[][] mmu Zap70 Gene 
functional annotation
Function   zeta-chain (TCR) associated protein kinase
GO BP
GO:0043366 [list] [network] beta selection  (3 genes)  IGI  
GO:0045061 [list] [network] thymic T cell selection  (5 genes)  IMP  
GO:0046638 [list] [network] positive regulation of alpha-beta T cell differentiation  (10 genes)  IGI IMP  
GO:0045059 [list] [network] positive thymic T cell selection  (11 genes)  IMP ISO  
GO:0046641 [list] [network] positive regulation of alpha-beta T cell proliferation  (11 genes)  IGI  
GO:0045060 [list] [network] negative thymic T cell selection  (14 genes)  IMP  
GO:0045582 [list] [network] positive regulation of T cell differentiation  (19 genes)  IMP ISO  
GO:0050850 [list] [network] positive regulation of calcium-mediated signaling  (22 genes)  IMP  
GO:0050852 [list] [network] T cell receptor signaling pathway  (42 genes)  IMP  
GO:0038083 [list] [network] peptidyl-tyrosine autophosphorylation  (48 genes)  IBA  
GO:0018108 [list] [network] peptidyl-tyrosine phosphorylation  (68 genes)  IDA IMP ISO  
GO:0007169 [list] [network] transmembrane receptor protein tyrosine kinase signaling pathway  (100 genes)  IBA  
GO:0002250 [list] [network] adaptive immune response  (146 genes)  IEA  
GO:0046777 [list] [network] protein autophosphorylation  (175 genes)  IDA IMP  
GO:0016477 [list] [network] cell migration  (196 genes)  IBA  
GO:0006955 [list] [network] immune response  (303 genes)  ISO  
GO:0035556 [list] [network] intracellular signal transduction  (394 genes)  IMP  
GO:0002376 [list] [network] immune system process  (425 genes)  IEA  
GO:0045087 [list] [network] innate immune response  (518 genes)  IBA  
GO:0006468 [list] [network] protein phosphorylation  (545 genes)  IDA ISO  
GO:0016310 [list] [network] phosphorylation  (607 genes)  IEA  
GO CC
GO:0042101 [list] [network] T cell receptor complex  (15 genes)  ISO  
GO:0031234 [list] [network] extrinsic component of cytoplasmic side of plasma membrane  (73 genes)  IBA  
GO:0005911 [list] [network] cell-cell junction  (174 genes)  IDA  
GO:0045121 [list] [network] membrane raft  (255 genes)  ISO  
GO:0005829 [list] [network] cytosol  (2800 genes)  IDA  
GO:0005886 [list] [network] plasma membrane  (3773 genes)  ISO  
GO:0016020 [list] [network] membrane  (6374 genes)  IDA  
GO MF
GO:0001784 [list] [network] phosphotyrosine residue binding  (39 genes)  IPI  
GO:0004715 [list] [network] non-membrane spanning protein tyrosine kinase activity  (49 genes)  IBA  
GO:0004713 [list] [network] protein tyrosine kinase activity  (115 genes)  IDA IMP ISO  
GO:0005102 [list] [network] signaling receptor binding  (398 genes)  IBA  
GO:0004672 [list] [network] protein kinase activity  (505 genes)  IDA  
GO:0016301 [list] [network] kinase activity  (614 genes)  IEA  
GO:0005524 [list] [network] ATP binding  (1368 genes)  IDA  
GO:0016740 [list] [network] transferase activity  (1664 genes)  IEA  
GO:0000166 [list] [network] nucleotide binding  (1666 genes)  IEA  
GO:0005515 [list] [network] protein binding  (4163 genes)  IPI  
KEGG mmu04014 Ras signaling pathway
mmu04064 NF-kappa B signaling pathway
mmu04650 Natural killer cell mediated cytotoxicity
mmu04658 Th1 and Th2 cell differentiation
mmu04659 Th17 cell differentiation
mmu04660 T cell receptor signaling pathway
mmu05340 Primary immunodeficiency
Orthologous [Ortholog page] SYK (hsa)ZAP70 (hsa)Syk (mmu)Syk (rno)Shark (dme)ZK622.1 (cel)Zap70 (rno)syk (dre)ZAP70 (gga)SYK (gga)SYK (cfa)zap70 (dre)SYK (mcc)LOC707555 (mcc)ZAP70 (cfa)LOC100910488 (rno)
Subcellular
localization
cyto 3,  cyto_mito 2,  nucl 2,  pero 2,  plas 1,  extr 1,  extr_plas 1  (predict for NP_001276541.1)
cyto 5,  cyto_pero 3,  cyto_nucl 3,  pero 2,  plas 1,  nucl 1,  extr_plas 1  (predict for NP_001276694.1)
plas 3,  cyto 2,  mito 2,  cysk_plas 2,  cyto_nucl 1,  mito_pero 1,  cyto_pero 1,  mito_nucl 1  (predict for NP_001276695.1)
cyto 5,  cyto_pero 3,  cyto_nucl 3,  pero 2,  plas 1,  nucl 1,  extr_plas 1  (predict for NP_033565.2)
cyto 5,  cyto_pero 3,  cyto_nucl 3,  pero 2,  plas 1,  nucl 1,  extr_plas 1  (predict for XP_006495959.1)
Gene coexpression
Network*for
coexpressed
genes
LCNloc
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
mmu04660 T cell receptor signaling pathway 7
mmu04658 Th1 and Th2 cell differentiation 5
mmu04659 Th17 cell differentiation 5
mmu05340 Primary immunodeficiency 5
mmu04650 Natural killer cell mediated cytotoxicity 4
Genes directly connected with Zap70 on the network
MR* Locus Fuction* Coexpression
detail
Entrez Gene ID*
119.3 Sh2d2a SH2 domain containing 2A [detail] 27371
210.3 Tcrb-J T cell receptor beta, joining region [detail] 21580
250.5 Lck lymphocyte protein tyrosine kinase [detail] 16818
675.9 Pglyrp2 peptidoglycan recognition protein 2 [detail] 57757
1068.1 Tlr12 toll-like receptor 12 [detail] 384059
Coexpressed
gene list
[Coexpressed gene list for Zap70]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity* tissue specificity
Link to other DBs
Entrez Gene ID 22637    
Refseq ID (protein) NP_001276541.1 
NP_001276694.1 
NP_001276695.1 
NP_033565.2 
XP_006495959.1 


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