[][] hsa SYK Gene 
functional annotation
Function   spleen associated tyrosine kinase
GO:0032928 [list] [network] regulation of superoxide anion generation  (1 genes)  ISS  
GO:0045401 [list] [network] positive regulation of interleukin-3 biosynthetic process  (1 genes)  IEA  
GO:0090237 [list] [network] regulation of arachidonic acid secretion  (1 genes)  ISS  
GO:0042991 [list] [network] obsolete transcription factor import into nucleus  (2 genes)  IMP  
GO:0043313 [list] [network] regulation of neutrophil degranulation  (2 genes)  ISS  
GO:0045425 [list] [network] positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process  (2 genes)  IEA  
GO:0071226 [list] [network] cellular response to molecule of fungal origin  (2 genes)  ISS  
GO:0002366 [list] [network] leukocyte activation involved in immune response  (3 genes)  ISS  
GO:0002554 [list] [network] serotonin secretion by platelet  (3 genes)  ISS  
GO:0043366 [list] [network] beta selection  (3 genes)  IEA  
GO:0045588 [list] [network] positive regulation of gamma-delta T cell differentiation  (3 genes)  IEA  
GO:0002283 [list] [network] neutrophil activation involved in immune response  (5 genes)  IBA ISS  
GO:0010543 [list] [network] regulation of platelet activation  (5 genes)  ISS  
GO:0090330 [list] [network] regulation of platelet aggregation  (5 genes)  IBA ISS  
GO:1900086 [list] [network] positive regulation of peptidyl-tyrosine autophosphorylation  (5 genes)  IEA  
GO:0001945 [list] [network] lymph vessel development  (7 genes)  ISS  
GO:0002281 [list] [network] macrophage activation involved in immune response  (7 genes)  IBA ISS  
GO:0046641 [list] [network] positive regulation of alpha-beta T cell proliferation  (8 genes)  IBA  
GO:0050764 [list] [network] regulation of phagocytosis  (8 genes)  ISS  
GO:0038063 [list] [network] collagen-activated tyrosine kinase receptor signaling pathway  (9 genes)  IEA  
GO:0043306 [list] [network] positive regulation of mast cell degranulation  (9 genes)  IBA  
GO:0019370 [list] [network] leukotriene biosynthetic process  (10 genes)  IEA  
GO:0046638 [list] [network] positive regulation of alpha-beta T cell differentiation  (10 genes)  IEA  
GO:0033630 [list] [network] positive regulation of cell adhesion mediated by integrin  (13 genes)  IBA ISS  
GO:0045579 [list] [network] positive regulation of B cell differentiation  (13 genes)  IMP  
GO:0045780 [list] [network] positive regulation of bone resorption  (16 genes)  ISS  
GO:0050850 [list] [network] positive regulation of calcium-mediated signaling  (17 genes)  IEA  
GO:0048514 [list] [network] blood vessel morphogenesis  (18 genes)  ISS  
GO:0071404 [list] [network] cellular response to low-density lipoprotein particle stimulus  (18 genes)  ISS  
GO:0002092 [list] [network] positive regulation of receptor internalization  (23 genes)  IEA  
GO:0050715 [list] [network] positive regulation of cytokine secretion  (25 genes)  IEA  
GO:0007159 [list] [network] leukocyte cell-cell adhesion  (26 genes)  IDA  
GO:0051090 [list] [network] regulation of DNA-binding transcription factor activity  (28 genes)  IMP  
GO:0070372 [list] [network] regulation of ERK1 and ERK2 cascade  (28 genes)  ISS  
GO:0010803 [list] [network] regulation of tumor necrosis factor-mediated signaling pathway  (32 genes)  IMP  
GO:0007257 [list] [network] activation of JUN kinase activity  (36 genes)  IEA  
GO:0031623 [list] [network] receptor internalization  (38 genes)  ISS  
GO:0038083 [list] [network] peptidyl-tyrosine autophosphorylation  (48 genes)  IBA  
GO:0032481 [list] [network] positive regulation of type I interferon production  (49 genes)  IEA  
GO:0030593 [list] [network] neutrophil chemotaxis  (61 genes)  IDA  
GO:0050853 [list] [network] B cell receptor signaling pathway  (74 genes)  IBA ISS  
GO:0009887 [list] [network] animal organ morphogenesis  (81 genes)  TAS  
GO:0007229 [list] [network] integrin-mediated signaling pathway  (87 genes)  ISS NAS  
GO:0007169 [list] [network] transmembrane receptor protein tyrosine kinase signaling pathway  (88 genes)  IBA  
GO:0030168 [list] [network] platelet activation  (110 genes)  TAS  
GO:0002223 [list] [network] stimulatory C-type lectin receptor signaling pathway  (123 genes)  TAS  
GO:0038096 [list] [network] Fc-gamma receptor signaling pathway involved in phagocytosis  (130 genes)  TAS  
