[][] hsa ZAP70 Gene 
functional annotation
Function   zeta chain of T cell receptor associated protein kinase 70
GO BP
GO:0070489 [list] [network] T cell aggregation  (2 genes)  TAS  
GO:0043366 [list] [network] beta selection  (3 genes)  IEA  
GO:0045059 [list] [network] positive thymic T cell selection  (8 genes)  IDA  
GO:0046641 [list] [network] positive regulation of alpha-beta T cell proliferation  (8 genes)  IEA  
GO:0072678 [list] [network] T cell migration  (8 genes)  TAS  
GO:0045060 [list] [network] negative thymic T cell selection  (10 genes)  IEA  
GO:0046638 [list] [network] positive regulation of alpha-beta T cell differentiation  (10 genes)  IEA  
GO:0045582 [list] [network] positive regulation of T cell differentiation  (16 genes)  IDA  
GO:0050850 [list] [network] positive regulation of calcium-mediated signaling  (17 genes)  IEA  
GO:0042113 [list] [network] B cell activation  (24 genes)  TAS  
GO:0030217 [list] [network] T cell differentiation  (31 genes)  NAS  
GO:0042110 [list] [network] T cell activation  (42 genes)  TAS  
GO:0038083 [list] [network] peptidyl-tyrosine autophosphorylation  (48 genes)  IBA  
GO:0007169 [list] [network] transmembrane receptor protein tyrosine kinase signaling pathway  (88 genes)  IBA  
GO:0050852 [list] [network] T cell receptor signaling pathway  (145 genes)  TAS  
GO:0018108 [list] [network] peptidyl-tyrosine phosphorylation  (153 genes)  IDA IMP  
GO:0042127 [list] [network] regulation of cell proliferation  (180 genes)  IBA  
GO:0002250 [list] [network] adaptive immune response  (203 genes)  TAS  
GO:0035556 [list] [network] intracellular signal transduction  (372 genes)  NAS  
GO:0006955 [list] [network] immune response  (399 genes)  IDA  
GO:0006468 [list] [network] protein phosphorylation  (453 genes)  IDA NAS  
GO:0045087 [list] [network] innate immune response  (467 genes)  IBA  
GO CC
GO:0042101 [list] [network] T cell receptor complex  (18 genes)  IDA  
GO:0001772 [list] [network] immunological synapse  (33 genes)  IEA  
GO:0031234 [list] [network] extrinsic component of cytoplasmic side of plasma membrane  (73 genes)  IBA  
GO:0005911 [list] [network] cell-cell junction  (148 genes)  IEA  
GO:0045121 [list] [network] membrane raft  (216 genes)  IDA  
GO:0005737 [list] [network] cytoplasm  (4013 genes)  TAS  
GO:0005886 [list] [network] plasma membrane  (4337 genes)  IDA TAS  
GO:0005829 [list] [network] cytosol  (4875 genes)  TAS  
GO MF
GO:0004715 [list] [network] non-membrane spanning protein tyrosine kinase activity  (51 genes)  TAS  
GO:0004713 [list] [network] protein tyrosine kinase activity  (124 genes)  IDA NAS TAS  
GO:0005102 [list] [network] signaling receptor binding  (365 genes)  IBA  
GO:0005524 [list] [network] ATP binding  (1477 genes)  NAS  
GO:0005515 [list] [network] protein binding  (9334 genes)  IPI  
KEGG hsa04014 Ras signaling pathway
hsa04064 NF-kappa B signaling pathway
hsa04650 Natural killer cell mediated cytotoxicity
hsa04658 Th1 and Th2 cell differentiation
hsa04659 Th17 cell differentiation
hsa04660 T cell receptor signaling pathway
hsa05340 Primary immunodeficiency
Orthologous [Ortholog page] SYK (hsa)Syk (mmu)Zap70 (mmu)Syk (rno)Shark (dme)ZK622.1 (cel)Zap70 (rno)syk (dre)ZAP70 (gga)SYK (gga)SYK (cfa)zap70 (dre)SYK (mcc)LOC707555 (mcc)ZAP70 (cfa)LOC100910488 (rno)
Subcellular
localization
cyto 6,  cyto_nucl 4,  cyto_pero 3,  nucl 1,  pero 1,  plas 1,  extr 1,  extr_plas 1  (predict for NP_001070.2)
cyto 3,  cyto_mito 2,  nucl 2,  pero 2,  plas 1,  extr 1,  extr_plas 1  (predict for NP_997402.1)
cyto 5,  cyto_nucl 3,  mito 2,  nucl 2,  mito_pero 2  (predict for XP_016860356.1)
cyto 5,  cyto_nucl 3,  mito 2,  nucl 2,  mito_pero 2  (predict for XP_016860357.1)
cyto 5,  cyto_nucl 3,  mito 2,  mito_pero 2,  nucl 1  (predict for XP_016860358.1)
cyto 5,  cyto_nucl 3,  mito 2,  nucl 2,  mito_pero 2  (predict for XP_016860359.1)
Gene coexpression
Network*for
coexpressed
genes
LCNloc
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
hsa04658 Th1 and Th2 cell differentiation 5
hsa04659 Th17 cell differentiation 5
hsa04660 T cell receptor signaling pathway 5
hsa04640 Hematopoietic cell lineage 4
hsa05166 HTLV-I infection 3
Genes directly connected with ZAP70 on the network
MR* Locus Fuction* Coexpression
detail
Entrez Gene ID*
75.8 CD247 CD247 molecule [detail] 919
119.0 TBC1D10C TBC1 domain family member 10C [detail] 374403
149.3 LCK LCK proto-oncogene, Src family tyrosine kinase [detail] 3932
232.3 SEPT1 septin 1 [detail] 1731
271.2 GZMM granzyme M [detail] 3004
525.3 CARD11 caspase recruitment domain family member 11 [detail] 84433
530.1 NLRC3 NLR family CARD domain containing 3 [detail] 197358
666.9 TAF5LP1 TATA-box binding protein associated factor 5 like pseudogene 1 [detail] 645744
1472.6 EVL Enah/Vasp-like [detail] 51466
Coexpressed
gene list
[Coexpressed gene list for ZAP70]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity* tissue specificity
Link to other DBs
Entrez Gene ID 7535    
Refseq ID (protein) NP_001070.2 
NP_997402.1 
XP_016860356.1 
XP_016860357.1 
XP_016860358.1 
XP_016860359.1 


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