[][] hsa SOD1 Gene 
functional annotation
Function   superoxide dismutase 1
GO BP
GO:0097332 [list] [network] response to antipsychotic drug  (1 genes)  IEA  
GO:0034465 [list] [network] response to carbon monoxide  (3 genes)  IEA  
GO:1902177 [list] [network] positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (4 genes)  IMP  
GO:0000303 [list] [network] response to superoxide  (5 genes)  IDA  
GO:0033081 [list] [network] regulation of T cell differentiation in thymus  (5 genes)  NAS  
GO:0045541 [list] [network] negative regulation of cholesterol biosynthetic process  (5 genes)  IDA  
GO:0060052 [list] [network] neurofilament cytoskeleton organization  (5 genes)  ISS  
GO:0032287 [list] [network] peripheral nervous system myelin maintenance  (7 genes)  ISS  
GO:0035865 [list] [network] cellular response to potassium ion  (8 genes)  IEA  
GO:0046620 [list] [network] regulation of organ growth  (8 genes)  NAS  
GO:0050665 [list] [network] hydrogen peroxide biosynthetic process  (8 genes)  IDA ISS  
GO:0060087 [list] [network] relaxation of vascular smooth muscle  (8 genes)  ISS  
GO:0002262 [list] [network] myeloid cell homeostasis  (9 genes)  ISS  
GO:0008090 [list] [network] retrograde axonal transport  (9 genes)  ISS  
GO:0060088 [list] [network] auditory receptor cell stereocilium organization  (11 genes)  ISS  
GO:0019430 [list] [network] removal of superoxide radicals  (12 genes)  IC ISS  
GO:0071318 [list] [network] cellular response to ATP  (12 genes)  IEA  
GO:0042554 [list] [network] superoxide anion generation  (13 genes)  IEA  
GO:0060047 [list] [network] heart contraction  (13 genes)  IDA  
GO:0032930 [list] [network] positive regulation of superoxide anion generation  (14 genes)  IDA  
GO:0046688 [list] [network] response to copper ion  (14 genes)  IEA  
GO:0019226 [list] [network] transmission of nerve impulse  (18 genes)  ISS  
GO:0046716 [list] [network] muscle cell cellular homeostasis  (18 genes)  ISS  
GO:0006801 [list] [network] superoxide metabolic process  (20 genes)  IDA ISS  
GO:0001819 [list] [network] positive regulation of cytokine production  (23 genes)  IDA  
GO:0007569 [list] [network] cell aging  (25 genes)  IMP  
GO:0001975 [list] [network] response to amphetamine  (26 genes)  IEA  
GO:0008089 [list] [network] anterograde axonal transport  (26 genes)  ISS  
GO:0048678 [list] [network] response to axon injury  (26 genes)  ISS  
GO:0040014 [list] [network] regulation of multicellular organism growth  (27 genes)  ISS  
GO:0010033 [list] [network] response to organic substance  (29 genes)  IDA  
GO:0051881 [list] [network] regulation of mitochondrial membrane potential  (29 genes)  IMP  
GO:0046677 [list] [network] response to antibiotic  (30 genes)  IEA  
GO:0071276 [list] [network] cellular response to cadmium ion  (31 genes)  IEA  
GO:0045859 [list] [network] regulation of protein kinase activity  (33 genes)  IDA  
GO:0072593 [list] [network] reactive oxygen species metabolic process  (33 genes)  IDA  
GO:0001890 [list] [network] placenta development  (35 genes)  NAS  
GO:0007566 [list] [network] embryo implantation  (38 genes)  ISS NAS  
GO:0001541 [list] [network] ovarian follicle development  (39 genes)  ISS  
GO:0001895 [list] [network] retina homeostasis  (40 genes)  ISS  
GO:0006749 [list] [network] glutathione metabolic process  (42 genes)  ISS  
GO:0048538 [list] [network] thymus development  (43 genes)  NAS  
GO:0009408 [list] [network] response to heat  (44 genes)  ISS  
GO:0042542 [list] [network] response to hydrogen peroxide  (50 genes)  ISS  
GO:0035722 [list] [network] interleukin-12-mediated signaling pathway  (57 genes)  TAS  
GO:0043087 [list] [network] regulation of GTPase activity  (60 genes)  IDA  
GO:0006879 [list] [network] cellular iron ion homeostasis  (61 genes)  ISS  
GO:0008217 [list] [network] regulation of blood pressure  (63 genes)  ISS  
GO:0043085 [list] [network] positive regulation of catalytic activity  (76 genes)  IDA  
GO:0007626 [list] [network] locomotory behavior  (80 genes)  ISS  
GO:0034599 [list] [network] cellular response to oxidative stress  (89 genes)  TAS  
