[][] mmu Syk Gene 
functional annotation
Function   spleen tyrosine kinase
GO:0042991 [list] [network] obsolete transcription factor import into nucleus  (2 genes)  ISO  
GO:0043366 [list] [network] beta selection  (3 genes)  IGI  
GO:0045401 [list] [network] positive regulation of interleukin-3 biosynthetic process  (3 genes)  IMP  
GO:0045425 [list] [network] positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process  (3 genes)  IMP  
GO:0001820 [list] [network] serotonin secretion  (4 genes)  IMP  
GO:0045588 [list] [network] positive regulation of gamma-delta T cell differentiation  (5 genes)  IMP  
GO:1900086 [list] [network] positive regulation of peptidyl-tyrosine autophosphorylation  (6 genes)  IMP  
GO:0010803 [list] [network] regulation of tumor necrosis factor-mediated signaling pathway  (7 genes)  ISO  
GO:0007167 [list] [network] enzyme linked receptor protein signaling pathway  (8 genes)  IDA  
GO:0046638 [list] [network] positive regulation of alpha-beta T cell differentiation  (10 genes)  IGI  
GO:0038063 [list] [network] collagen-activated tyrosine kinase receptor signaling pathway  (11 genes)  IMP  
GO:0046641 [list] [network] positive regulation of alpha-beta T cell proliferation  (11 genes)  IGI  
GO:0051090 [list] [network] regulation of DNA-binding transcription factor activity  (11 genes)  ISO  
GO:0019370 [list] [network] leukotriene biosynthetic process  (12 genes)  IMP  
GO:0045579 [list] [network] positive regulation of B cell differentiation  (12 genes)  IMP ISO  
GO:0032481 [list] [network] positive regulation of type I interferon production  (15 genes)  IMP  
GO:0043306 [list] [network] positive regulation of mast cell degranulation  (15 genes)  IMP ISO  
GO:0050850 [list] [network] positive regulation of calcium-mediated signaling  (22 genes)  IMP  
GO:0007159 [list] [network] leukocyte cell-cell adhesion  (24 genes)  ISO  
GO:0002092 [list] [network] positive regulation of receptor internalization  (25 genes)  IMP  
GO:0050715 [list] [network] positive regulation of cytokine secretion  (27 genes)  IGI  
GO:0050776 [list] [network] regulation of immune response  (27 genes)  ISO  
GO:0007257 [list] [network] activation of JUN kinase activity  (35 genes)  IMP  
GO:0030593 [list] [network] neutrophil chemotaxis  (62 genes)  ISO  
GO:0018108 [list] [network] peptidyl-tyrosine phosphorylation  (68 genes)  IDA  
GO:0000187 [list] [network] activation of MAPK activity  (74 genes)  IDA IMP  
GO:0050731 [list] [network] positive regulation of peptidyl-tyrosine phosphorylation  (105 genes)  IMP  
GO:0002250 [list] [network] adaptive immune response  (146 genes)  IBA  
GO:0018105 [list] [network] peptidyl-serine phosphorylation  (152 genes)  IDA  
GO:0050853 [list] [network] B cell receptor signaling pathway  (156 genes)  IDA  
GO:0046777 [list] [network] protein autophosphorylation  (175 genes)  IDA ISO  
GO:0007166 [list] [network] cell surface receptor signaling pathway  (178 genes)  IDA IMP  
GO:0016477 [list] [network] cell migration  (196 genes)  IBA  
GO:0001525 [list] [network] angiogenesis  (217 genes)  IEA  
GO:0035556 [list] [network] intracellular signal transduction  (394 genes)  IDA IMP  
GO:0002376 [list] [network] immune system process  (425 genes)  IEA  
GO:0006468 [list] [network] protein phosphorylation  (545 genes)  ISO  
GO:0016310 [list] [network] phosphorylation  (607 genes)  IEA  
GO:0007186 [list] [network] G-protein coupled receptor signaling pathway  (1671 genes)  TAS  
GO:0019815 [list] [network] B cell receptor complex  (7 genes)  IDA  
GO:0042101 [list] [network] T cell receptor complex  (15 genes)  ISO  
GO:0031234 [list] [network] extrinsic component of cytoplasmic side of plasma membrane  (73 genes)  IBA  
