[][] rno Zap70 Gene 
functional annotation
Function   zeta chain of T cell receptor associated protein kinase 70
GO BP
GO:0043366 [list] [network] beta selection  (3 genes)  IEA ISO  
GO:0045061 [list] [network] thymic T cell selection  (5 genes)  ISO  
GO:0046638 [list] [network] positive regulation of alpha-beta T cell differentiation  (10 genes)  IEA ISO  
GO:0046641 [list] [network] positive regulation of alpha-beta T cell proliferation  (11 genes)  IEA ISO  
GO:0045059 [list] [network] positive thymic T cell selection  (12 genes)  IEA ISO  
GO:0045060 [list] [network] negative thymic T cell selection  (14 genes)  IEA ISO  
GO:0045582 [list] [network] positive regulation of T cell differentiation  (22 genes)  ISO  
GO:0050850 [list] [network] positive regulation of calcium-mediated signaling  (23 genes)  IEA ISO  
GO:0050852 [list] [network] T cell receptor signaling pathway  (47 genes)  IEA ISO  
GO:0018108 [list] [network] peptidyl-tyrosine phosphorylation  (111 genes)  IEA ISO  
GO:0046777 [list] [network] protein autophosphorylation  (181 genes)  IEA ISO  
GO:0006955 [list] [network] immune response  (219 genes)  ISO  
GO:0035556 [list] [network] intracellular signal transduction  (408 genes)  IEA ISO  
GO:0006468 [list] [network] protein phosphorylation  (485 genes)  ISO  
GO CC
GO:0042101 [list] [network] T cell receptor complex  (14 genes)  ISO  
GO:0001772 [list] [network] immunological synapse  (34 genes)  IEA ISO  
GO:0005911 [list] [network] cell-cell junction  (180 genes)  IEA ISO  
GO:0045121 [list] [network] membrane raft  (292 genes)  ISO  
GO:0016020 [list] [network] membrane  (2183 genes)  ISO  
GO:0005829 [list] [network] cytosol  (3046 genes)  IEA ISO  
GO:0005886 [list] [network] plasma membrane  (4100 genes)  ISO  
GO:0005737 [list] [network] cytoplasm  (4459 genes)  ISO  
GO MF
GO:0001784 [list] [network] phosphotyrosine residue binding  (38 genes)  ISO  
GO:0004715 [list] [network] non-membrane spanning protein tyrosine kinase activity  (46 genes)  IEA  
GO:0004713 [list] [network] protein tyrosine kinase activity  (75 genes)  ISO  
GO:0004672 [list] [network] protein kinase activity  (271 genes)  ISO  
GO:0005524 [list] [network] ATP binding  (1374 genes)  IEA ISO  
KEGG rno04014 Ras signaling pathway
rno04064 NF-kappa B signaling pathway
rno04650 Natural killer cell mediated cytotoxicity
rno04658 Th1 and Th2 cell differentiation
rno04659 Th17 cell differentiation
rno04660 T cell receptor signaling pathway
rno05340 Primary immunodeficiency
Orthologous [Ortholog page] SYK (hsa)ZAP70 (hsa)Syk (mmu)Zap70 (mmu)Syk (rno)Shark (dme)ZK622.1 (cel)syk (dre)ZAP70 (gga)SYK (gga)SYK (cfa)zap70 (dre)SYK (mcc)LOC707555 (mcc)ZAP70 (cfa)LOC100910488 (rno)
Subcellular
localization
cyto 6,  cyto_nucl 3,  cyto_pero 3,  nucl 1,  pero 1,  plas 1  (predict for NP_001012002.1)
cyto 3,  cyto_mito 3,  cyto_nucl 2,  plas 2,  mito 2,  E.R._mito 1,  mito_pero 1,  nucl 1,  cysk_plas 1  (predict for XP_006244823.1)
cyto 6,  cyto_nucl 3,  cyto_pero 3,  nucl 1,  pero 1,  plas 1  (predict for XP_008765220.1)
Gene coexpression
Network*for
coexpressed
genes
LCNloc
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
rno04660 T cell receptor signaling pathway 9
rno04640 Hematopoietic cell lineage 7
rno04658 Th1 and Th2 cell differentiation 6
rno04659 Th17 cell differentiation 6
rno05340 Primary immunodeficiency 6
Genes directly connected with Zap70 on the network
MR* Locus Fuction* Coexpression
detail
Entrez Gene ID*
59.5 Cd3d CD3d molecule [detail] 25710
103.9 Cd2 Cd2 molecule [detail] 497761
199.9 Cd3e CD3e molecule [detail] 315609
286.9 Itgb7 integrin subunit beta 7 [detail] 25713
Coexpressed
gene list
[Coexpressed gene list for Zap70]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity*
Link to other DBs
Entrez Gene ID 301348    
Refseq ID (protein) NP_001012002.1 
XP_006244823.1 
XP_008765220.1 


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