[←][→] mmu  Actr3 Gene
functional annotation
Function   ARP3 actin-related protein 3  
GO BP
GO:1904171 [list] [network] negative regulation of bleb assembly  (1 genes)  ISO  
GO:0043519 [list] [network] regulation of myosin II filament organization  (2 genes)  ISO  
GO:0016344 [list] [network] meiotic chromosome movement towards spindle pole  (3 genes)  IGI  
GO:0033206 [list] [network] meiotic cytokinesis  (10 genes)  IGI  
GO:0048711 [list] [network] positive regulation of astrocyte differentiation  (13 genes)  ISO  
GO:0034314 [list] [network] Arp2/3 complex-mediated actin nucleation  (15 genes)  IBA ISO  
GO:0008356 [list] [network] asymmetric cell division  (17 genes)  IGI  
GO:0098974 [list] [network] postsynaptic actin cytoskeleton organization  (17 genes)  ISO  
GO:0010763 [list] [network] positive regulation of fibroblast migration  (20 genes)  ISO  
GO:2000251 [list] [network] positive regulation of actin cytoskeleton reorganization  (20 genes)  ISO  
GO:0061003 [list] [network] positive regulation of dendritic spine morphogenesis  (28 genes)  ISO  
GO:0010592 [list] [network] positive regulation of lamellipodium assembly  (29 genes)  ISO  
GO:0090314 [list] [network] positive regulation of protein targeting to membrane  (30 genes)  ISO  
GO:0051491 [list] [network] positive regulation of filopodium assembly  (36 genes)  ISO  
GO:0030517 [list] [network] negative regulation of axon extension  (49 genes)  ISO  
GO:0048708 [list] [network] astrocyte differentiation  (55 genes)  ISO  
GO:0051653 [list] [network] spindle localization  (56 genes)  IGI  
GO:0050775 [list] [network] positive regulation of dendrite morphogenesis  (58 genes)  ISO  
GO:1903078 [list] [network] positive regulation of protein localization to plasma membrane  (62 genes)  ISO  
GO:0051965 [list] [network] positive regulation of synapse assembly  (80 genes)  ISO  
GO:0030838 [list] [network] positive regulation of actin filament polymerization  (84 genes)  ISO  
GO:0071346 [list] [network] cellular response to interferon-gamma  (98 genes)  IGI  
GO:0032092 [list] [network] positive regulation of protein binding  (99 genes)  ISO  
GO:0045666 [list] [network] positive regulation of neuron differentiation  (119 genes)  ISO  
GO:0071560 [list] [network] cellular response to transforming growth factor beta stimulus  (128 genes)  ISO  
GO:0071356 [list] [network] cellular response to tumor necrosis factor  (145 genes)  ISO  
GO:0007163 [list] [network] establishment or maintenance of cell polarity  (206 genes)  IGI  
GO:0007015 [list] [network] actin filament organization  (267 genes)  IEA  
GO:0051321 [list] [network] meiotic cell cycle  (296 genes)  IGI  
GO:0060271 [list] [network] cilium assembly  (298 genes)  ISO  
GO:0030030 [list] [network] cell projection organization  (1199 genes)  IEA  
GO:0045944 [list] [network] positive regulation of transcription by RNA polymerase II  (1250 genes)  ISO  
GO CC
GO:0061828 [list] [network] apical tubulobulbar complex  (2 genes)  ISO  
GO:0061831 [list] [network] apical ectoplasmic specialization  (2 genes)  ISO  
GO:0061832 [list] [network] basal ectoplasmic specialization  (2 genes)  ISO  
GO:0061825 [list] [network] podosome core  (3 genes)  ISO  
GO:0061830 [list] [network] concave side of sperm head  (3 genes)  ISO  
GO:0061851 [list] [network] leading edge of lamellipodium  (3 genes)  ISO  
GO:0005885 [list] [network] Arp2/3 protein complex  (9 genes)  IBA ISO  
GO:0030056 [list] [network] hemidesmosome  (9 genes)  ISO  
GO:0030479 [list] [network] actin cortical patch  (15 genes)  IBA  
GO:0002102 [list] [network] podosome  (26 genes)  ISO  
GO:0060076 [list] [network] excitatory synapse  (79 genes)  ISO  
GO:0005884 [list] [network] actin filament  (131 genes)  ISO  
GO:0005903 [list] [network] brush border  (144 genes)  IDA  
GO:0001726 [list] [network] ruffle  (153 genes)  ISO  
