[][] mmu  Trp53 Gene
functional annotation
Function   transformation related protein 53
GO BP
GO:1905856 [list] [network] negative regulation of pentose-phosphate shunt  (1 genes)  ISO  
GO:1990248 [list] [network] regulation of transcription from RNA polymerase II promoter in response to DNA damage  (1 genes)  ISO ISS  
GO:0097252 [list] [network] oligodendrocyte apoptotic process  (2 genes)  ISO  
GO:1904024 [list] [network] negative regulation of glucose catabolic process to lactate via pyruvate  (2 genes)  IMP  
GO:0072717 [list] [network] cellular response to actinomycin D  (3 genes)  ISO  
GO:1990144 [list] [network] intrinsic apoptotic signaling pathway in response to hypoxia  (3 genes)  IMP  
GO:0002309 [list] [network] T cell proliferation involved in immune response  (4 genes)  IGI  
GO:0062100 [list] [network] positive regulation of programmed necrotic cell death  (4 genes)  IMP  
GO:0090403 [list] [network] oxidative stress-induced premature senescence  (4 genes)  ISO  
GO:1901525 [list] [network] negative regulation of mitophagy  (5 genes)  IMP  
GO:0002326 [list] [network] B cell lineage commitment  (6 genes)  IMP  
GO:0043504 [list] [network] mitochondrial DNA repair  (6 genes)  IMP  
GO:0060333 [list] [network] interferon-gamma-mediated signaling pathway  (6 genes)  IMP  
GO:0061419 [list] [network] positive regulation of transcription from RNA polymerase II promoter in response to hypoxia  (6 genes)  IMP  
GO:0070245 [list] [network] positive regulation of thymocyte apoptotic process  (6 genes)  IMP  
GO:0071494 [list] [network] cellular response to UV-C  (6 genes)  IGI  
GO:0007406 [list] [network] negative regulation of neuroblast proliferation  (9 genes)  IGI  
GO:0048539 [list] [network] bone marrow development  (10 genes)  ISO  
GO:1900119 [list] [network] positive regulation of execution phase of apoptosis  (10 genes)  ISO  
GO:1990440 [list] [network] positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  (11 genes)  IMP  
GO:0045899 [list] [network] positive regulation of RNA polymerase II transcription preinitiation complex assembly  (12 genes)  ISO  
GO:0090399 [list] [network] replicative senescence  (12 genes)  ISO  
GO:1903800 [list] [network] positive regulation of production of miRNAs involved in gene silencing by miRNA  (12 genes)  ISO  
GO:0006977 [list] [network] DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  (13 genes)  IGI ISO  
GO:0006983 [list] [network] ER overload response  (13 genes)  ISO  
GO:0051974 [list] [network] negative regulation of telomerase activity  (13 genes)  ISO  
GO:0006978 [list] [network] DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator  (14 genes)  IDA ISO  
GO:0090343 [list] [network] positive regulation of cell aging  (15 genes)  IMP  
GO:1903799 [list] [network] negative regulation of production of miRNAs involved in gene silencing by miRNA  (15 genes)  IGI  
GO:0070243 [list] [network] regulation of thymocyte apoptotic process  (17 genes)  IGI  
GO:0035794 [list] [network] positive regulation of mitochondrial membrane permeability  (18 genes)  IGI  
GO:0009299 [list] [network] mRNA transcription  (19 genes)  ISO  
GO:0010666 [list] [network] positive regulation of cardiac muscle cell apoptotic process  (20 genes)  IMP  
GO:0009303 [list] [network] rRNA transcription  (21 genes)  IGI  
GO:0070266 [list] [network] necroptotic process  (21 genes)  IGI  
GO:1902108 [list] [network] regulation of mitochondrial membrane permeability involved in apoptotic process  (21 genes)  IGI  
GO:2000269 [list] [network] regulation of fibroblast apoptotic process  (21 genes)  IGI  
