Publication for Anxa2 and Ahnak

Species	Symbol	Function*	Entrez Gene ID*	Other ID	Gene coexpression	CoexViewer
mmu	Anxa2	annexin A2	12306			[link]
mmu	Ahnak	AHNAK nucleoprotein (desmoyokin)	66395

Pubmed ID	Priority	Text
22505935	0.99	AnxA2 has also been shown to regulate the actin cytoskeleton via its interaction with the scaffold protein, AHNAK (also known as Desmoyokin) which recruited to cholesterol-rich domains of the plasma membrane in an AnxA2-dependent manner.
30760886	0.98	Ahnak, whose function in the brain has been obscure, stabilizes p11 and Anxa2 proteins in the hippocampus and prefrontal cortex in rodent brain.
	0.98	Ahnak is a stabilizer of the p11/Anxa2 protein complex and a pivotal regulator of L-type VGCCs in the brain.
	0.98	Ahnak is a major binding partner of the p11/Anxa2 complex in the brain.
	0.98	Anxa2 are required for the surface recruitment of Ahnak to the cell membrane.
	0.98	Ahnak, as a major binding partner of the p11/Anxa2 protein complex, stabilizes p11 and Anxa2 proteins in the brain.
	0.98	Ahnak functionally scaffolds L-type VGCCs as a downstream effector of the Ahnak/p11/Anxa2 complex.
	0.98	Ahnak, as a major binding partner of the p11/Anxa2 complex, stabilizes p11 and Anxa2 proteins.
	0.97	Ahnak, p11 and Anxa2 are highly and positively correlated in the brain.
	0.97	Ahnak, as a major binding partner of the p11/Anxa2 complex, stabilizes p11 and Anxa2 proteins in the brain
	0.97	Ahnak from brain extracts co-precipitated p11 and Anxa2 (Figure 1c).
	0.97	Anxa2 were drastically reduced in the hippocampus (Figure 1d and e) and prefrontal cortex (PFC) (Figure 1f and g) of Ahnak KO mice compared to their wild-type (WT) controls.
	0.97	Anxa2 proteins in primary cultured cortical neurons derived from Ahnak KO embryos (Supplementary Figure 1c).
	0.97	Ahnak by GST-p11/Anxa2 hybrid-immobilized beads but not by GST-immobilized beads (Figure 3a), suggesting that L-type VGCCs interact with the Ahnak/p11/Anxa2 complex.
	0.96	Ahnak/p11/Anxa2 complex, revealing a novel molecular connection involved in the control of depressive behavior.
	0.96	Ahnak's stabilization effect, we observed that protein levels of Ahnak, p11 and Anxa2 in the hippocampus (Figure 1h and i) and PFC (Figure 1j and 1k) are highly and positively correlated.
	0.96	Ahnak/p11/Anxa2 complex as an endogenous neuronal machinery controlling cell surface expression of L-type VGCCs and thereby scaling neuronal activity-induced calcium signaling.
	0.96	Ahnak, p11 and Anxa2 are positively correlated in an individual brain tissue (n=29).
	0.95	Ahnak in the stabilization of p11 and Anxa2 proteins and positive correlation in the levels of Ahnak, p11 and Anxa2 support the existence of the Ahnak/p11/Anxa2 complex in the brain.
	0.95	Ahnak co-precipitated beta4b subunit and endogenous p11 and Anxa2 (Figure 3c), which is consistent with previous reports for the interaction of the C-terminal region of Ahnak with p11/Anxa212 and beta2 subunit.
	0.95	Ahnak is a scaffolding protein interacting with L-type alpha1 subunit through its N-terminal region as well as beta subunit and p11/Anxa2 through its C-terminal region.
	0.94	Ahnak as a binding partner of the p11/Anxa2 complex.
	0.94	Anxa2 hybrid mimics the property of the heterotetrameric holocomplex in formation of a hydrophobic pocket for the binding to its effector proteins such as SMARCA3 and Ahnak.
	0.90	Ahnak/p11/Anxa2 complex in the brain.
	0.89	Ahnak/p11/Anxa2 complex in the brain.
	0.88	Ahnak scaffolds p11/Anxa2 complex and L-type voltage-gated calcium channel and modulates depressive behavior
	0.87	Ahnak/p11/Anxa2 protein complex.
	0.86	Ahnak, through its N-terminal region, scaffolds the L-type pore-forming alpha1 subunit and, through its C-terminal region, scaffolds the beta subunit of VGCC and the p11/Anxa2 complex.
	0.86	Ahnak and p11/Anxa2 complex was characterized in cell line, yeast triple-hybrid assays and in vitro experiments.
	0.79	Ahnak and the functional significance of its interaction with the p11/Anxa2 complex in the brain has not yet been investigated.
	0.68	Ahnak and the p11/Anxa2 complex at atomic level.
20713605	0.98	AHNAK and Annexin A2, have been shown to bind dysferlin and myoferlin during membrane repair.
22560623	0.98	AHNAK and annexin A2, both members of the membrane repair complex (reviewed in).
21468022	0.97	AHNAK, calveolin-3 and calpain-3 (ref.), two members of the annexin family, annexin-A1 (AnxA1) and A2 (AnxA2), have also been implicated in membrane repair, although their roles remain to be elucidated.
28954231	0.97	AHNAK, NPC1, ANXA2) were also induced on the cell surface of MMe macrophages in vitro.
30729030	0.77	desmoyokin and annexin II.