[][] rno Syk Gene 
functional annotation
Function   spleen associated tyrosine kinase
GO BP
GO:0032928 [list] [network] regulation of superoxide anion generation  (1 genes)  IEA ISO ISS  
GO:0042991 [list] [network] obsolete transcription factor import into nucleus  (1 genes)  IEA ISO  
GO:0090237 [list] [network] regulation of arachidonic acid secretion  (1 genes)  IEA ISO ISS  
GO:0002366 [list] [network] leukocyte activation involved in immune response  (2 genes)  ISO ISS  
GO:0043313 [list] [network] regulation of neutrophil degranulation  (2 genes)  IEA ISO ISS  
GO:0045401 [list] [network] positive regulation of interleukin-3 biosynthetic process  (2 genes)  IEA ISO  
GO:0045425 [list] [network] positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process  (2 genes)  IEA ISO  
GO:0071226 [list] [network] cellular response to molecule of fungal origin  (2 genes)  IEA ISO ISS  
GO:0001820 [list] [network] serotonin secretion  (3 genes)  ISO  
GO:0002283 [list] [network] neutrophil activation involved in immune response  (3 genes)  IBA IEA ISO ISS  
GO:0002554 [list] [network] serotonin secretion by platelet  (3 genes)  IEA ISO ISS  
GO:0043366 [list] [network] beta selection  (3 genes)  IEA ISO  
GO:0090330 [list] [network] regulation of platelet aggregation  (5 genes)  IBA IEA ISO ISS  
GO:0010543 [list] [network] regulation of platelet activation  (6 genes)  ISO ISS  
GO:1900086 [list] [network] positive regulation of peptidyl-tyrosine autophosphorylation  (6 genes)  IEA ISO  
GO:0007167 [list] [network] enzyme linked receptor protein signaling pathway  (7 genes)  ISO  
GO:0010803 [list] [network] regulation of tumor necrosis factor-mediated signaling pathway  (7 genes)  IEA ISO  
GO:0038096 [list] [network] Fc-gamma receptor signaling pathway involved in phagocytosis  (7 genes)  TAS  
GO:0045588 [list] [network] positive regulation of gamma-delta T cell differentiation  (7 genes)  IEA ISO  
GO:0050764 [list] [network] regulation of phagocytosis  (9 genes)  IEA ISO ISS  
GO:0002281 [list] [network] macrophage activation involved in immune response  (10 genes)  IBA IEA ISO ISS  
GO:0046638 [list] [network] positive regulation of alpha-beta T cell differentiation  (10 genes)  IEA ISO  
GO:0019370 [list] [network] leukotriene biosynthetic process  (11 genes)  IEA ISO  
GO:0038063 [list] [network] collagen-activated tyrosine kinase receptor signaling pathway  (11 genes)  IEA ISO  
GO:0038095 [list] [network] Fc-epsilon receptor signaling pathway  (11 genes)  TAS  
GO:0046641 [list] [network] positive regulation of alpha-beta T cell proliferation  (11 genes)  IBA IEA ISO  
GO:0001945 [list] [network] lymph vessel development  (13 genes)  IEA ISO ISS  
GO:0033630 [list] [network] positive regulation of cell adhesion mediated by integrin  (14 genes)  IBA IEA ISO ISS  
GO:0045579 [list] [network] positive regulation of B cell differentiation  (15 genes)  IBA IEA ISO  
GO:0051090 [list] [network] regulation of DNA-binding transcription factor activity  (15 genes)  IEA ISO  
GO:0071404 [list] [network] cellular response to low-density lipoprotein particle stimulus  (15 genes)  IEA ISO ISS  
GO:0032481 [list] [network] positive regulation of type I interferon production  (17 genes)  IEA ISO  
GO:0043306 [list] [network] positive regulation of mast cell degranulation  (17 genes)  IEA IMP ISO  