GO:0001836 [list] [network] release of cytochrome c from mitochondria  (22 genes)  IDA IGI  
GO:0031065 [list] [network] positive regulation of histone deacetylation  (23 genes)  IDA  
GO:0031571 [list] [network] mitotic G1 DNA damage checkpoint signaling  (24 genes)  IMP ISO  
GO:0010165 [list] [network] response to X-ray  (25 genes)  IDA IMP  
GO:0060218 [list] [network] hematopoietic stem cell differentiation  (26 genes)  ISO  
GO:0002360 [list] [network] T cell lineage commitment  (27 genes)  IMP  
GO:0036003 [list] [network] positive regulation of transcription from RNA polymerase II promoter in response to stress  (27 genes)  IDA ISO ISS  
GO:0008156 [list] [network] negative regulation of DNA replication  (28 genes)  IDA IMP  
GO:0048512 [list] [network] circadian behavior  (28 genes)  IMP  
GO:0071480 [list] [network] cellular response to gamma radiation  (28 genes)  IDA ISO  
GO:0090200 [list] [network] positive regulation of release of cytochrome c from mitochondria  (29 genes)  ISO  
GO:0008340 [list] [network] determination of adult lifespan  (30 genes)  IMP  
GO:0043153 [list] [network] entrainment of circadian clock by photoperiod  (30 genes)  IMP  
GO:0042771 [list] [network] intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (32 genes)  IDA IGI IMP ISO  
GO:1902253 [list] [network] regulation of intrinsic apoptotic signaling pathway by p53 class mediator  (32 genes)  IMP  
GO:1903205 [list] [network] regulation of hydrogen peroxide-induced cell death  (34 genes)  ISO  
GO:0009651 [list] [network] response to salt stress  (35 genes)  IGI  
GO:0043516 [list] [network] regulation of DNA damage response, signal transduction by p53 class mediator  (35 genes)  IGI  
GO:0048147 [list] [network] negative regulation of fibroblast proliferation  (35 genes)  IMP ISO  
GO:0030330 [list] [network] DNA damage response, signal transduction by p53 class mediator  (36 genes)  IDA IGI ISO  
GO:0070059 [list] [network] intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (38 genes)  IMP  
GO:0002931 [list] [network] response to ischemia  (39 genes)  IMP  
GO:2000279 [list] [network] negative regulation of DNA biosynthetic process  (41 genes)  ISO  
GO:0033209 [list] [network] tumor necrosis factor-mediated signaling pathway  (43 genes)  ISO  
GO:2000772 [list] [network] regulation of cellular senescence  (43 genes)  IGI  
GO:0006289 [list] [network] nucleotide-excision repair  (48 genes)  ISO  
GO:0010332 [list] [network] response to gamma radiation  (49 genes)  IDA IMP ISO  
GO:0042149 [list] [network] cellular response to glucose starvation  (49 genes)  ISO  
GO:0072332 [list] [network] intrinsic apoptotic signaling pathway by p53 class mediator  (54 genes)  IDA IGI ISO  
GO:2000378 [list] [network] negative regulation of reactive oxygen species metabolic process  (55 genes)  IMP  
GO:0051402 [list] [network] neuron apoptotic process  (57 genes)  IGI IMP  
GO:0033077 [list] [network] T cell differentiation in thymus  (66 genes)  IGI  
GO:0048662 [list] [network] negative regulation of smooth muscle cell proliferation  (67 genes)  ISO  
GO:1902895 [list] [network] positive regulation of pri-miRNA transcription by RNA polymerase II  (67 genes)  ISO  
GO:0071479 [list] [network] cellular response to ionizing radiation  (68 genes)  IDA IGI ISO  
GO:2001244 [list] [network] positive regulation of intrinsic apoptotic signaling pathway  (70 genes)  ISO  
GO:0001756 [list] [network] somitogenesis  (71 genes)  IGI  
GO:0030512 [list] [network] negative regulation of transforming growth factor beta receptor signaling pathway  (73 genes)  IMP  