GO:0045471 [list] [network] response to ethanol  (103 genes)  ISS  
GO:0000187 [list] [network] activation of MAPK activity  (111 genes)  ISS  
GO:0002576 [list] [network] platelet degranulation  (124 genes)  TAS  
GO:0043524 [list] [network] negative regulation of neuron apoptotic process  (132 genes)  ISS  
GO:0007605 [list] [network] sensory perception of sound  (135 genes)  ISS  
GO:0042493 [list] [network] response to drug  (195 genes)  ISS  
GO:0043065 [list] [network] positive regulation of apoptotic process  (327 genes)  IC  
GO:0007283 [list] [network] spermatogenesis  (394 genes)  ISS  
GO:0055114 [list] [network] oxidation-reduction process  (533 genes)  IEA  
GO CC
GO:0031045 [list] [network] dense core granule  (10 genes)  IEA  
GO:0032839 [list] [network] dendrite cytoplasm  (24 genes)  IDA  
GO:1904115 [list] [network] axon cytoplasm  (41 genes)  IEA  
GO:0005758 [list] [network] mitochondrial intermembrane space  (76 genes)  TAS  
GO:0005777 [list] [network] peroxisome  (104 genes)  IDA ISS  
GO:0043209 [list] [network] myelin sheath  (147 genes)  IEA  
GO:0031410 [list] [network] cytoplasmic vesicle  (223 genes)  IDA  
GO:0005764 [list] [network] lysosome  (229 genes)  IEA  
GO:0031012 [list] [network] extracellular matrix  (319 genes)  IDA  
GO:0043025 [list] [network] neuronal cell body  (323 genes)  IDA  
GO:0005759 [list] [network] mitochondrial matrix  (353 genes)  NAS  
GO:0043234 [list] [network] protein-containing complex  (566 genes)  IDA  
GO:0005739 [list] [network] mitochondrion  (1301 genes)  IDA  
GO:0005615 [list] [network] extracellular space  (1600 genes)  IDA  
GO:0005576 [list] [network] extracellular region  (1841 genes)  TAS  
GO:0070062 [list] [network] extracellular exosome  (2817 genes)  HDA  
GO:0005654 [list] [network] nucleoplasm  (3108 genes)  IDA  
GO:0005737 [list] [network] cytoplasm  (4013 genes)  IDA  
GO:0005886 [list] [network] plasma membrane  (4337 genes)  IDA  
GO:0005829 [list] [network] cytosol  (4875 genes)  IDA TAS  
GO:0005634 [list] [network] nucleus  (5173 genes)  HDA IDA  
GO MF
GO:0004784 [list] [network] superoxide dismutase activity  (5 genes)  EXP IDA TAS  
GO:0030346 [list] [network] protein phosphatase 2B binding  (7 genes)  IDA  
GO:0048365 [list] [network] Rac GTPase binding  (50 genes)  IDA  
GO:0005507 [list] [network] copper ion binding  (54 genes)  IDA  
GO:0051087 [list] [network] chaperone binding  (90 genes)  IPI  
GO:0042803 [list] [network] protein homodimerization activity  (797 genes)  NAS  
GO:0008270 [list] [network] zinc ion binding  (798 genes)  IDA  
GO:0042802 [list] [network] identical protein binding  (1013 genes)  IPI  
GO:0005515 [list] [network] protein binding  (9334 genes)  IPI  
KEGG hsa04146 Peroxisome
hsa04213 Longevity regulating pathway - multiple species
hsa05014 Amyotrophic lateral sclerosis (ALS)
hsa05016 Huntington's disease
hsa05020 Prion diseases
Orthologous [Ortholog page] Sod1 (mmu)Sod1 (rno)sod1 (dre)Sod3 (dme)Sod1 (dme)sod-5 (cel)sod-1 (cel)sod-4 (cel)T01D3.3 (cel)SOD1 (gga)SOD1 (cfa)SOD1 (mcc)LOC693966 (mcc)SOD1 (sce)sod1 (spo)CG45546 (dme)
Subcellular
localization
cyto 7,  cyto_nucl 4,  extr 1  (predict for NP_000445.1)
Gene coexpression
Network*for
coexpressed
genes
LCNloc
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
hsa05016 Huntington's disease 8
hsa00190 Oxidative phosphorylation 7
hsa04714 Thermogenesis 7
hsa05010 Alzheimer's disease 7
hsa05012 Parkinson's disease 7
Genes directly connected with SOD1 on the network
MR* Locus Fuction* Coexpression
detail
Entrez Gene ID*
373.9 ATP5PF ATP synthase peripheral stalk subunit F6 [detail] 522
390.5 PRDX1 peroxiredoxin 1 [detail] 5052
519.8 ATP5PO ATP synthase peripheral stalk subunit OSCP [detail] 539
684.3 C21orf59 chromosome 21 open reading frame 59 [detail] 56683
1064.7 PEBP1 phosphatidylethanolamine binding protein 1 [detail] 5037
1239.4 CBR3 carbonyl reductase 3 [detail] 874
Coexpressed
gene list
[Coexpressed gene list for SOD1]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity* tissue specificity
Link to other DBs
Entrez Gene ID 6647    
Refseq ID (protein) NP_000445.1 


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