[][] hsa TOP2A Gene 
functional annotation
Function   DNA topoisomerase II alpha
GO BP
GO:0045870 [list] [network] positive regulation of single stranded viral RNA replication via double stranded DNA intermediate  (1 genes)  IMP  
GO:1905463 [list] [network] negative regulation of DNA duplex unwinding  (1 genes)  IMP  
GO:0000819 [list] [network] sister chromatid segregation  (3 genes)  IBA  
GO:0044774 [list] [network] mitotic DNA integrity checkpoint  (3 genes)  IBA  
GO:0030263 [list] [network] apoptotic chromosome condensation  (5 genes)  IDA  
GO:0040016 [list] [network] embryonic cleavage  (7 genes)  IEA  
GO:0006265 [list] [network] DNA topological change  (9 genes)  IDA IMP  
GO:0006266 [list] [network] DNA ligation  (11 genes)  IDA  
GO:0000712 [list] [network] resolution of meiotic recombination intermediates  (15 genes)  IBA  
GO:0045070 [list] [network] positive regulation of viral genome replication  (27 genes)  IMP  
GO:0042752 [list] [network] regulation of circadian rhythm  (48 genes)  ISS  
GO:0048511 [list] [network] rhythmic process  (53 genes)  IEA  
GO:0002244 [list] [network] hematopoietic progenitor cell differentiation  (55 genes)  IEA  
GO:0007059 [list] [network] chromosome segregation  (64 genes)  IMP  
GO:0016925 [list] [network] protein sumoylation  (76 genes)  TAS  
GO:0006974 [list] [network] cellular response to DNA damage stimulus  (213 genes)  IDA  
GO:0043065 [list] [network] positive regulation of apoptotic process  (327 genes)  IDA  
GO:0045944 [list] [network] positive regulation of transcription by RNA polymerase II  (1044 genes)  IEA  
GO CC
GO:0019035 [list] [network] viral integration complex  (1 genes)  NAS  
GO:0009330 [list] [network] DNA topoisomerase complex (ATP-hydrolyzing)  (2 genes)  IDA  
GO:0000793 [list] [network] condensed chromosome  (24 genes)  IEA  
GO:0000228 [list] [network] nuclear chromosome  (50 genes)  IDA  
GO:0005814 [list] [network] centriole  (124 genes)  IDA  
GO:0030529 [list] [network] ribonucleoprotein complex  (124 genes)  IDA  
GO:0043234 [list] [network] protein-containing complex  (566 genes)  IDA  
GO:0005730 [list] [network] nucleolus  (839 genes)  IDA  
GO:0005654 [list] [network] nucleoplasm  (3108 genes)  IDA TAS  
GO:0005634 [list] [network] nucleus  (5173 genes)  IDA  
GO MF
GO:0003918 [list] [network] DNA topoisomerase type II (ATP-hydrolyzing) activity  (3 genes)  IDA IMP  
GO:0008301 [list] [network] DNA binding, bending  (17 genes)  IDA  
GO:0008094 [list] [network] DNA-dependent ATPase activity  (36 genes)  IDA  
GO:0005080 [list] [network] protein kinase C binding  (49 genes)  IPI  
GO:0008144 [list] [network] drug binding  (62 genes)  IDA  
GO:0043130 [list] [network] ubiquitin binding  (67 genes)  IMP  
GO:0042826 [list] [network] histone deacetylase binding  (108 genes)  IPI  
GO:0008022 [list] [network] protein C-terminus binding  (185 genes)  IPI  
GO:0000287 [list] [network] magnesium ion binding  (196 genes)  IDA  
GO:0019899 [list] [network] enzyme binding  (333 genes)  IPI  
GO:0003682 [list] [network] chromatin binding  (369 genes)  IDA  
GO:0046982 [list] [network] protein heterodimerization activity  (497 genes)  IPI  
GO:0042803 [list] [network] protein homodimerization activity  (797 genes)  IPI  
GO:0003723 [list] [network] RNA binding  (1394 genes)  HDA  
GO:0005524 [list] [network] ATP binding  (1477 genes)  IEA  
GO:0003677 [list] [network] DNA binding  (1486 genes)  IDA  
GO:0005515 [list] [network] protein binding  (9334 genes)  IPI  
KEGG hsa01524 Platinum drug resistance
Orthologous [Ortholog page] TOP2B (hsa)Top2a (mmu)Top2b (mmu)Top2 (dme)top-2 (cel)cin-4 (cel)R05D3.12 (cel)top2a (dre)Top2a (rno)Top2b (rno)TOP2A (gga)TOP2B (gga)TOP2B (cfa)TOP2A (cfa)top2b (dre)TOP2B (mcc)TOP2A (mcc)TOP2 (sce)top2 (spo)
Subcellular
localization
nucl 7,  cyto_nucl 5,  cyto 3,  cyto_mito 2  (predict for NP_001058.2)
cyto_nucl 6,  nucl 6,  cyto 4  (predict for XP_005257689.1)
nucl 6,  cyto_nucl 5,  cyto 4,  cyto_mito 2  (predict for XP_011523467.1)
Gene coexpression
Network*for
coexpressed
genes
LCNloc
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
hsa04110 Cell cycle 2
Genes directly connected with TOP2A on the network
MR* Locus Fuction* Coexpression
detail
Entrez Gene ID*
5.4 ASPM abnormal spindle microtubule assembly [detail] 259266
7.4 NUSAP1 nucleolar and spindle associated protein 1 [detail] 51203
16.7 DLGAP5 DLG associated protein 5 [detail] 9787
20.2 CENPF centromere protein F [detail] 1063
29.6 KIF11 kinesin family member 11 [detail] 3832
33.4 TTK TTK protein kinase [detail] 7272
50.5 CKAP2L cytoskeleton associated protein 2 like [detail] 150468
55.3 KIF15 kinesin family member 15 [detail] 56992
174.3 KIF23 kinesin family member 23 [detail] 9493
323.0 FBXO5 F-box protein 5 [detail] 26271
Coexpressed
gene list
[Coexpressed gene list for TOP2A]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity* tissue specificity
Link to other DBs
Entrez Gene ID 7153    
Refseq ID (protein) NP_001058.2 
XP_005257689.1 
XP_011523467.1 


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