GO:0051453 [list] [network] regulation of intracellular pH  (74 genes)  ISO  
GO:2000379 [list] [network] positive regulation of reactive oxygen species metabolic process  (77 genes)  ISO  
GO:0051262 [list] [network] protein tetramerization  (80 genes)  IEA  
GO:0072331 [list] [network] signal transduction by p53 class mediator  (82 genes)  ISO  
GO:0034103 [list] [network] regulation of tissue remodeling  (84 genes)  IMP  
GO:0043525 [list] [network] positive regulation of neuron apoptotic process  (85 genes)  IDA IGI IMP  
GO:0060411 [list] [network] cardiac septum morphogenesis  (86 genes)  IGI  
GO:0007179 [list] [network] transforming growth factor beta receptor signaling pathway  (87 genes)  IGI  
GO:0034644 [list] [network] cellular response to UV  (89 genes)  IDA IGI ISO  
GO:0006606 [list] [network] protein import into nucleus  (103 genes)  IDA  
GO:0034614 [list] [network] cellular response to reactive oxygen species  (105 genes)  ISO  
GO:0021549 [list] [network] cerebellum development  (111 genes)  IDA  
GO:0007569 [list] [network] cell aging  (115 genes)  IGI ISO  
GO:0031497 [list] [network] chromatin assembly  (115 genes)  ISO  
GO:0035264 [list] [network] multicellular organism growth  (132 genes)  IGI  
GO:0007623 [list] [network] circadian rhythm  (138 genes)  IEP  
GO:0002244 [list] [network] hematopoietic progenitor cell differentiation  (144 genes)  ISO  
GO:0009411 [list] [network] response to UV  (149 genes)  IDA IMP  
GO:0007369 [list] [network] gastrulation  (151 genes)  IGI  
GO:0002687 [list] [network] positive regulation of leukocyte migration  (152 genes)  ISO  
GO:0016032 [list] [network] viral process  (158 genes)  ISO  
GO:0006302 [list] [network] double-strand break repair  (182 genes)  IMP  
GO:0050821 [list] [network] protein stabilization  (188 genes)  IGI  
GO:0050731 [list] [network] positive regulation of peptidyl-tyrosine phosphorylation  (191 genes)  IMP  
GO:0030308 [list] [network] negative regulation of cell growth  (204 genes)  ISO  
GO:0045930 [list] [network] negative regulation of mitotic cell cycle  (216 genes)  IGI  
GO:0006914 [list] [network] autophagy  (241 genes)  ISO  
GO:0042493 [list] [network] response to drug  (253 genes)  IDA  
GO:0048511 [list] [network] rhythmic process  (264 genes)  IEA  
GO:0043523 [list] [network] regulation of neuron apoptotic process  (279 genes)  IGI  
GO:0006979 [list] [network] response to oxidative stress  (342 genes)  IGI IMP  
GO:0045787 [list] [network] positive regulation of cell cycle  (342 genes)  ISO  
GO:0045861 [list] [network] negative regulation of proteolysis  (356 genes)  IMP  
GO:0007346 [list] [network] regulation of mitotic cell cycle  (460 genes)  IDA  
GO:0048568 [list] [network] embryonic organ development  (518 genes)  IGI  
GO:0001701 [list] [network] in utero embryonic development  (547 genes)  IGI  
GO:0007507 [list] [network] heart development  (585 genes)  IGI  
GO:0043065 [list] [network] positive regulation of apoptotic process  (598 genes)  IGI IMP ISO  
GO:0006974 [list] [network] cellular response to DNA damage stimulus  (691 genes)  IDA IMP ISO  
GO:0008285 [list] [network] negative regulation of cell population proliferation  (764 genes)  IGI IMP ISO  
GO:0006915 [list] [network] apoptotic process  (831 genes)  IDA IGI  
GO:0009792 [list] [network] embryo development ending in birth or egg hatching  (858 genes)  IGI  
GO:0012501 [list] [network] programmed cell death  (877 genes)  IEA  
GO:0007417 [list] [network] central nervous system development  (901 genes)  IGI  