GO:0045780 [list] [network] positive regulation of bone resorption  (23 genes)  IEA ISO ISS  
GO:0050850 [list] [network] positive regulation of calcium-mediated signaling  (23 genes)  IEA ISO  
GO:0007159 [list] [network] leukocyte cell-cell adhesion  (27 genes)  IEA ISO ISS  
GO:0002092 [list] [network] positive regulation of receptor internalization  (28 genes)  IEA ISO  
GO:0050776 [list] [network] regulation of immune response  (28 genes)  IDA  
GO:0050715 [list] [network] positive regulation of cytokine secretion  (33 genes)  IEA ISO  
GO:0007257 [list] [network] activation of JUN kinase activity  (34 genes)  IEA ISO  
GO:0050853 [list] [network] B cell receptor signaling pathway  (34 genes)  IBA IEA ISO ISS  
GO:0048514 [list] [network] blood vessel morphogenesis  (35 genes)  IEA ISO ISS  
GO:0070372 [list] [network] regulation of ERK1 and ERK2 cascade  (35 genes)  IEA ISO ISS  
GO:0031623 [list] [network] receptor internalization  (42 genes)  IEA ISO ISS  
GO:0038083 [list] [network] peptidyl-tyrosine autophosphorylation  (47 genes)  IBA  
GO:0030593 [list] [network] neutrophil chemotaxis  (58 genes)  IEA ISO ISS  
GO:0002250 [list] [network] adaptive immune response  (74 genes)  IBA ISS  
GO:0000187 [list] [network] activation of MAPK activity  (83 genes)  ISO  
GO:0007169 [list] [network] transmembrane receptor protein tyrosine kinase signaling pathway  (86 genes)  IBA  
GO:0007229 [list] [network] integrin-mediated signaling pathway  (89 genes)  IEA ISO ISS  
GO:0050731 [list] [network] positive regulation of peptidyl-tyrosine phosphorylation  (106 genes)  ISO  
GO:0018108 [list] [network] peptidyl-tyrosine phosphorylation  (111 genes)  IEA ISO  
GO:0042742 [list] [network] defense response to bacterium  (128 genes)  IEA ISO ISS  
GO:0018105 [list] [network] peptidyl-serine phosphorylation  (150 genes)  IEA ISO  
GO:0007166 [list] [network] cell surface receptor signaling pathway  (157 genes)  ISO  
GO:0046777 [list] [network] protein autophosphorylation  (181 genes)  IDA IEA ISO  
GO:0001525 [list] [network] angiogenesis  (185 genes)  IEA  
GO:0016477 [list] [network] cell migration  (210 genes)  IBA  
GO:0045087 [list] [network] innate immune response  (257 genes)  IBA IEA ISO ISS  
GO:0006954 [list] [network] inflammatory response  (279 genes)  IBA  
GO:0035556 [list] [network] intracellular signal transduction  (408 genes)  IEA ISO  
GO:0030154 [list] [network] cell differentiation  (414 genes)  IBA  
GO:0006468 [list] [network] protein phosphorylation  (485 genes)  ISO ISS  
GO CC
GO:0019815 [list] [network] B cell receptor complex  (4 genes)  IEA ISO  
GO:0032009 [list] [network] early phagosome  (8 genes)  IEA ISO ISS  
GO:0042101 [list] [network] T cell receptor complex  (14 genes)  IEA ISO  
GO:0031234 [list] [network] extrinsic component of cytoplasmic side of plasma membrane  (75 genes)  IBA  
GO:0043234 [list] [network] protein-containing complex  (760 genes)  ISO  
GO:0005829 [list] [network] cytosol  (3046 genes)  TAS  
GO:0005737 [list] [network] cytoplasm  (4459 genes)  IEA ISO  
GO:0005634 [list] [network] nucleus  (4802 genes)  IEA ISO  
GO MF
GO:0035325 [list] [network] Toll-like receptor binding  (7 genes)  IEA ISO  
GO:0004716 [list] [network] obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity  (9 genes)  IEA ISO  
GO:0042169 [list] [network] SH2 domain binding  (33 genes)  IEA ISO  
GO:0001784 [list] [network] phosphotyrosine residue binding  (38 genes)  IEA ISO  
