[][] rno Top2a Gene 
functional annotation
Function   DNA topoisomerase II alpha
GO:0045870 [list] [network] positive regulation of single stranded viral RNA replication via double stranded DNA intermediate  (1 genes)  IEA ISO  
GO:1905463 [list] [network] negative regulation of DNA duplex unwinding  (1 genes)  IEA ISO ISS  
GO:0000819 [list] [network] sister chromatid segregation  (2 genes)  IBA  
GO:0044774 [list] [network] mitotic DNA integrity checkpoint  (2 genes)  IBA  
GO:0006266 [list] [network] DNA ligation  (5 genes)  IEA ISO  
GO:0030263 [list] [network] apoptotic chromosome condensation  (5 genes)  IBA IEA ISO  
GO:0071107 [list] [network] response to parathyroid hormone  (7 genes)  IEP  
GO:0040016 [list] [network] embryonic cleavage  (9 genes)  IEA ISO  
GO:0006265 [list] [network] DNA topological change  (10 genes)  IDA IEA ISO  
GO:0030261 [list] [network] chromosome condensation  (10 genes)  ISO  
GO:0021707 [list] [network] cerebellar granule cell differentiation  (11 genes)  IEP  
GO:0000712 [list] [network] resolution of meiotic recombination intermediates  (13 genes)  IBA  
GO:0021702 [list] [network] cerebellar Purkinje cell differentiation  (14 genes)  IEP  
GO:0045070 [list] [network] positive regulation of viral genome replication  (25 genes)  ISO  
GO:0048511 [list] [network] rhythmic process  (30 genes)  IEA  
GO:0042752 [list] [network] regulation of circadian rhythm  (48 genes)  IEA ISO ISS  
GO:0007059 [list] [network] chromosome segregation  (65 genes)  IEA ISO  
GO:0010212 [list] [network] response to ionizing radiation  (67 genes)  IEP  
GO:0002244 [list] [network] hematopoietic progenitor cell differentiation  (89 genes)  IEA ISO  
GO:0006974 [list] [network] cellular response to DNA damage stimulus  (242 genes)  IEA ISO  
GO:0007420 [list] [network] brain development  (308 genes)  IEP  
GO:0007568 [list] [network] aging  (319 genes)  IEP  
GO:0043065 [list] [network] positive regulation of apoptotic process  (348 genes)  IEA ISO  
GO:0042493 [list] [network] response to drug  (523 genes)  IEP  
GO:0045944 [list] [network] positive regulation of transcription by RNA polymerase II  (1110 genes)  IEA ISO  
GO:0009330 [list] [network] DNA topoisomerase complex (ATP-hydrolyzing)  (2 genes)  IDA IEA ISO  
GO:0000228 [list] [network] nuclear chromosome  (31 genes)  IEA ISO  
GO:0000793 [list] [network] condensed chromosome  (38 genes)  IEA ISO  
GO:0005814 [list] [network] centriole  (105 genes)  IEA ISO  
GO:0030529 [list] [network] ribonucleoprotein complex  (127 genes)  IEA ISO ISS  
GO:0043234 [list] [network] protein-containing complex  (760 genes)  ISO  
GO:0005730 [list] [network] nucleolus  (813 genes)  IDA IEA ISO  
GO:0005654 [list] [network] nucleoplasm  (1897 genes)  IEA ISO  
GO:0005634 [list] [network] nucleus  (4802 genes)  IDA ISO  
GO:0003916 [list] [network] DNA topoisomerase activity  (3 genes)  IDA  
GO:0003918 [list] [network] DNA topoisomerase type II (ATP-hydrolyzing) activity  (3 genes)  IDA IEA ISO  
GO:0008301 [list] [network] DNA binding, bending  (18 genes)  IEA ISO ISS  
GO:0008094 [list] [network] DNA-dependent ATPase activity  (36 genes)  ISO  
GO:0005080 [list] [network] protein kinase C binding  (54 genes)  IEA ISO  
GO:0043130 [list] [network] ubiquitin binding  (67 genes)  IEA ISO  
GO:0008144 [list] [network] drug binding  (111 genes)  IEA ISO  
GO:0042826 [list] [network] histone deacetylase binding  (118 genes)  IEA ISO  
GO:0000287 [list] [network] magnesium ion binding  (209 genes)  IEA ISO ISS  
GO:0008022 [list] [network] protein C-terminus binding  (225 genes)  IEA ISO  
GO:0019899 [list] [network] enzyme binding  (410 genes)  ISO  
GO:0003682 [list] [network] chromatin binding  (462 genes)  IDA IEA ISO  
GO:0043565 [list] [network] sequence-specific DNA binding  (555 genes)  IDA  
GO:0046982 [list] [network] protein heterodimerization activity  (593 genes)  IEA ISO  
GO:0042803 [list] [network] protein homodimerization activity  (878 genes)  IEA ISO  
GO:0003677 [list] [network] DNA binding  (1016 genes)  IDA IEA ISO TAS  
GO:0003723 [list] [network] RNA binding  (1366 genes)  IEA ISO  
GO:0005524 [list] [network] ATP binding  (1374 genes)  IDA IEA TAS  
KEGG rno01524 Platinum drug resistance
Orthologous [Ortholog page] TOP2A (hsa)TOP2B (hsa)Top2a (mmu)Top2b (mmu)Top2 (dme)top-2 (cel)cin-4 (cel)R05D3.12 (cel)top2a (dre)Top2b (rno)TOP2A (gga)TOP2B (gga)TOP2B (cfa)TOP2A (cfa)top2b (dre)TOP2B (mcc)TOP2A (mcc)TOP2 (sce)top2 (spo)
nucl 6,  cyto_nucl 5,  cyto 4,  cyto_mito 2  (predict for NP_071519.2)
Gene coexpression
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
rno04110 Cell cycle 3
rno04914 Progesterone-mediated oocyte maturation 3
rno04218 Cellular senescence 2
rno05169 Epstein-Barr virus infection 2
rno05203 Viral carcinogenesis 2
Genes directly connected with Top2a on the network
MR* Locus Fuction* Coexpression
Entrez Gene ID*
3.9 Nusap1 nucleolar and spindle associated protein 1 [detail] 311336
8.8 Depdc1 DEP domain containing 1 [detail] 295538
10.7 Pbk PDZ binding kinase [detail] 290326
20.8 Mki67 marker of proliferation Ki-67 [detail] 291234
21.8 Racgap1 Rac GTPase-activating protein 1 [detail] 315298
40.5 Spc25 SPC25, NDC80 kinetochore complex component [detail] 295661
gene list
[Coexpressed gene list for Top2a]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity*
Link to other DBs
Entrez Gene ID 360243    
Refseq ID (protein) NP_071519.2 

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