha+ DCs; no changes were seen in CD4-CD8alpha- DCs.
	0.97	LPL (Figure 6A), CD36 (Figure 6B), CD68 (Figure 6C), LRP-1 (Figure 6D) and VLDLr (Figure 6E) significantly increased in pDCs and CD4-CD8alpha+ DCs in elderly-derived livers; no changes in expression levels of these receptors were seen in the remaining DC subsets.
	0.97	CD36, CD68) and LPL.
	0.96	lipoprotein lipase, scavenger receptors (CD36, CD68 and LRP-1) in most tissues.
	0.96	LPL to cause lipid accumulation, e.g. by mediating uptake of the fatty acids released by LPL (e.g. CD36) or by increased lipoprotein uptake through formation of a complex with lipoprotein receptors (e.g. LRP-1 or VLDLr); in our study, liver DCs of aged mice had increases in both CD36 and LRP-1, as well as VLDLr and CD68.
	0.91	LPL, LRP-1, CD36, CD68 and VLDLr, and whether age influences their expression.
26476336	0.98	lipoprotein lipase is involved in a process that allows these fat molecules to be taken up by brown fat cells.
	0.98	lipoprotein lipase in white fat cells and is also found at high levels in brown fat cells.
	0.98	lipoprotein lipase in white fat cells to allow fat molecules to be shuttled specifically to the brown fat cells.
	0.95	lipoprotein lipase to increase so that these cells are able to take up more fat molecules.
	0.92	fat depot, cold-induced changes in Lpl mRNA, Angptl4 mRNA and LPL activity were similar to the changes observed in the gonadal fat depot described above, whereas changes in uptake of TRL-derived fatty acids upon cold exposure were quite distinct, most likely due to marked activation of browning in inguinal fat (Figure 6A,B; Figure 5:figure supplement 2).
21698114	0.98	LPL is involved in the uptake of blood TG by capillaries of mammary tissue for milk fat production and that LPL activity levels reflect its capacity to direct TG from the blood.
	0.95	LPL is critical for the assimilation of a high fat milk diet by suckling young.
	0.95	fat and protein were found in the feces of LPL pups compared with WT pups, which might indicate that intestinal absorption of suckling pups was enhanced by the reduced TG content of milk.
25212743	0.98	LPL activity in brown fat, in which, however, lipasin expression is increased.
	0.95	LPL hydrolyzes TAG in chylomicrons and VLDL, yielding FFAs, which are then taken up by peripheral tissues, including fat, muscle and heart.
	0.93	LPL, however, is mostly expressed in fat and muscle.
21569430	0.98	LPL are enzymes which control triglyceride transport, fatty acid synthesis and transport of long-chain fatty acids in differentiated fat cells.
	0.84	fat metabolism (Glut4, LPL, FAS, ACC1 and CPT-1beta) and of adipocyte differentiation markers (PPARgamma, C/EBPalpha, PPARalpha, aP2 and adiponectin) were determined in maturing C3H10 T1/2 cells.
21695273	0.98	FAT/CD36, aP2, LPL), and lipolysis (MGL) (Figure 5).
	0.96	fat mass development, body weight gain, cholesterolemia, insulinoresistance index, and expression of several genes that mediate differentiation and/or fatty acid uptake (PPARgamma, aP2, FAT/CD36, LPL, FIAF), fatty acid oxidation (CPT-1, ACO), short-chain fatty acid response (GPR43), and inflammation (IL6, F4/80) in the subcutaneous adipose tissue.
25241943	0.98	CD36/FAT, lipoprotein lipase (LPL), fat specific protein 27 (FSP27) and caveolin-2 were significantly increased in livers of 2-month-old CerS2 null mice, whereas FATP5 and FABP1 levels were down-regulated (Fig. 6A).
