[][] gga TOP2A Gene 
functional annotation
Function   topoisomerase (DNA) II alpha
GO BP
GO:0006266 [list] [network] DNA ligation  (1 genes)  ISS  
GO:0030263 [list] [network] apoptotic chromosome condensation  (1 genes)  IBA ISS  
GO:1905463 [list] [network] negative regulation of DNA duplex unwinding  (1 genes)  ISS  
GO:0000819 [list] [network] sister chromatid segregation  (2 genes)  IBA  
GO:0006265 [list] [network] DNA topological change  (2 genes)  ISS  
GO:0044774 [list] [network] mitotic DNA integrity checkpoint  (2 genes)  IBA  
GO:0000712 [list] [network] resolution of meiotic recombination intermediates  (4 genes)  IBA  
GO:0007059 [list] [network] chromosome segregation  (9 genes)  ISS  
GO:0048511 [list] [network] rhythmic process  (11 genes)  IEA  
GO:0043065 [list] [network] positive regulation of apoptotic process  (17 genes)  ISS  
GO:0006260 [list] [network] DNA replication  (19 genes)  IDA  
GO:0006974 [list] [network] cellular response to DNA damage stimulus  (23 genes)  ISS  
GO:0008283 [list] [network] cell proliferation  (23 genes)  IDA  
GO CC
GO:0009330 [list] [network] DNA topoisomerase complex (ATP-hydrolyzing)  (1 genes)  ISS  
GO:0000792 [list] [network] heterochromatin  (3 genes)  IDA  
GO:0000793 [list] [network] condensed chromosome  (6 genes)  IDA  
GO:0030529 [list] [network] ribonucleoprotein complex  (10 genes)  ISS  
GO:0005694 [list] [network] chromosome  (16 genes)  IDA  
GO:0005654 [list] [network] nucleoplasm  (117 genes)  ISS  
GO:0005634 [list] [network] nucleus  (588 genes)  IDA ISS  
GO MF
GO:0003918 [list] [network] DNA topoisomerase type II (ATP-hydrolyzing) activity  (2 genes)  ISS  
GO:0030332 [list] [network] cyclin binding  (2 genes)  IPI  
GO:0008144 [list] [network] drug binding  (4 genes)  ISS  
GO:0008301 [list] [network] DNA binding, bending  (4 genes)  ISS  
GO:0008094 [list] [network] DNA-dependent ATPase activity  (6 genes)  ISS  
GO:0000287 [list] [network] magnesium ion binding  (25 genes)  ISS  
GO:0003677 [list] [network] DNA binding  (163 genes)  ISS  
GO:0005524 [list] [network] ATP binding  (211 genes)  IEA  
KEGG
Orthologous [Ortholog page] TOP2A (hsa)TOP2B (hsa)Top2a (mmu)Top2b (mmu)Top2 (dme)top-2 (cel)cin-4 (cel)R05D3.12 (cel)top2a (dre)Top2a (rno)Top2b (rno)TOP2B (gga)TOP2B (cfa)TOP2A (cfa)top2b (dre)TOP2B (mcc)TOP2A (mcc)TOP2 (sce)top2 (spo)
Subcellular
localization
nucl 6,  cyto_nucl 5,  cyto 3,  cyto_mito 2  (predict for NP_990122.1)
Gene coexpression
Network*for
coexpressed
genes
LCNloc
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
gga04110 Cell cycle 6
gga04914 Progesterone-mediated oocyte maturation 4
gga04114 Oocyte meiosis 4
gga04068 FoxO signaling pathway 3
gga04218 Cellular senescence 3
Genes directly connected with TOP2A on the network
MR* Locus Fuction* Coexpression
detail
Entrez Gene ID*
40.4 PLK1 polo like kinase 1 [detail] 416575
74.3 KPNA2 karyopherin subunit alpha 2 [detail] 417420
83.8 RRM2 ribonucleotide reductase regulatory subunit M2 [detail] 421936
316.6 RRM1 ribonucleotide reductase catalytic subunit M1 [detail] 419081
394.4 NCAPD2 non-SMC condensin I complex subunit D2 [detail] 418275
565.8 CCDC15 coiled-coil domain containing 15 [detail] 419705
1053.0 SPIDR scaffolding protein involved in DNA repair [detail] 421107
Coexpressed
gene list
[Coexpressed gene list for TOP2A]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity*
Link to other DBs
Entrez Gene ID 395570    
Refseq ID (protein) NP_990122.1 


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