[←][→] mmu  Npm1 Gene
functional annotation
Function   nucleophosmin 1  
GO BP
GO:0060735 [list] [network] regulation of eIF2 alpha phosphorylation by dsRNA  (1 genes)  ISO  
GO:1902629 [list] [network] regulation of mRNA stability involved in cellular response to UV  (1 genes)  ISO  
GO:0006407 [list] [network] rRNA export from nucleus  (2 genes)  IBA IDA IMP  
GO:0000448 [list] [network] cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)  (3 genes)  ISO  
GO:0060699 [list] [network] regulation of endoribonuclease activity  (3 genes)  ISO  
GO:0010825 [list] [network] positive regulation of centrosome duplication  (6 genes)  IGI  
GO:1904751 [list] [network] positive regulation of protein localization to nucleolus  (6 genes)  IMP  
GO:0032071 [list] [network] regulation of endodeoxyribonuclease activity  (7 genes)  ISO  
GO:0044387 [list] [network] negative regulation of protein kinase activity by regulation of protein phosphorylation  (8 genes)  ISO  
GO:0000055 [list] [network] ribosomal large subunit export from nucleus  (9 genes)  IBA IMP  
GO:0000056 [list] [network] ribosomal small subunit export from nucleus  (9 genes)  IBA IDA  
GO:1900264 [list] [network] positive regulation of DNA-directed DNA polymerase activity  (10 genes)  ISO  
GO:0010826 [list] [network] negative regulation of centrosome duplication  (11 genes)  ISO  
GO:0046599 [list] [network] regulation of centriole replication  (20 genes)  ISO  
GO:0009303 [list] [network] rRNA transcription  (21 genes)  ISO  
GO:0048025 [list] [network] negative regulation of mRNA splicing, via spliceosome  (24 genes)  IDA  
GO:1902751 [list] [network] positive regulation of cell cycle G2/M phase transition  (30 genes)  ISO  
GO:0006884 [list] [network] cell volume homeostasis  (35 genes)  IDA IMP  
GO:0010667 [list] [network] negative regulation of cardiac muscle cell apoptotic process  (35 genes)  ISO  
GO:0043516 [list] [network] regulation of DNA damage response, signal transduction by p53 class mediator  (35 genes)  IGI  
GO:0010824 [list] [network] regulation of centrosome duplication  (46 genes)  IBA IMP  
GO:0045740 [list] [network] positive regulation of DNA replication  (47 genes)  ISO  
GO:0031648 [list] [network] protein destabilization  (56 genes)  IMP  
GO:0042273 [list] [network] ribosomal large subunit biogenesis  (72 genes)  IBA IDA IMP  
GO:0042274 [list] [network] ribosomal small subunit biogenesis  (72 genes)  IBA IDA IMP  
GO:0006334 [list] [network] nucleosome assembly  (81 genes)  ISO  
GO:0007098 [list] [network] centrosome cycle  (83 genes)  ISO  
GO:0034644 [list] [network] cellular response to UV  (89 genes)  ISO  
GO:0007569 [list] [network] cell aging  (115 genes)  ISO  
GO:0031398 [list] [network] positive regulation of protein ubiquitination  (122 genes)  IMP  
GO:0045727 [list] [network] positive regulation of translation  (130 genes)  ISO  
GO:0051092 [list] [network] positive regulation of NF-kappaB transcription factor activity  (152 genes)  ISO  
GO:0006338 [list] [network] chromatin remodeling  (155 genes)  IBA  
GO:0050680 [list] [network] negative regulation of epithelial cell proliferation  (171 genes)  ISO  