	0.94	CD36/FAT null mice exhibit elevated plasma FFA and TG levels and impaired LPL-mediated TG clearance.
27053679	0.98	LPL is a rate-limiting enzyme for hydrolysing TG presenting in circulating lipoproteins, generating free fatty acids that are taken up by peripheral tissues, including the heart, muscle and fat.
	0.97	LPL activity as well as VLDL-TG incorporation are increased in oxidative tissues, including heart, muscle and brown fat.
25754247	0.98	LPL, synthesized in adipose tissue, is the gatekeeper of fat storage; when upregulated, LPL acts on lipoproteins and may generate increased FAs that are either transported into tissues or mixed with circulating FFAs via a spillover mechanism (Lafontan,).
27777604	0.97	fat mass of offspring born from HF-LCD, AdipoQ and LPL genes expression were respectively up-regulated 15.8 and 4.2-folds compared with the LF-HCD-fed mothers (p < 0.001 and p = 0.03, respectively).
	0.96	fat mass of offspring born from HF-LCD, AdipoQ and LPL genes expression were respectively up-regulated 15.8 and 4.2-folds compared with the LF-HCD-fed mothers.
	0.92	LPL and FASN over-expression result in higher fat mass and more insulin resistance.
	0.77	LPL and AdipoQ genes expression in the retroperitoneal fat (p = 0.03 and p < 0.001, respectively), after being adjusted for the sex of offspring.
27703805	0.97	lipoprotein lipase (LPL) which causes accumulation of fat in peripheral tissues.
	0.97	LPL which leads to deposition of up to 60% higher epididymal fat compared to germ-free wild-type littermates expressing fiaf genes (fiaf +/+).
	0.93	LPL and fat storage is associated with a change in gut microbiota has been questioned in some studies as there was no difference in fiaf in serum of GF and conventionally raised mice.
28327588	0.97	fat concurred with a marked reduction of lipoprotein lipase (Lpl) mRNA levels (-43%) and enzyme activity (-87%) in gWAT of ATGLi mice after re-feeding (Fig. 3g,h).
	0.97	Lpl, Cd36, G0s2 and Srebp1c), which may contribute to resistance to hepatic fat accumulation in HFD-fed ATGLi mice.
19325873	0.97	fat diet enhanced triglyceride clearance, which may be related to the induction of lipoprotein lipase activity in the adipose tissue.
19818871	0.97	LpL overexpressing transgenic mice and attenuated cardiac dysfunction following high-fat feeding, presumably by increasing export of TG-rich particles from the heart.
21857651	0.97	fat') derived from adipose tissue (fatty acid-albumin complexes) or from the hydrolysis of hepatic very-low-density lipoprotein particles via LPL regulate cardiac PPAR-alpha activity.
29914522	0.97	Lpl with medium-fat diets in the untrained state is probably related to PPARalpha as this isotype also controls their transcription in the muscle.
31547031	0.97	fat can be hydrolyzed by lipolytic enzymes such as LPL and HSL to liberate glycerol and FFA.
22762794	0.96	CD36, and LPL.
	0.96	LPL and CD36 in liver.
	0.92	LPL, CD36 also influences the uptake of circulating fatty acids.
23929732	0.96	LpL) hydrolyzes circulating TAG, followed by tissue uptake through fatty acid transport proteins (FATPs) together with FAT/CD36.
	0.94	LpL activity and limit peripheral fat uptake, ApoC3 transgenic mice have marked hypertriglyceridemia, but normal hepatic lipid content when fed a regular chow-fed diet compared to wild-type littermate mice fed the same diet.
29042644	0.96	LPL mRNA expression in heart and inguinal fat, whereas perigonadal fat showed no difference and skeletal muscle showed increased LPL mRNA expression (Fig. 6D).
	0.94	Lpl mRNA in heart, inguinal fat, perigonadal fat and skeletal muscle of Vpr-Tg compared to WT mice (N = 7-8 per group).
20927337	0.95	fat and triglyceride levels told a story of inhibited LPL action through ANGPTL4 leading to decreased fat storage.