GO:0030027 [list] [network] lamellipodium  (175 genes)  IDA ISO  
GO:0000139 [list] [network] Golgi membrane  (268 genes)  ISO  
GO:0031252 [list] [network] cell leading edge  (411 genes)  ISO  
GO:0005911 [list] [network] cell-cell junction  (518 genes)  IDA ISO  
GO:0098978 [list] [network] glutamatergic synapse  (518 genes)  ISO  
GO:0048471 [list] [network] perinuclear region of cytoplasm  (687 genes)  ISO  
GO:0098794 [list] [network] postsynapse  (741 genes)  ISO  
GO:0005856 [list] [network] cytoskeleton  (2248 genes)  IEA  
GO:0042995 [list] [network] cell projection  (2594 genes)  IEA  
GO:0005634 [list] [network] nucleus  (7226 genes)  ISO  
GO:0005737 [list] [network] cytoplasm  (11434 genes)  ISO  
GO MF
GO:0005200 [list] [network] structural constituent of cytoskeleton  (64 genes)  ISO  
GO:0051117 [list] [network] ATPase binding  (99 genes)  ISO  
GO:0051015 [list] [network] actin filament binding  (213 genes)  IBA ISO  
GO:0003779 [list] [network] actin binding  (443 genes)  ISO  
GO:0005524 [list] [network] ATP binding  (1396 genes)  IEA  
GO:0000166 [list] [network] nucleotide binding  (2052 genes)  IEA  
GO:0005515 [list] [network] protein binding  (9507 genes)  IPI  
KEGG mmu04144 [list] [network] Endocytosis (272 genes)
mmu04530 [list] [network] Tight junction (167 genes)
mmu04666 [list] [network] Fc gamma R-mediated phagocytosis (92 genes)
mmu04810 [list] [network] Regulation of actin cytoskeleton (220 genes)
mmu05100 [list] [network] Bacterial invasion of epithelial cells (76 genes)
mmu05132 [list] [network] Salmonella infection (253 genes)
mmu05135 [list] [network] Yersinia infection (134 genes)
Protein NP_001192314.1  NP_001192315.1  NP_076224.1 
BLAST NP_001192314.1  NP_001192315.1  NP_076224.1 
Orthologous [Ortholog page] ACTR3 (hsa)  Arp3 (dme)  ACTR3B (hsa)  Actr3 (rno)  arx-1 (cel)  Actr3b (mmu)  Actr3b (rno)  ACTR3 (gga)  ACTR3 (cfa)  actr3 (dre)  ACTR3B (gga)  ACTR3B (cfa)  ACTR3 (mcc)  ACTR3B (mcc)  ARP3 (sce)  actr3b (dre)  ACTR3B (fca)  ACTR3 (fca) 
Subcellular
localization
wolf
cyto 8,  cyto_nucl 5,  mito 1  (predict for NP_001192314.1)
cyto 8,  cyto_nucl 5,  mito 1  (predict for NP_001192315.1)
cyto 8,  cyto_nucl 5,  mito 1  (predict for NP_076224.1)
Gene coexpression
Network*for
coexpressed
genes
LCNloc
[Cytoscape]
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
mmu04530 Tight junction 9
mmu04810 Regulation of actin cytoskeleton 8
mmu05132 Salmonella infection 8
mmu04144 Endocytosis 7
mmu04666 Fc gamma R-mediated phagocytosis 7
Genes directly connected with Actr3 on the network
coex z* Locus Function* Coexpression
detail		 CoexPub Entrez Gene ID*
12.3 Arpc5 actin related protein 2/3 complex, subunit 5 [detail] 7 67771
12.1 Arpc2 actin related protein 2/3 complex, subunit 2 [detail] 6 76709
9.6 Actg1 actin, gamma, cytoplasmic 1 [detail] 0 11465
9.5 Abi1 abl interactor 1 [detail] 2 11308
8.7 Capza2 capping protein (actin filament) muscle Z-line, alpha 2 [detail] 1 12343
8.7 Actr2 ARP2 actin-related protein 2 [detail] 31 66713
8.5 Wdr1 WD repeat domain 1 [detail] 1 22388
8.4 Rap1b RAS related protein 1b [detail] 1 215449
8.1 Capza1 capping protein (actin filament) muscle Z-line, alpha 1 [detail] 1 12340
8.0 Cdc42 cell division cycle 42 [detail] 9 12540
7.1 Vasp vasodilator-stimulated phosphoprotein [detail] 4 22323
6.8 Abracl ABRA C-terminal like [detail] 0 73112
6.4 Cyrib CYFIP related Rac1 interactor B [detail] 0 223601
6.1 Rap2c RAP2C, member of RAS oncogene family [detail] 0 72065
5.8 Cdc42se2 CDC42 small effector 2 [detail] 0 72729
5.8 Adss adenylosuccinate synthetase, non muscle [detail] 0 11566
Coexpressed
gene list		 [Coexpressed gene list for Actr3]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity* tissue specificity
Link to other DBs
Entrez Gene ID 74117      
Refseq ID (protein) NP_001192314.1 
NP_001192315.1 
NP_076224.1 


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