| functional annotation |
| Function |
proteasome (prosome, macropain) 26S subunit, ATPase 2 |
|
| GO BP |
|
GO:0045899 [list] [network] positive regulation of RNA polymerase II transcription preinitiation complex assembly
|
(12 genes)
|
IBA
|
 |
|
GO:0006511 [list] [network] ubiquitin-dependent protein catabolic process
|
(498 genes)
|
ISO
|
|
|
GO:0030163 [list] [network] protein catabolic process
|
(677 genes)
|
IEA
|
|
|
| GO CC |
|
GO:0008540 [list] [network] proteasome regulatory particle, base subcomplex
|
(12 genes)
|
IBA
|
|
|
GO:0022624 [list] [network] proteasome accessory complex
|
(25 genes)
|
IDA
|
|
|
GO:0000502 [list] [network] proteasome complex
|
(64 genes)
|
ISO
|
|
|
GO:0000932 [list] [network] P-body
|
(83 genes)
|
IDA
|
|
|
GO:0043197 [list] [network] dendritic spine
|
(199 genes)
|
IBA
ISO
|
|
|
GO:0036464 [list] [network] cytoplasmic ribonucleoprotein granule
|
(232 genes)
|
ISO
|
|
|
GO:0005829 [list] [network] cytosol
|
(3785 genes)
|
ISO
|
|
|
GO:0005634 [list] [network] nucleus
|
(7226 genes)
|
ISO
|
|
|
GO:0005737 [list] [network] cytoplasm
|
(11434 genes)
|
IEA
|
|
|
| GO MF |
|
GO:0036402 [list] [network] proteasome-activating activity
|
(6 genes)
|
ISO
|
|
|
GO:0017025 [list] [network] TBP-class protein binding
|
(27 genes)
|
IBA
ISO
|
|
|
GO:0140296 [list] [network] general transcription initiation factor binding
|
(52 genes)
|
ISO
|
|
|
GO:0016887 [list] [network] ATP hydrolysis activity
|
(248 genes)
|
IEA
|
|
|
GO:0005524 [list] [network] ATP binding
|
(1396 genes)
|
IEA
|
|
|
GO:0000166 [list] [network] nucleotide binding
|
(2052 genes)
|
IEA
|
|
|
GO:0005515 [list] [network] protein binding
|
(9507 genes)
|
IPI
|
|
|
| KEGG |
mmu03050 [list] [network] Proteasome (47 genes) |
 |
| mmu05010 [list] [network] Alzheimer disease (383 genes) |
|
| mmu05012 [list] [network] Parkinson disease (264 genes) |
|
| mmu05014 [list] [network] Amyotrophic lateral sclerosis (369 genes) |
|
| mmu05016 [list] [network] Huntington disease (302 genes) |
|
| mmu05017 [list] [network] Spinocerebellar ataxia (141 genes) |
|
| mmu05020 [list] [network] Prion disease (268 genes) |
|
| mmu05022 [list] [network] Pathways of neurodegeneration - multiple diseases (471 genes) |
|
| mmu05169 [list] [network] Epstein-Barr virus infection (231 genes) |
|
| Protein |
NP_001355590.1
NP_035318.2
|
| BLAST |
NP_001355590.1
NP_035318.2
|
| Orthologous |
[Ortholog page]
PSMC2 (hsa)
Psmc2 (rno)
Rpt1 (dme)
rpt-1 (cel)
psmc2 (dre)
PSMC2 (gga)
PSMC2 (cfa)
PSMC2 (mcc)
RPT1 (sce)
PSMC2 (fca)
|
Subcellular
localization
wolf |
|
cyto 6,
cyto_nucl 5,
cyto_pero 4,
nucl 3
|
(predict for NP_001355590.1)
|
|
cyto 6,
cyto_nucl 5,
cyto_pero 4,
nucl 3
|
(predict for NP_035318.2)
|
|
| Gene coexpression |
Network*for
coexpressed
genes |
| KEGG* ID |
Title |
#genes |
Link to the KEGG* map
(Multiple genes) |
| mmu03050 |
Proteasome |
14 |
 |
| mmu05010 |
Alzheimer disease |
14 |
 |
| mmu05012 |
Parkinson disease |
14 |
 |
| mmu05014 |
Amyotrophic lateral sclerosis |
14 |
 |
| mmu05016 |
Huntington disease |
14 |
 |
Genes directly connected with Psmc2 on the network
| coex z* |
Locus |
Function* |
Coexpression
detail |
CoexPub |
Entrez Gene ID* |
| 14.9 |
Psmd12 |
proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 |
[detail] |
4 |
66997 |
| 14.9 |
Psmc3 |
proteasome (prosome, macropain) 26S subunit, ATPase 3 |
[detail] |
2 |
19182 |
| 14.5 |
Psmc1 |
protease (prosome, macropain) 26S subunit, ATPase 1 |
[detail] |
1 |
19179 |
| 12.0 |
Psmd1 |
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 |
[detail] |
2 |
70247 |
| 12.0 |
Psmd14 |
proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 |
[detail] |
1 |
59029 |
| 11.7 |
Psmd7 |
proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 |
[detail] |
1 |
17463 |
| 10.4 |
Cops5 |
COP9 signalosome subunit 5 |
[detail] |
0 |
26754 |
| 10.1 |
Psmd11 |
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 |
[detail] |
2 |
69077 |
| 8.9 |
Ddx1 |
DEAD box helicase 1 |
[detail] |
0 |
104721 |
| 8.5 |
Ufd1 |
ubiquitin recognition factor in ER-associated degradation 1 |
[detail] |
0 |
22230 |
| 8.5 |
Cops6 |
COP9 signalosome subunit 6 |
[detail] |
0 |
26893 |
| 7.4 |
Nmt1 |
N-myristoyltransferase 1 |
[detail] |
0 |
18107 |
| 7.1 |
Mmadhc |
methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria |
[detail] |
0 |
109129 |
| 6.7 |
Med8 |
mediator complex subunit 8 |
[detail] |
0 |
80509 |
|
Coexpressed
gene list |
[Coexpressed gene list for Psmc2]
|
| Gene expression |
| All samples |
[Expression pattern for all samples]
|
| Tissue specificity* |
|
Psmc2 Gene
