[][] mmu Itgb3 Gene 
functional annotation
Function   integrin beta 3
GO BP
GO:0061097 [list] [network] regulation of protein tyrosine kinase activity  (1 genes)  IMP  
GO:1900731 [list] [network] positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway  (1 genes)  ISO  
GO:0050748 [list] [network] negative regulation of lipoprotein metabolic process  (2 genes)  ISO  
GO:0045715 [list] [network] negative regulation of low-density lipoprotein particle receptor biosynthetic process  (3 genes)  ISO  
GO:0038027 [list] [network] apolipoprotein A-I-mediated signaling pathway  (4 genes)  ISO  
GO:0048858 [list] [network] cell projection morphogenesis  (4 genes)  IC  
GO:0007044 [list] [network] cell-substrate junction assembly  (5 genes)  IDA  
GO:0032369 [list] [network] negative regulation of lipid transport  (5 genes)  ISO  
GO:0010888 [list] [network] negative regulation of lipid storage  (6 genes)  ISO  
GO:0072126 [list] [network] positive regulation of glomerular mesangial cell proliferation  (6 genes)  ISO  
GO:1903053 [list] [network] regulation of extracellular matrix organization  (6 genes)  IMP  
GO:0014909 [list] [network] smooth muscle cell migration  (8 genes)  ISO  
GO:0060055 [list] [network] angiogenesis involved in wound healing  (8 genes)  IEA  
GO:0010745 [list] [network] negative regulation of macrophage derived foam cell differentiation  (10 genes)  ISO  
GO:0033630 [list] [network] positive regulation of cell adhesion mediated by integrin  (11 genes)  ISO  
GO:0033690 [list] [network] positive regulation of osteoblast proliferation  (13 genes)  IMP  
GO:0051279 [list] [network] regulation of release of sequestered calcium ion into cytosol  (13 genes)  ISO  
GO:0010763 [list] [network] positive regulation of fibroblast migration  (14 genes)  IMP ISO  
GO:0034113 [list] [network] heterotypic cell-cell adhesion  (15 genes)  ISO  
GO:0033627 [list] [network] cell adhesion mediated by integrin  (16 genes)  ISO  
GO:0036120 [list] [network] cellular response to platelet-derived growth factor stimulus  (16 genes)  IMP  
GO:0031589 [list] [network] cell-substrate adhesion  (18 genes)  ISO  
GO:0043277 [list] [network] apoptotic cell clearance  (18 genes)  IGI ISO  
GO:0045780 [list] [network] positive regulation of bone resorption  (18 genes)  IC ISO  
GO:0046718 [list] [network] viral entry into host cell  (19 genes)  ISO  
GO:0002687 [list] [network] positive regulation of leukocyte migration  (21 genes)  ISO  
GO:0045672 [list] [network] positive regulation of osteoclast differentiation  (22 genes)  IC  
GO:0001954 [list] [network] positive regulation of cell-matrix adhesion  (23 genes)  IMP  
GO:0070527 [list] [network] platelet aggregation  (24 genes)  ISO  
GO:0050919 [list] [network] negative chemotaxis  (28 genes)  ISO  
GO:0008277 [list] [network] regulation of G-protein coupled receptor protein signaling pathway  (31 genes)  ISO  
GO:0030168 [list] [network] platelet activation  (31 genes)  ISO  
GO:1900026 [list] [network] positive regulation of substrate adhesion-dependent cell spreading  (31 genes)  IMP  
GO:0048008 [list] [network] platelet-derived growth factor receptor signaling pathway  (33 genes)  IMP  
GO:0034446 [list] [network] substrate adhesion-dependent cell spreading  (35 genes)  ISO  
GO:0014911 [list] [network] positive regulation of smooth muscle cell migration  (40 genes)  ISO  
GO:0010595 [list] [network] positive regulation of endothelial cell migration  (42 genes)  ISO  
GO:0032147 [list] [network] activation of protein kinase activity  (57 genes)  ISO  
GO:0001938 [list] [network] positive regulation of endothelial cell proliferation  (65 genes)  ISO  
GO:0048146 [list] [network] positive regulation of fibroblast proliferation  (65 genes)  IMP  
GO:0007229 [list] [network] integrin-mediated signaling pathway  (66 genes)  ISO  
GO:0030334 [list] [network] regulation of cell migration  (71 genes)  IMP  
GO:0048661 [list] [network] positive regulation of smooth muscle cell proliferation  (74 genes)  ISO  
GO:0007160 [list] [network] cell-matrix adhesion  (78 genes)  IGI ISO  
GO:0060548 [list] [network] negative regulation of cell death  (81 genes)  ISO  
GO:0006874 [list] [network] cellular calcium ion homeostasis  (88 genes)  ISO  
GO:0043410 [list] [network] positive regulation of MAPK cascade  (97 genes)  ISO  
GO:0050731 [list] [network] positive regulation of peptidyl-tyrosine phosphorylation  (105 genes)  ISO  
GO:0045766 [list] [network] positive regulation of angiogenesis  (129 genes)  ISO  
GO:0030335 [list] [network] positive regulation of cell migration  (177 genes)  IMP  
GO:0070374 [list] [network] positive regulation of ERK1 and ERK2 cascade  (181 genes)  ISO  