GO:0043524 [list] [network] negative regulation of neuron apoptotic process  (186 genes)  ISO  
GO:0050821 [list] [network] protein stabilization  (188 genes)  IGI IMP  
GO:0006913 [list] [network] nucleocytoplasmic transport  (219 genes)  IDA ISO  
GO:0051054 [list] [network] positive regulation of DNA metabolic process  (221 genes)  ISO  
GO:0043523 [list] [network] regulation of neuron apoptotic process  (279 genes)  ISO  
GO:0031647 [list] [network] regulation of protein stability  (305 genes)  IMP  
GO:0045860 [list] [network] positive regulation of protein kinase activity  (357 genes)  IDA  
GO:0006281 [list] [network] DNA repair  (450 genes)  ISO  
GO:0001558 [list] [network] regulation of cell growth  (452 genes)  IDA  
GO:0010608 [list] [network] posttranscriptional regulation of gene expression  (555 genes)  IMP  
GO:0008285 [list] [network] negative regulation of cell population proliferation  (764 genes)  ISO  
GO:0043066 [list] [network] negative regulation of apoptotic process  (968 genes)  IMP ISO  
GO:0051726 [list] [network] regulation of cell cycle  (1007 genes)  IMP  
GO:0008284 [list] [network] positive regulation of cell population proliferation  (1011 genes)  IDA IMP ISO  
GO:0043085 [list] [network] positive regulation of catalytic activity  (1060 genes)  ISO  
GO:0010629 [list] [network] negative regulation of gene expression  (1078 genes)  IGI  
GO:0045944 [list] [network] positive regulation of transcription by RNA polymerase II  (1250 genes)  IBA IMP ISO  
GO:0045893 [list] [network] positive regulation of transcription, DNA-templated  (1550 genes)  ISO  
GO:0031328 [list] [network] positive regulation of cellular biosynthetic process  (1899 genes)  IDA IMP  
GO:0008104 [list] [network] protein localization  (1925 genes)  IMP ISO  
GO CC
GO:0001652 [list] [network] granular component  (8 genes)  IDA  
GO:0031616 [list] [network] spindle pole centrosome  (20 genes)  ISO  
GO:0015935 [list] [network] small ribosomal subunit  (80 genes)  IDA  
GO:0016363 [list] [network] nuclear matrix  (89 genes)  ISO  
GO:0015934 [list] [network] large ribosomal subunit  (122 genes)  IDA  
GO:0032993 [list] [network] protein-DNA complex  (163 genes)  ISO  
GO:0016607 [list] [network] nuclear speck  (342 genes)  IDA  
GO:0005813 [list] [network] centrosome  (622 genes)  IBA IDA ISO  
GO:1990904 [list] [network] ribonucleoprotein complex  (831 genes)  IBA ISO  
GO:0005730 [list] [network] nucleolus  (895 genes)  IBA IDA ISO  
GO:0005856 [list] [network] cytoskeleton  (2248 genes)  IEA  
GO:0005654 [list] [network] nucleoplasm  (3580 genes)  IBA IDA ISO  
GO:0005829 [list] [network] cytosol  (3785 genes)  IDA  
GO:0032991 [list] [network] protein-containing complex  (5540 genes)  ISO  
GO:0005634 [list] [network] nucleus  (7226 genes)  IDA ISO  
GO:0005737 [list] [network] cytoplasm  (11434 genes)  IBA IDA ISO  
GO MF
GO:0030957 [list] [network] Tat protein binding  (9 genes)  ISO  
GO:0043024 [list] [network] ribosomal small subunit binding  (16 genes)  ISO  
GO:0043422 [list] [network] protein kinase B binding  (17 genes)  ISO  
GO:0043023 [list] [network] ribosomal large subunit binding  (21 genes)  ISO  
GO:0051059 [list] [network] NF-kappaB binding  (31 genes)  ISO  