GO:0018105 [list] [network] peptidyl-serine phosphorylation  (147 genes)  IEA  
GO:0042742 [list] [network] defense response to bacterium  (163 genes)  ISS  
GO:0038095 [list] [network] Fc-epsilon receptor signaling pathway  (178 genes)  TAS  
GO:0002250 [list] [network] adaptive immune response  (203 genes)  IBA ISS  
GO:0001525 [list] [network] angiogenesis  (219 genes)  IEA  
GO:0016032 [list] [network] viral process  (333 genes)  IEA  
GO:0008283 [list] [network] cell proliferation  (359 genes)  TAS  
GO:0006954 [list] [network] inflammatory response  (371 genes)  IBA  
GO:0006468 [list] [network] protein phosphorylation  (453 genes)  IDA ISS  
GO:0045087 [list] [network] innate immune response  (467 genes)  IBA ISS  
GO:0019815 [list] [network] B cell receptor complex  (3 genes)  IEA  
GO:0032009 [list] [network] early phagosome  (8 genes)  ISS  
GO:0042101 [list] [network] T cell receptor complex  (18 genes)  IDA  
GO:0031234 [list] [network] extrinsic component of cytoplasmic side of plasma membrane  (73 genes)  IBA  
GO:0043234 [list] [network] protein-containing complex  (566 genes)  IDA  
GO:0005737 [list] [network] cytoplasm  (4013 genes)  IDA  
GO:0005886 [list] [network] plasma membrane  (4337 genes)  TAS  
GO:0005829 [list] [network] cytosol  (4875 genes)  IC TAS  
GO:0005634 [list] [network] nucleus  (5173 genes)  IDA  
GO:0035325 [list] [network] Toll-like receptor binding  (5 genes)  IEA  
GO:0004716 [list] [network] obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity  (9 genes)  IEA  
GO:0042169 [list] [network] SH2 domain binding  (33 genes)  IEA  
GO:0001784 [list] [network] phosphotyrosine residue binding  (35 genes)  IPI  
GO:0019902 [list] [network] phosphatase binding  (45 genes)  IEA  
GO:0004715 [list] [network] non-membrane spanning protein tyrosine kinase activity  (51 genes)  IDA TAS  
GO:0005178 [list] [network] integrin binding  (113 genes)  IPI  
GO:0004713 [list] [network] protein tyrosine kinase activity  (124 genes)  EXP TAS  
GO:0004672 [list] [network] protein kinase activity  (199 genes)  IDA NAS  
GO:0004674 [list] [network] protein serine/threonine kinase activity  (357 genes)  IDA  
GO:0019901 [list] [network] protein kinase binding  (414 genes)  IEA  
GO:0005524 [list] [network] ATP binding  (1477 genes)  IEA  
GO:0005515 [list] [network] protein binding  (9334 genes)  IPI  
KEGG hsa04064 NF-kappa B signaling pathway
hsa04072 Phospholipase D signaling pathway
hsa04151 PI3K-Akt signaling pathway
hsa04380 Osteoclast differentiation
hsa04611 Platelet activation
hsa04650 Natural killer cell mediated cytotoxicity
hsa04662 B cell receptor signaling pathway
hsa04664 Fc epsilon RI signaling pathway
hsa04666 Fc gamma R-mediated phagocytosis
hsa05152 Tuberculosis
hsa05167 Kaposi's sarcoma-associated herpesvirus infection
hsa05169 Epstein-Barr virus infection
hsa05203 Viral carcinogenesis
Orthologous [Ortholog page] ZAP70 (hsa)Syk (mmu)Zap70 (mmu)Syk (rno)Shark (dme)ZK622.1 (cel)Zap70 (rno)syk (dre)ZAP70 (gga)SYK (gga)SYK (cfa)zap70 (dre)SYK (mcc)LOC707555 (mcc)ZAP70 (cfa)LOC100910488 (rno)
cyto 6,  cyto_nucl 4,  nucl 2,  mito 1,  pero 1,  mito_pero 1  (predict for NP_001128524.1)
cyto 6,  cyto_nucl 5,  nucl 2,  mito 1  (predict for NP_001167638.1)
cyto 6,  cyto_nucl 4,  nucl 2,  mito 1,  pero 1,  mito_pero 1  (predict for NP_001167639.1)
cyto 6,  cyto_nucl 5,  nucl 2,  mito 1  (predict for NP_003168.2)
cyto 6,  cyto_nucl 5,  nucl 2,  mito 1  (predict for XP_005252204.1)
cyto 6,  cyto_nucl 5,  nucl 2,  mito 1  (predict for XP_011517248.1)
Gene coexpression
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
hsa04664 Fc epsilon RI signaling pathway 5
hsa04666 Fc gamma R-mediated phagocytosis 4
hsa04380 Osteoclast differentiation 4
hsa04662 B cell receptor signaling pathway 4
hsa04062 Chemokine signaling pathway 3
Genes directly connected with SYK on the network
MR* Locus Fuction* Coexpression
Entrez Gene ID*
697.0 PTAFR platelet activating factor receptor [detail] 5724
1018.1 PARVG parvin gamma [detail] 64098
1022.5 NCF4 neutrophil cytosolic factor 4 [detail] 4689
1176.6 ARL11 ADP ribosylation factor like GTPase 11 [detail] 115761
gene list
[Coexpressed gene list for SYK]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity* tissue specificity
Link to other DBs
Entrez Gene ID 6850    
Refseq ID (protein) NP_001128524.1 

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