GO:0000122 [list] [network] negative regulation of transcription by RNA polymerase II  (948 genes)  IDA IGI IMP ISO  
GO:0043066 [list] [network] negative regulation of apoptotic process  (968 genes)  IMP ISO  
GO:0051276 [list] [network] chromosome organization  (974 genes)  IGI  
GO:0051726 [list] [network] regulation of cell cycle  (1007 genes)  IGI IMP ISO  
GO:0065003 [list] [network] protein-containing complex assembly  (1056 genes)  ISO  
GO:0010629 [list] [network] negative regulation of gene expression  (1078 genes)  IGI  
GO:0007049 [list] [network] cell cycle  (1198 genes)  IEA  
GO:0010628 [list] [network] positive regulation of gene expression  (1244 genes)  ISO  
GO:0045944 [list] [network] positive regulation of transcription by RNA polymerase II  (1250 genes)  IDA IGI IMP ISO  
GO:0045892 [list] [network] negative regulation of transcription, DNA-templated  (1298 genes)  IDA IMP ISO  
GO:0034613 [list] [network] cellular protein localization  (1396 genes)  ISO  
GO:0033554 [list] [network] cellular response to stress  (1482 genes)  IGI  
GO:0042981 [list] [network] regulation of apoptotic process  (1532 genes)  ISO  
GO:0045893 [list] [network] positive regulation of transcription, DNA-templated  (1550 genes)  IDA IGI ISO  
GO:0042127 [list] [network] regulation of cell population proliferation  (1747 genes)  IGI IMP  
GO:0008104 [list] [network] protein localization  (1925 genes)  ISO  
GO:0006357 [list] [network] regulation of transcription by RNA polymerase II  (2471 genes)  IBA IDA  
GO:0006355 [list] [network] regulation of transcription, DNA-templated  (3270 genes)  IDA ISO  
GO CC
GO:0005669 [list] [network] transcription factor TFIID complex  (33 genes)  ISO  
GO:0035861 [list] [network] site of double-strand break  (63 genes)  IDA  
GO:0005657 [list] [network] replication fork  (67 genes)  IDA  
GO:0016605 [list] [network] PML body  (76 genes)  ISO  
GO:0016363 [list] [network] nuclear matrix  (89 genes)  ISO  
GO:0090575 [list] [network] RNA polymerase II transcription regulator complex  (172 genes)  ISO  
GO:0005759 [list] [network] mitochondrial matrix  (276 genes)  IDA  
GO:0005667 [list] [network] transcription regulator complex  (474 genes)  ISO  
GO:0000785 [list] [network] chromatin  (583 genes)  ISO ISS  
GO:0005813 [list] [network] centrosome  (622 genes)  ISO  
GO:0016604 [list] [network] nuclear body  (732 genes)  ISO  
GO:0005730 [list] [network] nucleolus  (895 genes)  ISO  
GO:0005783 [list] [network] endoplasmic reticulum  (1825 genes)  IEA  
GO:0005739 [list] [network] mitochondrion  (1890 genes)  IDA ISO  
GO:0005856 [list] [network] cytoskeleton  (2248 genes)  IEA  
GO:0005654 [list] [network] nucleoplasm  (3580 genes)  ISO  
GO:0005829 [list] [network] cytosol  (3785 genes)  IDA ISO  
GO:0032991 [list] [network] protein-containing complex  (5540 genes)  ISO  
GO:0005634 [list] [network] nucleus  (7226 genes)  IDA ISO  
GO:0005737 [list] [network] cytoplasm  (11434 genes)  IDA ISO  
GO MF
GO:0035033 [list] [network] histone deacetylase regulator activity  (6 genes)  IDA  
GO:0001094 [list] [network] TFIID-class transcription factor complex binding  (10 genes)  ISO  
GO:0097371 [list] [network] MDM2/MDM4 family protein binding  (14 genes)  IPI ISO  
GO:0035035 [list] [network] histone acetyltransferase binding  (31 genes)  ISO  
GO:0051721 [list] [network] protein phosphatase 2A binding  (37 genes)  ISO  
GO:0097718 [list] [network] disordered domain specific binding  (37 genes)  ISO  
GO:0001046 [list] [network] core promoter sequence-specific DNA binding  (49 genes)  ISO  