GO:0005547 [list] [network] phosphatidylinositol-3,4,5-trisphosphate binding  (41 genes)  ISO  
GO:0001046 [list] [network] core promoter sequence-specific DNA binding  (49 genes)  ISO  
GO:0004860 [list] [network] protein kinase inhibitor activity  (62 genes)  ISO  
GO:0019843 [list] [network] rRNA binding  (75 genes)  IDA  
GO:0002039 [list] [network] p53 binding  (76 genes)  ISO  
GO:0051082 [list] [network] unfolded protein binding  (86 genes)  ISO  
GO:0047485 [list] [network] protein N-terminus binding  (131 genes)  IPI  
GO:0003713 [list] [network] transcription coactivator activity  (253 genes)  ISO  
GO:0042393 [list] [network] histone binding  (286 genes)  IBA ISO  
GO:0140297 [list] [network] DNA-binding transcription factor binding  (410 genes)  ISO  
GO:0003682 [list] [network] chromatin binding  (648 genes)  IBA  
GO:0008134 [list] [network] transcription factor binding  (673 genes)  ISO  
GO:0019901 [list] [network] protein kinase binding  (774 genes)  ISO  
GO:0042803 [list] [network] protein homodimerization activity  (780 genes)  ISO  
GO:0003723 [list] [network] RNA binding  (1194 genes)  IBA IDA ISO  
GO:0005524 [list] [network] ATP binding  (1396 genes)  ISO  
GO:0019899 [list] [network] enzyme binding  (2298 genes)  ISO  
GO:0003677 [list] [network] DNA binding  (2338 genes)  ISO  
GO:0042802 [list] [network] identical protein binding  (2357 genes)  IPI ISO  
GO:0003676 [list] [network] nucleic acid binding  (3446 genes)  IEA  
GO:0005515 [list] [network] protein binding  (9507 genes)  IPI  
KEGG
Protein NP_001239189.1  NP_001239190.1  NP_032748.1 
BLAST NP_001239189.1  NP_001239190.1  NP_032748.1 
Orthologous [Ortholog page] NPM1 (hsa)  NPM3 (hsa)  NPM2 (hsa)  Npm3 (mmu)  Npm1 (rno)  Nph (dme)  Nlp (dme)  npm1a (dre)  Npm2 (rno)  Npm2 (mmu)  NPM1 (gga)  NPM2 (cfa)  NPM3 (cfa)  NPM1 (cfa)  Npm3 (rno)  npm3 (dre)  npm1b (dre)  npm2b (dre)  LOC608047 (cfa)  LOC697644 (mcc)  NPM1 (mcc)  NPM3 (mcc)  NPM2 (mcc)  NPM3 (gga)  npm2a (dre)  NPM1 (fca)  NPM3 (fca)  NPM2 (fca)  NPM2 (gga)  LOC114676394 (mcc)  LOC117654556 (gga) 
Subcellular
localization
wolf
nucl 8,  cyto_nucl 5,  cyto 1  (predict for NP_001239189.1)
nucl 8,  cyto 1  (predict for NP_001239190.1)
nucl 8,  cyto 2  (predict for NP_032748.1)
Gene coexpression
Network*for
coexpressed
genes
LCNloc
[Cytoscape]
KEGG* ID Title #genes Link to the KEGG* map
(Multiple genes)
mmu03010 Ribosome 6
mmu05171 Coronavirus disease - COVID-19 6
Genes directly connected with Npm1 on the network
coex z* Locus Function* Coexpression
detail		 CoexPub Entrez Gene ID*
16.0 Ncl nucleolin [detail] 29 17975
13.9 Naca nascent polypeptide-associated complex alpha polypeptide [detail] 0 17938
12.6 Rpl7 ribosomal protein L7 [detail] 1 19989
10.7 Nap1l1 nucleosome assembly protein 1-like 1 [detail] 0 53605
7.8 Sfr1 SWI5 dependent recombination repair 1 [detail] 0 67788
Coexpressed
gene list		 [Coexpressed gene list for Npm1]
Gene expression
All samples [Expression pattern for all samples]
Tissue specificity* tissue specificity
Link to other DBs
Entrez Gene ID 18148      
Refseq ID (protein) NP_001239189.1 
NP_001239190.1 
NP_032748.1 


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