GO:0004715 [list] [network] non-membrane spanning protein tyrosine kinase activity  (46 genes)  IBA IEA ISO ISS  
GO:0019902 [list] [network] phosphatase binding  (54 genes)  IEA ISO  
GO:0004713 [list] [network] protein tyrosine kinase activity  (75 genes)  EXP ISO  
GO:0005178 [list] [network] integrin binding  (104 genes)  IEA ISO  
GO:0004672 [list] [network] protein kinase activity  (271 genes)  IDA ISO  
GO:0004674 [list] [network] protein serine/threonine kinase activity  (313 genes)  IEA ISO  
GO:0031625 [list] [network] ubiquitin protein ligase binding  (317 genes)  IPI  
GO:0019904 [list] [network] protein domain specific binding  (347 genes)  IMP  
GO:0005102 [list] [network] signaling receptor binding  (372 genes)  IBA  
GO:0019901 [list] [network] protein kinase binding  (468 genes)  IEA ISO  
GO:0005524 [list] [network] ATP binding  (1374 genes)  IEA ISO  
GO:0005515 [list] [network] protein binding  (1646 genes)  IPI  
KEGG rno04064 NF-kappa B signaling pathway
rno04072 Phospholipase D signaling pathway
rno04151 PI3K-Akt signaling pathway
rno04380 Osteoclast differentiation
rno04611 Platelet activation
rno04650 Natural killer cell mediated cytotoxicity
rno04662 B cell receptor signaling pathway
rno04664 Fc epsilon RI signaling pathway
rno04666 Fc gamma R-mediated phagocytosis
rno05152 Tuberculosis
rno05167 Kaposi's sarcoma-associated herpesvirus infection
rno05169 Epstein-Barr virus infection
rno05203 Viral carcinogenesis
Orthologous [Ortholog page] SYK (hsa)ZAP70 (hsa)Syk (mmu)Zap70 (mmu)Shark (dme)ZK622.1 (cel)Zap70 (rno)syk (dre)ZAP70 (gga)SYK (gga)SYK (cfa)zap70 (dre)SYK (mcc)LOC707555 (mcc)ZAP70 (cfa)LOC100910488 (rno)
Subcellular
localization
cyto 7,  cyto_nucl 5,  nucl 1,  pero 1  (predict for NP_036890.1)
Gene coexpression
Network*for
coexpressed
genes
LCNloc
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
rno04662 B cell receptor signaling pathway 4
rno04664 Fc epsilon RI signaling pathway 4
rno05100 Bacterial invasion of epithelial cells 3
rno04380 Osteoclast differentiation 3
rno04611 Platelet activation 3
Genes directly connected with Syk on the network
MR* Locus Fuction* Coexpression
detail
Entrez Gene ID*
78.7 Hcls1 hematopoietic cell specific Lyn substrate 1 [detail] 288077
91.5 Arhgap4 Rho GTPase activating protein 4 [detail] 246249
97.1 Btk Bruton tyrosine kinase [detail] 367901
118.7 Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta [detail] 366508
163.5 Inpp5d inositol polyphosphate-5-phosphatase D [detail] 54259
237.9 Arhgap45 Rho GTPase activating protein 45 [detail] 314618
269.9 Zfp710 zinc finger protein 710 [detail] 293044
320.4 Ptpn7 protein tyrosine phosphatase, non-receptor type 7 [detail] 246781
419.8 Sh3bp1 SH3-domain binding protein 1 [detail] 300067
504.5 Pla2g2d phospholipase A2, group IID [detail] 298579
511.4 Gmip Gem-interacting protein [detail] 306357
523.4 Ppp1r18 protein phosphatase 1, regulatory subunit 18 [detail] 361790
540.3 RGD1561145 similar to novel protein [detail] 498580
941.2 Slc12a6 solute carrier family 12, member 6 [detail] 691209
1144.7 Dock8 dedicator of cytokinesis 8 [detail] 499337
Coexpressed
gene list
[Coexpressed gene list for Syk]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity*
Link to other DBs
Entrez Gene ID 25155    
Refseq ID (protein) NP_036890.1 


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