GO:0005507 [list] [network] copper ion binding  (68 genes)  ISO  
GO:0043621 [list] [network] protein self-association  (71 genes)  ISO  
GO:1990841 [list] [network] promoter-specific chromatin binding  (72 genes)  ISO  
GO:0002039 [list] [network] p53 binding  (76 genes)  ISO  
GO:0001221 [list] [network] transcription coregulator binding  (79 genes)  ISO  
GO:0030971 [list] [network] receptor tyrosine kinase binding  (80 genes)  ISO  
GO:0003730 [list] [network] mRNA 3'-UTR binding  (106 genes)  ISO  
GO:0051087 [list] [network] chaperone binding  (107 genes)  ISO  
GO:0042826 [list] [network] histone deacetylase binding  (130 genes)  ISO  
GO:0047485 [list] [network] protein N-terminus binding  (131 genes)  ISO  
GO:0019903 [list] [network] protein phosphatase binding  (182 genes)  ISO  
GO:0002020 [list] [network] protease binding  (183 genes)  ISO  
GO:0008022 [list] [network] protein C-terminus binding  (232 genes)  ISO  
GO:0046982 [list] [network] protein heterodimerization activity  (305 genes)  ISO  
GO:0031625 [list] [network] ubiquitin protein ligase binding  (316 genes)  IPI ISO  
GO:0061629 [list] [network] RNA polymerase II-specific DNA-binding transcription factor binding  (323 genes)  ISO  
GO:0001228 [list] [network] DNA-binding transcription activator activity, RNA polymerase II-specific  (502 genes)  IDA IGI ISO  
GO:0001216 [list] [network] DNA-binding transcription activator activity  (509 genes)  ISO  
GO:0003682 [list] [network] chromatin binding  (648 genes)  IDA ISO  
GO:0008134 [list] [network] transcription factor binding  (673 genes)  ISO  
GO:0019901 [list] [network] protein kinase binding  (774 genes)  ISO  
GO:0000978 [list] [network] RNA polymerase II cis-regulatory region sequence-specific DNA binding  (1148 genes)  IBA IDA ISO  
GO:0000987 [list] [network] cis-regulatory region sequence-specific DNA binding  (1169 genes)  ISO  
GO:0000981 [list] [network] DNA-binding transcription factor activity, RNA polymerase II-specific  (1279 genes)  IBA ISO  
GO:0003700 [list] [network] DNA-binding transcription factor activity  (1336 genes)  IDA ISO  
GO:0000977 [list] [network] RNA polymerase II transcription regulatory region sequence-specific DNA binding  (1356 genes)  IDA  
GO:0000976 [list] [network] transcription cis-regulatory region binding  (1454 genes)  ISO  
GO:0043565 [list] [network] sequence-specific DNA binding  (1606 genes)  ISO  
GO:0019899 [list] [network] enzyme binding  (2298 genes)  ISO  
GO:0003677 [list] [network] DNA binding  (2338 genes)  ISO  
GO:0042802 [list] [network] identical protein binding  (2357 genes)  ISO  
GO:0046872 [list] [network] metal ion binding  (3573 genes)  IEA  
GO:0005515 [list] [network] protein binding  (9507 genes)  IPI  
KEGG mmu01522 [list] [network] Endocrine resistance (93 genes)
mmu01524 [list] [network] Platinum drug resistance (80 genes)
mmu04010 [list] [network] MAPK signaling pathway (294 genes)
mmu04071 [list] [network] Sphingolipid signaling pathway (124 genes)
mmu04110 [list] [network] Cell cycle (125 genes)
mmu04115 [list] [network] p53 signaling pathway (72 genes)
mmu04137 [list] [network] Mitophagy - animal (68 genes)
mmu04151 [list] [network] PI3K-Akt signaling pathway (359 genes)
mmu04210 [list] [network] Apoptosis (136 genes)
mmu04211 [list] [network] Longevity regulating pathway (90 genes)
mmu04216 [list] [network] Ferroptosis (40 genes)
mmu04218 [list] [network] Cellular senescence (184 genes)
mmu04310 [list] [network] Wnt signaling pathway (169 genes)
mmu04722 [list] [network] Neurotrophin signaling pathway (121 genes)
mmu04919 [list] [network] Thyroid hormone signaling pathway (120 genes)