	0.95	LPL activity through ANGPTL4, central to fat storage regulation, by manipulating the gut flora could be one important mechanism by which various interventions may modulate body fat storage.
30287090	0.93	Lpl, Dgat1, Fasn, and Elovl6 were higher in the inguinal fat in the intact AF2ERKI than in the OVX AF2ERKI females.
	0.74	fat accumulation in the adipose tissues, we analyzed the expression profile of lipid metabolism related genes (lipoprotein lipase, Lpl; diglyceride acyltransferase, Dgat1; hormone sensitive lipase, Lipe; adipose triglyceride lipase, Pnpla2; ATP citrate lyase, Acly; acetyl-CoA carboxylase alpha, Acaca; fatty acid synthase, Fasn; stearoyl-CoA desaturase 1, Scd1; elongation of very long chain fatty acids-like 6, Elovl6; 3-hydroxy-3-methylglutaryl-CoA reductase, Hmgcr) in inguinal and visceral fats.
27897405	0.93	fat emulsions, lipids are organized in artificial chylomicrons that have to be broken down by lipoprotein lipase (LPL) to generate free fatty acids.44, 45 Although the regulation of LPL activity during critical illness is complex, evidence suggests that during sepsis, LPL activity decreases during the initial stages of the disease.46, 47 This could induce inefficient utilization of exogenously administered lipids from parenteral nutrition.
32079362	0.92	LPL), CD36/SR-B2 (also known as cluster of differentiation 36, platelet glycoprotein 4, or fatty acid translocase/FAT), CD206 (also known as cluster of differentiation 206, C-type lectin mannose receptor), CD11C (also known as cluster of differentiation 11c or integrin alpha X), and murine macrophage F4/80 glycoprotein (F4/80) compared to THOP1-/- males that were fed an SD (Table 7).
26388673	0.91	LPL, which are involved in fatty acid oxidation and are located downstream of liver fat metabolism genes, were insignificantly increased, and the lipid synthesis gene FAS was significantly suppressed by dietary 5-ALA.
27284309	0.90	FAT, Ldlr, Hmgcs, Hmgcr, Socs3 and Ptpn1 were also significantly increased, while the expression levels of Gys, Hk2, Acox, Cpt1, Acadm, Adipor1, Pdk4, Ucp3, Slc2a4, Ppargcla, Lpl and Adipoq were significantly decreased in both the insulin-resistant and diabetic groups compared with the control group (Fig. 2B-D).
19303979	0.87	lipoprotein lipase, we tested whether changes in adipose tissue lipase activity contributed to the selective changes in size of fat pad as seen for male A5tg mice.
30800481	0.86	fat LPL activity were found between both groups of fasted animals; however, there was a consistent, although nonsignificant, higher LPL activity in NS mice, showing a sustained 25.9% increase than those control mice (Figure 6(a)).
	0.84	LPL activity associated with epididymal fat.
24389130	0.77	LPL to prevent its lipolysis and promote de novo lipogenesis, did not activate BAT or induce browning of WAT in response to high fat diet or ADRB3 stimulation.
22912823	0.74	LPL mRNA expression in the subcutaneous fat compared to all other groups, but no significant differences for LPL were found in the visceral fat.
	0.69	LPL mRNA expression in the subcutaneous fat compared to all other groups (p<0.05), but no significant differences for LPL were found in the visceral fat.
26997622	0.69	LPL, and CD36 which are especially highest in A+G. Oxct1, a key enzyme in ketone body catabolism that is induced by exercise (Askew et al. 1975), tended to be highest in A+G. Furthermore, together with increased gene expression not exclusive to A+G (Hsl, Atgl, Cpt1b, Cs, Vegfa, and Ppard) would support the observed elevated intramuscular NEFA level at the point of exhaustion and the shift to whole-body substrate oxidation to fat toward exhaustion in this group.