GO:0007155 [list] [network] cell adhesion  (522 genes)  ISO  
GO CC
GO:0034683 [list] [network] integrin alphav-beta3 complex  (2 genes)  ISO  
GO:0035866 [list] [network] alphav-beta3 integrin-PKCalpha complex  (2 genes)  IDA ISO  
GO:0035868 [list] [network] alphav-beta3 integrin-HMGB1 complex  (2 genes)  ISO  
GO:0071133 [list] [network] alpha9-beta1 integrin-ADAM8 complex  (2 genes)  IDA  
GO:0034679 [list] [network] integrin alpha9-beta1 complex  (3 genes)  TAS  
GO:0035867 [list] [network] alphav-beta3 integrin-IGF-1-IGF1R complex  (4 genes)  ISO  
GO:0031258 [list] [network] lamellipodium membrane  (8 genes)  ISO  
GO:0031527 [list] [network] filopodium membrane  (16 genes)  ISO  
GO:0031528 [list] [network] microvillus membrane  (16 genes)  ISO  
GO:0042470 [list] [network] melanosome  (21 genes)  ISO  
GO:0008305 [list] [network] integrin complex  (27 genes)  ISO  
GO:0032587 [list] [network] ruffle membrane  (58 genes)  ISO  
GO:0005925 [list] [network] focal adhesion  (120 genes)  ISO  
GO:0043235 [list] [network] receptor complex  (140 genes)  ISO  
GO:0016324 [list] [network] apical plasma membrane  (279 genes)  IDA ISO  
GO:0009897 [list] [network] external side of plasma membrane  (430 genes)  IDA  
GO:0009986 [list] [network] cell surface  (588 genes)  ISO  
GO:0030054 [list] [network] cell junction  (766 genes)  IEA  
GO:0042995 [list] [network] cell projection  (840 genes)  IEA  
GO:0005886 [list] [network] plasma membrane  (3773 genes)  ISO  
GO:0016021 [list] [network] integral component of membrane  (5345 genes)  IEA  
GO:0005634 [list] [network] nucleus  (5524 genes)  ISO  
GO:0016020 [list] [network] membrane  (6374 genes)  ISO  
GO MF
GO:0019960 [list] [network] C-X3-C chemokine binding  (5 genes)  ISO  
GO:0070051 [list] [network] fibrinogen binding  (5 genes)  ISO  
GO:0038132 [list] [network] neuregulin binding  (6 genes)  ISO  
GO:0043184 [list] [network] vascular endothelial growth factor receptor 2 binding  (7 genes)  ISO  
GO:0031994 [list] [network] insulin-like growth factor I binding  (12 genes)  ISO  
GO:0003756 [list] [network] protein disulfide isomerase activity  (19 genes)  ISO  
GO:0017134 [list] [network] fibroblast growth factor binding  (25 genes)  ISO  
GO:0050840 [list] [network] extracellular matrix binding  (25 genes)  ISO  
GO:0001968 [list] [network] fibronectin binding  (28 genes)  ISO  
GO:0005080 [list] [network] protein kinase C binding  (56 genes)  IPI  
GO:0050839 [list] [network] cell adhesion molecule binding  (68 genes)  ISO  
GO:0042277 [list] [network] peptide binding  (92 genes)  ISO  
GO:0005178 [list] [network] integrin binding  (103 genes)  IPI ISO  
GO:0002020 [list] [network] protease binding  (124 genes)  ISO  
GO:0004872 [list] [network] signaling receptor activity  (176 genes)  IEA  
GO:0019899 [list] [network] enzyme binding  (389 genes)  ISO  
GO:0042802 [list] [network] identical protein binding  (1135 genes)  ISO  
GO:0005515 [list] [network] protein binding  (4163 genes)  IPI  
KEGG mmu04015 Rap1 signaling pathway
mmu04145 Phagosome
mmu04151 PI3K-Akt signaling pathway
mmu04380 Osteoclast differentiation
mmu04510 Focal adhesion
mmu04512 ECM-receptor interaction
mmu04611 Platelet activation
mmu04640 Hematopoietic cell lineage
mmu04810 Regulation of actin cytoskeleton
mmu04919 Thyroid hormone signaling pathway
mmu05165 Human papillomavirus infection
mmu05205 Proteoglycans in cancer
mmu05206 MicroRNAs in cancer
mmu05410 Hypertrophic cardiomyopathy (HCM)
mmu05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
mmu05414 Dilated cardiomyopathy (DCM)
mmu05418 Fluid shear stress and atherosclerosis
Orthologous [Ortholog page] ITGB3 (hsa)Itgb3 (rno)ITGB3 (gga)ITGB3 (cfa)ITGB3 (mcc)itgb3b (dre)
Subcellular
localization
extr 7,  extr_plas 4,  pero 1,  lyso 1,  E.R. 1,  cyto_pero 1  (predict for NP_058060.2)
pero 5,  extr_plas 2,  plas 2,  extr 1,  cyto 1  (predict for XP_006532375.1)
Gene coexpression
Network*for
coexpressed
genes
LCNloc
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
mmu04611 Platelet activation 7
mmu04512 ECM-receptor interaction 6
mmu04640 Hematopoietic cell lineage 6
mmu04060 Cytokine-cytokine receptor interaction 2
mmu04015 Rap1 signaling pathway 2
Genes directly connected with Itgb3 on the network
MR* Locus Fuction* Coexpression
detail
Entrez Gene ID*
662.5 Itga2b integrin alpha 2b [detail] 16399
996.9 Clec1b C-type lectin domain family 1, member b [detail] 56760
1079.3 Tubb1 tubulin, beta 1 class VI [detail] 545486
Coexpressed
gene list
[Coexpressed gene list for Itgb3]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity* tissue specificity
Link to other DBs
Entrez Gene ID 16416    
Refseq ID (protein) NP_058060.2 
XP_006532375.1 


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