mmu05012 [list] [network] Parkinson disease (264 genes)
mmu05014 [list] [network] Amyotrophic lateral sclerosis (369 genes)
mmu05016 [list] [network] Huntington disease (302 genes)
mmu05160 [list] [network] Hepatitis C (165 genes)
mmu05161 [list] [network] Hepatitis B (163 genes)
mmu05162 [list] [network] Measles (146 genes)
mmu05163 [list] [network] Human cytomegalovirus infection (256 genes)
mmu05165 [list] [network] Human papillomavirus infection (362 genes)
mmu05166 [list] [network] Human T-cell leukemia virus 1 infection (250 genes)
mmu05167 [list] [network] Kaposi sarcoma-associated herpesvirus infection (224 genes)
mmu05168 [list] [network] Herpes simplex virus 1 infection (459 genes)
mmu05169 [list] [network] Epstein-Barr virus infection (231 genes)
mmu05200 [list] [network] Pathways in cancer (543 genes)
mmu05202 [list] [network] Transcriptional misregulation in cancer (223 genes)
mmu05203 [list] [network] Viral carcinogenesis (229 genes)
mmu05205 [list] [network] Proteoglycans in cancer (205 genes)
mmu05206 [list] [network] MicroRNAs in cancer (303 genes)
mmu05210 [list] [network] Colorectal cancer (88 genes)
mmu05212 [list] [network] Pancreatic cancer (76 genes)
mmu05213 [list] [network] Endometrial cancer (58 genes)
mmu05214 [list] [network] Glioma (74 genes)
mmu05215 [list] [network] Prostate cancer (99 genes)
mmu05216 [list] [network] Thyroid cancer (37 genes)
mmu05217 [list] [network] Basal cell carcinoma (63 genes)
mmu05218 [list] [network] Melanoma (72 genes)
mmu05219 [list] [network] Bladder cancer (41 genes)
mmu05220 [list] [network] Chronic myeloid leukemia (76 genes)
mmu05222 [list] [network] Small cell lung cancer (93 genes)
mmu05223 [list] [network] Non-small cell lung cancer (72 genes)
mmu05224 [list] [network] Breast cancer (147 genes)
mmu05225 [list] [network] Hepatocellular carcinoma (174 genes)
mmu05226 [list] [network] Gastric cancer (150 genes)
mmu05230 [list] [network] Central carbon metabolism in cancer (69 genes)
mmu05417 [list] [network] Lipid and atherosclerosis (216 genes)
mmu05418 [list] [network] Fluid shear stress and atherosclerosis (148 genes)
Protein NP_001120705.1  NP_035770.2  XP_006533220.1  XP_030101782.1  XP_030101783.1 
BLAST NP_001120705.1  NP_035770.2  XP_006533220.1  XP_030101782.1  XP_030101783.1 
Orthologous [Ortholog page] TP53 (hsa)Tp53 (rno)tp53 (dre)TP53 (gga)TP53 (cfa)TP53 (fca)TP53 (mcc)p53 (dme)
Subcellular
localization
wolf
nucl 10,  cyto_nucl 5  (predict for NP_001120705.1)
nucl 10,  cyto_nucl 5  (predict for NP_035770.2)
nucl 10,  cyto_nucl 5  (predict for XP_006533220.1)
nucl 10,  cyto_nucl 5  (predict for XP_030101782.1)
nucl 10,  cyto_nucl 5  (predict for XP_030101783.1)
Gene coexpression
Network*for
coexpressed
genes
LCNloc
[Cytoscape]
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
mmu03040 Spliceosome 5
mmu05160 Hepatitis C 3
mmu01524 Platinum drug resistance 2
mmu04110 Cell cycle 2
mmu04210 Apoptosis 2
Genes directly connected with Trp53 on the network
coex z* Locus Function* Coexpression
detail
CoexPub Entrez Gene ID*
7.5 Raver1 ribonucleoprotein, PTB-binding 1 [detail] 0 71766
7.4 Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase [detail] 0 108147
6.8 Sf3b4 splicing factor 3b, subunit 4 [detail] 0 107701
Coexpressed
gene list
[Coexpressed gene list for Trp53]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity* tissue specificity
Link to other DBs
Entrez Gene ID 22059    
Refseq ID (protein) NP_001120705.1 
NP_035770.2 
XP_006533220.1 
XP_030101782.1 
XP_030101783.1 


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