GO:0031410 [list] [network] cytoplasmic vesicle  (698 genes)  IEA  
GO:0043234 [list] [network] protein-containing complex  (748 genes)  IDA ISO  
GO:0005886 [list] [network] plasma membrane  (3773 genes)  IEA  
GO:0005634 [list] [network] nucleus  (5524 genes)  ISO  
GO:0005737 [list] [network] cytoplasm  (6086 genes)  ISO  
GO:0016020 [list] [network] membrane  (6374 genes)  IEA  
GO:0004716 [list] [network] obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity  (7 genes)  IDA  
GO:0042169 [list] [network] SH2 domain binding  (33 genes)  IDA  
GO:0001784 [list] [network] phosphotyrosine residue binding  (39 genes)  ISO  
GO:0004715 [list] [network] non-membrane spanning protein tyrosine kinase activity  (49 genes)  IDA ISO  
GO:0019902 [list] [network] phosphatase binding  (50 genes)  IPI  
GO:0005178 [list] [network] integrin binding  (103 genes)  ISO  
GO:0004713 [list] [network] protein tyrosine kinase activity  (115 genes)  IDA ISO  
GO:0031625 [list] [network] ubiquitin protein ligase binding  (300 genes)  ISO  
GO:0019904 [list] [network] protein domain specific binding  (326 genes)  ISO  
GO:0004674 [list] [network] protein serine/threonine kinase activity  (392 genes)  ISO  
GO:0004672 [list] [network] protein kinase activity  (505 genes)  ISO  
GO:0016301 [list] [network] kinase activity  (614 genes)  IEA  
GO:0005524 [list] [network] ATP binding  (1368 genes)  IDA  
GO:0016740 [list] [network] transferase activity  (1664 genes)  IEA  
GO:0000166 [list] [network] nucleotide binding  (1666 genes)  IEA  
GO:0005515 [list] [network] protein binding  (4163 genes)  IPI  
KEGG mmu04064 NF-kappa B signaling pathway
mmu04072 Phospholipase D signaling pathway
mmu04151 PI3K-Akt signaling pathway
mmu04380 Osteoclast differentiation
mmu04611 Platelet activation
mmu04650 Natural killer cell mediated cytotoxicity
mmu04662 B cell receptor signaling pathway
mmu04664 Fc epsilon RI signaling pathway
mmu04666 Fc gamma R-mediated phagocytosis
mmu05152 Tuberculosis
mmu05167 Kaposi's sarcoma-associated herpesvirus infection
mmu05169 Epstein-Barr virus infection
mmu05203 Viral carcinogenesis
Orthologous [Ortholog page] SYK (hsa)ZAP70 (hsa)Zap70 (mmu)Syk (rno)Shark (dme)ZK622.1 (cel)Zap70 (rno)syk (dre)ZAP70 (gga)SYK (gga)SYK (cfa)zap70 (dre)SYK (mcc)LOC707555 (mcc)ZAP70 (cfa)LOC100910488 (rno)
cyto 6,  cyto_nucl 5,  nucl 2,  pero 1  (predict for NP_001185906.1)
cyto 6,  cyto_nucl 5,  nucl 2,  pero 1  (predict for NP_035648.2)
cyto 6,  cyto_nucl 5,  nucl 2,  pero 1  (predict for XP_006516958.1)
cyto 6,  cyto_nucl 5,  nucl 2,  pero 1  (predict for XP_006516959.1)
cyto 6,  cyto_nucl 5,  nucl 2,  pero 1  (predict for XP_006516960.1)
cyto 5,  cyto_nucl 4,  nucl 3,  cysk 2  (predict for XP_017170959.1)
cyto 7,  cyto_nucl 4,  nucl 1,  extr 1,  mito 1,  cysk 1  (predict for XP_017170960.1)
Gene coexpression
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
mmu04380 Osteoclast differentiation 8
mmu04662 B cell receptor signaling pathway 5
mmu04145 Phagosome 3
mmu04670 Leukocyte transendothelial migration 3
mmu05140 Leishmaniasis 3
Genes directly connected with Syk on the network
MR* Locus Fuction* Coexpression
Entrez Gene ID*
617.6 Pirb paired Ig-like receptor B [detail] 18733
646.6 Ncf2 neutrophil cytosolic factor 2 [detail] 17970
685.8 Spi1 spleen focus forming virus (SFFV) proviral integration oncogene [detail] 20375
1343.4 Aim2 absent in melanoma 2 [detail] 383619
1588.5 Irak3 interleukin-1 receptor-associated kinase 3 [detail] 73914
1597.5 Blnk B cell linker [detail] 17060
gene list
[Coexpressed gene list for Syk]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity* tissue specificity
Link to other DBs
Entrez Gene ID 20963    
Refseq ID (protein) NP_001185906.1 

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